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The map label for this gene is metC [H]

Identifier: 161869747

GI number: 161869747

Start: 772225

End: 773451

Strand: Reverse

Name: metC [H]

Synonym: NMCC_0767

Alternate gene names: 161869747

Gene position: 773451-772225 (Counterclockwise)

Preceding gene: 161869750

Following gene: 161869743

Centisome position: 35.92

GC content: 51.83

Gene sequence:

>1227_bases
TTGATTGTTTCTATTTTTCAGATAGTGATAAAATCTTCGATTATTCACATCTACATAGGCAGAGACCAAATGAAATTCGC
CACGAAAGCCATTCATTCCAGCTACGATTGCGACGAACACAACCGCGCGCTGATGCCGCCGATTTATCAAAACAGTATGT
TTGCGTTGCACGAGATTGGCGAAAATGTGCCTTACCGTTATTCGCGCCTGAGCAACCCGACCCGTCAGATTTTGGAAGAC
ACCGTTGCCGATTTGGAACACGGTGCGACAGGGTTTGCGTTTTCCAGCGGTATGGCGGGGATTGATGCCGTATGGCGTAC
CTTCCTGCAACAGGGCGACACCATCGTCGCGGTCGCCGATATTTACGGCGGCGCGTATGACTTATTGGTCGATGTTTATC
AAAAATGGGGGGTGAACGTTGTTTTTGCCGATTTGGGCAATCCCGATAATCTGGACGAGCTGCTCAAAGCGCACAAGGTC
AAACTGGTCTGGCTGGAAACGCCGTCCAATCCGCTTTTACGCTTGGTAGACATCAAAGCCCTTGCCGCGAAAGCCAAAGC
GACCGGCGCACTGGTCGGTATCGACAACACCTTTGCCACGCCGTATCTGCAACAGCCCTTGGATATGGGTTGCGATTTTG
TATTCCATTCCGCTACCAAATATTTGTGCGGCCATTCCGACGTATTGATGGGCATCGTCGTTGCCAAAACCAAAGAACTG
GCGCAGCCTTTGCACGATATGATGGTGCATACCGGCGCGGTTGCCGGCCCGCTGGACTGCTGGCTGGTGTTGCGCGGCAT
CAAAACGCTTGCCCTGCGTATGGAGGCACACTGCAAAAACGCACTCGAAATCGCGCGCCGTCTGGAAGACCATCCTGCCA
TTGAAAAAGTGTTCCATCCCGGCCTGCCGTCGCACGAACATTATGAACTCGCCCAAGCGCAAATGCCTAAAGGCATCGGC
GGCGTGGTGACGGTTTATCTCAAAAACGACACGCGCGAAGCGGCAAACAGCGTGATTAAAAACATGAAACTGGTCAAAAT
GGCTTCCAGCCTCGGCGGCGTGGAAAGTTTGGTCAACCATTGCTATTCCCAGTCCCACAGCGGCGTGCCGCATAATGTGA
AAATGGAAATGGGCATCAGGGTCGGTCTGCTGCGTTTCTCTGTCGGTATCGAAGATGTAGATGATATTTGGAATGATATT
TCCGCCGCACTGGATACGACTGTATAA

Upstream 100 bases:

>100_bases
ATGTAATTGTTGAGATGTGTGCATGGTATGGCGTTTCCGCCGGGGAATATACCGTCAATCTGCAAATGCGAGATTATATC
ACTCGCTTTTAGCAGCTGCA

Downstream 100 bases:

>100_bases
TCCACGAAAAATGCCGTCTGAAACCATGGTTTCAGACGGCATTTCAATCAAACCGACCGAAAATCAACGCTTCAGCATCT
TTGCCGCCTCAATGGCATAA

Product: cystathionine gamma-synthase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 408; Mature: 408

Protein sequence:

>408_residues
MIVSIFQIVIKSSIIHIYIGRDQMKFATKAIHSSYDCDEHNRALMPPIYQNSMFALHEIGENVPYRYSRLSNPTRQILED
TVADLEHGATGFAFSSGMAGIDAVWRTFLQQGDTIVAVADIYGGAYDLLVDVYQKWGVNVVFADLGNPDNLDELLKAHKV
KLVWLETPSNPLLRLVDIKALAAKAKATGALVGIDNTFATPYLQQPLDMGCDFVFHSATKYLCGHSDVLMGIVVAKTKEL
AQPLHDMMVHTGAVAGPLDCWLVLRGIKTLALRMEAHCKNALEIARRLEDHPAIEKVFHPGLPSHEHYELAQAQMPKGIG
GVVTVYLKNDTREAANSVIKNMKLVKMASSLGGVESLVNHCYSQSHSGVPHNVKMEMGIRVGLLRFSVGIEDVDDIWNDI
SAALDTTV

Sequences:

>Translated_408_residues
MIVSIFQIVIKSSIIHIYIGRDQMKFATKAIHSSYDCDEHNRALMPPIYQNSMFALHEIGENVPYRYSRLSNPTRQILED
TVADLEHGATGFAFSSGMAGIDAVWRTFLQQGDTIVAVADIYGGAYDLLVDVYQKWGVNVVFADLGNPDNLDELLKAHKV
KLVWLETPSNPLLRLVDIKALAAKAKATGALVGIDNTFATPYLQQPLDMGCDFVFHSATKYLCGHSDVLMGIVVAKTKEL
AQPLHDMMVHTGAVAGPLDCWLVLRGIKTLALRMEAHCKNALEIARRLEDHPAIEKVFHPGLPSHEHYELAQAQMPKGIG
GVVTVYLKNDTREAANSVIKNMKLVKMASSLGGVESLVNHCYSQSHSGVPHNVKMEMGIRVGLLRFSVGIEDVDDIWNDI
SAALDTTV
>Mature_408_residues
MIVSIFQIVIKSSIIHIYIGRDQMKFATKAIHSSYDCDEHNRALMPPIYQNSMFALHEIGENVPYRYSRLSNPTRQILED
TVADLEHGATGFAFSSGMAGIDAVWRTFLQQGDTIVAVADIYGGAYDLLVDVYQKWGVNVVFADLGNPDNLDELLKAHKV
KLVWLETPSNPLLRLVDIKALAAKAKATGALVGIDNTFATPYLQQPLDMGCDFVFHSATKYLCGHSDVLMGIVVAKTKEL
AQPLHDMMVHTGAVAGPLDCWLVLRGIKTLALRMEAHCKNALEIARRLEDHPAIEKVFHPGLPSHEHYELAQAQMPKGIG
GVVTVYLKNDTREAANSVIKNMKLVKMASSLGGVESLVNHCYSQSHSGVPHNVKMEMGIRVGLLRFSVGIEDVDDIWNDI
SAALDTTV

Specific function: The enzymatic degradation of amino acids in cheese is believed to generate aroma compounds and therefore to be essential for flavor development. Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine but is also able to catalyze an alpha

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=366, Percent_Identity=40.1639344262295, Blast_Score=261, Evalue=9e-70,
Organism=Homo sapiens, GI299473759, Length=366, Percent_Identity=37.7049180327869, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI25453487, Length=365, Percent_Identity=35.8904109589041, Blast_Score=208, Evalue=6e-54,
Organism=Escherichia coli, GI1790375, Length=376, Percent_Identity=39.3617021276596, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI1789383, Length=347, Percent_Identity=29.971181556196, Blast_Score=143, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17560056, Length=370, Percent_Identity=40.8108108108108, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17538055, Length=370, Percent_Identity=40.8108108108108, Blast_Score=266, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI71980708, Length=372, Percent_Identity=34.6774193548387, Blast_Score=216, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6319307, Length=387, Percent_Identity=38.7596899224806, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6323333, Length=434, Percent_Identity=31.5668202764977, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6321254, Length=404, Percent_Identity=30.1980198019802, Blast_Score=169, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6321904, Length=344, Percent_Identity=29.9418604651163, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6321170, Length=325, Percent_Identity=29.8461538461538, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6322970, Length=349, Percent_Identity=24.9283667621776, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922554, Length=386, Percent_Identity=40.6735751295337, Blast_Score=288, Evalue=5e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44916; Mature: 44916

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVSIFQIVIKSSIIHIYIGRDQMKFATKAIHSSYDCDEHNRALMPPIYQNSMFALHEIG
CHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCHHHHHHHC
ENVPYRYSRLSNPTRQILEDTVADLEHGATGFAFSSGMAGIDAVWRTFLQQGDTIVAVAD
CCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHCCCEEEEEHH
IYGGAYDLLVDVYQKWGVNVVFADLGNPDNLDELLKAHKVKLVWLETPSNPLLRLVDIKA
HCCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCEEEEEEECCCCCCEEHHHHHH
LAAKAKATGALVGIDNTFATPYLQQPLDMGCDFVFHSATKYLCGHSDVLMGIVVAKTKEL
HHHHHHHCEEEEECCCCCCCHHHHCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AQPLHDMMVHTGAVAGPLDCWLVLRGIKTLALRMEAHCKNALEIARRLEDHPAIEKVFHP
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCC
GLPSHEHYELAQAQMPKGIGGVVTVYLKNDTREAANSVIKNMKLVKMASSLGGVESLVNH
CCCCCCHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
CYSQSHSGVPHNVKMEMGIRVGLLRFSVGIEDVDDIWNDISAALDTTV
HHHCCCCCCCCCEEEECCCEEEEHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIVSIFQIVIKSSIIHIYIGRDQMKFATKAIHSSYDCDEHNRALMPPIYQNSMFALHEIG
CHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCHHCCCHHHHHHHC
ENVPYRYSRLSNPTRQILEDTVADLEHGATGFAFSSGMAGIDAVWRTFLQQGDTIVAVAD
CCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHCCCEEEEEHH
IYGGAYDLLVDVYQKWGVNVVFADLGNPDNLDELLKAHKVKLVWLETPSNPLLRLVDIKA
HCCCHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHCEEEEEEECCCCCCEEHHHHHH
LAAKAKATGALVGIDNTFATPYLQQPLDMGCDFVFHSATKYLCGHSDVLMGIVVAKTKEL
HHHHHHHCEEEEECCCCCCCHHHHCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AQPLHDMMVHTGAVAGPLDCWLVLRGIKTLALRMEAHCKNALEIARRLEDHPAIEKVFHP
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCC
GLPSHEHYELAQAQMPKGIGGVVTVYLKNDTREAANSVIKNMKLVKMASSLGGVESLVNH
CCCCCCHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
CYSQSHSGVPHNVKMEMGIRVGLLRFSVGIEDVDDIWNDISAALDTTV
HHHCCCCCCCCCEEEECCCEEEEHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]