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The map label for this gene is pcm [H]

Identifier: 161524624

GI number: 161524624

Start: 1597277

End: 1598206

Strand: Direct

Name: pcm [H]

Synonym: Bmul_1451

Alternate gene names: 161524624

Gene position: 1597277-1598206 (Clockwise)

Preceding gene: 161524623

Following gene: 161524625

Centisome position: 46.32

GC content: 71.94

Gene sequence:

>930_bases
ATGAGCGGCGAGCGCGCGAAGCGGTTCCCGCTCGCGCTCGAAGATCTCAAGCGAGCGCCACGCAAATCCGACGGGCGGCC
CGGCGAACGCCATGCGCTCGCCGCATCGAAGTCCGCCGACGGTCCGGTCGCCGTGCCGAAGCCCGGCGCGGCGCGCGGCG
TGCCGGCCGGCCTCGCTGCCGCGAAGCCCGCGACGGCGCCGAAGGCCACCGCACCGAAGCCGACGCTGCCGAAGCCTGCC
GCACCGCGGCCGATCGCACCGAGCGCGGCGCCGGCCGGCGCGTTCGCGCTCACCTCGGAACGCGTGCGCGAGCGCATGGT
CGAACGGTTGCGTGCGAACGGCGTCGCCGACGCGCGCGTGCTGGCGGCGATGGCGGCGGTGCCGCGCCACCTGTTCGTGG
ATCCCGGCCTCGCGACGCAGGCCTACGAGGATTCCGCACTGCCGATCGGCCACCAGCAGACCATTTCGAAGCCGTCGGTC
GTCGCGCGCATGATCGAGCTCGCGATGGCCGGCCGCTCCCTCGAGCGCGTCCTCGAAATCGGCACCGGCTGCGGCTATCA
GGCCGCGGTGCTGAGCCACGTGGCGCGCGACGTGTATTCGATTGAACGCATCAAGCCGCTGTACGAGCGCGCGAAGCTGA
ACCTGAGGCCGCTGCGCGTGCCGAACATCCGTCTGCACTACGGCGACGGGCGTGTCGGCCTGCCGTCCGCCGCCCCGTTC
GATGCGATCGTGATCGCAGCCGCGGGGCTCGACGTGCCGCAGGCGCTGCTCGAGCAGCTCGCGATCGGCGGGCGCCTCAT
CGCGCCGGTCGGTGCGCAGAGCGGGCAGCCGCAGGTCCTCACGCTCGTCGAGCGCGTCGCGCACGCGCAGTGGCGGGAGT
CTCGGCTTGATCGCGTTTTCTTTGTCCCTTTAAAATCCGGAGTGATTTGA

Upstream 100 bases:

>100_bases
CGAACGGGTTCGTCTCGATCACGCCGTTGCAGCTCGATCTCACGCACACGCAGATGCTGCCTGCGACGCGCGAATGGGCG
CGCGCCGGAGGGCGGGCTTC

Downstream 100 bases:

>100_bases
AACCGATGAGTATGTTGCGCGCGATGCAAAACAACCGTTCCAGGGAACCGCTTACGCTCGCCCAGCGCGCGATCTGCGTG
GCCGCGTTCTCCACGTTACT

Product: protein-L-isoaspartate O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MSGERAKRFPLALEDLKRAPRKSDGRPGERHALAASKSADGPVAVPKPGAARGVPAGLAAAKPATAPKATAPKPTLPKPA
APRPIAPSAAPAGAFALTSERVRERMVERLRANGVADARVLAAMAAVPRHLFVDPGLATQAYEDSALPIGHQQTISKPSV
VARMIELAMAGRSLERVLEIGTGCGYQAAVLSHVARDVYSIERIKPLYERAKLNLRPLRVPNIRLHYGDGRVGLPSAAPF
DAIVIAAAGLDVPQALLEQLAIGGRLIAPVGAQSGQPQVLTLVERVAHAQWRESRLDRVFFVPLKSGVI

Sequences:

>Translated_309_residues
MSGERAKRFPLALEDLKRAPRKSDGRPGERHALAASKSADGPVAVPKPGAARGVPAGLAAAKPATAPKATAPKPTLPKPA
APRPIAPSAAPAGAFALTSERVRERMVERLRANGVADARVLAAMAAVPRHLFVDPGLATQAYEDSALPIGHQQTISKPSV
VARMIELAMAGRSLERVLEIGTGCGYQAAVLSHVARDVYSIERIKPLYERAKLNLRPLRVPNIRLHYGDGRVGLPSAAPF
DAIVIAAAGLDVPQALLEQLAIGGRLIAPVGAQSGQPQVLTLVERVAHAQWRESRLDRVFFVPLKSGVI
>Mature_308_residues
SGERAKRFPLALEDLKRAPRKSDGRPGERHALAASKSADGPVAVPKPGAARGVPAGLAAAKPATAPKATAPKPTLPKPAA
PRPIAPSAAPAGAFALTSERVRERMVERLRANGVADARVLAAMAAVPRHLFVDPGLATQAYEDSALPIGHQQTISKPSVV
ARMIELAMAGRSLERVLEIGTGCGYQAAVLSHVARDVYSIERIKPLYERAKLNLRPLRVPNIRLHYGDGRVGLPSAAPFD
AIVIAAAGLDVPQALLEQLAIGGRLIAPVGAQSGQPQVLTLVERVAHAQWRESRLDRVFFVPLKSGVI

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins [H]

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI226530908, Length=212, Percent_Identity=33.0188679245283, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1789100, Length=211, Percent_Identity=44.5497630331754, Blast_Score=156, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71983477, Length=223, Percent_Identity=32.2869955156951, Blast_Score=83, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI193207222, Length=219, Percent_Identity=31.5068493150685, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17981723, Length=217, Percent_Identity=32.7188940092166, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000682 [H]

Pfam domain/function: PF01135 PCMT [H]

EC number: =2.1.1.77 [H]

Molecular weight: Translated: 32614; Mature: 32483

Theoretical pI: Translated: 11.16; Mature: 11.16

Prosite motif: PS01279 PCMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGERAKRFPLALEDLKRAPRKSDGRPGERHALAASKSADGPVAVPKPGAARGVPAGLAA
CCCCCCHHCCCHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCEECCCCCCCCCCCCCHHC
AKPATAPKATAPKPTLPKPAAPRPIAPSAAPAGAFALTSERVRERMVERLRANGVADARV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
LAAMAAVPRHLFVDPGLATQAYEDSALPIGHQQTISKPSVVARMIELAMAGRSLERVLEI
HHHHHHHHHHHEECCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
GTGCGYQAAVLSHVARDVYSIERIKPLYERAKLNLRPLRVPNIRLHYGDGRVGLPSAAPF
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCEEEEEECCCCCCCCCCCCH
DAIVIAAAGLDVPQALLEQLAIGGRLIAPVGAQSGQPQVLTLVERVAHAQWRESRLDRVF
HHEEHHHCCCCHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEE
FVPLKSGVI
EEECCCCCC
>Mature Secondary Structure 
SGERAKRFPLALEDLKRAPRKSDGRPGERHALAASKSADGPVAVPKPGAARGVPAGLAA
CCCCCHHCCCHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCEECCCCCCCCCCCCCHHC
AKPATAPKATAPKPTLPKPAAPRPIAPSAAPAGAFALTSERVRERMVERLRANGVADARV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHH
LAAMAAVPRHLFVDPGLATQAYEDSALPIGHQQTISKPSVVARMIELAMAGRSLERVLEI
HHHHHHHHHHHEECCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
GTGCGYQAAVLSHVARDVYSIERIKPLYERAKLNLRPLRVPNIRLHYGDGRVGLPSAAPF
HCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCEEEEEECCCCCCCCCCCCH
DAIVIAAAGLDVPQALLEQLAIGGRLIAPVGAQSGQPQVLTLVERVAHAQWRESRLDRVF
HHEEHHHCCCCHHHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEE
FVPLKSGVI
EEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA