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The map label for this gene is ltaA

Identifier: 161509214

GI number: 161509214

Start: 1019791

End: 1020981

Strand: Reverse

Name: ltaA

Synonym: USA300HOU_0974

Alternate gene names: 161509214

Gene position: 1020981-1019791 (Counterclockwise)

Preceding gene: 161509215

Following gene: 161509210

Centisome position: 35.54

GC content: 32.16

Gene sequence:

>1191_bases
ATGCAAGATTCTTCGTTAAATAATTACGCTAATCATAAAAATTTCATTTTAATGCTTATTATCTTATTTTTAATGGAATT
TGCGAGAGGCATGTATATCCTAAGCTATATTAATTTCTTGCCAACAGTTACATCCATTGCTGTAGCAATAACGTCTCTAG
CATTTTCAATACATTTTATTGCTGATGCATCTACAAACTTTGTTATAGGATTTTTACTGAAAAAATTCGGCACAAAAATC
GTTTTAACGACTGGATTTATTTTAGCATTTACAAGTTTATTTTTAGTTATTTGGTTTCCAGCATCACCTTTTGTAATCAT
ATTTAGTGCTATGATGCTCGGTATTGCAGTTAGTCCTATTTGGGTCATTATGTTATCCAGTGTTGAAGAAGATAAACGTG
GCAAACAAATGGGCTATGTTTATTTTTCATGGTTGTTAGGCCTATTGGTAGGTATGGTTTTTATGAATCTACTTATCAAA
GTGCACCCAACACGCTTTGCCTTCATGATGTCTTTAGTCGTTTTAATTGCATGGATATTATATTATTTTGTCGATGTAAA
GTTAACAAATTATAATACTCGTCCAGTTAAAGCTCAATTGAGACAAATTGTTGATGTGACAAAGCGCCATTTATTGTTGT
TCCCTGGTATTCTTTTACAAGGTGCCGCAATTGCTGCCCTAGTTCCTATATTACCAACATATGCTACTAAGGTTATTAAC
GTAAGCACAATTGAATATACTGTTGCAATCATTATTGGTGGTATCGGCTGTGCAGTTTCGATGCTATTTTTATCGAAACT
AATAGATAACCGCAGCAGAAACTTTATGTATGGTGTTATTCTAAGCGGATTTATTTTATACATGATATTAATTTTTACTC
TATCTATGATTGTTAATATTCACATCTTGTGGATTATCGCTTTAGCTATCGGTCTAATGTATGGCATCTTATTACCAGCA
TGGAATACCTTTATGGCACGATTTATCAAATCAGATGAACAAGAAGAAACTTGGGGTGTTTTTAATAGTATCCAAGGATT
CGGCTCAATGATAGGGCCATTATTTGGCGGATTAATTACACAATTTACCAACAATTTAAACAATACATTTTATTTCTCGG
CATTAATCTTTTTAGTCTTAGCTGTATTTTATGGAAGCTACTTTATAGTAAATAGAGAAAAAGCTAAGTAA

Upstream 100 bases:

>100_bases
GATAAAATTAAGTATGCTACACAGACAATATGTCGAGACTTACTTGATTTAATCGGTCATTCATCACAACCACAAGAGAT
TTATGGAAAGGTTCCTTTAT

Downstream 100 bases:

>100_bases
GGTTAAAACGTATTTTAAAATAAAGAAAATGGTCATTTTTATTACATTCAATAAAAATGACCATTTTCTTATTAATTCAA
ACATACTACGATTAACAATA

Product: major facilitator transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: Lipoteichoic acid protein A

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MQDSSLNNYANHKNFILMLIILFLMEFARGMYILSYINFLPTVTSIAVAITSLAFSIHFIADASTNFVIGFLLKKFGTKI
VLTTGFILAFTSLFLVIWFPASPFVIIFSAMMLGIAVSPIWVIMLSSVEEDKRGKQMGYVYFSWLLGLLVGMVFMNLLIK
VHPTRFAFMMSLVVLIAWILYYFVDVKLTNYNTRPVKAQLRQIVDVTKRHLLLFPGILLQGAAIAALVPILPTYATKVIN
VSTIEYTVAIIIGGIGCAVSMLFLSKLIDNRSRNFMYGVILSGFILYMILIFTLSMIVNIHILWIIALAIGLMYGILLPA
WNTFMARFIKSDEQEETWGVFNSIQGFGSMIGPLFGGLITQFTNNLNNTFYFSALIFLVLAVFYGSYFIVNREKAK

Sequences:

>Translated_396_residues
MQDSSLNNYANHKNFILMLIILFLMEFARGMYILSYINFLPTVTSIAVAITSLAFSIHFIADASTNFVIGFLLKKFGTKI
VLTTGFILAFTSLFLVIWFPASPFVIIFSAMMLGIAVSPIWVIMLSSVEEDKRGKQMGYVYFSWLLGLLVGMVFMNLLIK
VHPTRFAFMMSLVVLIAWILYYFVDVKLTNYNTRPVKAQLRQIVDVTKRHLLLFPGILLQGAAIAALVPILPTYATKVIN
VSTIEYTVAIIIGGIGCAVSMLFLSKLIDNRSRNFMYGVILSGFILYMILIFTLSMIVNIHILWIIALAIGLMYGILLPA
WNTFMARFIKSDEQEETWGVFNSIQGFGSMIGPLFGGLITQFTNNLNNTFYFSALIFLVLAVFYGSYFIVNREKAK
>Mature_396_residues
MQDSSLNNYANHKNFILMLIILFLMEFARGMYILSYINFLPTVTSIAVAITSLAFSIHFIADASTNFVIGFLLKKFGTKI
VLTTGFILAFTSLFLVIWFPASPFVIIFSAMMLGIAVSPIWVIMLSSVEEDKRGKQMGYVYFSWLLGLLVGMVFMNLLIK
VHPTRFAFMMSLVVLIAWILYYFVDVKLTNYNTRPVKAQLRQIVDVTKRHLLLFPGILLQGAAIAALVPILPTYATKVIN
VSTIEYTVAIIIGGIGCAVSMLFLSKLIDNRSRNFMYGVILSGFILYMILIFTLSMIVNIHILWIIALAIGLMYGILLPA
WNTFMARFIKSDEQEETWGVFNSIQGFGSMIGPLFGGLITQFTNNLNNTFYFSALIFLVLAVFYGSYFIVNREKAK

Specific function: Probable permease that is required for glycolipid anchoring of LTA. May facilitate the transport of diglucosyl- diacylglycerol (Glc2-DAG) from the inner to the outer leaflet of the cytoplasmic membrane, delivering Glc2-DAG as a substrate for LTA synthesis

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. LtaA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LTAA_STAA3 (Q2FI61)

Other databases:

- EMBL:   CP000255
- RefSeq:   YP_493617.1
- ProteinModelPortal:   Q2FI61
- STRING:   Q2FI61
- EnsemblBacteria:   EBSTAT00000038467
- GeneID:   3912948
- GenomeReviews:   CP000255_GR
- KEGG:   saa:SAUSA300_0917
- eggNOG:   COG0477
- GeneTree:   EBGT00050000023933
- HOGENOM:   HBG535585
- ProtClustDB:   CLSK885072
- GO:   GO:0009405
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 44618; Mature: 44618

Theoretical pI: Translated: 9.92; Mature: 9.92

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x15afc884)-; HASH(0x14d623d4)-; HASH(0x15b21270)-; HASH(0x14d078e0)-; HASH(0x14e07e68)-; HASH(0x15895db0)-; HASH(0x15a889d0)-; HASH(0x14880710)-; HASH(0x15625240)-; HASH(0x151a7b7c)-; HASH(0x13f41538)-; HASH(0x15c59ce4)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCH
>Mature Secondary Structure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HHHHCCCCHHHHHHHHHHHHHHHHCCEEEEECCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA