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The map label for this gene is hbd [H]

Identifier: 161525224

GI number: 161525224

Start: 2247393

End: 2248310

Strand: Reverse

Name: hbd [H]

Synonym: Bmul_2054

Alternate gene names: 161525224

Gene position: 2248310-2247393 (Counterclockwise)

Preceding gene: 161525227

Following gene: 161525222

Centisome position: 65.2

GC content: 68.19

Gene sequence:

>918_bases
ATGGACATGCAACGCATCGCGATCGTCGGCACCGGCGTGATCGGCGCCAGTTGGGCGGCTTTCTATCTGGCGAAGGGCTT
CGACGTCGTCGCGACCGATCCCGCGCCGCAGGCCGAAGCGCGACTGCGCGAATCGCTGGCCGCGTTTCTCGGCGACGACG
CCGACGCGGCGTGCGCACGACTCACGTTCGACGCGGATCTCGTGCGTGCGCTCGACGGCGTCGATTTCGTGCAGGAAAAC
GGCCCCGAGCGGCTCGACCTCAAGCGCGCGCTGTACCGGCAGATGGACGACGTGCTGCCCGCGCACGTGCCGATCGCGTC
GAGCTCGTCGGGACTCAAGATGTCGGATATCCAGACCGCATGCGAGCAGCATCCGGAACGCTGCCTGATCGGGCATCCGT
TCAATCCGCCGCATCTGATTCCGCTCGTCGAGCTGGTCGGCGGCGAGGCGACCGACGCGGCCGTGATCGAACGCGCGAAG
GCGTTCTACGATGCGCTCGGCAAGGTCACGATCGTGCTGAACAAGGAGATGGCCGGTCACGTCGCGAACCGGCTCGCGGC
GGCGCTGTTTCGCGAGGTGTATCACCTCGTCGGCGAAGGCGTGGTGAGCGTCGCCGATGCGGACAAGGCCGTCGCGTGGG
GCCCCGGGCTGCGCTGGGCGCTGATGGGGCAGTGCCTGACCTATCACCTCGGCGGCGGCGCGGGCGGAATCGCGCACTTT
CTCGAACACCTGTCGGGGCCGATGACGAGCTGGTGGAACGACCTCGGCACGCCGTCGTTCGATCCGGACGTCGATCGCAA
GCTGATCGACGGGTTGCGCACGATCCAGGGCGAGCGCTCGATGCAGGACCTGGCGGCCGAGCGCGACCGGCTGCTCGTCG
AGCTGATCGACGCGCGGCGCCGCAGTTTCCTGCCGTAA

Upstream 100 bases:

>100_bases
AACCCGTAATTAGTGGCCGCGCGGCGCATTTCAAGGACGTCATGCGCGGTTCGGTGCGACAATCGGCGCGCCATCAACGG
ATCATGGAGACGGGACGTAT

Downstream 100 bases:

>100_bases
CGGCGAAGCGGCGCGCGCGGCGCGTCGTTGCCGATCGCACGACGGCCGCCGTGCGACGGCTGCGATGCGACACCGCCCGC
TACAACTGCGCGGCGGCCGC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MDMQRIAIVGTGVIGASWAAFYLAKGFDVVATDPAPQAEARLRESLAAFLGDDADAACARLTFDADLVRALDGVDFVQEN
GPERLDLKRALYRQMDDVLPAHVPIASSSSGLKMSDIQTACEQHPERCLIGHPFNPPHLIPLVELVGGEATDAAVIERAK
AFYDALGKVTIVLNKEMAGHVANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWALMGQCLTYHLGGGAGGIAHF
LEHLSGPMTSWWNDLGTPSFDPDVDRKLIDGLRTIQGERSMQDLAAERDRLLVELIDARRRSFLP

Sequences:

>Translated_305_residues
MDMQRIAIVGTGVIGASWAAFYLAKGFDVVATDPAPQAEARLRESLAAFLGDDADAACARLTFDADLVRALDGVDFVQEN
GPERLDLKRALYRQMDDVLPAHVPIASSSSGLKMSDIQTACEQHPERCLIGHPFNPPHLIPLVELVGGEATDAAVIERAK
AFYDALGKVTIVLNKEMAGHVANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWALMGQCLTYHLGGGAGGIAHF
LEHLSGPMTSWWNDLGTPSFDPDVDRKLIDGLRTIQGERSMQDLAAERDRLLVELIDARRRSFLP
>Mature_305_residues
MDMQRIAIVGTGVIGASWAAFYLAKGFDVVATDPAPQAEARLRESLAAFLGDDADAACARLTFDADLVRALDGVDFVQEN
GPERLDLKRALYRQMDDVLPAHVPIASSSSGLKMSDIQTACEQHPERCLIGHPFNPPHLIPLVELVGGEATDAAVIERAK
AFYDALGKVTIVLNKEMAGHVANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWALMGQCLTYHLGGGAGGIAHF
LEHLSGPMTSWWNDLGTPSFDPDVDRKLIDGLRTIQGERSMQDLAAERDRLLVELIDARRRSFLP

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=266, Percent_Identity=32.7067669172932, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI20127408, Length=210, Percent_Identity=29.0476190476191, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI296179429, Length=229, Percent_Identity=25.764192139738, Blast_Score=71, Evalue=1e-12,
Organism=Escherichia coli, GI1787661, Length=227, Percent_Identity=28.6343612334802, Blast_Score=82, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI115533614, Length=249, Percent_Identity=31.7269076305221, Blast_Score=124, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI193203623, Length=249, Percent_Identity=31.7269076305221, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17553560, Length=229, Percent_Identity=24.0174672489083, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17549919, Length=231, Percent_Identity=24.2424242424242, Blast_Score=65, Evalue=5e-11,
Organism=Drosophila melanogaster, GI20129993, Length=316, Percent_Identity=32.5949367088608, Blast_Score=156, Evalue=1e-38,
Organism=Drosophila melanogaster, GI45549573, Length=270, Percent_Identity=31.8518518518519, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 33005; Mature: 33005

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMQRIAIVGTGVIGASWAAFYLAKGFDVVATDPAPQAEARLRESLAAFLGDDADAACAR
CCCCEEEEEECCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHH
LTFDADLVRALDGVDFVQENGPERLDLKRALYRQMDDVLPAHVPIASSSSGLKMSDIQTA
HCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
CEQHPERCLIGHPFNPPHLIPLVELVGGEATDAAVIERAKAFYDALGKVTIVLNKEMAGH
HHHCCCCEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEECCHHHHH
VANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWALMGQCLTYHLGGGAGGIAHF
HHHHHHHHHHHHHHHHHCCCCEEECCCCCCEECCCCHHHHHHHHHHHHHCCCCCCHHHHH
LEHLSGPMTSWWNDLGTPSFDPDVDRKLIDGLRTIQGERSMQDLAAERDRLLVELIDARR
HHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RSFLP
HCCCC
>Mature Secondary Structure
MDMQRIAIVGTGVIGASWAAFYLAKGFDVVATDPAPQAEARLRESLAAFLGDDADAACAR
CCCCEEEEEECCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHCCCCHHHHHH
LTFDADLVRALDGVDFVQENGPERLDLKRALYRQMDDVLPAHVPIASSSSGLKMSDIQTA
HCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
CEQHPERCLIGHPFNPPHLIPLVELVGGEATDAAVIERAKAFYDALGKVTIVLNKEMAGH
HHHCCCCEECCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEEECCHHHHH
VANRLAAALFREVYHLVGEGVVSVADADKAVAWGPGLRWALMGQCLTYHLGGGAGGIAHF
HHHHHHHHHHHHHHHHHCCCCEEECCCCCCEECCCCHHHHHHHHHHHHHCCCCCCHHHHH
LEHLSGPMTSWWNDLGTPSFDPDVDRKLIDGLRTIQGERSMQDLAAERDRLLVELIDARR
HHHHCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
RSFLP
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]