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The map label for this gene is gmk [H]

Identifier: 160901591

GI number: 160901591

Start: 97757

End: 98365

Strand: Direct

Name: gmk [H]

Synonym: Pmob_0100

Alternate gene names: 160901591

Gene position: 97757-98365 (Clockwise)

Preceding gene: 160901590

Following gene: 160901592

Centisome position: 4.51

GC content: 32.35

Gene sequence:

>609_bases
ATGGAGGGTTTACTTTACATCGTTAGTGGACCATCAGGTGCAGGAAAATCTACATTGATAAAAAATGTTTTAGACAAAAT
TATTGGCTTTTCATTTTCTGTTTCCTATACCACAAGAGAAAAAAGACCAGGAGAGATTGACGGAAAAGATTATTTTTTTG
TTGATAAAAGCACCTTTTTTAAAATGAAAGAAGATGGAGAATTTCTCGAGTGGGCTGAGGTTCATGGAAATTATTATGCA
ACTTCCAAAAAATTTATTGAGGAAAAGTTAAAAGAAAGTCGAGGCCTTGTTTTAGATGTCGATGTTCAAGGAGCTTTAAA
TATTAAAAAAATTTATAAGAACGCCATATACATTTTTATTTTACCTCCCTCAAATGAGGATCTAGAAAAAAGACTAAAAA
AAAGGGGTACCGAATCAAAAGATTCTTTGGAAATAAGGCTAAAAGATGCACAGTGGGAGATTTCTCATATGAAAGATTTC
GATTACGTTATTGTCAACCAGGAAATTGAAGAATCAACAAATCAACTCATATCAGTTCTCGTGGCAGAACAACTTAAGAG
AGAAAGGTTCGATGACAAAACTCCGTTTTTTTTTAAAAAACAACTATGA

Upstream 100 bases:

>100_bases
CCAGCGCAATCCAACCAGAAACAATTACCAATAGATTTTTGCAGAACTATTATGACATAGAAAAAGTTTTGGATAAAATA
CGCAAGGAAGTACTATAAAA

Downstream 100 bases:

>100_bases
ATTTTAAATTAAGAGGTGAAATCAAATGAATTTGGGAATAAATTACGATAGAATATTAAATAAAGCGAAGTATAAATATG
TAATTCCTATTATTGCAGCT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MEGLLYIVSGPSGAGKSTLIKNVLDKIIGFSFSVSYTTREKRPGEIDGKDYFFVDKSTFFKMKEDGEFLEWAEVHGNYYA
TSKKFIEEKLKESRGLVLDVDVQGALNIKKIYKNAIYIFILPPSNEDLEKRLKKRGTESKDSLEIRLKDAQWEISHMKDF
DYVIVNQEIEESTNQLISVLVAEQLKRERFDDKTPFFFKKQL

Sequences:

>Translated_202_residues
MEGLLYIVSGPSGAGKSTLIKNVLDKIIGFSFSVSYTTREKRPGEIDGKDYFFVDKSTFFKMKEDGEFLEWAEVHGNYYA
TSKKFIEEKLKESRGLVLDVDVQGALNIKKIYKNAIYIFILPPSNEDLEKRLKKRGTESKDSLEIRLKDAQWEISHMKDF
DYVIVNQEIEESTNQLISVLVAEQLKRERFDDKTPFFFKKQL
>Mature_202_residues
MEGLLYIVSGPSGAGKSTLIKNVLDKIIGFSFSVSYTTREKRPGEIDGKDYFFVDKSTFFKMKEDGEFLEWAEVHGNYYA
TSKKFIEEKLKESRGLVLDVDVQGALNIKKIYKNAIYIFILPPSNEDLEKRLKKRGTESKDSLEIRLKDAQWEISHMKDF
DYVIVNQEIEESTNQLISVLVAEQLKRERFDDKTPFFFKKQL

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=187, Percent_Identity=44.9197860962567, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI226874833, Length=187, Percent_Identity=44.9197860962567, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI4504221, Length=187, Percent_Identity=44.9197860962567, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI38570142, Length=177, Percent_Identity=28.8135593220339, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI14780902, Length=195, Percent_Identity=27.6923076923077, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI262118255, Length=172, Percent_Identity=28.4883720930233, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI4505237, Length=172, Percent_Identity=28.4883720930233, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI262118259, Length=172, Percent_Identity=28.4883720930233, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI262118263, Length=172, Percent_Identity=28.4883720930233, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1790080, Length=190, Percent_Identity=44.2105263157895, Blast_Score=163, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI193203132, Length=179, Percent_Identity=41.340782122905, Blast_Score=134, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17508835, Length=179, Percent_Identity=41.340782122905, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=42.8571428571429, Blast_Score=147, Evalue=1e-36,
Organism=Drosophila melanogaster, GI21356141, Length=181, Percent_Identity=38.6740331491713, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI45554481, Length=188, Percent_Identity=26.5957446808511, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI85724806, Length=188, Percent_Identity=26.5957446808511, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24640542, Length=188, Percent_Identity=26.5957446808511, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI116007136, Length=188, Percent_Identity=26.5957446808511, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI45554489, Length=188, Percent_Identity=26.5957446808511, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI161077626, Length=188, Percent_Identity=26.5957446808511, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23459; Mature: 23459

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGLLYIVSGPSGAGKSTLIKNVLDKIIGFSFSVSYTTREKRPGEIDGKDYFFVDKSTFF
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCEEEEEECCEEE
KMKEDGEFLEWAEVHGNYYATSKKFIEEKLKESRGLVLDVDVQGALNIKKIYKNAIYIFI
EECCCCCHHHHHHHCCCEEEHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCEEEEEE
LPPSNEDLEKRLKKRGTESKDSLEIRLKDAQWEISHMKDFDYVIVNQEIEESTNQLISVL
ECCCCHHHHHHHHHCCCCCCCCEEEEEECCEEEECCCCCCCEEEECCHHHHHHHHHHHHH
VAEQLKRERFDDKTPFFFKKQL
HHHHHHHHHCCCCCCCEEECCC
>Mature Secondary Structure
MEGLLYIVSGPSGAGKSTLIKNVLDKIIGFSFSVSYTTREKRPGEIDGKDYFFVDKSTFF
CCCEEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCEEEEEECCEEE
KMKEDGEFLEWAEVHGNYYATSKKFIEEKLKESRGLVLDVDVQGALNIKKIYKNAIYIFI
EECCCCCHHHHHHHCCCEEEHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHCEEEEEE
LPPSNEDLEKRLKKRGTESKDSLEIRLKDAQWEISHMKDFDYVIVNQEIEESTNQLISVL
ECCCCHHHHHHHHHCCCCCCCCEEEEEECCEEEECCCCCCCEEEECCHHHHHHHHHHHHH
VAEQLKRERFDDKTPFFFKKQL
HHHHHHHHHCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]