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The map label for this gene is epiP [H]

Identifier: 161510034

GI number: 161510034

Start: 1948591

End: 1949964

Strand: Reverse

Name: epiP [H]

Synonym: USA300HOU_1811

Alternate gene names: 161510034

Gene position: 1949964-1948591 (Counterclockwise)

Preceding gene: 161510035

Following gene: 161510033

Centisome position: 67.87

GC content: 33.33

Gene sequence:

>1374_bases
ATGAAAATCATAAAGCGCGCTATTATTAGTTTAATAATATTGAGTCTTTTAATATCTATTACAATGAGTAATGCATCAGC
GTCAGAAGAACTATATTACAGTGTTGAATACAAAAATACAGCAACATTTAACAAGTTAGTTAAAAAGAAGTCCTTAAACG
TTGTCTATAATATACCGGAATTACATGTGGCACAGATTAAAATGACGAAAATGCATGCTAATGCTTTAGCAAACTATAAA
AATGATATTAAATATATCAATGCCACATGTTCAACTTGTATTACTAGCGAGAAAACAATAGACAGAACATCAAATGAGTC
ATTATTTTCAAGACAATGGGATATGAATAAAATAACCAATAATGGTGCATCGTATGATGATTTGCCAAAACATGCTAACA
CCAAAATAGCAATCATAGATACAGGTGTGATGAAAAACCATGACGATTTGAAAAATAATTTCTCGACTGATTCTAAAAAT
TTAGTACCTTTAAACGGTTTTAGAGGTACTGAACCGGAGGAAACAGGTGATGTTCACGATGTCAATGATAGGAAAGGACA
TGGCACGATGGTGTCGGGTCAAACGAGTGCTAATGGTAAGTTAATAGGTGTTGCACCGAATAACAAATTTACAATGTATC
GCGTGTTTGGTAGTAAAAAAACAGAACTGCTTTGGGTATCAAAAGCGATTGTTCAAGCTGCAAATGATGGAAATCAAGTC
ATTAATATTAGTGTTGGTAGTTATATTATTTTGGACAAAAATGACCATCAAACATTTAGAAAAGATGAAAAAGTAGAATA
CGATGCGTTACAGAAAGCAATCAATTACGCCAAGAAGAAAAAATCTATCGTTGTTGCTGCAGCTGGTAATGATGGTATTG
ATGTCAATGACAAACAGAAACTAAAATTACAGCGTGAATATCAAGGTAATGGCGAAGTGAAAGATGTTCCTGCATCTATG
GACAATGTCGTTACAGTAGGATCTACAGATCAAAAGAGTAATCTATCTGAGTTTTCCAATTTTGGTATGAATTATACAGA
TATTGCTGCGCCCGGAGGATCATTTGCTTATTTAAATCAATTCGGTGTGGATAAATGGATGAATGAAGGGTATATGCATA
AGGAGAACATTTTAACTACTGCCAATAACGGAAGATATATTTATCAAGCTGGAACTTCATTAGCCACACCTAAAGTTTCG
GGAGCACTAGCTTTAATCATTGATAAATATCATCTTGAAAAACATCCAGATAAAGCGATTGAATTGTTATATCAGCATGG
GACATCTAAGAATAATAAACCATTTAGTAGATATGGGCATGGTGAGCTTGATGTGTATAAAGCATTAAATGTAGCAAATC
AAAAAGCAAGTTAA

Upstream 100 bases:

>100_bases
AAATATTTCAGAAAGTTATGAATTAGCGTCAAAAACATTTAAAAAGAATGTTGTCGCACCTGAACCATATAAAGTTCTGG
AATTCATTTGAGATTAGAAT

Downstream 100 bases:

>100_bases
TAAATCAAAGGAGTTTTTGATTATGGCAAAATTAGTTACTGAAAACATTTCGAAGCGGTTTAAAAATCAAGATGTATTAA
AGCATATTAATATCACTTTA

Product: lantibiotic epidermin serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MKIIKRAIISLIILSLLISITMSNASASEELYYSVEYKNTATFNKLVKKKSLNVVYNIPELHVAQIKMTKMHANALANYK
NDIKYINATCSTCITSEKTIDRTSNESLFSRQWDMNKITNNGASYDDLPKHANTKIAIIDTGVMKNHDDLKNNFSTDSKN
LVPLNGFRGTEPEETGDVHDVNDRKGHGTMVSGQTSANGKLIGVAPNNKFTMYRVFGSKKTELLWVSKAIVQAANDGNQV
INISVGSYIILDKNDHQTFRKDEKVEYDALQKAINYAKKKKSIVVAAAGNDGIDVNDKQKLKLQREYQGNGEVKDVPASM
DNVVTVGSTDQKSNLSEFSNFGMNYTDIAAPGGSFAYLNQFGVDKWMNEGYMHKENILTTANNGRYIYQAGTSLATPKVS
GALALIIDKYHLEKHPDKAIELLYQHGTSKNNKPFSRYGHGELDVYKALNVANQKAS

Sequences:

>Translated_457_residues
MKIIKRAIISLIILSLLISITMSNASASEELYYSVEYKNTATFNKLVKKKSLNVVYNIPELHVAQIKMTKMHANALANYK
NDIKYINATCSTCITSEKTIDRTSNESLFSRQWDMNKITNNGASYDDLPKHANTKIAIIDTGVMKNHDDLKNNFSTDSKN
LVPLNGFRGTEPEETGDVHDVNDRKGHGTMVSGQTSANGKLIGVAPNNKFTMYRVFGSKKTELLWVSKAIVQAANDGNQV
INISVGSYIILDKNDHQTFRKDEKVEYDALQKAINYAKKKKSIVVAAAGNDGIDVNDKQKLKLQREYQGNGEVKDVPASM
DNVVTVGSTDQKSNLSEFSNFGMNYTDIAAPGGSFAYLNQFGVDKWMNEGYMHKENILTTANNGRYIYQAGTSLATPKVS
GALALIIDKYHLEKHPDKAIELLYQHGTSKNNKPFSRYGHGELDVYKALNVANQKAS
>Mature_457_residues
MKIIKRAIISLIILSLLISITMSNASASEELYYSVEYKNTATFNKLVKKKSLNVVYNIPELHVAQIKMTKMHANALANYK
NDIKYINATCSTCITSEKTIDRTSNESLFSRQWDMNKITNNGASYDDLPKHANTKIAIIDTGVMKNHDDLKNNFSTDSKN
LVPLNGFRGTEPEETGDVHDVNDRKGHGTMVSGQTSANGKLIGVAPNNKFTMYRVFGSKKTELLWVSKAIVQAANDGNQV
INISVGSYIILDKNDHQTFRKDEKVEYDALQKAINYAKKKKSIVVAAAGNDGIDVNDKQKLKLQREYQGNGEVKDVPASM
DNVVTVGSTDQKSNLSEFSNFGMNYTDIAAPGGSFAYLNQFGVDKWMNEGYMHKENILTTANNGRYIYQAGTSLATPKVS
GALALIIDKYHLEKHPDKAIELLYQHGTSKNNKPFSRYGHGELDVYKALNVANQKAS

Specific function: Protease which cleaves the matured lantibiotic from the modified prepeptide (Probable) [H]

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR008357
- InterPro:   IPR015500 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 50736; Mature: 50736

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS00136 SUBTILASE_ASP ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIKRAIISLIILSLLISITMSNASASEELYYSVEYKNTATFNKLVKKKSLNVVYNIPE
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCEEEECCC
LHVAQIKMTKMHANALANYKNDIKYINATCSTCITSEKTIDRTSNESLFSRQWDMNKITN
EEEEEEEEEHHHHHHHHCCCCCCEEEECHHHHHHCCCHHCCCCCCCCHHHHCCCCHHHCC
NGASYDDLPKHANTKIAIIDTGVMKNHDDLKNNFSTDSKNLVPLNGFRGTEPEETGDVHD
CCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCC
VNDRKGHGTMVSGQTSANGKLIGVAPNNKFTMYRVFGSKKTELLWVSKAIVQAANDGNQV
CCCCCCCCEEEECCCCCCCEEEEECCCCCEEEEEEECCCCCEEEEHHHHHHHHCCCCCEE
INISVGSYIILDKNDHQTFRKDEKVEYDALQKAINYAKKKKSIVVAAAGNDGIDVNDKQK
EEEEECEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHH
LKLQREYQGNGEVKDVPASMDNVVTVGSTDQKSNLSEFSNFGMNYTDIAAPGGSFAYLNQ
HEEEEHHCCCCCEEECCCCCCCEEEECCCCCCCCHHHHHHCCCCCEEECCCCCCCHHHHH
FGVDKWMNEGYMHKENILTTANNGRYIYQAGTSLATPKVSGALALIIDKYHLEKHPDKAI
HCHHHHHCCCCEECCCEEEECCCCEEEEECCCCCCCCCCCCEEEEEEEHHHHCCCCHHHH
ELLYQHGTSKNNKPFSRYGHGELDVYKALNVANQKAS
HHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MKIIKRAIISLIILSLLISITMSNASASEELYYSVEYKNTATFNKLVKKKSLNVVYNIPE
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCHHHHHHHHHCCCCEEEECCC
LHVAQIKMTKMHANALANYKNDIKYINATCSTCITSEKTIDRTSNESLFSRQWDMNKITN
EEEEEEEEEHHHHHHHHCCCCCCEEEECHHHHHHCCCHHCCCCCCCCHHHHCCCCHHHCC
NGASYDDLPKHANTKIAIIDTGVMKNHDDLKNNFSTDSKNLVPLNGFRGTEPEETGDVHD
CCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCC
VNDRKGHGTMVSGQTSANGKLIGVAPNNKFTMYRVFGSKKTELLWVSKAIVQAANDGNQV
CCCCCCCCEEEECCCCCCCEEEEECCCCCEEEEEEECCCCCEEEEHHHHHHHHCCCCCEE
INISVGSYIILDKNDHQTFRKDEKVEYDALQKAINYAKKKKSIVVAAAGNDGIDVNDKQK
EEEEECEEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHH
LKLQREYQGNGEVKDVPASMDNVVTVGSTDQKSNLSEFSNFGMNYTDIAAPGGSFAYLNQ
HEEEEHHCCCCCEEECCCCCCCEEEECCCCCCCCHHHHHHCCCCCEEECCCCCCCHHHHH
FGVDKWMNEGYMHKENILTTANNGRYIYQAGTSLATPKVSGALALIIDKYHLEKHPDKAI
HCHHHHHCCCCEECCCEEEECCCCEEEEECCCCCCCCCCCCEEEEEEEHHHHCCCCHHHH
ELLYQHGTSKNNKPFSRYGHGELDVYKALNVANQKAS
HHHHHCCCCCCCCCHHHCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1740156 [H]