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The map label for this gene is ilvA

Identifier: 161523742

GI number: 161523742

Start: 611781

End: 613304

Strand: Reverse

Name: ilvA

Synonym: Bmul_0562

Alternate gene names: 161523742

Gene position: 613304-611781 (Counterclockwise)

Preceding gene: 161523743

Following gene: 161523741

Centisome position: 17.78

GC content: 67.06

Gene sequence:

>1524_bases
ATGGCCTCCCACGATTACCTGAAGAAAATCCTGACCGCGCGCGTCTACGACGTCGCGTTCGAGACCGAACTCGAACCGGC
CCGCAACCTGTCCGCGCGACTGCGCAACCCCGTGTACCTGAAGCGCGAGGACAACCAGCCGGTGTTCTCGTTCAAGCTGC
GCGGCGCATACAACAAGATGGCGCACATTCCCGCCGATGCGCTCGCGCGCGGCGTGATTACCGCATCGGCCGGCAATCAC
GCGCAGGGCGTCGCGTTCTCGGCGGCCCGGATGGGCGTGAAGGCCGTGATCGTCGTGCCCGTCACGACGCCGCAGGTGAA
GGTCGACGCGGTGCGCGCGCACGGCGGCCCGGGTGTCGAGGTGATTCAGGCCGGCGAATCGTACAGCGATGCGTACGCGC
ACGCGCTCAAGGTACAGGAGGAGCGCGGTCTCACGTTCGTGCACCCGTTCGACGATCCGTACGTGATCGCCGGCCAGGGC
ACGATCGCGATGGAGATCCTGCGCCAGCACCAGGGCCCGATCCACGCGATCTTCGTGCCGATCGGCGGCGGCGGGCTCGC
GGCGGGCGTCGCCGCGTACGTGAAGGCCGTGCGTCCGGAGATCAAGGTGATCGGCGTGCAGGCCGAGGATTCGTGCGCGA
TGGCGCAGTCGCTGCAGGCCGGCAAGCGCGTCGAGCTCGCCGAGGTCGGCCTGTTCGCGGACGGCACAGCGGTGAAGCTC
GTCGGCGAGGAAACTTTCCGGCTCTGCAAGGAATATCTCGACGGCGTCGTGACCGTCGATACCGACGCGCTCTGTGCGGC
GATCAAGGACGTGTTCCAGGACACGCGCAGCGTGCTCGAGCCGTCGGGCGCGCTCGCGGTGGCCGGCGCGAAGCTCTATG
CGGAACGCGAAGGCATCGAGAACCAGACGCTCGTCGCCGTCACGTCGGGCGCCAACATGAACTTCGACCGGATGCGCTTC
GTCGCCGAACGCGCGGAGGTCGGCGAGGCGCGCGAGGCCGTGTTCGCCGTCACGATTCCCGAGGAGCGCGGCAGCTTCAA
GCGCTTCTGCTCGCTCGTCGGCGACCGCAACGTGACCGAGTTCAACTACCGGATCGCCGATGCGCAATCCGCGCACATCT
TCGTCGGCGTGCAGATCCGTCGCCGCGGCGAATCGGCCGACATCGCCGCGAACTTCGAGTCGCACGGCTTCAAGACGGCC
GACCTCACGCACGACGAGCTGTCGAAGGAGCATATCCGCTACATGGTCGGCGGCCGCTCGCCGCTCGCGCTCGACGAGCG
CCTGTTCCGCTTCGAATTTCCCGAACGGCCGGGCGCGCTGATGAAGTTCCTGTCGTCGATGGCGCCGGACTGGAACATCA
GCCTGTTCCACTACCGCAACCAGGGCGCGGACTACAGCTCGATCCTCGTCGGGCTGCAGGTGCCGCAGGCCGATCATGCC
GAGTTCGAACGCTTCCTCGCGGCGCTCGGCTATCCGTATGTCGAAGAGAGCGCCAATCCGGCGTATCGCCTCTTCCTGTC
GTAA

Upstream 100 bases:

>100_bases
GCGCCGATCGGCCCGCGCGGCGCCGCGTTTGCGTGCAGGCAGACCCTTGGCGCTATCATTGACCCTTTACCGTCCGCTTC
CGCACCGCACGCGAGCATCC

Downstream 100 bases:

>100_bases
AGGCACTGCCATGAATCCCGAACATTCCCCGCTCGGCAAGGCGACCGTCTACGCATCGCAGTACGACGCGTCGCTGCTGT
TCCCGATCCCGCGCGCGGGC

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase

Number of amino acids: Translated: 507; Mature: 506

Protein sequence:

>507_residues
MASHDYLKKILTARVYDVAFETELEPARNLSARLRNPVYLKREDNQPVFSFKLRGAYNKMAHIPADALARGVITASAGNH
AQGVAFSAARMGVKAVIVVPVTTPQVKVDAVRAHGGPGVEVIQAGESYSDAYAHALKVQEERGLTFVHPFDDPYVIAGQG
TIAMEILRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIKVIGVQAEDSCAMAQSLQAGKRVELAEVGLFADGTAVKL
VGEETFRLCKEYLDGVVTVDTDALCAAIKDVFQDTRSVLEPSGALAVAGAKLYAEREGIENQTLVAVTSGANMNFDRMRF
VAERAEVGEAREAVFAVTIPEERGSFKRFCSLVGDRNVTEFNYRIADAQSAHIFVGVQIRRRGESADIAANFESHGFKTA
DLTHDELSKEHIRYMVGGRSPLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADHA
EFERFLAALGYPYVEESANPAYRLFLS

Sequences:

>Translated_507_residues
MASHDYLKKILTARVYDVAFETELEPARNLSARLRNPVYLKREDNQPVFSFKLRGAYNKMAHIPADALARGVITASAGNH
AQGVAFSAARMGVKAVIVVPVTTPQVKVDAVRAHGGPGVEVIQAGESYSDAYAHALKVQEERGLTFVHPFDDPYVIAGQG
TIAMEILRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIKVIGVQAEDSCAMAQSLQAGKRVELAEVGLFADGTAVKL
VGEETFRLCKEYLDGVVTVDTDALCAAIKDVFQDTRSVLEPSGALAVAGAKLYAEREGIENQTLVAVTSGANMNFDRMRF
VAERAEVGEAREAVFAVTIPEERGSFKRFCSLVGDRNVTEFNYRIADAQSAHIFVGVQIRRRGESADIAANFESHGFKTA
DLTHDELSKEHIRYMVGGRSPLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADHA
EFERFLAALGYPYVEESANPAYRLFLS
>Mature_506_residues
ASHDYLKKILTARVYDVAFETELEPARNLSARLRNPVYLKREDNQPVFSFKLRGAYNKMAHIPADALARGVITASAGNHA
QGVAFSAARMGVKAVIVVPVTTPQVKVDAVRAHGGPGVEVIQAGESYSDAYAHALKVQEERGLTFVHPFDDPYVIAGQGT
IAMEILRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEIKVIGVQAEDSCAMAQSLQAGKRVELAEVGLFADGTAVKLV
GEETFRLCKEYLDGVVTVDTDALCAAIKDVFQDTRSVLEPSGALAVAGAKLYAEREGIENQTLVAVTSGANMNFDRMRFV
AERAEVGEAREAVFAVTIPEERGSFKRFCSLVGDRNVTEFNYRIADAQSAHIFVGVQIRRRGESADIAANFESHGFKTAD
LTHDELSKEHIRYMVGGRSPLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADHAE
FERFLAALGYPYVEESANPAYRLFLS

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family

Homologues:

Organism=Homo sapiens, GI11345492, Length=298, Percent_Identity=34.5637583892617, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI33469958, Length=319, Percent_Identity=29.4670846394984, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI19923959, Length=297, Percent_Identity=27.9461279461279, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790207, Length=505, Percent_Identity=54.2574257425743, Blast_Score=520, Evalue=1e-149,
Organism=Escherichia coli, GI1789505, Length=311, Percent_Identity=36.0128617363344, Blast_Score=166, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17537387, Length=342, Percent_Identity=32.4561403508772, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI71991565, Length=325, Percent_Identity=30.4615384615385, Blast_Score=135, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17508781, Length=279, Percent_Identity=29.3906810035842, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320930, Length=517, Percent_Identity=47.7756286266925, Blast_Score=462, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6322631, Length=306, Percent_Identity=33.6601307189542, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6319788, Length=270, Percent_Identity=26.2962962962963, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21355833, Length=316, Percent_Identity=30.0632911392405, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24645328, Length=255, Percent_Identity=29.0196078431373, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THD1_BURM1 (P53607)

Other databases:

- EMBL:   U40630
- EMBL:   CP000868
- EMBL:   AP009385
- RefSeq:   YP_001578754.1
- RefSeq:   YP_001947125.1
- ProteinModelPortal:   P53607
- SMR:   P53607
- GeneID:   5765538
- GeneID:   6358674
- GenomeReviews:   AP009385_GR
- GenomeReviews:   CP000868_GR
- KEGG:   bmj:BMULJ_02699
- KEGG:   bmu:Bmul_0562
- HOGENOM:   HBG714501
- OMA:   SKEHIRY
- ProtClustDB:   PRK09224
- BRENDA:   4.3.1.19
- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721
- TIGRFAMs:   TIGR01124

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.3.1.19

Molecular weight: Translated: 55327; Mature: 55196

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASHDYLKKILTARVYDVAFETELEPARNLSARLRNPVYLKREDNQPVFSFKLRGAYNKM
CCCHHHHHHHHHHHHHHEEEECCCCHHHCHHHHHCCCEEEEECCCCCEEEEEECCCHHHH
AHIPADALARGVITASAGNHAQGVAFSAARMGVKAVIVVPVTTPQVKVDAVRAHGGPGVE
HCCCHHHHHCCEEEECCCCCCCCEEEHHHHCCEEEEEEEECCCCCEEEEEEECCCCCCEE
VIQAGESYSDAYAHALKVQEERGLTFVHPFDDPYVIAGQGTIAMEILRQHQGPIHAIFVP
EEECCCCHHHHHHHHHHHHHHCCCEEECCCCCCEEEECCCHHHHHHHHHCCCCEEEEEEE
IGGGGLAAGVAAYVKAVRPEIKVIGVQAEDSCAMAQSLQAGKRVELAEVGLFADGTAVKL
ECCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCEEHHHCCEEECCCEEEE
VGEETFRLCKEYLDGVVTVDTDALCAAIKDVFQDTRSVLEPSGALAVAGAKLYAEREGIE
ECHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHCCCC
NQTLVAVTSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFKRFCSLVGDRNVTE
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCCHHHHHHHHCCCCCEE
FNYRIADAQSAHIFVGVQIRRRGESADIAANFESHGFKTADLTHDELSKEHIRYMVGGRS
EEEEEECCCCCEEEEEEEEEECCCCCCEEECHHHCCEEECCCCHHHHHHHHHHHEECCCC
PLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADHA
CCHHHHHHHEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHEEEEEECCCCCHH
EFERFLAALGYPYVEESANPAYRLFLS
HHHHHHHHHCCCHHHCCCCCEEEEEEC
>Mature Secondary Structure 
ASHDYLKKILTARVYDVAFETELEPARNLSARLRNPVYLKREDNQPVFSFKLRGAYNKM
CCHHHHHHHHHHHHHHEEEECCCCHHHCHHHHHCCCEEEEECCCCCEEEEEECCCHHHH
AHIPADALARGVITASAGNHAQGVAFSAARMGVKAVIVVPVTTPQVKVDAVRAHGGPGVE
HCCCHHHHHCCEEEECCCCCCCCEEEHHHHCCEEEEEEEECCCCCEEEEEEECCCCCCEE
VIQAGESYSDAYAHALKVQEERGLTFVHPFDDPYVIAGQGTIAMEILRQHQGPIHAIFVP
EEECCCCHHHHHHHHHHHHHHCCCEEECCCCCCEEEECCCHHHHHHHHHCCCCEEEEEEE
IGGGGLAAGVAAYVKAVRPEIKVIGVQAEDSCAMAQSLQAGKRVELAEVGLFADGTAVKL
ECCCHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHCCCCEEHHHCCEEECCCEEEE
VGEETFRLCKEYLDGVVTVDTDALCAAIKDVFQDTRSVLEPSGALAVAGAKLYAEREGIE
ECHHHHHHHHHHHCCEEEECCHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHCCCC
NQTLVAVTSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFKRFCSLVGDRNVTE
CCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECHHCCCHHHHHHHHCCCCCEE
FNYRIADAQSAHIFVGVQIRRRGESADIAANFESHGFKTADLTHDELSKEHIRYMVGGRS
EEEEEECCCCCEEEEEEEEEECCCCCCEEECHHHCCEEECCCCHHHHHHHHHHHEECCCC
PLALDERLFRFEFPERPGALMKFLSSMAPDWNISLFHYRNQGADYSSILVGLQVPQADHA
CCHHHHHHHEECCCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCHHHEEEEEECCCCCHH
EFERFLAALGYPYVEESANPAYRLFLS
HHHHHHHHHCCCHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA