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The map label for this gene is thrC [H]

Identifier: 160902628

GI number: 160902628

Start: 1252245

End: 1253663

Strand: Direct

Name: thrC [H]

Synonym: Pmob_1168

Alternate gene names: 160902628

Gene position: 1252245-1253663 (Clockwise)

Preceding gene: 160902627

Following gene: 160902629

Centisome position: 57.72

GC content: 37.98

Gene sequence:

>1419_bases
ATGGATAAATCTTACAAAGCGGTGATGGAAAGACAGGTAGAGATCATCAAAAAATCTGTAGGACTTGATTACAATAAATA
TGAAATAGAAGGAATCGCCTTTGATTATGAAAAGATGATGAATGAATCGGGTTTTTCAATCGAAGAAGTTGTAAGAATCC
AAAAAGAAACAGGTGTTGGAAACACTCCCCTTGTTGAACTAAAAAATATAAACAAATTGATTAAAAAATTGTCTGATAAA
GGGAAAGGTGCAAGGATCTTCGTTAAGGATGAACAAACTAACCCATCCGGTTCTTTCAAAGATAGAAGGGCTTCTATAAG
TGTATATATGGCAAAAAAATTAGGGTATGAAGGCGTTATAGCAGCTACAAGTGGTAATTATGGTGCCGCTGTAGCTTCTC
AAGCAGCTAAAAGAGGTTTAAAATCTATTATAATTCAAGAATGTTTCGATTCTCGAGGTGTTGGTCAACCTGAGATCTTA
GAAAAAGAAAGGTCGTGTGCAGCTTATGGAAGTGAAGTTGTTCAAGTAAGTGTAGGACCAGAATTATTTTATTATACCCT
TCTTCTTCTTGAAGAAACAGGATTTTTTAATGCATCGCTTTACTCACCTTACGGCATTACCGGAATAGAAACGTTGGGGG
TGGAGATAGCTAATCAAACCAAAGAATTGACAGGGAAATTCCCAGATCTTGTTGTAAGTACCCATGCAGGAGGAGGTTTG
ACCACTGGAACTGCAAGAGGATTAAAAAAAGCTGGGGCAGATTCAACCAAGATTGTTGGGGCAAGCGTTGATTTAAGAGG
CTTGCATATGGCTTCTGATAAAGATTTCAATAGAAAATCTTTTACTACAGGACACACAGGATTTGGGATCCCGTTTGCGG
TCTTTCCTGACAGATCCGATGTTCCAAGGAATGCGGCAAGGGTGTTGAGGTATATGGACAGATATGTTCTTGTAACTCAA
GGAGAAGTATTCTATATGACTGAATTACTCGCAAAACTCGAAGGGCTACAAAGAGGACCTGCTGGTAATACCTCGCTGGT
GGCAGCTTTTGCTTTGGCAAGGGAAATGAATGAGGATGAAATAATAGTTGTAAACGAAACAGAATACACAGGAGCAGGGA
AGTTACCAAGTGCCCAACTCACTTTTGCCAAAGAAAATGGGATTCAAGTAATATCAGGCGATCCAATAAAAGATGATAAA
CCAGGGGAAAGAATCGTGATACCTGAAGATCCTTCACAAATAGGCTACATTGAAATTCCAATGTCTCAATTGAAAGAATC
GTATGTAAACCAGCTTATAAAAAGACTTGGAAAAACTGATTTCACTCAAAAAGAAATTCAATTCATATCAGAGGAAATAA
GGGAAGATGAAGATTCGGTAATAAACTTGATTAAAAAGGCAAAGGAGGAGTCTTTGTGA

Upstream 100 bases:

>100_bases
AAATTGGAAAAAGTTAATCCTAAATACGAGCATAACTTTGGGGAACCTATTCCCGAATTGTTAAAAATTAATAAAGATGA
TTTGTTGGCAGGTGAAAGAA

Downstream 100 bases:

>100_bases
AAGAAAGAGCCGATGACTTTCAGGAAAGGTCAAAGAAACTTCAAAACTTGACTGATGAGGAATTAGACAATTATTTTTGG
AATTTAGTTGGAAAGGTAGT

Product: pyridoxal-5'-phosphate-dependent protein subunit beta

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MDKSYKAVMERQVEIIKKSVGLDYNKYEIEGIAFDYEKMMNESGFSIEEVVRIQKETGVGNTPLVELKNINKLIKKLSDK
GKGARIFVKDEQTNPSGSFKDRRASISVYMAKKLGYEGVIAATSGNYGAAVASQAAKRGLKSIIIQECFDSRGVGQPEIL
EKERSCAAYGSEVVQVSVGPELFYYTLLLLEETGFFNASLYSPYGITGIETLGVEIANQTKELTGKFPDLVVSTHAGGGL
TTGTARGLKKAGADSTKIVGASVDLRGLHMASDKDFNRKSFTTGHTGFGIPFAVFPDRSDVPRNAARVLRYMDRYVLVTQ
GEVFYMTELLAKLEGLQRGPAGNTSLVAAFALAREMNEDEIIVVNETEYTGAGKLPSAQLTFAKENGIQVISGDPIKDDK
PGERIVIPEDPSQIGYIEIPMSQLKESYVNQLIKRLGKTDFTQKEIQFISEEIREDEDSVINLIKKAKEESL

Sequences:

>Translated_472_residues
MDKSYKAVMERQVEIIKKSVGLDYNKYEIEGIAFDYEKMMNESGFSIEEVVRIQKETGVGNTPLVELKNINKLIKKLSDK
GKGARIFVKDEQTNPSGSFKDRRASISVYMAKKLGYEGVIAATSGNYGAAVASQAAKRGLKSIIIQECFDSRGVGQPEIL
EKERSCAAYGSEVVQVSVGPELFYYTLLLLEETGFFNASLYSPYGITGIETLGVEIANQTKELTGKFPDLVVSTHAGGGL
TTGTARGLKKAGADSTKIVGASVDLRGLHMASDKDFNRKSFTTGHTGFGIPFAVFPDRSDVPRNAARVLRYMDRYVLVTQ
GEVFYMTELLAKLEGLQRGPAGNTSLVAAFALAREMNEDEIIVVNETEYTGAGKLPSAQLTFAKENGIQVISGDPIKDDK
PGERIVIPEDPSQIGYIEIPMSQLKESYVNQLIKRLGKTDFTQKEIQFISEEIREDEDSVINLIKKAKEESL
>Mature_472_residues
MDKSYKAVMERQVEIIKKSVGLDYNKYEIEGIAFDYEKMMNESGFSIEEVVRIQKETGVGNTPLVELKNINKLIKKLSDK
GKGARIFVKDEQTNPSGSFKDRRASISVYMAKKLGYEGVIAATSGNYGAAVASQAAKRGLKSIIIQECFDSRGVGQPEIL
EKERSCAAYGSEVVQVSVGPELFYYTLLLLEETGFFNASLYSPYGITGIETLGVEIANQTKELTGKFPDLVVSTHAGGGL
TTGTARGLKKAGADSTKIVGASVDLRGLHMASDKDFNRKSFTTGHTGFGIPFAVFPDRSDVPRNAARVLRYMDRYVLVTQ
GEVFYMTELLAKLEGLQRGPAGNTSLVAAFALAREMNEDEIIVVNETEYTGAGKLPSAQLTFAKENGIQVISGDPIKDDK
PGERIVIPEDPSQIGYIEIPMSQLKESYVNQLIKRLGKTDFTQKEIQFISEEIREDEDSVINLIKKAKEESL

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0133

COG function: function code E; Tryptophan synthase beta chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6321412, Length=321, Percent_Identity=25.8566978193146, Blast_Score=78, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 51850; Mature: 51850

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00012 PHOSPHOPANTETHEINE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKSYKAVMERQVEIIKKSVGLDYNKYEIEGIAFDYEKMMNESGFSIEEVVRIQKETGVG
CCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECHHHHHCCCCCCHHHHHHHHHHCCCC
NTPLVELKNINKLIKKLSDKGKGARIFVKDEQTNPSGSFKDRRASISVYMAKKLGYEGVI
CCCEEEHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHEEEEEHHHCCCCEEE
AATSGNYGAAVASQAAKRGLKSIIIQECFDSRGVGQPEILEKERSCAAYGSEVVQVSVGP
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEECCC
ELFYYTLLLLEETGFFNASLYSPYGITGIETLGVEIANQTKELTGKFPDLVVSTHAGGGL
HHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
TTGTARGLKKAGADSTKIVGASVDLRGLHMASDKDFNRKSFTTGHTGFGIPFAVFPDRSD
CCHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCC
VPRNAARVLRYMDRYVLVTQGEVFYMTELLAKLEGLQRGPAGNTSLVAAFALAREMNEDE
CCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
IIVVNETEYTGAGKLPSAQLTFAKENGIQVISGDPIKDDKPGERIVIPEDPSQIGYIEIP
EEEEECCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCEEEECCCCCCCEEEECC
MSQLKESYVNQLIKRLGKTDFTQKEIQFISEEIREDEDSVINLIKKAKEESL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDKSYKAVMERQVEIIKKSVGLDYNKYEIEGIAFDYEKMMNESGFSIEEVVRIQKETGVG
CCCHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEECHHHHHCCCCCCHHHHHHHHHHCCCC
NTPLVELKNINKLIKKLSDKGKGARIFVKDEQTNPSGSFKDRRASISVYMAKKLGYEGVI
CCCEEEHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHEEEEEHHHCCCCEEE
AATSGNYGAAVASQAAKRGLKSIIIQECFDSRGVGQPEILEKERSCAAYGSEVVQVSVGP
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEEECCC
ELFYYTLLLLEETGFFNASLYSPYGITGIETLGVEIANQTKELTGKFPDLVVSTHAGGGL
HHHHHHHHHHHCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCC
TTGTARGLKKAGADSTKIVGASVDLRGLHMASDKDFNRKSFTTGHTGFGIPFAVFPDRSD
CCHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCCCCEEECCCCCC
VPRNAARVLRYMDRYVLVTQGEVFYMTELLAKLEGLQRGPAGNTSLVAAFALAREMNEDE
CCHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
IIVVNETEYTGAGKLPSAQLTFAKENGIQVISGDPIKDDKPGERIVIPEDPSQIGYIEIP
EEEEECCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCEEEECCCCCCCEEEECC
MSQLKESYVNQLIKRLGKTDFTQKEIQFISEEIREDEDSVINLIKKAKEESL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]