Click here to switch to the map view.

The map label for this gene is pyrG [H]

Identifier: 160902476

GI number: 160902476

Start: 1079210

End: 1080793

Strand: Direct

Name: pyrG [H]

Synonym: Pmob_1012

Alternate gene names: 160902476

Gene position: 1079210-1080793 (Clockwise)

Preceding gene: 160902475

Following gene: 160902477

Centisome position: 49.74

GC content: 35.16

Gene sequence:

>1584_bases
ATGGCTGAAAAATATATTATAGTAACTGGCGGCGTGCTCAGTGGCATAGGAAAAGGAGTCGTTTCCGCTTCAATAGGAAG
GCTATTAAAAGAATTGGGATTAAAAGTCAATTCTTTGAAAATAGATCCCTATCTAAACGTAGATGCAGGAACTATGAATC
CCAATCAACATGGAGAAGTTTTTGTGACCGAAGATGGTTACGAAGCAGACCTTGATTTGGGACATTACGAGAGATTTTTA
GGAATAGAGATGAAAAGTTTTAACAATATGACAGCTGGCCAAGTGTATAAATACGTTATCGAAAAAGAAAGGGAAGGAAA
GTATTTAGGAGCCACCGTTCAGATGGTGCCTCACGTCACCGAAAGAATAAAAGAAAGAATCGAAGAGATAGACACAGAAG
TCTTGCTCATTGAAATAGGGGGTACCGTTGGCGATATTGAAGGTGAAATATTTTTAGAGGCAGTAAGAGAGCTATCCTTT
GAGAAAGGCCGAGAAAATTTTATGTTTATACATGTAACCTTTGTTCCCTATTTACATGTAACCAACGAGTTTAAAACCAA
GCCAACTCAACAATCTATTCAACTTTTAAGAAGAATAGGAATCCAACCAGATATGCTTTTGGTAAGAACGGAAAAAGAGA
TAGATCTTTCCAGTCTTGAAAAAGTAGCTCTGTTTGGCGGCGTCCCTTTAGAGTACGTTGTCAACCTTCCTGATTTAGCT
AATGTTTATGAAGTTCCTCAAATGCTATATGAAAAGAATATTCATGTGCTTATCTCAAGTAAATTGAATCTGGAAATATC
AAAAGAAGTAGGAGAATTAAGTTGGAAATGTCCCAAAACATTTAAAAACCTAAAAATTGCTATGATTTGCAAGTATTTAG
GTACCGATGATGCCTACAAGAGCATAATGGAAAGTGTTTTTTTAAGTGGCACTAAAAGGCCCGATCTAATCAACTCCGAA
GAACTGGAAGAAATGAATGAAGAGGAAATTAGAATACTTTTAAGTAAATACGAAGGTATAATTATCCCAGGTGGATTTGG
ATCAAGAGGAATAGAAGGAAAAATAAAGGCTATAAAATATGCTCGTGAAAATAATGTTCCTCTTCTAGGGATCTGCCTAG
GTATGCAACTAATGGTCATTGAATATGCCAGAAATGTTTTCGACTACAAAGAAGCAAATTCTACAGAATTCGATGAAAAT
ACTCCTTATCCTGTTATAGATTTGATGGAAGAACAAAAAAAGATGTTGAATTTGGGTGGTACTATGAGACTAGGCGCCCA
AAAAATTGAAATATTTCCAAACACGAAACTTCACAAGATTTATGGAGAAAAAAATTCTGTCCTTGAAAGGCACAGACACC
GTTATGAAGTCAATTACAAAGAGTTCGAGAATATGTTTGAAAAAGGAAAAAATGTTCCTAATAAACTTTCTATTTCAGCT
ATGACAGATTTCGTTGAAGCCATTGAATTGAATTCTCATCCTTTTTATATTGGCATTCAATACCATCCGGAATTTAAAAC
AAAAGTTGGAGATCCGCATCCTATCTTCAAAGCATTTATTGAAGCGATTGAAAAAAACAAATAA

Upstream 100 bases:

>100_bases
GACGATGAGGATTGAATTAATCACAAAAAGAGGGGAGCTTTCGCTCCCCCTTGTTTTTTAAAATATGGTAATTTTTTCTT
AAAAAAGAGGTGAAAAAATA

Downstream 100 bases:

>100_bases
ATGAAAAGGGGGAAAATAAATGACTTTTTATGAATTATATTTACGTTCTTTTTATGATTCAAATGGTGACGGCCTGGGAG
ATTTACAGGGATTAAAACAA

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MAEKYIIVTGGVLSGIGKGVVSASIGRLLKELGLKVNSLKIDPYLNVDAGTMNPNQHGEVFVTEDGYEADLDLGHYERFL
GIEMKSFNNMTAGQVYKYVIEKEREGKYLGATVQMVPHVTERIKERIEEIDTEVLLIEIGGTVGDIEGEIFLEAVRELSF
EKGRENFMFIHVTFVPYLHVTNEFKTKPTQQSIQLLRRIGIQPDMLLVRTEKEIDLSSLEKVALFGGVPLEYVVNLPDLA
NVYEVPQMLYEKNIHVLISSKLNLEISKEVGELSWKCPKTFKNLKIAMICKYLGTDDAYKSIMESVFLSGTKRPDLINSE
ELEEMNEEEIRILLSKYEGIIIPGGFGSRGIEGKIKAIKYARENNVPLLGICLGMQLMVIEYARNVFDYKEANSTEFDEN
TPYPVIDLMEEQKKMLNLGGTMRLGAQKIEIFPNTKLHKIYGEKNSVLERHRHRYEVNYKEFENMFEKGKNVPNKLSISA
MTDFVEAIELNSHPFYIGIQYHPEFKTKVGDPHPIFKAFIEAIEKNK

Sequences:

>Translated_527_residues
MAEKYIIVTGGVLSGIGKGVVSASIGRLLKELGLKVNSLKIDPYLNVDAGTMNPNQHGEVFVTEDGYEADLDLGHYERFL
GIEMKSFNNMTAGQVYKYVIEKEREGKYLGATVQMVPHVTERIKERIEEIDTEVLLIEIGGTVGDIEGEIFLEAVRELSF
EKGRENFMFIHVTFVPYLHVTNEFKTKPTQQSIQLLRRIGIQPDMLLVRTEKEIDLSSLEKVALFGGVPLEYVVNLPDLA
NVYEVPQMLYEKNIHVLISSKLNLEISKEVGELSWKCPKTFKNLKIAMICKYLGTDDAYKSIMESVFLSGTKRPDLINSE
ELEEMNEEEIRILLSKYEGIIIPGGFGSRGIEGKIKAIKYARENNVPLLGICLGMQLMVIEYARNVFDYKEANSTEFDEN
TPYPVIDLMEEQKKMLNLGGTMRLGAQKIEIFPNTKLHKIYGEKNSVLERHRHRYEVNYKEFENMFEKGKNVPNKLSISA
MTDFVEAIELNSHPFYIGIQYHPEFKTKVGDPHPIFKAFIEAIEKNK
>Mature_526_residues
AEKYIIVTGGVLSGIGKGVVSASIGRLLKELGLKVNSLKIDPYLNVDAGTMNPNQHGEVFVTEDGYEADLDLGHYERFLG
IEMKSFNNMTAGQVYKYVIEKEREGKYLGATVQMVPHVTERIKERIEEIDTEVLLIEIGGTVGDIEGEIFLEAVRELSFE
KGRENFMFIHVTFVPYLHVTNEFKTKPTQQSIQLLRRIGIQPDMLLVRTEKEIDLSSLEKVALFGGVPLEYVVNLPDLAN
VYEVPQMLYEKNIHVLISSKLNLEISKEVGELSWKCPKTFKNLKIAMICKYLGTDDAYKSIMESVFLSGTKRPDLINSEE
LEEMNEEEIRILLSKYEGIIIPGGFGSRGIEGKIKAIKYARENNVPLLGICLGMQLMVIEYARNVFDYKEANSTEFDENT
PYPVIDLMEEQKKMLNLGGTMRLGAQKIEIFPNTKLHKIYGEKNSVLERHRHRYEVNYKEFENMFEKGKNVPNKLSISAM
TDFVEAIELNSHPFYIGIQYHPEFKTKVGDPHPIFKAFIEAIEKNK

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI28559085, Length=561, Percent_Identity=43.3155080213904, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI28559083, Length=561, Percent_Identity=43.3155080213904, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI221316689, Length=561, Percent_Identity=43.3155080213904, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI148491070, Length=551, Percent_Identity=42.8312159709619, Blast_Score=437, Evalue=1e-122,
Organism=Escherichia coli, GI1789142, Length=543, Percent_Identity=43.4622467771639, Blast_Score=452, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI25148299, Length=604, Percent_Identity=38.5761589403974, Blast_Score=389, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322563, Length=562, Percent_Identity=44.3060498220641, Blast_Score=433, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6319432, Length=571, Percent_Identity=43.2574430823117, Blast_Score=423, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24664469, Length=558, Percent_Identity=43.5483870967742, Blast_Score=435, Evalue=1e-122,
Organism=Drosophila melanogaster, GI21357815, Length=503, Percent_Identity=41.1530815109344, Blast_Score=355, Evalue=3e-98,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 60047; Mature: 59916

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKYIIVTGGVLSGIGKGVVSASIGRLLKELGLKVNSLKIDPYLNVDAGTMNPNQHGEV
CCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCEEECCCCCCCCCCCCCE
FVTEDGYEADLDLGHYERFLGIEMKSFNNMTAGQVYKYVIEKEREGKYLGATVQMVPHVT
EEECCCCCCCCCHHHHHHHHCEEHHHCCCCCHHHHHHHHHHHCCCCCEECHHHHHHHHHH
ERIKERIEEIDTEVLLIEIGGTVGDIEGEIFLEAVRELSFEKGRENFMFIHVTFVPYLHV
HHHHHHHHHCCCEEEEEEECCCEECCCHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEE
TNEFKTKPTQQSIQLLRRIGIQPDMLLVRTEKEIDLSSLEKVALFGGVPLEYVVNLPDLA
CCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCHHHEECCCCHH
NVYEVPQMLYEKNIHVLISSKLNLEISKEVGELSWKCPKTFKNLKIAMICKYLGTDDAYK
HHHHHHHHHHHCCEEEEEECCCCEEECCCHHCCCCCCCHHHHCCHHHHHHHHHCCCHHHH
SIMESVFLSGTKRPDLINSEELEEMNEEEIRILLSKYEGIIIPGGFGSRGIEGKIKAIKY
HHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHCCCEEEECCCCCCCCCCHHHEEEE
ARENNVPLLGICLGMQLMVIEYARNVFDYKEANSTEFDENTPYPVIDLMEEQKKMLNLGG
HHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
TMRLGAQKIEIFPNTKLHKIYGEKNSVLERHRHRYEVNYKEFENMFEKGKNVPNKLSISA
CEEECCEEEEECCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEHHH
MTDFVEAIELNSHPFYIGIQYHPEFKTKVGDPHPIFKAFIEAIEKNK
HHHHHHHHHCCCCCEEEEEEECCCHHCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
AEKYIIVTGGVLSGIGKGVVSASIGRLLKELGLKVNSLKIDPYLNVDAGTMNPNQHGEV
CCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCEEECCCCCCCCCCCCCE
FVTEDGYEADLDLGHYERFLGIEMKSFNNMTAGQVYKYVIEKEREGKYLGATVQMVPHVT
EEECCCCCCCCCHHHHHHHHCEEHHHCCCCCHHHHHHHHHHHCCCCCEECHHHHHHHHHH
ERIKERIEEIDTEVLLIEIGGTVGDIEGEIFLEAVRELSFEKGRENFMFIHVTFVPYLHV
HHHHHHHHHCCCEEEEEEECCCEECCCHHHHHHHHHHHHHHCCCCCEEEEEEEEEEEEEE
TNEFKTKPTQQSIQLLRRIGIQPDMLLVRTEKEIDLSSLEKVALFGGVPLEYVVNLPDLA
CCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCHHHEECCCCHH
NVYEVPQMLYEKNIHVLISSKLNLEISKEVGELSWKCPKTFKNLKIAMICKYLGTDDAYK
HHHHHHHHHHHCCEEEEEECCCCEEECCCHHCCCCCCCHHHHCCHHHHHHHHHCCCHHHH
SIMESVFLSGTKRPDLINSEELEEMNEEEIRILLSKYEGIIIPGGFGSRGIEGKIKAIKY
HHHHHHHHCCCCCCCCCCHHHHHHCCHHHHHHHHHHCCCEEEECCCCCCCCCCHHHEEEE
ARENNVPLLGICLGMQLMVIEYARNVFDYKEANSTEFDENTPYPVIDLMEEQKKMLNLGG
HHCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
TMRLGAQKIEIFPNTKLHKIYGEKNSVLERHRHRYEVNYKEFENMFEKGKNVPNKLSISA
CEEECCEEEEECCCCCEEEECCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEHHH
MTDFVEAIELNSHPFYIGIQYHPEFKTKVGDPHPIFKAFIEAIEKNK
HHHHHHHHHCCCCCEEEEEEECCCHHCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]