Click here to switch to the map view.

The map label for this gene is lon [H]

Identifier: 161524524

GI number: 161524524

Start: 1484300

End: 1486726

Strand: Direct

Name: lon [H]

Synonym: Bmul_1351

Alternate gene names: 161524524

Gene position: 1484300-1486726 (Clockwise)

Preceding gene: 161524523

Following gene: 161524525

Centisome position: 43.04

GC content: 63.16

Gene sequence:

>2427_bases
ATGTCAGGCACCCAACTTCTCCCGCCGGAACGCATCACGCTCCCGCTGCTGCCGCTGCGGGACGTCGTCGTTTTCCCGCA
CATGGTGATTCCGCTCTTCGTGGGCCGGCCGAAATCGATCAAGGCCCTCGAAGCAGCGATGGAAGGCGGCAAGCACATCA
TGCTCGTCGCCCAGAAGACCGCGGCGAAGGACGAACCGACCGACAAGGACATGTACGAAGTCGGTTGTATTGCCAACATC
CTGCAGATGCTGAAGCTGCCGGACGGCACCGTGAAGGTGCTCGTCGAGGGGCTGCAGCGCGCGAAGGCATTGTCGATCGA
GGAACAGGAGACGCAGTTCTCCTGCGAAGTGATGCCGCTCGAGCCCGATCATGCGGACAGCGCCGAAACGGAAGCGCTGC
GCCGTGCGATCGTGTCGCAGTTCGACCAGTACGTGAAGCTGAACAAGAAGATCCCGCCGGAGATTCTCACGTCGCTGTCG
GGCATCGACGAAGCAGGCCGTCTCGCCGACATGATCGCCGAGCGTCTGCCGCTGAAGCTCGACCAGAAGCAGCACATCCT
CGAGATGTTCCCGGTCATCGAGCGTCTCGAGCATCTGCTCGCGCAGCTCGAAGCCGAGATCGACATCCTGCAGGTCGAAA
AGCGCATCCGCGGGCGCGTGAAGCGCCAGATGGAAAAGAGCCAGCGCGAGTACTACCTGAACGAGCAGGTCAAGGCGATC
CAGAAGGAACTGGGCGAAGGCGAAGAGGGTGCGGATCTCGAGGAGCTCGAGAAGCGCATCAATGCCGCGCGCATGCCGAA
GGAAGCCAAGAAGAAGGCCGACGCCGAGCTGAAGAAGCTGAAGCTGATGTCGCCGATGTCGGCGGAAGCAACGGTCGTGC
GCAACTACATCGACACGCTGATCGGCCTGCCGTGGCGCAAGAAGAGTAAGGTCAACAACGACCTGTCGAATGCCGAGCAG
GTGCTCGACGAGGATCACTACGGCCTCGAGAAGGTCAAGGAACGGATCCTCGAGTATCTCGCGGTGCAGCAACGCGTCGA
CAAGGTCAAGGCGCCGATCCTGTGCCTCGTCGGGCCTCCGGGCGTCGGCAAGACCTCGCTCGGCCAGTCGATCGCCCGTG
CGACGAACCGCAAGTTCGTCCGGATGGCGCTCGGCGGCGTGCGTGACGAAGCCGAGATCCGCGGTCACCGTCGTACCTAC
ATCGGGTCGATGCCGGGCAAGATCCTGCAGAGCCTCGCGAAGGTCGGCGTGCGCAATCCGCTCTTCCTGCTCGACGAAGT
CGACAAGATGGGCATGGATTTCCGCGGCGATCCGTCGTCGGCGCTGCTCGAAGTGCTCGATCCGGAACAGAACCACACGT
TCGCCGACCACTACATCGAAGTCGACTTCGATCTGTCGGACGTGATGTTCGTCGCGACGTCGAACTCGCTGAACATCCCG
CCGCCGCTGCTCGACCGGATGGAAGTGATTCGTCTGTCGGGCTACACGGAAGACGAGAAGGTCAGCATCGCGCAGCGCTA
TCTGCTGCCGAAGCAGAAGAAGAACAACGGTCTGAAGGACGGCGAAATCGAGGTCACCGAGCAGGCGATCCGCGACATCA
TCCGCTACTACACGCGCGAAGCCGGTGTGCGTTCGCTCGAGCGCGAAGTGTCGAAGATCTGCCGCAAGGTCGTGAAGATG
CTGCTGCTGAAGAAGGCATCGGGTGCGATCAAGGTCGACGGCGACAACCTCGACACGTTCCTCGGCGTGCGCAAGTACGA
CTTCGGCCTCGCGGCGAAGGAAAACCAGGTCGGTCAGGTGACGGGCCTCGCGTGGACGGAAGTCGGCGGCGATCTGCTGA
CGATCGAAGCCGCGGTGATGCCGGGCAAGGGCAACGTGATCCGCACCGGTTCGCTCGGCGACGTGATGAAGGAGTCGGTC
GAGGCGGCGCGTTCGGTCGTGCGCTCGCGTTCGCGGCGTCTGGGCATCAAGGACGAAGCGTTCGAGAAGCAGGACATCCA
CATCCACGTGCCGGAAGGCGCGACGCCGAAGGACGGTCCGTCCGCCGGCGGAGCGATGACGACGGCGCTGGTGTCGGTGC
TGACCGGTATCCCGGTGCGTGCCGATGTCGCGATGACGGGTGAAATCACGCTGCGCGGCGAAGTGTTGCCGATCGGCGGG
CTGAAGGAGAAGCTGCTCGCGGCGCATCGCGGTGGCATCAAGCTCGTGCTGATCCCGGAAGAGAACGTGAAGGATCTCGC
CGAGATTCCGGACAACGTGAAGAACGCGATCGAGATCGTGCCGGTCCGCTGGATCGACAAGGTGCTGGAACTCGCGCTCG
AACGTCTGCCGACGCCGCTGCCGCCGGAAGAGGAGGCGAAGGCTTCGTCGGCGCCGGTAGCCGATGCGTCGAAGGACGCC
GGCTCGACCGAAGTCGTCAAGCACTGA

Upstream 100 bases:

>100_bases
TGGTTACTTTCTTACCGAATATTTCCCGCACTTGAAGGCTTGCAATCCGATGTGCCGGCCTCAATTACCGAACAATTGAT
TCCACTCATGGGGAAATGAA

Downstream 100 bases:

>100_bases
ACCCGAACGCCGTCCTGACGGTCGTTCACGAAACCCGCGGCGTGTCCGCGGGCTTTTTTTATGTGCGTCGTCGGGAGCGT
GTGCATCGGCCGATGAAAAA

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 808; Mature: 807

Protein sequence:

>808_residues
MSGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKTAAKDEPTDKDMYEVGCIANI
LQMLKLPDGTVKVLVEGLQRAKALSIEEQETQFSCEVMPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEAGRLADMIAERLPLKLDQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIGLPWRKKSKVNNDLSNAEQ
VLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLAKVGVRNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYIEVDFDLSDVMFVATSNSLNIP
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEIEVTEQAIRDIIRYYTREAGVRSLEREVSKICRKVVKM
LLLKKASGAIKVDGDNLDTFLGVRKYDFGLAAKENQVGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESV
EAARSVVRSRSRRLGIKDEAFEKQDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLVLIPEENVKDLAEIPDNVKNAIEIVPVRWIDKVLELALERLPTPLPPEEEAKASSAPVADASKDA
GSTEVVKH

Sequences:

>Translated_808_residues
MSGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKTAAKDEPTDKDMYEVGCIANI
LQMLKLPDGTVKVLVEGLQRAKALSIEEQETQFSCEVMPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLS
GIDEAGRLADMIAERLPLKLDQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIGLPWRKKSKVNNDLSNAEQ
VLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTY
IGSMPGKILQSLAKVGVRNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYIEVDFDLSDVMFVATSNSLNIP
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEIEVTEQAIRDIIRYYTREAGVRSLEREVSKICRKVVKM
LLLKKASGAIKVDGDNLDTFLGVRKYDFGLAAKENQVGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESV
EAARSVVRSRSRRLGIKDEAFEKQDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
LKEKLLAAHRGGIKLVLIPEENVKDLAEIPDNVKNAIEIVPVRWIDKVLELALERLPTPLPPEEEAKASSAPVADASKDA
GSTEVVKH
>Mature_807_residues
SGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKTAAKDEPTDKDMYEVGCIANIL
QMLKLPDGTVKVLVEGLQRAKALSIEEQETQFSCEVMPLEPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSG
IDEAGRLADMIAERLPLKLDQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAIQ
KELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTLIGLPWRKKSKVNNDLSNAEQV
LDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPPGVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYI
GSMPGKILQSLAKVGVRNPLFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYIEVDFDLSDVMFVATSNSLNIPP
PLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEIEVTEQAIRDIIRYYTREAGVRSLEREVSKICRKVVKML
LLKKASGAIKVDGDNLDTFLGVRKYDFGLAAKENQVGQVTGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVE
AARSVVRSRSRRLGIKDEAFEKQDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGGL
KEKLLAAHRGGIKLVLIPEENVKDLAEIPDNVKNAIEIVPVRWIDKVLELALERLPTPLPPEEEAKASSAPVADASKDAG
STEVVKH

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=568, Percent_Identity=46.6549295774648, Blast_Score=517, Evalue=1e-146,
Organism=Homo sapiens, GI21396489, Length=682, Percent_Identity=40.3225806451613, Blast_Score=502, Evalue=1e-142,
Organism=Escherichia coli, GI1786643, Length=770, Percent_Identity=70.2597402597403, Blast_Score=1082, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=692, Percent_Identity=39.4508670520231, Blast_Score=474, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17556486, Length=540, Percent_Identity=41.2962962962963, Blast_Score=435, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319449, Length=720, Percent_Identity=40.5555555555556, Blast_Score=514, Evalue=1e-146,
Organism=Drosophila melanogaster, GI24666867, Length=671, Percent_Identity=42.1758569299553, Blast_Score=514, Evalue=1e-146,
Organism=Drosophila melanogaster, GI221513036, Length=671, Percent_Identity=42.1758569299553, Blast_Score=514, Evalue=1e-146,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89413; Mature: 89282

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKT
CCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECC
AAKDEPTDKDMYEVGCIANILQMLKLPDGTVKVLVEGLQRAKALSIEEQETQFSCEVMPL
CCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCEEEEEEEC
EPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADMIAERLPLKL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC
DQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IGLPWRKKSKVNNDLSNAEQVLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP
HCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLAKVGVRNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCC
LFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYIEVDFDLSDVMFVATSNSLNIP
CHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEECCEEEEEECCCCEEEEEECCCCCCC
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEIEVTEQAIRDIIRYYTRE
CHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
AGVRSLEREVSKICRKVVKMLLLKKASGAIKVDGDNLDTFLGVRKYDFGLAAKENQVGQV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHCCHHHCCCCCCCCCCCCCE
TGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVEAARSVVRSRSRRLGIKDEA
ECEEHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
FEKQDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
CCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIKLVLIPEENVKDLAEIPDNVKNAIEIVPVRWIDKVLELALERLPTPL
HHHHHHHHHCCCEEEEEECCCCHHHHHHCCHHHHHHHEEECHHHHHHHHHHHHHHCCCCC
PPEEEAKASSAPVADASKDAGSTEVVKH
CCCHHCCCCCCCCCCCCCCCCCCHHCCC
>Mature Secondary Structure 
SGTQLLPPERITLPLLPLRDVVVFPHMVIPLFVGRPKSIKALEAAMEGGKHIMLVAQKT
CCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECC
AAKDEPTDKDMYEVGCIANILQMLKLPDGTVKVLVEGLQRAKALSIEEQETQFSCEVMPL
CCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCEEEEEEEC
EPDHADSAETEALRRAIVSQFDQYVKLNKKIPPEILTSLSGIDEAGRLADMIAERLPLKL
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCC
DQKQHILEMFPVIERLEHLLAQLEAEIDILQVEKRIRGRVKRQMEKSQREYYLNEQVKAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QKELGEGEEGADLEELEKRINAARMPKEAKKKADAELKKLKLMSPMSAEATVVRNYIDTL
HHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
IGLPWRKKSKVNNDLSNAEQVLDEDHYGLEKVKERILEYLAVQQRVDKVKAPILCLVGPP
HCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
GVGKTSLGQSIARATNRKFVRMALGGVRDEAEIRGHRRTYIGSMPGKILQSLAKVGVRNP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHCCCCHHHHHHHHHHHCCCCC
LFLLDEVDKMGMDFRGDPSSALLEVLDPEQNHTFADHYIEVDFDLSDVMFVATSNSLNIP
CHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCEEECCEEEEEECCCCEEEEEECCCCCCC
PPLLDRMEVIRLSGYTEDEKVSIAQRYLLPKQKKNNGLKDGEIEVTEQAIRDIIRYYTRE
CHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
AGVRSLEREVSKICRKVVKMLLLKKASGAIKVDGDNLDTFLGVRKYDFGLAAKENQVGQV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHCCHHHCCCCCCCCCCCCCE
TGLAWTEVGGDLLTIEAAVMPGKGNVIRTGSLGDVMKESVEAARSVVRSRSRRLGIKDEA
ECEEHHHCCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCHHC
FEKQDIHIHVPEGATPKDGPSAGGAMTTALVSVLTGIPVRADVAMTGEITLRGEVLPIGG
CCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECEEEECEEEEECEEEECCC
LKEKLLAAHRGGIKLVLIPEENVKDLAEIPDNVKNAIEIVPVRWIDKVLELALERLPTPL
HHHHHHHHHCCCEEEEEECCCCHHHHHHCCHHHHHHHEEECHHHHHHHHHHHHHHCCCCC
PPEEEAKASSAPVADASKDAGSTEVVKH
CCCHHCCCCCCCCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8981986; 12620739 [H]