Click here to switch to the map view.

The map label for this gene is icaA [H]

Identifier: 160902395

GI number: 160902395

Start: 984481

End: 985536

Strand: Direct

Name: icaA [H]

Synonym: Pmob_0930

Alternate gene names: 160902395

Gene position: 984481-985536 (Clockwise)

Preceding gene: 160902394

Following gene: 160902396

Centisome position: 45.38

GC content: 26.42

Gene sequence:

>1056_bases
TTGATCATTAAAGTATTTATATTTACTCTTCTAATCATGCCTATAGCTTTATCAGGGGTTAGCATTTTACATATCTTATT
TAGGAAAAATGAACAAATTATTGTACATACAAAAGAAAATGAATTAAAATTTGTGAGTGTTTTAGTACCTGCTTTTAATG
AGGAAAGTAATATTGCTAACAAAATAAATAATATATTATCTTTAGATTATCCAAAAAATAAATTAGAAATAATTATAGGA
TCAGATGGTTCAACTGATAATACTGTTGCAATCTGCCAGAGATTCGCAAGTAAATTTGATAACGTAATCTATATTGAAGA
AAAAAGAGGTGGAAAGGCGAATATAATCAATAAATTAGTAACTAGAGCTAAAGGAGAATATGTCCTTATTACAGATGCAG
ACACATTAATAATGAATAAAGATGCATTAAAAATTGCCCAGTCTTTAAATAAAGATTTTGTTAGCGCTAAACTATCTTAC
CCAAAAAATACTTATTGGAATCTAGATTATGCCATTAGGTCTTTTGAAAGCAAGTTTAATAGACTTTTAACTTCAAATGG
TGCATTCATGTTTTTAAAAAAAGAATTTTTTGAACCACTTCCCAAATACATTATAGCTGATGACCTTTTTATTCCTTTAA
CAGTACTTATAAAAAAAGGAAAATCTGTTCTTTCTGAGCAAATATATTGTTCTACAGAAGACGAAACGCTCACTTTTCCA
AAATATTTTAACAAAAGAGCCCGTGTAATAAAAGGAGGTTTACAAACATCTTTTTTGTTGTTTAGAAAACTCTTAATAAA
TGATTTTTTGTCGACGATTTTTTTGTTATCTCATAAAATTTTAAGATGGTTTTTTTTGCTTCTCTTATTCCTTAATATAT
TCATTTTTTTTGGTCTGAAATATTTTTTGCTTTCAGTACTATTTATTTTTTTGCTTCTGATAATCAAAAAAACAAGGTAT
TTCCTAATCGATATGATAATTCCATTTTTTTTAATTATAGATATAGCGAAATTAAAGAACAGAGATCACTCTGGATGGAA
TACAGAAAGACATTAA

Upstream 100 bases:

>100_bases
ATATGATCTGTATTACATAAAAAATCAAAATATTCTTCTGGACATTAAAATAATGTTTAAAACTCTTGAAACAATAGTAG
GAATGAGGGGGACAAGGTGA

Downstream 100 bases:

>100_bases
ATATAGATAGGGGAGAAAAAATGATTTTAGGTCTTTTATTTTCTTTACAACATCTTATATCTATTCTCATTTATTATAAT
AAAAAATACAAATTTTTTTT

Product: glycosyl transferase family protein

Products: NA

Alternate protein names: PNAG synthase; Poly-beta-1,6-GlcNAc synthase; Biofilm polysaccharide intercellular adhesin synthesis protein IcaA; Biofilm PIA synthesis protein IcaA; Intercellular adhesion protein A; N-acetylglucosaminyltransferase IcaA [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MIIKVFIFTLLIMPIALSGVSILHILFRKNEQIIVHTKENELKFVSVLVPAFNEESNIANKINNILSLDYPKNKLEIIIG
SDGSTDNTVAICQRFASKFDNVIYIEEKRGGKANIINKLVTRAKGEYVLITDADTLIMNKDALKIAQSLNKDFVSAKLSY
PKNTYWNLDYAIRSFESKFNRLLTSNGAFMFLKKEFFEPLPKYIIADDLFIPLTVLIKKGKSVLSEQIYCSTEDETLTFP
KYFNKRARVIKGGLQTSFLLFRKLLINDFLSTIFLLSHKILRWFFLLLLFLNIFIFFGLKYFLLSVLFIFLLLIIKKTRY
FLIDMIIPFFLIIDIAKLKNRDHSGWNTERH

Sequences:

>Translated_351_residues
MIIKVFIFTLLIMPIALSGVSILHILFRKNEQIIVHTKENELKFVSVLVPAFNEESNIANKINNILSLDYPKNKLEIIIG
SDGSTDNTVAICQRFASKFDNVIYIEEKRGGKANIINKLVTRAKGEYVLITDADTLIMNKDALKIAQSLNKDFVSAKLSY
PKNTYWNLDYAIRSFESKFNRLLTSNGAFMFLKKEFFEPLPKYIIADDLFIPLTVLIKKGKSVLSEQIYCSTEDETLTFP
KYFNKRARVIKGGLQTSFLLFRKLLINDFLSTIFLLSHKILRWFFLLLLFLNIFIFFGLKYFLLSVLFIFLLLIIKKTRY
FLIDMIIPFFLIIDIAKLKNRDHSGWNTERH
>Mature_351_residues
MIIKVFIFTLLIMPIALSGVSILHILFRKNEQIIVHTKENELKFVSVLVPAFNEESNIANKINNILSLDYPKNKLEIIIG
SDGSTDNTVAICQRFASKFDNVIYIEEKRGGKANIINKLVTRAKGEYVLITDADTLIMNKDALKIAQSLNKDFVSAKLSY
PKNTYWNLDYAIRSFESKFNRLLTSNGAFMFLKKEFFEPLPKYIIADDLFIPLTVLIKKGKSVLSEQIYCSTEDETLTFP
KYFNKRARVIKGGLQTSFLLFRKLLINDFLSTIFLLSHKILRWFFLLLLFLNIFIFFGLKYFLLSVLFIFLLLIIKKTRY
FLIDMIIPFFLIIDIAKLKNRDHSGWNTERH

Specific function: N-acetylglucosaminyltransferase that catalyzes the polymerization of single monomer units of UDP-N-acetylglucosamine to produce the linear homopolymer poly-beta-1,6-N-acetyl-D- glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide.

COG id: COG1215

COG function: function code M; Glycosyltransferases, probably involved in cell wall biogenesis

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 2 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001173 [H]

Pfam domain/function: PF00535 Glycos_transf_2 [H]

EC number: NA

Molecular weight: Translated: 40792; Mature: 40792

Theoretical pI: Translated: 10.15; Mature: 10.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIKVFIFTLLIMPIALSGVSILHILFRKNEQIIVHTKENELKFVSVLVPAFNEESNIAN
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEECCCCCCHHHHH
KINNILSLDYPKNKLEIIIGSDGSTDNTVAICQRFASKFDNVIYIEEKRGGKANIINKLV
HHHHHEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHH
TRAKGEYVLITDADTLIMNKDALKIAQSLNKDFVSAKLSYPKNTYWNLDYAIRSFESKFN
HHCCCCEEEEECCCCEEECHHHHHHHHHHCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
RLLTSNGAFMFLKKEFFEPLPKYIIADDLFIPLTVLIKKGKSVLSEQIYCSTEDETLTFP
HHHHCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCEECCCCCCEECH
KYFNKRARVIKGGLQTSFLLFRKLLINDFLSTIFLLSHKILRWFFLLLLFLNIFIFFGLK
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YFLLSVLFIFLLLIIKKTRYFLIDMIIPFFLIIDIAKLKNRDHSGWNTERH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MIIKVFIFTLLIMPIALSGVSILHILFRKNEQIIVHTKENELKFVSVLVPAFNEESNIAN
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEEEECCCCCCHHHHH
KINNILSLDYPKNKLEIIIGSDGSTDNTVAICQRFASKFDNVIYIEEKRGGKANIINKLV
HHHHHEECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHH
TRAKGEYVLITDADTLIMNKDALKIAQSLNKDFVSAKLSYPKNTYWNLDYAIRSFESKFN
HHCCCCEEEEECCCCEEECHHHHHHHHHHCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
RLLTSNGAFMFLKKEFFEPLPKYIIADDLFIPLTVLIKKGKSVLSEQIYCSTEDETLTFP
HHHHCCCCEEEEHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCEECCCCCCEECH
KYFNKRARVIKGGLQTSFLLFRKLLINDFLSTIFLLSHKILRWFFLLLLFLNIFIFFGLK
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YFLLSVLFIFLLLIIKKTRYFLIDMIIPFFLIIDIAKLKNRDHSGWNTERH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA