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The map label for this gene is hldE [H]

Identifier: 161525422

GI number: 161525422

Start: 2465505

End: 2466470

Strand: Reverse

Name: hldE [H]

Synonym: Bmul_2252

Alternate gene names: 161525422

Gene position: 2466470-2465505 (Counterclockwise)

Preceding gene: 161525423

Following gene: 161525421

Centisome position: 71.52

GC content: 68.53

Gene sequence:

>966_bases
ATGGATGAACGCACGATGACCACGCTTCGCGAAGTCGTTCCGGTTCCGCGCGACCAGATTGCTCGATCGCGCGTGCTCGT
CGTCGGCGACGTGATGCTCGACCGCTACTGGTTCGGCAACGTCGATCGCATTTCGCCGGAAGCGCCGGTGCCCGTCGTGC
ACGTGCAGCGTCACGAGGAGCGGCTCGGCGGCGCGGCGAACGTCGCGCGCAACGCGGTGACGCTCGGCGGCCAGGCGGGC
CTGCTCTGCGTGGTCGGCTGCGACGAGCCCGGCGAGCGCATCGTCGAGCTGCTCGACCATAGCGGCGTCACACCGCATCT
CGAGCGCGATCCGGCGCTGCCGACGACGATCAAGCTGCGCGTGCTCGCGCGCCAGCAGCAGCTGCTGCGCGTCGACTTCG
AATCGACGCCGACGCACGAAGTGCTGCTCGCGGGCCTCGCGCGCTTCGACACGCTGCTGCCGCAGCACGACGTCGTGCTG
ATGTCCGACTACGCGAAGGGCGGTCTCACGCACGTGACGACGATGATCGAGAAGGCGCGTGCGGCCGGCAAGCCGGTACT
CGTCGATCCGAAGGGCGACGACTGGGCGCGTTATCGCGGCGCATCGCTGATCACGCCGAACCGCGCGGAATTGCGCGAGG
TCGTCGGTCAGTGGAAATCGGAAGACGATTTGCGCGCGCGTGTTGCGAAGCTGCGCGCGGAGCTCGACATCGATGCGCTG
CTGCTCACGCGTTCGGAAGAGGGGATGACGCTCTTTTCCGCGACGGGCGAGTTGCACGCGCCGGCGCTCGCACGCGAGGT
GTTCGACGTGTCGGGCGCGGGCGACACGGTGATCGCGACGGTCGCGACCATGCTCGGCGCCGGCGTGCCGCTCGTCGATG
CGGTGGTGCTCGCGAATCGCGCGGCCGGCATCGTGGTCGGCAAGCTCGGCACGGCCACGGTCGACTACGACGAACTGTTT
CACTAA

Upstream 100 bases:

>100_bases
TTCGACGGGCGCAACCTGTACGAGCCCGACGCAATGGCCGAGCTCGGCATCGATTACTACGCGATCGGGCGCCCCCATCT
CGACCCGCAGGCCCACTCCC

Downstream 100 bases:

>100_bases
GCGAGTCGCGCCACGCGCGAACCGCTTCCTTTTCCAGGCAGGACGATCATGACTCTCATCGTCACCGGCGCGGCCGGTTT
TATCGGCGCGAACATCGTCA

Product: rfaE bifunctional protein

Products: NA

Alternate protein names: D-beta-D-heptose 7-phosphate kinase; D-beta-D-heptose 7-phosphotransferase; D-beta-D-heptose 1-phosphate adenosyltransferase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MDERTMTTLREVVPVPRDQIARSRVLVVGDVMLDRYWFGNVDRISPEAPVPVVHVQRHEERLGGAANVARNAVTLGGQAG
LLCVVGCDEPGERIVELLDHSGVTPHLERDPALPTTIKLRVLARQQQLLRVDFESTPTHEVLLAGLARFDTLLPQHDVVL
MSDYAKGGLTHVTTMIEKARAAGKPVLVDPKGDDWARYRGASLITPNRAELREVVGQWKSEDDLRARVAKLRAELDIDAL
LLTRSEEGMTLFSATGELHAPALAREVFDVSGAGDTVIATVATMLGAGVPLVDAVVLANRAAGIVVGKLGTATVDYDELF
H

Sequences:

>Translated_321_residues
MDERTMTTLREVVPVPRDQIARSRVLVVGDVMLDRYWFGNVDRISPEAPVPVVHVQRHEERLGGAANVARNAVTLGGQAG
LLCVVGCDEPGERIVELLDHSGVTPHLERDPALPTTIKLRVLARQQQLLRVDFESTPTHEVLLAGLARFDTLLPQHDVVL
MSDYAKGGLTHVTTMIEKARAAGKPVLVDPKGDDWARYRGASLITPNRAELREVVGQWKSEDDLRARVAKLRAELDIDAL
LLTRSEEGMTLFSATGELHAPALAREVFDVSGAGDTVIATVATMLGAGVPLVDAVVLANRAAGIVVGKLGTATVDYDELF
H
>Mature_321_residues
MDERTMTTLREVVPVPRDQIARSRVLVVGDVMLDRYWFGNVDRISPEAPVPVVHVQRHEERLGGAANVARNAVTLGGQAG
LLCVVGCDEPGERIVELLDHSGVTPHLERDPALPTTIKLRVLARQQQLLRVDFESTPTHEVLLAGLARFDTLLPQHDVVL
MSDYAKGGLTHVTTMIEKARAAGKPVLVDPKGDDWARYRGASLITPNRAELREVVGQWKSEDDLRARVAKLRAELDIDAL
LLTRSEEGMTLFSATGELHAPALAREVFDVSGAGDTVIATVATMLGAGVPLVDAVVLANRAAGIVVGKLGTATVDYDELF
H

Specific function: Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose [H]

COG id: COG2870

COG function: function code M; ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the cytidylyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789432, Length=309, Percent_Identity=49.8381877022654, Blast_Score=276, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023030
- InterPro:   IPR011611
- InterPro:   IPR002173
- InterPro:   IPR004821
- InterPro:   IPR004820
- InterPro:   IPR011913
- InterPro:   IPR011914
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01467 CTP_transf_2; PF00294 PfkB [H]

EC number: 2.7.-.- [C]

Molecular weight: Translated: 34800; Mature: 34800

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDERTMTTLREVVPVPRDQIARSRVLVVGDVMLDRYWFGNVDRISPEAPVPVVHVQRHEE
CCCHHHHHHHHHCCCCHHHHHHCCEEEEHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHH
RLGGAANVARNAVTLGGQAGLLCVVGCDEPGERIVELLDHSGVTPHLERDPALPTTIKLR
HCCCHHHHHHHHEEECCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHH
VLARQQQLLRVDFESTPTHEVLLAGLARFDTLLPQHDVVLMSDYAKGGLTHVTTMIEKAR
HHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHH
AAGKPVLVDPKGDDWARYRGASLITPNRAELREVVGQWKSEDDLRARVAKLRAELDIDAL
HCCCCEEECCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEE
LLTRSEEGMTLFSATGELHAPALAREVFDVSGAGDTVIATVATMLGAGVPLVDAVVLANR
EEEECCCCCEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCC
AAGIVVGKLGTATVDYDELFH
CCCEEEECCCCCEECHHHHCC
>Mature Secondary Structure
MDERTMTTLREVVPVPRDQIARSRVLVVGDVMLDRYWFGNVDRISPEAPVPVVHVQRHEE
CCCHHHHHHHHHCCCCHHHHHHCCEEEEHHHHHHHHHCCCCCCCCCCCCCCEEEEEHHHH
RLGGAANVARNAVTLGGQAGLLCVVGCDEPGERIVELLDHSGVTPHLERDPALPTTIKLR
HCCCHHHHHHHHEEECCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHH
VLARQQQLLRVDFESTPTHEVLLAGLARFDTLLPQHDVVLMSDYAKGGLTHVTTMIEKAR
HHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHH
AAGKPVLVDPKGDDWARYRGASLITPNRAELREVVGQWKSEDDLRARVAKLRAELDIDAL
HCCCCEEECCCCCCHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEE
LLTRSEEGMTLFSATGELHAPALAREVFDVSGAGDTVIATVATMLGAGVPLVDAVVLANR
EEEECCCCCEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHCC
AAGIVVGKLGTATVDYDELFH
CCCEEEECCCCCEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA