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The map label for this gene is groEL

Identifier: 160902618

GI number: 160902618

Start: 1241122

End: 1242744

Strand: Direct

Name: groEL

Synonym: Pmob_1158

Alternate gene names: 160902618

Gene position: 1241122-1242744 (Clockwise)

Preceding gene: 160902617

Following gene: 160902619

Centisome position: 57.21

GC content: 36.78

Gene sequence:

>1623_bases
ATGGCAAAAATGTTGAAATTTAATGAAGATGCAAGAAGAGCTTTAGAAAGAGGCGTTAATACAGTTGCAGATGCTGTTAA
AATAACTTTGGGACCTAAAGGAAGAAACGTAGTTTTAGAAAAGAGTTGGGGATCTCCAACTATCACAAATGATGGTGTTT
CCATTGCTAAAGAAATTGAATTGAAAGATAAATTTGAAGCACTTGGAGCAGAGTTAGTTAAAGAAGTAGCTTCCAAAACA
AATGACGTTGCGGGAGATGGAACAACTACCGCTACAGTTTTAGCCCAAGCTATGATTCAAGAGGGATTGAAAAATGTTGC
AGCCGGTGCTAATCCAATATTGATGAGAAACGGTATCGCTAAGGCTACAGACAAAGCTGTAGAACAGATAAGGAATGCCA
GCAGAAAGTTATCGAGCAAAGAAGACATAGCCCACGTTGCTTCTATATCTGCTAATAACGAAGAAATTGGAAATATTATT
GCAGAAGCTATGGACAAAGTCGGAGAGGATGGAGTTATAACCGTCGAAGACTCTAAAACTCTTGAAACTTATGTAGAATT
CACAGAAGGAATGCAATTCGATAGAGGATACATCTCTCCATATTTTGTAACAAATACAGAAAAAATGGAAGCAGAAATGA
AAGAACCTTATATATTAATTACAGATAGAAAGATTTCAGCTGTAAAATCAATAGTTCCAATTTTAGAAAAAGTTGCTCAA
GCTGGGAAACCGTTGGTAATAATTGCTGAAGATGTGGAAGGGGAAGCCCTTTCTACCTTGGTTCTCAACAAGCTAAGAGG
AACATTGGAATCAGTAGCTGTTAAAGCTCCTGGTTTTGGAGACAGAAGGAAAGAAATGCTAAGAGATATTGCAATTTTAA
CCGGTGGTACTGTAATATCCGAAGAAATTGGTCTCACCTTAGAAGATATTTCCATTAATGATCTTGGTCAAGCTGATTTG
GTAAGAGTCGCAAAAGAAGATACTATCATTGTTGGAGGAAAAGGTGAACCTACAGCAATAAAAGAAAGAATAGCACAGAT
AAAAGCTCAAATTGAAAATACAAGTTCTGATTACGAGAAAGAGACATTACAAGAGAGATTAGCAAAATTATCTGGTGGAG
TTGCAGTAATTAAAGCTGGAGCGGCTACAGAAACTGAGTTGAAGGAAAAGAAGCATAGAATAGAAGATGCTTTATCTGCA
ACAAGAGCAGCTGTAGAAGAAGGGATCGTTGCAGGTGGAGGAGTAACGTTACTCAGAGCAAAGAAAGCTGTTGAGGAATT
CGCAAACACATTATCAGGAGATGAGAAAATAGGCGCACAATTAGTAGCAAAATCTTTAGACGCTCCTGTAAAACAGATAA
TCAGAAATGCCGGTTTAGAACCTGCTATAATTATTGAAAAAATAATTGAAAAAGATGATTCAAAATATGGATATGATGTT
TTGAAAGAAAGATATGTAAATATGTTTGAATCTGGAATAATTGATCCAACTAAGGTTACAAGAAGTGCACTTCAAAATGC
TGCATCGATTGCTTCCATGCTTCTAACAACGGAAGTTTTGGTAGCGGAAGAACCAAAAGAAGAAAAAGGTCCAGAAATGC
CAGCAACACCAGATATGTACTAA

Upstream 100 bases:

>100_bases
GAACTGAAATCAAGATAGATGATGAGGATTATATCATCATTGATGTGGAAGACGTACTAGCAAAAGTAGAAGACTAAAAA
ACAGGAGGTGTTGAGATAAG

Downstream 100 bases:

>100_bases
ATTTAGACAGTAATAAAAACAAGCGTGCCATTGAATATGGCACGTTTTTTTATGGTATAATAAAATAGTATGTTTCACTA
ACAAAAAACGAGGTGAAAAA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MAKMLKFNEDARRALERGVNTVADAVKITLGPKGRNVVLEKSWGSPTITNDGVSIAKEIELKDKFEALGAELVKEVASKT
NDVAGDGTTTATVLAQAMIQEGLKNVAAGANPILMRNGIAKATDKAVEQIRNASRKLSSKEDIAHVASISANNEEIGNII
AEAMDKVGEDGVITVEDSKTLETYVEFTEGMQFDRGYISPYFVTNTEKMEAEMKEPYILITDRKISAVKSIVPILEKVAQ
AGKPLVIIAEDVEGEALSTLVLNKLRGTLESVAVKAPGFGDRRKEMLRDIAILTGGTVISEEIGLTLEDISINDLGQADL
VRVAKEDTIIVGGKGEPTAIKERIAQIKAQIENTSSDYEKETLQERLAKLSGGVAVIKAGAATETELKEKKHRIEDALSA
TRAAVEEGIVAGGGVTLLRAKKAVEEFANTLSGDEKIGAQLVAKSLDAPVKQIIRNAGLEPAIIIEKIIEKDDSKYGYDV
LKERYVNMFESGIIDPTKVTRSALQNAASIASMLLTTEVLVAEEPKEEKGPEMPATPDMY

Sequences:

>Translated_540_residues
MAKMLKFNEDARRALERGVNTVADAVKITLGPKGRNVVLEKSWGSPTITNDGVSIAKEIELKDKFEALGAELVKEVASKT
NDVAGDGTTTATVLAQAMIQEGLKNVAAGANPILMRNGIAKATDKAVEQIRNASRKLSSKEDIAHVASISANNEEIGNII
AEAMDKVGEDGVITVEDSKTLETYVEFTEGMQFDRGYISPYFVTNTEKMEAEMKEPYILITDRKISAVKSIVPILEKVAQ
AGKPLVIIAEDVEGEALSTLVLNKLRGTLESVAVKAPGFGDRRKEMLRDIAILTGGTVISEEIGLTLEDISINDLGQADL
VRVAKEDTIIVGGKGEPTAIKERIAQIKAQIENTSSDYEKETLQERLAKLSGGVAVIKAGAATETELKEKKHRIEDALSA
TRAAVEEGIVAGGGVTLLRAKKAVEEFANTLSGDEKIGAQLVAKSLDAPVKQIIRNAGLEPAIIIEKIIEKDDSKYGYDV
LKERYVNMFESGIIDPTKVTRSALQNAASIASMLLTTEVLVAEEPKEEKGPEMPATPDMY
>Mature_539_residues
AKMLKFNEDARRALERGVNTVADAVKITLGPKGRNVVLEKSWGSPTITNDGVSIAKEIELKDKFEALGAELVKEVASKTN
DVAGDGTTTATVLAQAMIQEGLKNVAAGANPILMRNGIAKATDKAVEQIRNASRKLSSKEDIAHVASISANNEEIGNIIA
EAMDKVGEDGVITVEDSKTLETYVEFTEGMQFDRGYISPYFVTNTEKMEAEMKEPYILITDRKISAVKSIVPILEKVAQA
GKPLVIIAEDVEGEALSTLVLNKLRGTLESVAVKAPGFGDRRKEMLRDIAILTGGTVISEEIGLTLEDISINDLGQADLV
RVAKEDTIIVGGKGEPTAIKERIAQIKAQIENTSSDYEKETLQERLAKLSGGVAVIKAGAATETELKEKKHRIEDALSAT
RAAVEEGIVAGGGVTLLRAKKAVEEFANTLSGDEKIGAQLVAKSLDAPVKQIIRNAGLEPAIIIEKIIEKDDSKYGYDVL
KERYVNMFESGIIDPTKVTRSALQNAASIASMLLTTEVLVAEEPKEEKGPEMPATPDMY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=532, Percent_Identity=53.0075187969925, Blast_Score=551, Evalue=1e-157,
Organism=Homo sapiens, GI31542947, Length=532, Percent_Identity=53.0075187969925, Blast_Score=551, Evalue=1e-157,
Organism=Homo sapiens, GI302058290, Length=517, Percent_Identity=23.9845261121857, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI58331173, Length=553, Percent_Identity=22.7848101265823, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI38455427, Length=136, Percent_Identity=33.0882352941176, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790586, Length=528, Percent_Identity=58.7121212121212, Blast_Score=616, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=52.5519848771267, Blast_Score=558, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI193210679, Length=208, Percent_Identity=53.3653846153846, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI17564182, Length=554, Percent_Identity=20.0361010830325, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25144674, Length=529, Percent_Identity=24.5746691871456, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17532603, Length=546, Percent_Identity=23.0769230769231, Blast_Score=68, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25147750, Length=561, Percent_Identity=21.74688057041, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=525, Percent_Identity=52.3809523809524, Blast_Score=535, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6322350, Length=529, Percent_Identity=23.8185255198488, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322524, Length=533, Percent_Identity=24.202626641651, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6322049, Length=563, Percent_Identity=23.0905861456483, Blast_Score=77, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6320058, Length=144, Percent_Identity=28.4722222222222, Blast_Score=63, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24641193, Length=529, Percent_Identity=51.6068052930057, Blast_Score=538, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24641191, Length=529, Percent_Identity=51.6068052930057, Blast_Score=538, Evalue=1e-153,
Organism=Drosophila melanogaster, GI45550936, Length=532, Percent_Identity=49.4360902255639, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI45550132, Length=532, Percent_Identity=49.4360902255639, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI45550935, Length=532, Percent_Identity=49.4360902255639, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI17864606, Length=530, Percent_Identity=41.8867924528302, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24584129, Length=551, Percent_Identity=35.2087114337568, Blast_Score=311, Evalue=7e-85,
Organism=Drosophila melanogaster, GI19921262, Length=551, Percent_Identity=35.2087114337568, Blast_Score=311, Evalue=7e-85,
Organism=Drosophila melanogaster, GI24645179, Length=538, Percent_Identity=23.9776951672862, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24583944, Length=558, Percent_Identity=21.8637992831541, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17647245, Length=478, Percent_Identity=24.0585774058577, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24652903, Length=478, Percent_Identity=24.0585774058577, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH60_PETMO (A9BHK4)

Other databases:

- EMBL:   CP000879
- RefSeq:   YP_001568199.1
- ProteinModelPortal:   A9BHK4
- SMR:   A9BHK4
- GeneID:   5758122
- GenomeReviews:   CP000879_GR
- KEGG:   pmo:Pmob_1158
- HOGENOM:   HBG625289
- OMA:   ENTTLAM
- ProtClustDB:   PRK00013
- BioCyc:   PMOB403833:PMOB_1158-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 58090; Mature: 57959

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKMLKFNEDARRALERGVNTVADAVKITLGPKGRNVVLEKSWGSPTITNDGVSIAKEIE
CCCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHH
LKDKFEALGAELVKEVASKTNDVAGDGTTTATVLAQAMIQEGLKNVAAGANPILMRNGIA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCH
KATDKAVEQIRNASRKLSSKEDIAHVASISANNEEIGNIIAEAMDKVGEDGVITVEDSKT
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECCCHH
LETYVEFTEGMQFDRGYISPYFVTNTEKMEAEMKEPYILITDRKISAVKSIVPILEKVAQ
HHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
AGKPLVIIAEDVEGEALSTLVLNKLRGTLESVAVKAPGFGDRRKEMLRDIAILTGGTVIS
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCCEEEH
EEIGLTLEDISINDLGQADLVRVAKEDTIIVGGKGEPTAIKERIAQIKAQIENTSSDYEK
HHHCCEEECCCCCCCCHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHH
ETLQERLAKLSGGVAVIKAGAATETELKEKKHRIEDALSATRAAVEEGIVAGGGVTLLRA
HHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
KKAVEEFANTLSGDEKIGAQLVAKSLDAPVKQIIRNAGLEPAIIIEKIIEKDDSKYGYDV
HHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHH
LKERYVNMFESGIIDPTKVTRSALQNAASIASMLLTTEVLVAEEPKEEKGPEMPATPDMY
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCC
>Mature Secondary Structure 
AKMLKFNEDARRALERGVNTVADAVKITLGPKGRNVVLEKSWGSPTITNDGVSIAKEIE
CCCCCCCHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCCCCCCCCCCCHHHHHHH
LKDKFEALGAELVKEVASKTNDVAGDGTTTATVLAQAMIQEGLKNVAAGANPILMRNGIA
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCH
KATDKAVEQIRNASRKLSSKEDIAHVASISANNEEIGNIIAEAMDKVGEDGVITVEDSKT
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEEECCCHH
LETYVEFTEGMQFDRGYISPYFVTNTEKMEAEMKEPYILITDRKISAVKSIVPILEKVAQ
HHHHHHHHHCCCCCCCCCCCEEEECHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHH
AGKPLVIIAEDVEGEALSTLVLNKLRGTLESVAVKAPGFGDRRKEMLRDIAILTGGTVIS
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHCCCEEEH
EEIGLTLEDISINDLGQADLVRVAKEDTIIVGGKGEPTAIKERIAQIKAQIENTSSDYEK
HHHCCEEECCCCCCCCHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHH
ETLQERLAKLSGGVAVIKAGAATETELKEKKHRIEDALSATRAAVEEGIVAGGGVTLLRA
HHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
KKAVEEFANTLSGDEKIGAQLVAKSLDAPVKQIIRNAGLEPAIIIEKIIEKDDSKYGYDV
HHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHH
LKERYVNMFESGIIDPTKVTRSALQNAASIASMLLTTEVLVAEEPKEEKGPEMPATPDMY
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA