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The map label for this gene is folP-A [H]

Identifier: 161525192

GI number: 161525192

Start: 2215735

End: 2216676

Strand: Reverse

Name: folP-A [H]

Synonym: Bmul_2022

Alternate gene names: 161525192

Gene position: 2216676-2215735 (Counterclockwise)

Preceding gene: 161525193

Following gene: 161525191

Centisome position: 64.28

GC content: 69.21

Gene sequence:

>942_bases
GTGTGGTTCCACACCGGCCCGTTTTGTATTCTCCCCCTCAGCCGCTCCGTGTCCGATTCCACCGCTTTCCCGTCCATTCC
CGCGCCGCTGCGTTGCGGCCGCTTCACGCTGACCTTCGAACGCCCGCTCGTGATGGGCATCCTGAACGCGACGCCCGATT
CGTTTTCCGACGGCGGCCGTTTTCTCGCCTACGACGACGCAGTGCGACAAGCCGAACGGATGATTGCCGACGGCGCCGAC
ATACTCGATATCGGCGGCGAATCGACGCGTCCCGGTGCGCCGCCCGTGCCGCTCGATGAAGAGCTCGCACGCGTGATCCC
GCTCGTCGAAGCGCTGCGGCCGCTCAACGTGCCGTTGTCGATCGACACGTACAAGCCGGCGGTCATGCGCGCGGCGCTCG
CGGCCGGTGCGGACTTGATCAACGACATCTGGGGTTTCCGTCAGCCGGGCGCGATCGACGCCGTGCGCGACGGCGACAGC
GGACTCTGTGCGATGCACATGCTCGGCGAGCCGCAGACGATGCAGGTCGGCGAGCCCGATTACGGCGACGTCGTCGCGGA
CGTGCGCGATTTTCTCGCGGCGCGCGCGCAGGCGCTGCGCGACGCCGGCGTCGCGCCGGAACGGATTTGCGTCGATCCCG
GTTTCGGGTTCGGCAAGGCAGTCGTCGACGACAACTATGCGCTGCTGGCCGCGCTGCCCGACACGGCGCCGCTGCGGCCC
GACGGACGCGCGTATCCGGTACTCGCCGGGATGTCGCGCAAGTCGATGCTCGGCGCGGTGATCGGCGGCAAGCCGCCGAT
GGAGCGGATCGCGGCGAGTGTCGCCGCCGCGTTGTGCGCGGTCGAGCGCGGCGCCGCGATCGTGCGCGTGCACGACGTCG
CGGCGACGGTCGACGCGCTGAAAGTATGGTGTGCCGTGCGCGAAGCCGCGCGGCAACGATAA

Upstream 100 bases:

>100_bases
GATTCGCCCGGCGGCGGCGCCGCTGCCGAGGTGAAGCCGGGCAACGCACCGGCACCTGCCTCGCCGGTATAAACTTCGTC
CTAGCACCGTTCACGGGCTG

Downstream 100 bases:

>100_bases
GTCAGAAAACCGAAGGAGGAAGATTCGTCATGGGACGTCGATATTTCGGCACGGATGGCATTCGCGGCACGGTCGGCGAT
GCGCCGATCACGCCCGATTT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 313; Mature: 313

Protein sequence:

>313_residues
MWFHTGPFCILPLSRSVSDSTAFPSIPAPLRCGRFTLTFERPLVMGILNATPDSFSDGGRFLAYDDAVRQAERMIADGAD
ILDIGGESTRPGAPPVPLDEELARVIPLVEALRPLNVPLSIDTYKPAVMRAALAAGADLINDIWGFRQPGAIDAVRDGDS
GLCAMHMLGEPQTMQVGEPDYGDVVADVRDFLAARAQALRDAGVAPERICVDPGFGFGKAVVDDNYALLAALPDTAPLRP
DGRAYPVLAGMSRKSMLGAVIGGKPPMERIAASVAAALCAVERGAAIVRVHDVAATVDALKVWCAVREAARQR

Sequences:

>Translated_313_residues
MWFHTGPFCILPLSRSVSDSTAFPSIPAPLRCGRFTLTFERPLVMGILNATPDSFSDGGRFLAYDDAVRQAERMIADGAD
ILDIGGESTRPGAPPVPLDEELARVIPLVEALRPLNVPLSIDTYKPAVMRAALAAGADLINDIWGFRQPGAIDAVRDGDS
GLCAMHMLGEPQTMQVGEPDYGDVVADVRDFLAARAQALRDAGVAPERICVDPGFGFGKAVVDDNYALLAALPDTAPLRP
DGRAYPVLAGMSRKSMLGAVIGGKPPMERIAASVAAALCAVERGAAIVRVHDVAATVDALKVWCAVREAARQR
>Mature_313_residues
MWFHTGPFCILPLSRSVSDSTAFPSIPAPLRCGRFTLTFERPLVMGILNATPDSFSDGGRFLAYDDAVRQAERMIADGAD
ILDIGGESTRPGAPPVPLDEELARVIPLVEALRPLNVPLSIDTYKPAVMRAALAAGADLINDIWGFRQPGAIDAVRDGDS
GLCAMHMLGEPQTMQVGEPDYGDVVADVRDFLAARAQALRDAGVAPERICVDPGFGFGKAVVDDNYALLAALPDTAPLRP
DGRAYPVLAGMSRKSMLGAVIGGKPPMERIAASVAAALCAVERGAAIVRVHDVAATVDALKVWCAVREAARQR

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=279, Percent_Identity=46.2365591397849, Blast_Score=236, Evalue=1e-63,
Organism=Saccharomyces cerevisiae, GI6324073, Length=313, Percent_Identity=30.0319488817891, Blast_Score=111, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 33171; Mature: 33171

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWFHTGPFCILPLSRSVSDSTAFPSIPAPLRCGRFTLTFERPLVMGILNATPDSFSDGGR
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEHHHHCCCCCCCCCCC
FLAYDDAVRQAERMIADGADILDIGGESTRPGAPPVPLDEELARVIPLVEALRPLNVPLS
EEEEHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEE
IDTYKPAVMRAALAAGADLINDIWGFRQPGAIDAVRDGDSGLCAMHMLGEPQTMQVGEPD
ECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEEEECCCCCEEECCCCC
YGDVVADVRDFLAARAQALRDAGVAPERICVDPGFGFGKAVVDDNYALLAALPDTAPLRP
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEECCCEEEEEECCCCCCCCC
DGRAYPVLAGMSRKSMLGAVIGGKPPMERIAASVAAALCAVERGAAIVRVHDVAATVDAL
CCCCCCEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHH
KVWCAVREAARQR
HHHHHHHHHHHCC
>Mature Secondary Structure
MWFHTGPFCILPLSRSVSDSTAFPSIPAPLRCGRFTLTFERPLVMGILNATPDSFSDGGR
CCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEHHHHCCCCCCCCCCC
FLAYDDAVRQAERMIADGADILDIGGESTRPGAPPVPLDEELARVIPLVEALRPLNVPLS
EEEEHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEE
IDTYKPAVMRAALAAGADLINDIWGFRQPGAIDAVRDGDSGLCAMHMLGEPQTMQVGEPD
ECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEEEECCCCCEEECCCCC
YGDVVADVRDFLAARAQALRDAGVAPERICVDPGFGFGKAVVDDNYALLAALPDTAPLRP
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCEEECCCEEEEEECCCCCCCCC
DGRAYPVLAGMSRKSMLGAVIGGKPPMERIAASVAAALCAVERGAAIVRVHDVAATVDAL
CCCCCCEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHH
KVWCAVREAARQR
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]