Click here to switch to the map view.

The map label for this gene is gyaR [H]

Identifier: 161525370

GI number: 161525370

Start: 2416387

End: 2417376

Strand: Reverse

Name: gyaR [H]

Synonym: Bmul_2200

Alternate gene names: 161525370

Gene position: 2417376-2416387 (Counterclockwise)

Preceding gene: 161525371

Following gene: 161525369

Centisome position: 70.1

GC content: 69.29

Gene sequence:

>990_bases
ATGCAGAAGATCCTCGTCGCGCGTCCGATCTTTCCGGACGTGATCGAACGGCTCAAGCAGTATTTCGACGTCGACTGGAA
CAACGGCGATGCGCTCGCACCCGACGCGCTCGCCGCGCGGCTCGCCGACAAGGACGGCGCGCTGACGGCCGGCGATCCGG
TCGGCGCATCGACGCTGGCGGCGGCGCCGCGCCTGCGCGTCGTGTCGAACATGGCGGTCGGCTACAACAACTTCGACATG
GCCGCGTTCAACGCGGCGAACGTGCTCGCGACGAACACGCCCGACGTCCTGAACGAATCGACGGCCGATTTCGGCTGGGC
GCTGATGATGGCCGCCGCGCGGCGGATCGCCGAATCCGAGCACTGGCTGCGTGCCGGGCACTGGCAGAAGTGGGCGTACG
ACGGCTTTCTCGGCAGCGACATCTACGGGTCGACGCTCGGCGTGATCGGCATGGGCCGCATCGGCCAGGCGCTCGCGCGT
CGCGCGCGCGGCTTCGGGATGCAGGTGATCTACCACAACCGGTCGCGCGTCGCGCCCGAGATCGAGGCGGAGCTCGGCGC
CGAATACGTGTCGAAGGACGCGCTGCTCGCGCGCGCCGATCACGTCGTGCTCGTGCTGCCCTATACGAAGGAAAACCACC
ACACGATCGGCGCGGCCGAACTCGCGAAAATGAAGCCGACCGCGACGCTGACCAACATCGCGCGCGGCGGGATCGTCGAC
GATGCGGCGCTCGCGGCTGCGCTGCGCAACGGCACGATCGCGGCGGCCGGCCTCGACGTCTACGAAGGCGAGCCGAACGT
GCATCCGGCGCTGCTCGAAGTGCCGAACGTCGTGCTGACGCCGCATATCGCGAGCGCGACGGAAAAGACGCGCCGCGCGA
TGGCGAACCTCGCGGCCGACAACCTGATCGCCGCGCTCGGCGAAGGGCCGCGCGCGGGGCAGCCGCCGAATCCGATCAAC
CCGGACGTGATCGGGAAGCCGCGCGCATGA

Upstream 100 bases:

>100_bases
GATCTTCTTCACGGCGTAAGCTGACGATTTTCAACCTCACGCGGGCGGCTCGGGCGGCACATGGCGCGCCGCGCGCCGTC
CGCCGCATGCGGAGATGGCG

Downstream 100 bases:

>100_bases
CGATCACGTTGCTGGTGGCCGCGCTCGTCGTGCTGGCCGTCGCGCTGGCGGTGGCCGTCGTCGCGCTCGTGCGCGGCGGC
GGCCGCCACGACGACGCGGC

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MQKILVARPIFPDVIERLKQYFDVDWNNGDALAPDALAARLADKDGALTAGDPVGASTLAAAPRLRVVSNMAVGYNNFDM
AAFNAANVLATNTPDVLNESTADFGWALMMAAARRIAESEHWLRAGHWQKWAYDGFLGSDIYGSTLGVIGMGRIGQALAR
RARGFGMQVIYHNRSRVAPEIEAELGAEYVSKDALLARADHVVLVLPYTKENHHTIGAAELAKMKPTATLTNIARGGIVD
DAALAAALRNGTIAAAGLDVYEGEPNVHPALLEVPNVVLTPHIASATEKTRRAMANLAADNLIAALGEGPRAGQPPNPIN
PDVIGKPRA

Sequences:

>Translated_329_residues
MQKILVARPIFPDVIERLKQYFDVDWNNGDALAPDALAARLADKDGALTAGDPVGASTLAAAPRLRVVSNMAVGYNNFDM
AAFNAANVLATNTPDVLNESTADFGWALMMAAARRIAESEHWLRAGHWQKWAYDGFLGSDIYGSTLGVIGMGRIGQALAR
RARGFGMQVIYHNRSRVAPEIEAELGAEYVSKDALLARADHVVLVLPYTKENHHTIGAAELAKMKPTATLTNIARGGIVD
DAALAAALRNGTIAAAGLDVYEGEPNVHPALLEVPNVVLTPHIASATEKTRRAMANLAADNLIAALGEGPRAGQPPNPIN
PDVIGKPRA
>Mature_329_residues
MQKILVARPIFPDVIERLKQYFDVDWNNGDALAPDALAARLADKDGALTAGDPVGASTLAAAPRLRVVSNMAVGYNNFDM
AAFNAANVLATNTPDVLNESTADFGWALMMAAARRIAESEHWLRAGHWQKWAYDGFLGSDIYGSTLGVIGMGRIGQALAR
RARGFGMQVIYHNRSRVAPEIEAELGAEYVSKDALLARADHVVLVLPYTKENHHTIGAAELAKMKPTATLTNIARGGIVD
DAALAAALRNGTIAAAGLDVYEGEPNVHPALLEVPNVVLTPHIASATEKTRRAMANLAADNLIAALGEGPRAGQPPNPIN
PDVIGKPRA

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=290, Percent_Identity=37.2413793103448, Blast_Score=174, Evalue=8e-44,
Organism=Homo sapiens, GI23308577, Length=292, Percent_Identity=29.1095890410959, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI145580578, Length=250, Percent_Identity=35.6, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI4557499, Length=250, Percent_Identity=35.6, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI145580575, Length=250, Percent_Identity=35.6, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI61743967, Length=249, Percent_Identity=33.7349397590361, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI4557497, Length=249, Percent_Identity=33.7349397590361, Blast_Score=124, Evalue=9e-29,
Organism=Escherichia coli, GI87082289, Length=325, Percent_Identity=42.1538461538462, Blast_Score=237, Evalue=8e-64,
Organism=Escherichia coli, GI1787645, Length=252, Percent_Identity=29.7619047619048, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1789279, Length=309, Percent_Identity=28.4789644012945, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI87081824, Length=215, Percent_Identity=29.7674418604651, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=305, Percent_Identity=31.1475409836066, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI25147481, Length=256, Percent_Identity=30.078125, Blast_Score=103, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6324055, Length=246, Percent_Identity=34.5528455284553, Blast_Score=158, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6320925, Length=278, Percent_Identity=29.8561151079137, Blast_Score=113, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6322116, Length=328, Percent_Identity=28.0487804878049, Blast_Score=112, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6321253, Length=307, Percent_Identity=23.7785016286645, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6325144, Length=167, Percent_Identity=28.1437125748503, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45551003, Length=318, Percent_Identity=38.3647798742138, Blast_Score=188, Evalue=4e-48,
Organism=Drosophila melanogaster, GI45552429, Length=318, Percent_Identity=38.3647798742138, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI24585514, Length=318, Percent_Identity=38.3647798742138, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI28574282, Length=318, Percent_Identity=38.3647798742138, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI28574284, Length=318, Percent_Identity=38.3647798742138, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI28574286, Length=306, Percent_Identity=35.9477124183007, Blast_Score=174, Evalue=9e-44,
Organism=Drosophila melanogaster, GI28571528, Length=311, Percent_Identity=36.3344051446945, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24585516, Length=262, Percent_Identity=35.4961832061069, Blast_Score=154, Evalue=1e-37,
Organism=Drosophila melanogaster, GI19921140, Length=329, Percent_Identity=30.0911854103343, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI62472511, Length=252, Percent_Identity=35.3174603174603, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24646446, Length=252, Percent_Identity=35.3174603174603, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646448, Length=252, Percent_Identity=35.3174603174603, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646452, Length=252, Percent_Identity=35.3174603174603, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646450, Length=252, Percent_Identity=35.3174603174603, Blast_Score=126, Evalue=2e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 34962; Mature: 34962

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKILVARPIFPDVIERLKQYFDVDWNNGDALAPDALAARLADKDGALTAGDPVGASTLA
CCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCCCHHHH
AAPRLRVVSNMAVGYNNFDMAAFNAANVLATNTPDVLNESTADFGWALMMAAARRIAESE
HCCHHHHHHHHHCCCCCCCHHHCCCCCEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHHH
HWLRAGHWQKWAYDGFLGSDIYGSTLGVIGMGRIGQALARRARGFGMQVIYHNRSRVAPE
HHHHCCCCCHHEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCEEEEEECCCCCCCH
IEAELGAEYVSKDALLARADHVVLVLPYTKENHHTIGAAELAKMKPTATLTNIARGGIVD
HHHHHHHHHHHHHHHHEECCCEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHCCCCCH
DAALAAALRNGTIAAAGLDVYEGEPNVHPALLEVPNVVLTPHIASATEKTRRAMANLAAD
HHHHHHHHHCCCEEEECCEEECCCCCCCHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
NLIAALGEGPRAGQPPNPINPDVIGKPRA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQKILVARPIFPDVIERLKQYFDVDWNNGDALAPDALAARLADKDGALTAGDPVGASTLA
CCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCEECCCCCCCHHHH
AAPRLRVVSNMAVGYNNFDMAAFNAANVLATNTPDVLNESTADFGWALMMAAARRIAESE
HCCHHHHHHHHHCCCCCCCHHHCCCCCEEECCCCHHHCCCCHHHHHHHHHHHHHHHHHHH
HWLRAGHWQKWAYDGFLGSDIYGSTLGVIGMGRIGQALARRARGFGMQVIYHNRSRVAPE
HHHHCCCCCHHEECCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCEEEEEECCCCCCCH
IEAELGAEYVSKDALLARADHVVLVLPYTKENHHTIGAAELAKMKPTATLTNIARGGIVD
HHHHHHHHHHHHHHHHEECCCEEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHCCCCCH
DAALAAALRNGTIAAAGLDVYEGEPNVHPALLEVPNVVLTPHIASATEKTRRAMANLAAD
HHHHHHHHHCCCEEEECCEEECCCCCCCHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHH
NLIAALGEGPRAGQPPNPINPDVIGKPRA
HHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA