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The map label for this gene is nhaA [H]

Identifier: 161525359

GI number: 161525359

Start: 2403735

End: 2404727

Strand: Reverse

Name: nhaA [H]

Synonym: Bmul_2189

Alternate gene names: 161525359

Gene position: 2404727-2403735 (Counterclockwise)

Preceding gene: 161525360

Following gene: 161525356

Centisome position: 69.73

GC content: 66.47

Gene sequence:

>993_bases
ATGACCGACCAACCGAATTTCCCTGAATCCTCGTCCCGCCCCGACAATCGCGAGCCGAATTGGGAGCGCGCCGCGCTCGA
GCGGATCGCGCTTGCGGCCGTCAAAGAGCAGCGCGCAGCGCGGCGCTGGAAGATCTTCTTCCGCTTCGCGTTTCTCGCGG
TGTTCCTGCTGCTCGCATTCGCGCTGATCGACTTCTCGAGCGACGCGAAATTCGCGTCGGGCGGGCGGCACACGGCGCTC
GTGACGATCGACGGCGAAATCGCGGCCGGCACCAATGCCAACGCCGAGGACATCAACACCGCGCTCGACGCCGCATTCGA
GGACGACGGCACGGCCGGCGTCGTGCTGCGGATCAACAGCCCGGGCGGCAGCCCCGTGCAGGCCGGGATGGTCTACGACG
AGATCCGGCGCCTGCGCGGCAAGTATCCGGACAAGCCGCTGTACGTCGTCGTGACCGACATGTGCGCGTCGGGCGGCTAT
TACATCGCGTCGGCGGCCGATAAGATCTTCGTCGACAAGGCGAGCATCGTCGGATCGATCGGCGTGCTGATGGACGGCTT
CGGCTTCACCGGGCTGATGGGCAAGCTCGGCGTCGAGCGCCGGCTGCATACGTCGGGCGAAAACAAGGGCTTTTACGATC
CGTTCTCGCCCGAAACGCCGAAGATGGACGCGCATGCGCAGGAACTGCTCGATCAGGTCCACGCGCAGTTCATCAAGGCG
GTGAAGGACGGCCGCGGCAAGCGGCTGCACGAAACGCCCGACATGTTCTCCGGGCTGTTCTGGACCGGCGAGAAGAGCGT
CGAACTCGGGCTCGCCGACGGTTACGGCACGACCGACTCCGTCGCGCGCGACGTCATCAAGGCGCCGGATCTCGTCGACT
ACACGGTCAAGGAAAGCCTGACGAACCGCGTCGCACGCAAGTTCGGCGCGGCCGTCGGCGGCGCCGCGATGAAGGCGTTG
ACGGCCGCCGGCGCGTCGGTTCAGCTGCGCTGA

Upstream 100 bases:

>100_bases
GGTCGAAGTCGACGAGCGCGACACGCCCGACGGGCGTGCGGTATTCTGGCTTCCCGACGCGGACCTGCGTCCCGCCACGC
AAGACTGACGACAATCCTGC

Downstream 100 bases:

>100_bases
CGGGCAGGGCGGCCCCGCCGCGGCCGCGGCCGCCGGATTCGGCGATCGGATTGCGGCGCCGCATGCCGCGGCGCCGAGTC
CTGCCTCAGTGCGCGAGCAG

Product: peptidase S49

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 330; Mature: 329

Protein sequence:

>330_residues
MTDQPNFPESSSRPDNREPNWERAALERIALAAVKEQRAARRWKIFFRFAFLAVFLLLAFALIDFSSDAKFASGGRHTAL
VTIDGEIAAGTNANAEDINTALDAAFEDDGTAGVVLRINSPGGSPVQAGMVYDEIRRLRGKYPDKPLYVVVTDMCASGGY
YIASAADKIFVDKASIVGSIGVLMDGFGFTGLMGKLGVERRLHTSGENKGFYDPFSPETPKMDAHAQELLDQVHAQFIKA
VKDGRGKRLHETPDMFSGLFWTGEKSVELGLADGYGTTDSVARDVIKAPDLVDYTVKESLTNRVARKFGAAVGGAAMKAL
TAAGASVQLR

Sequences:

>Translated_330_residues
MTDQPNFPESSSRPDNREPNWERAALERIALAAVKEQRAARRWKIFFRFAFLAVFLLLAFALIDFSSDAKFASGGRHTAL
VTIDGEIAAGTNANAEDINTALDAAFEDDGTAGVVLRINSPGGSPVQAGMVYDEIRRLRGKYPDKPLYVVVTDMCASGGY
YIASAADKIFVDKASIVGSIGVLMDGFGFTGLMGKLGVERRLHTSGENKGFYDPFSPETPKMDAHAQELLDQVHAQFIKA
VKDGRGKRLHETPDMFSGLFWTGEKSVELGLADGYGTTDSVARDVIKAPDLVDYTVKESLTNRVARKFGAAVGGAAMKAL
TAAGASVQLR
>Mature_329_residues
TDQPNFPESSSRPDNREPNWERAALERIALAAVKEQRAARRWKIFFRFAFLAVFLLLAFALIDFSSDAKFASGGRHTALV
TIDGEIAAGTNANAEDINTALDAAFEDDGTAGVVLRINSPGGSPVQAGMVYDEIRRLRGKYPDKPLYVVVTDMCASGGYY
IASAADKIFVDKASIVGSIGVLMDGFGFTGLMGKLGVERRLHTSGENKGFYDPFSPETPKMDAHAQELLDQVHAQFIKAV
KDGRGKRLHETPDMFSGLFWTGEKSVELGLADGYGTTDSVARDVIKAPDLVDYTVKESLTNRVARKFGAAVGGAAMKALT
AAGASVQLR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1787527, Length=218, Percent_Identity=33.0275229357798, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1788064, Length=216, Percent_Identity=29.1666666666667, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR002142 [H]

Pfam domain/function: PF06965 Na_H_antiport_1; PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 35595; Mature: 35463

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00626 RCC1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDQPNFPESSSRPDNREPNWERAALERIALAAVKEQRAARRWKIFFRFAFLAVFLLLAF
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALIDFSSDAKFASGGRHTALVTIDGEIAAGTNANAEDINTALDAAFEDDGTAGVVLRINS
HHHCCCCCCCCCCCCCEEEEEEECCCEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEC
PGGSPVQAGMVYDEIRRLRGKYPDKPLYVVVTDMCASGGYYIASAADKIFVDKASIVGSI
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCCEEEEECCCHHHHHHHHHHHHH
GVLMDGFGFTGLMGKLGVERRLHTSGENKGFYDPFSPETPKMDAHAQELLDQVHAQFIKA
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
VKDGRGKRLHETPDMFSGLFWTGEKSVELGLADGYGTTDSVARDVIKAPDLVDYTVKESL
HHCCCCCCCCCCHHHHHCEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHH
TNRVARKFGAAVGGAAMKALTAAGASVQLR
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEC
>Mature Secondary Structure 
TDQPNFPESSSRPDNREPNWERAALERIALAAVKEQRAARRWKIFFRFAFLAVFLLLAF
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ALIDFSSDAKFASGGRHTALVTIDGEIAAGTNANAEDINTALDAAFEDDGTAGVVLRINS
HHHCCCCCCCCCCCCCEEEEEEECCCEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEC
PGGSPVQAGMVYDEIRRLRGKYPDKPLYVVVTDMCASGGYYIASAADKIFVDKASIVGSI
CCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEHHCCCCEEEEECCCHHHHHHHHHHHHH
GVLMDGFGFTGLMGKLGVERRLHTSGENKGFYDPFSPETPKMDAHAQELLDQVHAQFIKA
HHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
VKDGRGKRLHETPDMFSGLFWTGEKSVELGLADGYGTTDSVARDVIKAPDLVDYTVKESL
HHCCCCCCCCCCHHHHHCEEECCCCCEEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHH
TNRVARKFGAAVGGAAMKALTAAGASVQLR
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA