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The map label for this gene is eryA [H]

Identifier: 161525126

GI number: 161525126

Start: 2151141

End: 2152742

Strand: Reverse

Name: eryA [H]

Synonym: Bmul_1954

Alternate gene names: 161525126

Gene position: 2152742-2151141 (Counterclockwise)

Preceding gene: 161525127

Following gene: 161525125

Centisome position: 62.43

GC content: 71.91

Gene sequence:

>1602_bases
ATGGAACGACGCGGGTTGAACGGTGCGCACGCCAGCGGCTGCGCGTTCCTGTTTCCGGGACAGGGCGCGTTCTACGCGAG
CGCGATGCGCGAACTGGCCGGCACGCACGCGAGCGTGCGCGACGCGCTCGATACGGTCGATGCGGTCGCGCAGGCGCGGC
TCGGGCGGCCGCTGACCGGCGCGCTGTGGCGCGACGGTGCCGCACCCGACGTATGGCTGCGCGACGCGCCCGATCTGCTC
CAGCTCGGCATCTATGCGGCCTCGGTCGGCGTGTTCGGCGTGCTGCGCGCACACGGCGTCGCGCCCGACGTATCGATCGG
GCACAGCTTCGGCGAAATCGCGGCGCTCGTATGCGGCGGCGCGTATTCGGTCGAGCAGGGCGCGCAGATCGTCTGCGACC
GGATCGCGGCGCTGCAGGCGGACGCACCGGCCGACGGCGTGATGGCCGCGGTGTCCGCCGATGCCGACGCGACGCGCGCG
CTGATCGACGCCGACGCGGTCGCGGGCCGCGTCTGCATCGCGGTCGAGAACCATGCGTCGCAGACCGTCGTGTCGGGCCC
GCGCGCTGCGCTCGAACGCTTCCTCGATGCGTGCGCGGCGCGCGGCATCGCCGCGCAGCGGCTGCGCTCGCCGTATGCCT
TTCATCATCCCGATCTGGCGCGTGCGCGCGAACGCTTTGCGGCGCGCCTCGCAACCTATGGCCGCGCGCCGTTCGCGCAT
GCGGTTCATTCGCCGATTCTCGGCCGCCGCTATCGCGACGACGACGATCTCGGCGCCTGTCTCGCGTCGCACCTGGTGAT
GCCGGTGCGCTTCGCGGACGCGATCCGCGACGCATGCGCGCACGGCATCGTGCGCTACGTCGAATGCGGCGCGCTCAACG
CGCTCGCGCGCATCGTCGTGCGCGTCGCGGGACCGGGCGCGGTCCGCACGTTCGGCGGCCCGTCGCGCGTCGACGACGAA
GCGAGCGTCGTCGCAACGATCATCCGTTACTTCGAGGAGAACCGAATCATGAAAGACGACATCCGTTTCGACACGGCCGG
TCATGGCTTCGACGCATTCTGGAATGCGCGCGGGCCGCTGATCGTCGACTGGCTGAAGGGCGAGCTGCGCCAGGCGTTCG
ACGCCGCGCATGCCGCACGGTGGACGGCTGCGCCGGCGCACGCCGAGCCGGCGTCGGCGGCGGCCGCGCCGGTCGCACAG
CCGGTTGCCGCGGCGCCGGTGATCGCCGCGCCGGTGATCGCGCTCGCGACGGCCGCGGAACCGGCCGCGCTGCGCGTCGC
AGCGGCGGGCTCCGATGCGCCGGCTGCCGCGCCCGCGGCGCGTGCCGCGAAACCCGCGCACGTGCCGCGCGAGCGGCTGT
TCGCCGAACTCGTCGACATCTATGCGGAGGCGATGGAGTACCCGGCCGAGGTGTTCTCGGAGACGATCGAGCTCGAAGCC
GAGCTCGGCATCGACTCGGTCAAGCAGACCGAGATCATCCAGCGGATCATCGCGCGCTACGCGTTGCCGCCGCTGCCCGC
GAACTTCCGCAGCGGCGACTTCAAGGCGATGGGGCAGATCGTCGACTTCGTCTACGAGAACCAGGGCAAGGCGCTCGACT
GA

Upstream 100 bases:

>100_bases
AGTCGGCGCTCGCCGACGCGCGCCGGCAGCGCGTGCTTGCGGTGTCGAAATGGCGTATCGCGCGACTGAAACTGGCCGAA
AGCCTCGGGAGGTTGGGACT

Downstream 100 bases:

>100_bases
GCGGCCCGACACGCGGTACGCGGGCCGGCCGGGACGACCCTGGCCGGCGATCACAGTTATCGATGAGGCAGGCTCCATGT
CGAATGCCAGCATGCGCGGC

Product: acyl transferase

Products: NA

Alternate protein names: 6-deoxyerythronolide B synthase II; DEBS 2; ORF 2 [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MERRGLNGAHASGCAFLFPGQGAFYASAMRELAGTHASVRDALDTVDAVAQARLGRPLTGALWRDGAAPDVWLRDAPDLL
QLGIYAASVGVFGVLRAHGVAPDVSIGHSFGEIAALVCGGAYSVEQGAQIVCDRIAALQADAPADGVMAAVSADADATRA
LIDADAVAGRVCIAVENHASQTVVSGPRAALERFLDACAARGIAAQRLRSPYAFHHPDLARARERFAARLATYGRAPFAH
AVHSPILGRRYRDDDDLGACLASHLVMPVRFADAIRDACAHGIVRYVECGALNALARIVVRVAGPGAVRTFGGPSRVDDE
ASVVATIIRYFEENRIMKDDIRFDTAGHGFDAFWNARGPLIVDWLKGELRQAFDAAHAARWTAAPAHAEPASAAAAPVAQ
PVAAAPVIAAPVIALATAAEPAALRVAAAGSDAPAAAPAARAAKPAHVPRERLFAELVDIYAEAMEYPAEVFSETIELEA
ELGIDSVKQTEIIQRIIARYALPPLPANFRSGDFKAMGQIVDFVYENQGKALD

Sequences:

>Translated_533_residues
MERRGLNGAHASGCAFLFPGQGAFYASAMRELAGTHASVRDALDTVDAVAQARLGRPLTGALWRDGAAPDVWLRDAPDLL
QLGIYAASVGVFGVLRAHGVAPDVSIGHSFGEIAALVCGGAYSVEQGAQIVCDRIAALQADAPADGVMAAVSADADATRA
LIDADAVAGRVCIAVENHASQTVVSGPRAALERFLDACAARGIAAQRLRSPYAFHHPDLARARERFAARLATYGRAPFAH
AVHSPILGRRYRDDDDLGACLASHLVMPVRFADAIRDACAHGIVRYVECGALNALARIVVRVAGPGAVRTFGGPSRVDDE
ASVVATIIRYFEENRIMKDDIRFDTAGHGFDAFWNARGPLIVDWLKGELRQAFDAAHAARWTAAPAHAEPASAAAAPVAQ
PVAAAPVIAAPVIALATAAEPAALRVAAAGSDAPAAAPAARAAKPAHVPRERLFAELVDIYAEAMEYPAEVFSETIELEA
ELGIDSVKQTEIIQRIIARYALPPLPANFRSGDFKAMGQIVDFVYENQGKALD
>Mature_533_residues
MERRGLNGAHASGCAFLFPGQGAFYASAMRELAGTHASVRDALDTVDAVAQARLGRPLTGALWRDGAAPDVWLRDAPDLL
QLGIYAASVGVFGVLRAHGVAPDVSIGHSFGEIAALVCGGAYSVEQGAQIVCDRIAALQADAPADGVMAAVSADADATRA
LIDADAVAGRVCIAVENHASQTVVSGPRAALERFLDACAARGIAAQRLRSPYAFHHPDLARARERFAARLATYGRAPFAH
AVHSPILGRRYRDDDDLGACLASHLVMPVRFADAIRDACAHGIVRYVECGALNALARIVVRVAGPGAVRTFGGPSRVDDE
ASVVATIIRYFEENRIMKDDIRFDTAGHGFDAFWNARGPLIVDWLKGELRQAFDAAHAARWTAAPAHAEPASAAAAPVAQ
PVAAAPVIAAPVIALATAAEPAALRVAAAGSDAPAAAPAARAAKPAHVPRERLFAELVDIYAEAMEYPAEVFSETIELEA
ELGIDSVKQTEIIQRIIARYALPPLPANFRSGDFKAMGQIVDFVYENQGKALD

Specific function: Fatty acid biosynthesis. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 acyl carrier domains [H]

Homologues:

Organism=Escherichia coli, GI1787334, Length=310, Percent_Identity=28.7096774193548, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17550940, Length=310, Percent_Identity=24.8387096774194, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR009081
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR000794
- InterPro:   IPR002198
- InterPro:   IPR015357
- InterPro:   IPR011032
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016036
- InterPro:   IPR016040
- InterPro:   IPR006163
- InterPro:   IPR020842
- InterPro:   IPR020801
- InterPro:   IPR020841
- InterPro:   IPR020807
- InterPro:   IPR020843
- InterPro:   IPR020806
- InterPro:   IPR015083
- InterPro:   IPR006162
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00698 Acyl_transf_1; PF08240 ADH_N; PF00106 adh_short; PF00107 ADH_zinc_N; PF08990 Docking; PF09277 Erythro-docking; PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C; PF00550 PP-binding [H]

EC number: =2.3.1.94 [H]

Molecular weight: Translated: 56074; Mature: 56074

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERRGLNGAHASGCAFLFPGQGAFYASAMRELAGTHASVRDALDTVDAVAQARLGRPLTG
CCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCH
ALWRDGAAPDVWLRDAPDLLQLGIYAASVGVFGVLRAHGVAPDVSIGHSFGEIAALVCGG
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCC
AYSVEQGAQIVCDRIAALQADAPADGVMAAVSADADATRALIDADAVAGRVCIAVENHAS
CCCHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCHHHHHHHHHHHHCCEEEEEEECCCC
QTVVSGPRAALERFLDACAARGIAAQRLRSPYAFHHPDLARARERFAARLATYGRAPFAH
HHHHCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHH
AVHSPILGRRYRDDDDLGACLASHLVMPVRFADAIRDACAHGIVRYVECGALNALARIVV
HHHCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVAGPGAVRTFGGPSRVDDEASVVATIIRYFEENRIMKDDIRFDTAGHGFDAFWNARGPL
HHCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCHHHCCCCCCE
IVDWLKGELRQAFDAAHAARWTAAPAHAEPASAAAAPVAQPVAAAPVIAAPVIALATAAE
EEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PAALRVAAAGSDAPAAAPAARAAKPAHVPRERLFAELVDIYAEAMEYPAEVFSETIELEA
CCCEEEEECCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
ELGIDSVKQTEIIQRIIARYALPPLPANFRSGDFKAMGQIVDFVYENQGKALD
HCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MERRGLNGAHASGCAFLFPGQGAFYASAMRELAGTHASVRDALDTVDAVAQARLGRPLTG
CCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCH
ALWRDGAAPDVWLRDAPDLLQLGIYAASVGVFGVLRAHGVAPDVSIGHSFGEIAALVCGG
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCC
AYSVEQGAQIVCDRIAALQADAPADGVMAAVSADADATRALIDADAVAGRVCIAVENHAS
CCCHHHHHHHHHHHHHHHCCCCCCCHHEEECCCCCHHHHHHHHHHHHCCEEEEEEECCCC
QTVVSGPRAALERFLDACAARGIAAQRLRSPYAFHHPDLARARERFAARLATYGRAPFAH
HHHHCCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHH
AVHSPILGRRYRDDDDLGACLASHLVMPVRFADAIRDACAHGIVRYVECGALNALARIVV
HHHCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVAGPGAVRTFGGPSRVDDEASVVATIIRYFEENRIMKDDIRFDTAGHGFDAFWNARGPL
HHCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCHHHCCCCCCE
IVDWLKGELRQAFDAAHAARWTAAPAHAEPASAAAAPVAQPVAAAPVIAAPVIALATAAE
EEHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PAALRVAAAGSDAPAAAPAARAAKPAHVPRERLFAELVDIYAEAMEYPAEVFSETIELEA
CCCEEEEECCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
ELGIDSVKQTEIIQRIIARYALPPLPANFRSGDFKAMGQIVDFVYENQGKALD
HCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2024119; 1740151 [H]