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The map label for this gene is cobA [H]

Identifier: 161524758

GI number: 161524758

Start: 1739406

End: 1740425

Strand: Direct

Name: cobA [H]

Synonym: Bmul_1585

Alternate gene names: 161524758

Gene position: 1739406-1740425 (Clockwise)

Preceding gene: 161524751

Following gene: 161524759

Centisome position: 50.44

GC content: 74.41

Gene sequence:

>1020_bases
ATGCCACTGCCCTTCAGCGGGCGGGAAGGCTGCGGCCTGGCAAGCGGCCAGCCCGGATACCGGCCGACGCAAGGGGCGAG
CGCCGCGCTCGCCGAACGCCCGATCCGCGGGGGACGGAGAGTGTGCGCGTTGTCATCCGCCCGCTACGGGCGCTTCGTTT
CGCTCCGTCATGTCACGCCATTTCGCAGGCCGTCCGCGCGCGGCCGTTTCGTCGCCCTGTCCCGTCTCGTCACGGCGCGC
GCCGTGCTGCGCGCGATGAGCCGCGCATGGCTCGTCGGCGCCGGTCCCGGTGATGCCGACCTGCTGACGCTGAAGGCCGT
CCGCGCGATCGCGGCCGCCGACGTGCTGCTCGTCGACGATCTCGTCAACCCCGAGGTGCTGCGCCATGCGCGCGCGGACG
CGCGGATCGAGTACGTCGGCAAGCGCGGCGGTCATGCGTCGACGCCGCAGGCCGAGATCGTCGCGACGATGCTCGCGCAT
CTGCGCGCGGGCCGCAGCGTCGCGCGGCTGAAAGGCGGCGATCCGTTCGTGTTCGGCCGCGGCGGCGAGGAACTGATCGC
GCTCGGTGCGGCAGGCATTGAGGTCGAGGTCGTGAGCGGGATCACGGCCGGCATCGCGGCACCGGCCGCGCTCGGCATTC
CGGTCACGCATCGCGGCGACGCGCAGGGCGTGATCTTCGTCACCGGACACGGCGCGGGCGCCGACGAGCCGGACTGGCGC
GCGCTCGCCGCGACGCGCATGACGATCGTCGTCTACATGGGGATGCGCCGGCTCGAAGCGATTGCCGCGGCGCTGCGCGA
CGGCGGCCTGCCCGGCGACACGCCGTGCGCGGCGATCGCGAACGCGACGCGCGACACGCAGCGGCACGTGCTCGCGACGC
TCGACCGGATCGTCGAACGTACGGGTGCGGCCGGCATCGGCTCGCCGGCGATCGTCGTGATCGGCCGCGTCGCCGCGCTG
GCCGCCGATCCGGCCGTGCAGACCGCACTGGCCGGCGGCGGCCGCGCGGAGCGCGCGTGA

Upstream 100 bases:

>100_bases
AACGGGAAACAGGAGGCGGAGCATCGCCCGGCCTGTGCTGTCCCCGCAACGGTACGCCGCCCGCGCGACGCGCCTTGCGC
ACGCGCCCACGCCGCCCACG

Downstream 100 bases:

>100_bases
TGCGCGTCGCGCTCGGCATCGGCTTTCGTGCGGGCGTGCGCGCCGCGCAGCTCGACGCGGCCGTGCGTGCGGCGCTCGCG
GCGTATCCCGATGCGCAGCC

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MPLPFSGREGCGLASGQPGYRPTQGASAALAERPIRGGRRVCALSSARYGRFVSLRHVTPFRRPSARGRFVALSRLVTAR
AVLRAMSRAWLVGAGPGDADLLTLKAVRAIAAADVLLVDDLVNPEVLRHARADARIEYVGKRGGHASTPQAEIVATMLAH
LRAGRSVARLKGGDPFVFGRGGEELIALGAAGIEVEVVSGITAGIAAPAALGIPVTHRGDAQGVIFVTGHGAGADEPDWR
ALAATRMTIVVYMGMRRLEAIAAALRDGGLPGDTPCAAIANATRDTQRHVLATLDRIVERTGAAGIGSPAIVVIGRVAAL
AADPAVQTALAGGGRAERA

Sequences:

>Translated_339_residues
MPLPFSGREGCGLASGQPGYRPTQGASAALAERPIRGGRRVCALSSARYGRFVSLRHVTPFRRPSARGRFVALSRLVTAR
AVLRAMSRAWLVGAGPGDADLLTLKAVRAIAAADVLLVDDLVNPEVLRHARADARIEYVGKRGGHASTPQAEIVATMLAH
LRAGRSVARLKGGDPFVFGRGGEELIALGAAGIEVEVVSGITAGIAAPAALGIPVTHRGDAQGVIFVTGHGAGADEPDWR
ALAATRMTIVVYMGMRRLEAIAAALRDGGLPGDTPCAAIANATRDTQRHVLATLDRIVERTGAAGIGSPAIVVIGRVAAL
AADPAVQTALAGGGRAERA
>Mature_338_residues
PLPFSGREGCGLASGQPGYRPTQGASAALAERPIRGGRRVCALSSARYGRFVSLRHVTPFRRPSARGRFVALSRLVTARA
VLRAMSRAWLVGAGPGDADLLTLKAVRAIAAADVLLVDDLVNPEVLRHARADARIEYVGKRGGHASTPQAEIVATMLAHL
RAGRSVARLKGGDPFVFGRGGEELIALGAAGIEVEVVSGITAGIAAPAALGIPVTHRGDAQGVIFVTGHGAGADEPDWRA
LAATRMTIVVYMGMRRLEAIAAALRDGGLPGDTPCAAIANATRDTQRHVLATLDRIVERTGAAGIGSPAIVVIGRVAALA
ADPAVQTALAGGGRAERA

Specific function: Catalyzes both methylations at C-2 and C-7 of uroporphyrinogen III leading to precorrin-1 and precorrin-2; their oxidative esterification gives respectively factor I octamethyl ester and sirohydrochlorin [H]

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=230, Percent_Identity=47.3913043478261, Blast_Score=199, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6322922, Length=233, Percent_Identity=31.3304721030043, Blast_Score=108, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR003043 [H]

Pfam domain/function: PF00590 TP_methylase [H]

EC number: =2.1.1.107 [H]

Molecular weight: Translated: 34902; Mature: 34771

Theoretical pI: Translated: 11.51; Mature: 11.51

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLPFSGREGCGLASGQPGYRPTQGASAALAERPIRGGRRVCALSSARYGRFVSLRHVTP
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCC
FRRPSARGRFVALSRLVTARAVLRAMSRAWLVGAGPGDADLLTLKAVRAIAAADVLLVDD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHEEHH
LVNPEVLRHARADARIEYVGKRGGHASTPQAEIVATMLAHLRAGRSVARLKGGDPFVFGR
CCCHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCEEECC
GGEELIALGAAGIEVEVVSGITAGIAAPAALGIPVTHRGDAQGVIFVTGHGAGADEPDWR
CCCEEEEEECCCEEEEEECCCHHHHHCCHHHCCCEECCCCCCEEEEEEECCCCCCCCCHH
ALAATRMTIVVYMGMRRLEAIAAALRDGGLPGDTPCAAIANATRDTQRHVLATLDRIVER
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
TGAAGIGSPAIVVIGRVAALAADPAVQTALAGGGRAERA
HCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
PLPFSGREGCGLASGQPGYRPTQGASAALAERPIRGGRRVCALSSARYGRFVSLRHVTP
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCC
FRRPSARGRFVALSRLVTARAVLRAMSRAWLVGAGPGDADLLTLKAVRAIAAADVLLVDD
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHEEHH
LVNPEVLRHARADARIEYVGKRGGHASTPQAEIVATMLAHLRAGRSVARLKGGDPFVFGR
CCCHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCEEECC
GGEELIALGAAGIEVEVVSGITAGIAAPAALGIPVTHRGDAQGVIFVTGHGAGADEPDWR
CCCEEEEEECCCEEEEEECCCHHHHHCCHHHCCCEECCCCCCEEEEEEECCCCCCCCCHH
ALAATRMTIVVYMGMRRLEAIAAALRDGGLPGDTPCAAIANATRDTQRHVLATLDRIVER
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHH
TGAAGIGSPAIVVIGRVAALAADPAVQTALAGGGRAERA
HCCCCCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]