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The map label for this gene is hldD [H]

Identifier: 161525421

GI number: 161525421

Start: 2464464

End: 2465456

Strand: Reverse

Name: hldD [H]

Synonym: Bmul_2251

Alternate gene names: 161525421

Gene position: 2465456-2464464 (Counterclockwise)

Preceding gene: 161525422

Following gene: 161525420

Centisome position: 71.49

GC content: 63.44

Gene sequence:

>993_bases
ATGACTCTCATCGTCACCGGCGCGGCCGGTTTTATCGGCGCGAACATCGTCAAGGCGCTCAACGAGCGCGGCGAGACGCG
CATCATCGCGGTCGACAACCTGACGCGCGCGGACAAATTCAAGAATCTCGTCGATTGCGAGATCGACGACTATCTCGACA
AGACCGAATTCGTCGAGCGCTTCGCGCGCGGCGATTTCGGCAAGGTGCGTGCGGTGTTCCACGAAGGCGCCTGTTCGGAC
ACGATGGAAACCGACGGCCGCTACATGATGGACAACAACTTCCGCTACAGCCGCGCCGTGCTCGACGCGTGCCTCGCGCA
GGGCGCGCAGTTCCTGTATGCGTCGTCGGCGGCGATCTACGGCGGCTCGACGCGCTTCGTCGAAGAGCGCAGCGTCGAGG
CGCCGCTGAATGTGTACGGCTATTCGAAGTTCCTGTTCGACCAGGTCGTGCGCCGCGTGCTGCCGAATGCGAAGAGCCAG
ATCGCGGGCTTCCGCTATTTCAACGTGTACGGCCCGCGCGAAACGCACAAGGGCCGCATGGCGTCGGTCGCGTTCCACAA
CTTCAACCAGTTCCGCGCGGAAGGCAAGGTGAAGCTGTTCGGCGAGTACAACGGCTATGCGGCGGGCGAGCAGACGCGCG
ATTTCGTGTCGGTCGAGGACGTCGCGAAGGTGAACCTGTTCTTCTTCGATCATCCGGAGAAATCGGGCATCTTCAACCTC
GGCACCGGCCGCGCGCAACCGTTCAACGACATCGCGTCGACGGTCGTGAACACGCTGCGCGCACTCGACAATCTGCCGCC
GCTGACGCTGGCACAGCAGGTCGAGCAGGGGCTGATCGAATACGTGCCGTTCCCGGACGCGCTGCGCGGCAAGTACCAGT
GCTTCACGCAGGCCGACCAGACGAAGCTGCGTGCGGCCGGCTACGATGCGCCGTTCCTGACCGTGCAGGAAGGCGTCGAC
CGCTACGTTCGTTGGCTGTCCGGCCAGGTTTAA

Upstream 100 bases:

>100_bases
GGTCGGCAAGCTCGGCACGGCCACGGTCGACTACGACGAACTGTTTCACTAAGCGAGTCGCGCCACGCGCGAACCGCTTC
CTTTTCCAGGCAGGACGATC

Downstream 100 bases:

>100_bases
GCGCGAGCGTTGCATCGCTAGACTGGGTCTCACGGTCGGCAGCCGCCGGCCGCTTTTCATCGGGAGATCCAGGACATGAT
CAGAAAGTGGTTTGCAGCGG

Product: ADP-L-glycero-D-manno-heptose-6-epimerase

Products: NA

Alternate protein names: ADP-L-glycero-beta-D-manno-heptose-6-epimerase; ADP-glyceromanno-heptose 6-epimerase; ADP-hep 6-epimerase; AGME [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MTLIVTGAAGFIGANIVKALNERGETRIIAVDNLTRADKFKNLVDCEIDDYLDKTEFVERFARGDFGKVRAVFHEGACSD
TMETDGRYMMDNNFRYSRAVLDACLAQGAQFLYASSAAIYGGSTRFVEERSVEAPLNVYGYSKFLFDQVVRRVLPNAKSQ
IAGFRYFNVYGPRETHKGRMASVAFHNFNQFRAEGKVKLFGEYNGYAAGEQTRDFVSVEDVAKVNLFFFDHPEKSGIFNL
GTGRAQPFNDIASTVVNTLRALDNLPPLTLAQQVEQGLIEYVPFPDALRGKYQCFTQADQTKLRAAGYDAPFLTVQEGVD
RYVRWLSGQV

Sequences:

>Translated_330_residues
MTLIVTGAAGFIGANIVKALNERGETRIIAVDNLTRADKFKNLVDCEIDDYLDKTEFVERFARGDFGKVRAVFHEGACSD
TMETDGRYMMDNNFRYSRAVLDACLAQGAQFLYASSAAIYGGSTRFVEERSVEAPLNVYGYSKFLFDQVVRRVLPNAKSQ
IAGFRYFNVYGPRETHKGRMASVAFHNFNQFRAEGKVKLFGEYNGYAAGEQTRDFVSVEDVAKVNLFFFDHPEKSGIFNL
GTGRAQPFNDIASTVVNTLRALDNLPPLTLAQQVEQGLIEYVPFPDALRGKYQCFTQADQTKLRAAGYDAPFLTVQEGVD
RYVRWLSGQV
>Mature_329_residues
TLIVTGAAGFIGANIVKALNERGETRIIAVDNLTRADKFKNLVDCEIDDYLDKTEFVERFARGDFGKVRAVFHEGACSDT
METDGRYMMDNNFRYSRAVLDACLAQGAQFLYASSAAIYGGSTRFVEERSVEAPLNVYGYSKFLFDQVVRRVLPNAKSQI
AGFRYFNVYGPRETHKGRMASVAFHNFNQFRAEGKVKLFGEYNGYAAGEQTRDFVSVEDVAKVNLFFFDHPEKSGIFNLG
TGRAQPFNDIASTVVNTLRALDNLPPLTLAQQVEQGLIEYVPFPDALRGKYQCFTQADQTKLRAAGYDAPFLTVQEGVDR
YVRWLSGQV

Specific function: Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family. HldD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790049, Length=327, Percent_Identity=57.4923547400612, Blast_Score=352, Evalue=2e-98,
Organism=Caenorhabditis elegans, GI71982035, Length=280, Percent_Identity=26.4285714285714, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: 220 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR011912
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.20 [H]

Molecular weight: Translated: 36985; Mature: 36854

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLIVTGAAGFIGANIVKALNERGETRIIAVDNLTRADKFKNLVDCEIDDYLDKTEFVER
CEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCHHHHCCHHHHHHH
FARGDFGKVRAVFHEGACSDTMETDGRYMMDNNFRYSRAVLDACLAQGAQFLYASSAAIY
HHCCCHHHHHHHHHCCCCCCCHHCCCCEEECCCCHHHHHHHHHHHHCCCCEEEECCEEEE
GGSTRFVEERSVEAPLNVYGYSKFLFDQVVRRVLPNAKSQIAGFRYFNVYGPRETHKGRM
CCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEEECCCCCCCCCCE
ASVAFHNFNQFRAEGKVKLFGEYNGYAAGEQTRDFVSVEDVAKVNLFFFDHPEKSGIFNL
EEHHHHHHHHHHCCCCEEEEECCCCEECCCHHHHHCCHHHHHEEEEEEEECCCCCCEEEC
GTGRAQPFNDIASTVVNTLRALDNLPPLTLAQQVEQGLIEYVPFPDALRGKYQCFTQADQ
CCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHCCCHHHHHCHHH
TKLRAAGYDAPFLTVQEGVDRYVRWLSGQV
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TLIVTGAAGFIGANIVKALNERGETRIIAVDNLTRADKFKNLVDCEIDDYLDKTEFVER
EEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCHHHHCCHHHHHHH
FARGDFGKVRAVFHEGACSDTMETDGRYMMDNNFRYSRAVLDACLAQGAQFLYASSAAIY
HHCCCHHHHHHHHHCCCCCCCHHCCCCEEECCCCHHHHHHHHHHHHCCCCEEEECCEEEE
GGSTRFVEERSVEAPLNVYGYSKFLFDQVVRRVLPNAKSQIAGFRYFNVYGPRETHKGRM
CCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEEECCCCCCCCCCE
ASVAFHNFNQFRAEGKVKLFGEYNGYAAGEQTRDFVSVEDVAKVNLFFFDHPEKSGIFNL
EEHHHHHHHHHHCCCCEEEEECCCCEECCCHHHHHCCHHHHHEEEEEEEECCCCCCEEEC
GTGRAQPFNDIASTVVNTLRALDNLPPLTLAQQVEQGLIEYVPFPDALRGKYQCFTQADQ
CCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHCCCHHHHHCHHH
TKLRAAGYDAPFLTVQEGVDRYVRWLSGQV
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA