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The map label for this gene is fkpA [H]

Identifier: 160877104

GI number: 160877104

Start: 4709408

End: 4710190

Strand: Reverse

Name: fkpA [H]

Synonym: Sbal195_4000

Alternate gene names: 160877104

Gene position: 4710190-4709408 (Counterclockwise)

Preceding gene: 160877105

Following gene: 160877103

Centisome position: 88.09

GC content: 44.96

Gene sequence:

>783_bases
ATGAAAACACGTATGCCAACTTCTTTTATCCCAAAAACGTTAACCGTGGCGACCTGTGCTGCGCTATTTGTTTCTGTGAC
AAGTTTTGCTGCCCCTAGCCTAAAAAGTGATGCGGATAAAACCTCTTACAGTATTGGCGCGTCCATTGGCAATTACATTT
CAGGCCAAGTTTATAACCAAGTTGAATTAGGGTCTGAGGTCAATATTGATCTAGTCGTGCAAGGTTTTGTGGATGCGCTG
AAGGATAAGCAACAACTGACGGATGAGGAGGTCGTGACCTATCTTAATCAAAGGGCTGAAGAGCTTAATGCTGCCAGAAA
AATCCTTGCTGAAAAAGAAATGGCGGAAACGAAAAAAGCTAGCGCTGACTACCTTGCACAAAATGCCAAGCAATCAAATG
TGAAAGTCACAGCTTCCGGTCTGCAATACCAAGTGATAACCCAAGGCTCTGGTCAAAAGCCAAACCCTGAGGATGTTGTC
ACTGTGGAATATGTTGGCACGCTCATCGACGGTACAGAGTTTGAAAATACTGTCGGCCGCAAAGAGCATACTCGGTTTGC
ATTAATGACTGTCATTCCCGGTTGGGAAGAGGGACTGAAATTGATGCCTATGGGATCTAAATACCGATTTGTGGTTCCCG
CTAGTCTGGCCTATGGCACAGAAGCCGTGGGCATTATCCCGCCAGAGTCAGCACTTATCTTTGAAATTGAGCTGAAAAAT
ATCGAAAAACCGAGTGAAATTAAAGAGATGAAGCATCAAAGCATGATGCCTGCCCACGGTTAG

Upstream 100 bases:

>100_bases
AAAAACCATAGTAAAGAACACGCGAACTGATTTTCTAGAAGATCTGTTTGCAGGGCCAAGAGGCTAAACCCACAGGGTTC
ATCATTGTAGAGAACATAAA

Downstream 100 bases:

>100_bases
TGCACCGTTTGAGTTAGCTTGGGTAAATGTGTCACTTGCTATGACCTGTTTGGGGAATGAGATGGTCAGTTTAGGGTTAG
TTATTTGCATGTGTTTAGGT

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MKTRMPTSFIPKTLTVATCAALFVSVTSFAAPSLKSDADKTSYSIGASIGNYISGQVYNQVELGSEVNIDLVVQGFVDAL
KDKQQLTDEEVVTYLNQRAEELNAARKILAEKEMAETKKASADYLAQNAKQSNVKVTASGLQYQVITQGSGQKPNPEDVV
TVEYVGTLIDGTEFENTVGRKEHTRFALMTVIPGWEEGLKLMPMGSKYRFVVPASLAYGTEAVGIIPPESALIFEIELKN
IEKPSEIKEMKHQSMMPAHG

Sequences:

>Translated_260_residues
MKTRMPTSFIPKTLTVATCAALFVSVTSFAAPSLKSDADKTSYSIGASIGNYISGQVYNQVELGSEVNIDLVVQGFVDAL
KDKQQLTDEEVVTYLNQRAEELNAARKILAEKEMAETKKASADYLAQNAKQSNVKVTASGLQYQVITQGSGQKPNPEDVV
TVEYVGTLIDGTEFENTVGRKEHTRFALMTVIPGWEEGLKLMPMGSKYRFVVPASLAYGTEAVGIIPPESALIFEIELKN
IEKPSEIKEMKHQSMMPAHG
>Mature_260_residues
MKTRMPTSFIPKTLTVATCAALFVSVTSFAAPSLKSDADKTSYSIGASIGNYISGQVYNQVELGSEVNIDLVVQGFVDAL
KDKQQLTDEEVVTYLNQRAEELNAARKILAEKEMAETKKASADYLAQNAKQSNVKVTASGLQYQVITQGSGQKPNPEDVV
TVEYVGTLIDGTEFENTVGRKEHTRFALMTVIPGWEEGLKLMPMGSKYRFVVPASLAYGTEAVGIIPPESALIFEIELKN
IEKPSEIKEMKHQSMMPAHG

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=107, Percent_Identity=36.4485981308411, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4503725, Length=107, Percent_Identity=36.4485981308411, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI33469985, Length=91, Percent_Identity=39.5604395604396, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI206725530, Length=98, Percent_Identity=39.7959183673469, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI17149844, Length=98, Percent_Identity=39.7959183673469, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI17149842, Length=98, Percent_Identity=39.7959183673469, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1789745, Length=213, Percent_Identity=38.9671361502347, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI87082390, Length=213, Percent_Identity=40.3755868544601, Blast_Score=133, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17540882, Length=98, Percent_Identity=38.7755102040816, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=94, Percent_Identity=39.3617021276596, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324194, Length=97, Percent_Identity=37.1134020618557, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281363946, Length=116, Percent_Identity=37.9310344827586, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI17352457, Length=116, Percent_Identity=37.9310344827586, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24655568, Length=107, Percent_Identity=36.4485981308411, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 28403; Mature: 28403

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTRMPTSFIPKTLTVATCAALFVSVTSFAAPSLKSDADKTSYSIGASIGNYISGQVYNQ
CCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHH
VELGSEVNIDLVVQGFVDALKDKQQLTDEEVVTYLNQRAEELNAARKILAEKEMAETKKA
EECCCCCCHHEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SADYLAQNAKQSNVKVTASGLQYQVITQGSGQKPNPEDVVTVEYVGTLIDGTEFENTVGR
HHHHHHHCCCCCCEEEEECCEEEEEEECCCCCCCCCCCEEEHEEHHHHHCCCCHHHHCCC
KEHTRFALMTVIPGWEEGLKLMPMGSKYRFVVPASLAYGTEAVGIIPPESALIFEIELKN
CHHCEEEEEEECCCHHHCCEEEECCCCEEEEEECHHHCCCCEEEEECCCCEEEEEEEECC
IEKPSEIKEMKHQSMMPAHG
CCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKTRMPTSFIPKTLTVATCAALFVSVTSFAAPSLKSDADKTSYSIGASIGNYISGQVYNQ
CCCCCCCHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHH
VELGSEVNIDLVVQGFVDALKDKQQLTDEEVVTYLNQRAEELNAARKILAEKEMAETKKA
EECCCCCCHHEEHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SADYLAQNAKQSNVKVTASGLQYQVITQGSGQKPNPEDVVTVEYVGTLIDGTEFENTVGR
HHHHHHHCCCCCCEEEEECCEEEEEEECCCCCCCCCCCEEEHEEHHHHHCCCCHHHHCCC
KEHTRFALMTVIPGWEEGLKLMPMGSKYRFVVPASLAYGTEAVGIIPPESALIFEIELKN
CHHCEEEEEEECCCHHHCCEEEECCCCEEEEEECHHHCCCCEEEEECCCCEEEEEEEECC
IEKPSEIKEMKHQSMMPAHG
CCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]