| Definition | Burkholderia multivorans ATCC 17616 chromosome chromosome 1, complete sequence. |
|---|---|
| Accession | NC_010084 |
| Length | 3,448,466 |
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The map label for this gene is gyrA [H]
Identifier: 161525434
GI number: 161525434
Start: 2478091
End: 2480694
Strand: Reverse
Name: gyrA [H]
Synonym: Bmul_2264
Alternate gene names: 161525434
Gene position: 2480694-2478091 (Counterclockwise)
Preceding gene: 161525438
Following gene: 161525433
Centisome position: 71.94
GC content: 64.82
Gene sequence:
>2604_bases ATGGATCAATTCGCCAAAGAGACCCTGCCCACCTCCCTCGAGGAGGAAATGCGCCGTTCGTATCTCGATTACGCGATGAG CGTGATCGTCGGACGTGCCCTCCCGGATGTCCGCGATGGCCTGAAGCCCGTGCACCGGCGCGTACTGTTCGCGATGCACG AACTGAACAACGACTGGAACCGGGCCTACAAGAAGTCGGCGCGTATCGTCGGCGACGTGATCGGTAAATACCACCCGCAC GGCGACAGCGCGGTCTACGAAACGATCGTGCGGATGGCGCAGGACTTCTCGCTGCGCTACATGCTGGTCGACGGGCAAGG CAACTTCGGCTCGATCGACGGCGACAACGCCGCCGCGATGCGTTACACCGAAATTCGCATGGCGAAGATCGGTCACGAGC TGCTTGCCGACATCGACAAGGAAACGGTCGACTTCGGCCCGAACTACGACGGCAGCGAAATGCAGCCGCTGATCCTGCCC GCGCGGATCCCGAACCTGCTGATCAACGGTTCGTCGGGCATCGCGGTCGGCATGGCCACCAACATTCCGCCGCACAACCT GAACGAAGTCGTCGATGCCTGCCAGCATCTGCTGAACAATCCCGACGCGACGATCGACGAGCTGATCGAGATCATCCCGG CGCCCGATTTCCCGACGGCCGGCATCATCTACGGCGTCGCCGGCGTGCGCGACGGCTACCGCACCGGGCGCGGCCGCGTC GTGATGCGCGCGGCCACGCACTTCGAGGAAATCGACCGCGGCCAGCGCATGGCGATCATCGTCGACGAGCTGCCGTACCA GGTCAACAAGCGCTCGCTGCTCGAGCGCATCGCCGAGCTCGTCAACGAGAAGAAGCTCGAGGGCATCTCCGATATCCGCG ACGAGTCCGACAAGAGCGGCATGCGCGTCGTGATCGAGCTCAAGCGCGGCGAAGTGCCGGAAGTGGTGCTGAACAACCTC TACAAGGCGACGCAGCTGCAGGACACGTTCGGCATGAACATGGTCGCGCTCGTCGACGGCCAGCCGAAGCTGCTGAACCT GAAGGAAATCCTTCAGTGCTTCCTGTCGCACCGCCGCGAAGTGCTGACGCGCCGCACGGTCTACGAACTGCGCAAGGCGC GCGAACGCGGCCACGTGCTCGAAGGTCTCGCGGTCGCGCTCGCGAACATCGACGAATTCATCGCGATCATCAAGGCCGCG CCGACGCCGCCGATCGCGAAGCAGGAACTGATGGCGAAGGCGTGGGATTCGTCGCTCGTGCGCGAGATGCTCACGCGCGC CGAAGCCGAGAACGCGGCGGCCGGCGGCCGCGCGGCGTATCGTCCGGAAGGGCTGAACCCGGCGTTCGGGATGCAGGGCG ACGGGCTCTACAAGCTGTCCGACACGCAGGCGCAGGAAATTCTGCAGATGCGTCTGCAGCGCCTGACGGGCCTCGAGCAG GACAAGATCATCGGCGAGTATCGCGACGTGATGGCGCAGATCTCCGATCTGCTCGACATCCTCGCGCGTCCGGAGCGGAT CACGACGATGATCGGCGAAGAGCTGACCACGGTGAAGGCCGAGTTCGGCGACGCGCGCCGCTCGAAGATCGAGCTGAACG CGACCGAGCTCAACACCGAAGACCTGATCACGCCGCAGGACATGGTCGTCACGATGTCGCACGCGGGCTACGTGAAGTCG CAGCCGCTGTCCGAGTACCGCGCGCAGAAGCGCGGCGGTCGCGGCAAGCAGGCGACGCAGATGAAGGAAGACGACTGGAT CGAGACGCTGTTCATCGCGAACACGCACGATTACATGCTCTGCTTCTCGAACCGCGGCCGCGTGTACTGGATCAAGGTCT ACGAGGTGCCGCAGGGCTCGCGCAACTCGCGCGGCCGTCCGATCGTCAACATGTTCCCGCTGCAGGACGGCGAGAAGATC AACGTCGTGCTGCCGGTGAAGGAATTCTCGGCCGACAAGTTCGTGTTCATGGCGACGTCGCTCGGCACCGTGAAGAAGAC GCCGCTCGAGGCATTCAGCCGACCGATGAAGAAGGGCATCATCGCGGTCGGCCTCGACGAGGGCGACTACCTGATCGGCG CGTCGATCACCGACGGTGCGCACGACGTGATGCTGTTCTCCGACGCCGGCAAGGCCGTGCGCTTCGACGAGAACGACGTG CGGCCGATGGGGCGCGAAGCGCGCGGCGTGCGCGGCATGCAGCTCGACGAAGGGCAGCAGGTCATCGCGCTGCTGGTGGC CGGCAGCGAAGACCAGTCGGTGCTCACCGCGACCGAGAACGGCTTCGGCAAGCGCACGCCGATCACCGAATACACGCGCC ACGGCCGCGGCACGAAGGGTATGATCGCGATCCAGACGTCCGAGCGTAACGGCAAGGTCGTCGCGGCGACGCTCGTCGAC GCCGAAGACCAGATCATGCTGATCACGACGGCCGGCGTGCTGATCCGCACGCGCGTGTCGGAGATCCGCGAGATGGGACG CGCGACGCAAGGTGTTACACTCATCAGTCTCGATGAGGGTACGAAGCTCTCTGGCCTGCAGCAGATCGCCGAGGCCGAGG ACGGTGACGGCGAAGCCGACGAGGCGTCGGACGGCGAAGCCTGA
Upstream 100 bases:
>100_bases TTGGCGGCTGTTGGGCGCATGTTAGAATCTCACGTTGCGTTGCGCATGCATCGCTCACGCGAAAGGCGTTCCCGTCTTCG CTCCGAAAAGATACGGATAC
Downstream 100 bases:
>100_bases ACGGATGAGACTCTCGGGCCGCCGCACGCGTGCCGCGCAAGCGGGTGAGCGCAGCACGCTGCGATCGGCGAGAAAACATT CATATTTCCAAGAGGGAGTG
Product: DNA gyrase subunit A
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 867; Mature: 867
Protein sequence:
>867_residues MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRAYKKSARIVGDVIGKYHPH GDSAVYETIVRMAQDFSLRYMLVDGQGNFGSIDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILP ARIPNLLINGSSGIAVGMATNIPPHNLNEVVDACQHLLNNPDATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL YKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRREVLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAA PTPPIAKQELMAKAWDSSLVREMLTRAEAENAAAGGRAAYRPEGLNPAFGMQGDGLYKLSDTQAQEILQMRLQRLTGLEQ DKIIGEYRDVMAQISDLLDILARPERITTMIGEELTTVKAEFGDARRSKIELNATELNTEDLITPQDMVVTMSHAGYVKS QPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYMLCFSNRGRVYWIKVYEVPQGSRNSRGRPIVNMFPLQDGEKI NVVLPVKEFSADKFVFMATSLGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDAGKAVRFDENDV RPMGREARGVRGMQLDEGQQVIALLVAGSEDQSVLTATENGFGKRTPITEYTRHGRGTKGMIAIQTSERNGKVVAATLVD AEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEAEDGDGEADEASDGEA
Sequences:
>Translated_867_residues MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRAYKKSARIVGDVIGKYHPH GDSAVYETIVRMAQDFSLRYMLVDGQGNFGSIDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILP ARIPNLLINGSSGIAVGMATNIPPHNLNEVVDACQHLLNNPDATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL YKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRREVLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAA PTPPIAKQELMAKAWDSSLVREMLTRAEAENAAAGGRAAYRPEGLNPAFGMQGDGLYKLSDTQAQEILQMRLQRLTGLEQ DKIIGEYRDVMAQISDLLDILARPERITTMIGEELTTVKAEFGDARRSKIELNATELNTEDLITPQDMVVTMSHAGYVKS QPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYMLCFSNRGRVYWIKVYEVPQGSRNSRGRPIVNMFPLQDGEKI NVVLPVKEFSADKFVFMATSLGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDAGKAVRFDENDV RPMGREARGVRGMQLDEGQQVIALLVAGSEDQSVLTATENGFGKRTPITEYTRHGRGTKGMIAIQTSERNGKVVAATLVD AEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEAEDGDGEADEASDGEA >Mature_867_residues MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWNRAYKKSARIVGDVIGKYHPH GDSAVYETIVRMAQDFSLRYMLVDGQGNFGSIDGDNAAAMRYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILP ARIPNLLINGSSGIAVGMATNIPPHNLNEVVDACQHLLNNPDATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL YKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRREVLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAA PTPPIAKQELMAKAWDSSLVREMLTRAEAENAAAGGRAAYRPEGLNPAFGMQGDGLYKLSDTQAQEILQMRLQRLTGLEQ DKIIGEYRDVMAQISDLLDILARPERITTMIGEELTTVKAEFGDARRSKIELNATELNTEDLITPQDMVVTMSHAGYVKS QPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYMLCFSNRGRVYWIKVYEVPQGSRNSRGRPIVNMFPLQDGEKI NVVLPVKEFSADKFVFMATSLGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDAGKAVRFDENDV RPMGREARGVRGMQLDEGQQVIALLVAGSEDQSVLTATENGFGKRTPITEYTRHGRGTKGMIAIQTSERNGKVVAATLVD AEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEGTKLSGLQQIAEAEDGDGEADEASDGEA
Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]
COG id: COG0188
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]
Homologues:
Organism=Homo sapiens, GI19913408, Length=378, Percent_Identity=25.9259259259259, Blast_Score=93, Evalue=1e-18, Organism=Homo sapiens, GI19913406, Length=320, Percent_Identity=25.625, Blast_Score=91, Evalue=5e-18, Organism=Escherichia coli, GI1788562, Length=870, Percent_Identity=60, Blast_Score=1047, Evalue=0.0, Organism=Escherichia coli, GI1789396, Length=725, Percent_Identity=36.2758620689655, Blast_Score=397, Evalue=1e-111, Organism=Caenorhabditis elegans, GI17535065, Length=493, Percent_Identity=25.7606490872211, Blast_Score=86, Evalue=1e-16, Organism=Caenorhabditis elegans, GI212645657, Length=379, Percent_Identity=25.5936675461741, Blast_Score=82, Evalue=9e-16, Organism=Caenorhabditis elegans, GI212645845, Length=171, Percent_Identity=31.5789473684211, Blast_Score=73, Evalue=7e-13, Organism=Saccharomyces cerevisiae, GI6324241, Length=347, Percent_Identity=26.8011527377522, Blast_Score=84, Evalue=1e-16, Organism=Drosophila melanogaster, GI17136538, Length=349, Percent_Identity=26.647564469914, Blast_Score=93, Evalue=7e-19,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020899 - InterPro: IPR005743 - InterPro: IPR006691 - InterPro: IPR002205 - InterPro: IPR013758 - InterPro: IPR013757 - InterPro: IPR013760 [H]
Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]
EC number: =5.99.1.3 [H]
Molecular weight: Translated: 96084; Mature: 96084
Theoretical pI: Translated: 5.11; Mature: 5.11
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 3.9 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 3.9 %Met (Mature Protein) 4.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWN CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHH RAYKKSARIVGDVIGKYHPHGDSAVYETIVRMAQDFSLRYMLVDGQGNFGSIDGDNAAAM HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE RYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILPARIPNLLINGSSGIAVGMAT EHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEEECCCCCCEEEECCCCEEEEEEC NIPPHNLNEVVDACQHLLNNPDATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCE VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSG EEHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC MRVVIELKRGEVPEVVLNNLYKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRRE CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHHHH VLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAAPTPPIAKQELMAKAWDSSLV HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH REMLTRAEAENAAAGGRAAYRPEGLNPAFGMQGDGLYKLSDTQAQEILQMRLQRLTGLEQ HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCH DKIIGEYRDVMAQISDLLDILARPERITTMIGEELTTVKAEFGDARRSKIELNATELNTE HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHEECCHH DLITPQDMVVTMSHAGYVKSQPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYML HCCCCCHHEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEE CFSNRGRVYWIKVYEVPQGSRNSRGRPIVNMFPLQDGEKINVVLPVKEFSADKFVFMATS EECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEEHHHCCCCCEEEEEEC LGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDAGKAVRFDENDV CCCCCCCCHHHHHHHHHCCEEEEEECCCCEEEEEEECCCCCEEEEEECCCCEEECCCCCC RPMGREARGVRGMQLDEGQQVIALLVAGSEDQSVLTATENGFGKRTPITEYTRHGRGTKG CCCCHHHCCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCC MIAIQTSERNGKVVAATLVDAEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEG EEEEEECCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCHHCCEEEEEECCC TKLSGLQQIAEAEDGDGEADEASDGEA CCHHHHHHHHHCCCCCCCCCCCCCCCC >Mature Secondary Structure MDQFAKETLPTSLEEEMRRSYLDYAMSVIVGRALPDVRDGLKPVHRRVLFAMHELNNDWN CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHH RAYKKSARIVGDVIGKYHPHGDSAVYETIVRMAQDFSLRYMLVDGQGNFGSIDGDNAAAM HHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE RYTEIRMAKIGHELLADIDKETVDFGPNYDGSEMQPLILPARIPNLLINGSSGIAVGMAT EHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCEEECCCCCCEEEECCCCEEEEEEC NIPPHNLNEVVDACQHLLNNPDATIDELIEIIPAPDFPTAGIIYGVAGVRDGYRTGRGRV CCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCCCE VMRAATHFEEIDRGQRMAIIVDELPYQVNKRSLLERIAELVNEKKLEGISDIRDESDKSG EEHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC MRVVIELKRGEVPEVVLNNLYKATQLQDTFGMNMVALVDGQPKLLNLKEILQCFLSHRRE CEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCEECHHHHHHHHHHHHHH VLTRRTVYELRKARERGHVLEGLAVALANIDEFIAIIKAAPTPPIAKQELMAKAWDSSLV HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH REMLTRAEAENAAAGGRAAYRPEGLNPAFGMQGDGLYKLSDTQAQEILQMRLQRLTGLEQ HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHCCCCH DKIIGEYRDVMAQISDLLDILARPERITTMIGEELTTVKAEFGDARRSKIELNATELNTE HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHEECCHH DLITPQDMVVTMSHAGYVKSQPLSEYRAQKRGGRGKQATQMKEDDWIETLFIANTHDYML HCCCCCHHEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEE CFSNRGRVYWIKVYEVPQGSRNSRGRPIVNMFPLQDGEKINVVLPVKEFSADKFVFMATS EECCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEEHHHCCCCCEEEEEEC LGTVKKTPLEAFSRPMKKGIIAVGLDEGDYLIGASITDGAHDVMLFSDAGKAVRFDENDV CCCCCCCCHHHHHHHHHCCEEEEEECCCCEEEEEEECCCCCEEEEEECCCCEEECCCCCC RPMGREARGVRGMQLDEGQQVIALLVAGSEDQSVLTATENGFGKRTPITEYTRHGRGTKG CCCCHHHCCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCCCCCCCHHHHHCCCCCCC MIAIQTSERNGKVVAATLVDAEDQIMLITTAGVLIRTRVSEIREMGRATQGVTLISLDEG EEEEEECCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCHHCCEEEEEECCC TKLSGLQQIAEAEDGDGEADEASDGEA CCHHHHHHHHHCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 7811002; 10984043 [H]