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The map label for this gene is lysA [H]

Identifier: 161869233

GI number: 161869233

Start: 246772

End: 248016

Strand: Direct

Name: lysA [H]

Synonym: NMCC_0237

Alternate gene names: 161869233

Gene position: 246772-248016 (Clockwise)

Preceding gene: 161869232

Following gene: 161869235

Centisome position: 11.46

GC content: 55.02

Gene sequence:

>1245_bases
ATGACCCTATTTTGCGAACAAGTCCCCTACCCCCGCCTTGCCGAAGCATTCGGCACACCGCTTTATGTGTACAGCCAATC
CGCGCTGACCGAAGCATTTGAACACTACCAAACTGCCTTTGCCGAGCTCTCCCCGCTCGTCTGCTATGCGGTTAAAGCCA
ATGGCAACCTGAGCATCATCAAACACTTTGCTTCTTTGGGGAGCGGTTTTGACATTGTGTCCGGCGGCGAATTGGCACGC
GTTTTGGCGGCAGGCGGCGACGCGGCAAAAACCATATTTTCAGGCGTAGGCAAAAGCGAGGCGGAAATCGAGTTCGCGCT
GAATGCAGGCGTGAAATGCTTCAATATGGAAAGCATCCCCGAAATCGACCGTATTCAGAAAGTTGCCGCGCGTTTGGGTA
AAACCGCGCCCGTCTCCCTGCGCGTCAACCCCGATGTCGATGCCAAAACCCATCCCTACATCTCCACAGGTCTGAAAGCC
AACAAATTCGGCATCGCCTACGCCGACGCGCTCGAAGCCTACCGCCATGCCGCACAACAGCCCAATTTGAAAATCATCGG
CATCGACTGCCACATCGGCTCCCAACTAACCGACTTAAGCCCGCTGGTCGAAGCCTGCGAACGCATTTTGATTTTGGTTG
ACGCGCTTGCCGCCGAAGGCATTGTTTTGGAACATTTGGACTTAGGCGGCGGCGTCGGCATTGTTTACCAAAACGAAAAA
GTGCCTGATTTGGGCGCGTATGCCCAAGCGGTTCAAAAACTGATCGGCACACGCCGTCTGAAACTCATTCTTGAGCCCGG
CCGCAGCTTGGTCGGCAACGCAGGCGCGTTGTTGACGCGTGTCGAATTCGTCAAATACGGCGAAGAGAAAAACTTTGTGA
TGGTCGATGCGGCGATGAACGATTTAATGCGCCCCGCCCTATATGATGCCTATCATCACATCGAAGCGGTAGAACCAAAA
AACATCGCGCCGCTGACTGCCAACATCGTCGGCCCGATTTGTGAAACCGGCGACTTCCTCGGCAAAGACCGCACCATCGC
CTGCGAAGAAGGGGATTTGCTGCTTATCCGCAGCGCGGGCGCATACGGAGCCAGTATGGCGAGCAATTACAACGCGCGCA
ACCGTGCGGCGGAAGTGTTGGTTAACGGTGGCGGATACAAACTCATCCGCCGACGCGAAACCTTAGAACAGCAAATGGCA
AACGAACTCGCCTGCCTGCAAGCCGAACATCAAAATGCCGTCTGA

Upstream 100 bases:

>100_bases
AAAGAAGGCGACAAGGCGCGTTTCGGCGTAATCCAAACCGGTTTGCAGCTTCAAGGCAAACCGCAATCCGCCCCTCCAAC
CCAAAAATGAAAACGAAAAT

Downstream 100 bases:

>100_bases
AGCGGTTCAGACGGCATTTTTAACGCTCTAAAGGCTTACTCGTTCGGCAGCCTTAACAGGGAAAGCAGCAGCCCTCCCCA
GATTATCACGATTGAGACAA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MTLFCEQVPYPRLAEAFGTPLYVYSQSALTEAFEHYQTAFAELSPLVCYAVKANGNLSIIKHFASLGSGFDIVSGGELAR
VLAAGGDAAKTIFSGVGKSEAEIEFALNAGVKCFNMESIPEIDRIQKVAARLGKTAPVSLRVNPDVDAKTHPYISTGLKA
NKFGIAYADALEAYRHAAQQPNLKIIGIDCHIGSQLTDLSPLVEACERILILVDALAAEGIVLEHLDLGGGVGIVYQNEK
VPDLGAYAQAVQKLIGTRRLKLILEPGRSLVGNAGALLTRVEFVKYGEEKNFVMVDAAMNDLMRPALYDAYHHIEAVEPK
NIAPLTANIVGPICETGDFLGKDRTIACEEGDLLLIRSAGAYGASMASNYNARNRAAEVLVNGGGYKLIRRRETLEQQMA
NELACLQAEHQNAV

Sequences:

>Translated_414_residues
MTLFCEQVPYPRLAEAFGTPLYVYSQSALTEAFEHYQTAFAELSPLVCYAVKANGNLSIIKHFASLGSGFDIVSGGELAR
VLAAGGDAAKTIFSGVGKSEAEIEFALNAGVKCFNMESIPEIDRIQKVAARLGKTAPVSLRVNPDVDAKTHPYISTGLKA
NKFGIAYADALEAYRHAAQQPNLKIIGIDCHIGSQLTDLSPLVEACERILILVDALAAEGIVLEHLDLGGGVGIVYQNEK
VPDLGAYAQAVQKLIGTRRLKLILEPGRSLVGNAGALLTRVEFVKYGEEKNFVMVDAAMNDLMRPALYDAYHHIEAVEPK
NIAPLTANIVGPICETGDFLGKDRTIACEEGDLLLIRSAGAYGASMASNYNARNRAAEVLVNGGGYKLIRRRETLEQQMA
NELACLQAEHQNAV
>Mature_413_residues
TLFCEQVPYPRLAEAFGTPLYVYSQSALTEAFEHYQTAFAELSPLVCYAVKANGNLSIIKHFASLGSGFDIVSGGELARV
LAAGGDAAKTIFSGVGKSEAEIEFALNAGVKCFNMESIPEIDRIQKVAARLGKTAPVSLRVNPDVDAKTHPYISTGLKAN
KFGIAYADALEAYRHAAQQPNLKIIGIDCHIGSQLTDLSPLVEACERILILVDALAAEGIVLEHLDLGGGVGIVYQNEKV
PDLGAYAQAVQKLIGTRRLKLILEPGRSLVGNAGALLTRVEFVKYGEEKNFVMVDAAMNDLMRPALYDAYHHIEAVEPKN
IAPLTANIVGPICETGDFLGKDRTIACEEGDLLLIRSAGAYGASMASNYNARNRAAEVLVNGGGYKLIRRRETLEQQMAN
ELACLQAEHQNAV

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=423, Percent_Identity=25.531914893617, Blast_Score=96, Evalue=8e-20,
Organism=Escherichia coli, GI1789203, Length=418, Percent_Identity=34.688995215311, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17562780, Length=372, Percent_Identity=23.9247311827957, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24586472, Length=380, Percent_Identity=25.5263157894737, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24586474, Length=369, Percent_Identity=25.7452574525745, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 44539; Mature: 44407

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLFCEQVPYPRLAEAFGTPLYVYSQSALTEAFEHYQTAFAELSPLVCYAVKANGNLSII
CCEECCCCCCCHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHH
KHFASLGSGFDIVSGGELARVLAAGGDAAKTIFSGVGKSEAEIEFALNAGVKCFNMESIP
HHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCCC
EIDRIQKVAARLGKTAPVSLRVNPDVDAKTHPYISTGLKANKFGIAYADALEAYRHAAQQ
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHCC
PNLKIIGIDCHIGSQLTDLSPLVEACERILILVDALAAEGIVLEHLDLGGGVGIVYQNEK
CCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEECCCC
VPDLGAYAQAVQKLIGTRRLKLILEPGRSLVGNAGALLTRVEFVKYGEEKNFVMVDAAMN
CCCHHHHHHHHHHHHCCHHEEEEECCCCHHHCCCHHHHHHHHHHHCCCCCCEEEEHHHHH
DLMRPALYDAYHHIEAVEPKNIAPLTANIVGPICETGDFLGKDRTIACEEGDLLLIRSAG
HHHHHHHHHHHHHHCCCCCCCCCCEEHHHHCCHHHCCCCCCCCCEEEECCCCEEEEEECC
AYGASMASNYNARNRAAEVLVNGGGYKLIRRRETLEQQMANELACLQAEHQNAV
CCCHHHHCCCCHHCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TLFCEQVPYPRLAEAFGTPLYVYSQSALTEAFEHYQTAFAELSPLVCYAVKANGNLSII
CEECCCCCCCHHHHHHCCEEEEECHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHH
KHFASLGSGFDIVSGGELARVLAAGGDAAKTIFSGVGKSEAEIEFALNAGVKCFNMESIP
HHHHHHCCCCCCCCCCHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEECCCEEEECCCCCC
EIDRIQKVAARLGKTAPVSLRVNPDVDAKTHPYISTGLKANKFGIAYADALEAYRHAAQQ
HHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHCCCCCCCCCCHHHHHHHHHHHHHCC
PNLKIIGIDCHIGSQLTDLSPLVEACERILILVDALAAEGIVLEHLDLGGGVGIVYQNEK
CCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEECCCC
VPDLGAYAQAVQKLIGTRRLKLILEPGRSLVGNAGALLTRVEFVKYGEEKNFVMVDAAMN
CCCHHHHHHHHHHHHCCHHEEEEECCCCHHHCCCHHHHHHHHHHHCCCCCCEEEEHHHHH
DLMRPALYDAYHHIEAVEPKNIAPLTANIVGPICETGDFLGKDRTIACEEGDLLLIRSAG
HHHHHHHHHHHHHHCCCCCCCCCCEEHHHHCCHHHCCCCCCCCCEEEECCCCEEEEEECC
AYGASMASNYNARNRAAEVLVNGGGYKLIRRRETLEQQMANELACLQAEHQNAV
CCCHHHHCCCCHHCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10710307 [H]