Click here to switch to the map view.

The map label for this gene is ispD [H]

Identifier: 161524501

GI number: 161524501

Start: 1461060

End: 1461770

Strand: Direct

Name: ispD [H]

Synonym: Bmul_1328

Alternate gene names: 161524501

Gene position: 1461060-1461770 (Clockwise)

Preceding gene: 161524495

Following gene: 161524502

Centisome position: 42.37

GC content: 72.15

Gene sequence:

>711_bases
GTGACTCCCCGACTTTTCGCCCTGATTCCCTGTGCCGGCACGGGCAGCCGTTCCGGCTCGGCCGTGCCGAAGCAATACCG
GACGCTCGCCGGCCGCGCGCTGCTGCACTACACGCTGGCCGCGTTCGACGCGTGCAGCGAATTCGCGCAGACGCTCGTCG
TGCTCGCGCCCGACGACACGCACTTCGATGCGCGCCGCTTCGCGGGGCTGCGCTTCGCGGTGCGCCGCTGCGGCGGCGCG
TCGCGGCAGGCGTCGGTGCTCAACGGGCTGCTCGGGCTCGCCGAATTCGGCGCGGCCGATCACGACTGGGTGCTCGTGCA
CGACGCCGCGCGCCCGGGCATCACGCCGGAGCTGATCCGCACGCTGGTCGCGACGCTGAAGGACGATCCGGTCGGCGGCA
TCGTCGCGCTGCCCGTCGCCGATACGCTCAAGCGCGTGCCGGCCGGCGGCGACGCGATCGCGCGCACCGAGCCGCGCGAC
GCGCTCTGGCAGGCGCAGACGCCGCAGATGTTTCGCATCGGCATGCTGCGCGACGCGATCCAGCGCGCGCAGCGCGAAGG
GCACGACCTGACCGACGAGGCGAGCGCGATCGAATGGTCCGGCCATACGCCGCGCGTCGTGCAGGGCAGCCTGCGCAACT
TCAAGGTCACGTATCCCGAAGATTTCGCGCTCGCGGAGGCGATTCTCGCGCGCGCCGCGAACGCTTCGTGA

Upstream 100 bases:

>100_bases
GGCAGGGTGGCGGACGCGCGCGCATGGCAAGGCGGCGGCCGGGACGAAAGACCTATTATAAAATCCGCTTCTCGATTTCA
CCTTTCCGGCGTTCTCCTTC

Downstream 100 bases:

>100_bases
TTGTCAATTTCCCCTCAATCGGAACACGCATGGATTTCAGAATCGGACAAGGCTACGACGTGCACCAGCTCGTTGCGGGG
CGCCCGCTCATCATCGGCGG

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MTPRLFALIPCAGTGSRSGSAVPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVLAPDDTHFDARRFAGLRFAVRRCGGA
SRQASVLNGLLGLAEFGAADHDWVLVHDAARPGITPELIRTLVATLKDDPVGGIVALPVADTLKRVPAGGDAIARTEPRD
ALWQAQTPQMFRIGMLRDAIQRAQREGHDLTDEASAIEWSGHTPRVVQGSLRNFKVTYPEDFALAEAILARAANAS

Sequences:

>Translated_236_residues
MTPRLFALIPCAGTGSRSGSAVPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVLAPDDTHFDARRFAGLRFAVRRCGGA
SRQASVLNGLLGLAEFGAADHDWVLVHDAARPGITPELIRTLVATLKDDPVGGIVALPVADTLKRVPAGGDAIARTEPRD
ALWQAQTPQMFRIGMLRDAIQRAQREGHDLTDEASAIEWSGHTPRVVQGSLRNFKVTYPEDFALAEAILARAANAS
>Mature_235_residues
TPRLFALIPCAGTGSRSGSAVPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVLAPDDTHFDARRFAGLRFAVRRCGGAS
RQASVLNGLLGLAEFGAADHDWVLVHDAARPGITPELIRTLVATLKDDPVGGIVALPVADTLKRVPAGGDAIARTEPRDA
LWQAQTPQMFRIGMLRDAIQRAQREGHDLTDEASAIEWSGHTPRVVQGSLRNFKVTYPEDFALAEAILARAANAS

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=232, Percent_Identity=24.5689655172414, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI1789104, Length=225, Percent_Identity=40.8888888888889, Blast_Score=156, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228
- InterPro:   IPR018294 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 25352; Mature: 25221

Theoretical pI: Translated: 8.10; Mature: 8.10

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPRLFALIPCAGTGSRSGSAVPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVLAPDDT
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
HFDARRFAGLRFAVRRCGGASRQASVLNGLLGLAEFGAADHDWVLVHDAARPGITPELIR
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHH
TLVATLKDDPVGGIVALPVADTLKRVPAGGDAIARTEPRDALWQAQTPQMFRIGMLRDAI
HHHHHHCCCCCCCEEEECHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHH
QRAQREGHDLTDEASAIEWSGHTPRVVQGSLRNFKVTYPEDFALAEAILARAANAS
HHHHHCCCCCCCCCCEEEECCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TPRLFALIPCAGTGSRSGSAVPKQYRTLAGRALLHYTLAAFDACSEFAQTLVVLAPDDT
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
HFDARRFAGLRFAVRRCGGASRQASVLNGLLGLAEFGAADHDWVLVHDAARPGITPELIR
CHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHH
TLVATLKDDPVGGIVALPVADTLKRVPAGGDAIARTEPRDALWQAQTPQMFRIGMLRDAI
HHHHHHCCCCCCCEEEECHHHHHHHCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHH
QRAQREGHDLTDEASAIEWSGHTPRVVQGSLRNFKVTYPEDFALAEAILARAANAS
HHHHHCCCCCCCCCCEEEECCCCCHHHHCCCCCEEEECCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA