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The map label for this gene is 160877057

Identifier: 160877057

GI number: 160877057

Start: 4657664

End: 4659106

Strand: Reverse

Name: 160877057

Synonym: Sbal195_3953

Alternate gene names: NA

Gene position: 4659106-4657664 (Counterclockwise)

Preceding gene: 160877058

Following gene: 160877056

Centisome position: 87.13

GC content: 49.83

Gene sequence:

>1443_bases
ATGCGAATGACACTGCAGTTTTTAGGGGCGACAGAGGAAGTGACCGGCTCGTGCCATTTACTCTCGGTCGATCATGAACA
CTTATTACTCGATTGTGGTTTGATCCAAGGTGGTAAAGCGGATGAACTGCGTAATCATGATCCCTTCGCCTTCGACCCTG
AGTCTATTTCCGCTGTTGTGCTTAGCCATGCCCATATCGACCATTCAGGGCGTTTACCACTCTTAGTTAAAGCGGGTTTT
GATGGGCCAATCTACACCCATAAAGCCACGGCAGAACTGTGCGCCATCATGCTCAAAGATGCGGCCATGCTGCAGACCCG
CGACACCGAAAGGGTCAATAAAAAGCGCGCTAAACATGATCTTGAACCCTTAGAACCGCTATTCACCGTCGAAGATGCCG
AACAGGCCATCACCCAATTTGTGCCGCTGGAATACGGCCAAGTAACTCGGGTCATTCCCCATGTGGATATTTGCCTCTCA
GATGCGGGGCATATTTTAGGTTCTGCTTTGGTTGAATTGTGGTTAGGCGAGGGTAAGTCCCAGAAAAAAGTCGTCTTCAG
TGGCGATCTTGGTCGTGCGGGTATGCCGATTTTACGCAATCCGACCTTAGTGGATACGGCGGATTTAGTGTTAATGGAAA
GCACCTACGGCAACCGTTTTCACCGCAGTTGGACTGAAACCTTAGCCGAGTTGAAAGACATTTTTGCTAAGACAGTTAAC
GAGAGCCAAGGCAATATCTTGCTGCCAGCTTTCTCGGTTGGACGGGCGCAGGAATTATTATATCTATTTCATTTATATGC
TAAAGAATGGGATCTCGGCCGCTGGAAAATCTGTCTAGATAGCCCCATGGCGATTGAAGCGACTCGCGTCTACGTCAATA
ATTATCCGCTGATGGATGAGGATTTTAAACGCTTTACCCGCCAACATCCTGGTCAGCATCCGCTGCTGTCGAATGTCGAG
TTTATCCAGACGACCGAAGAGTCGATGGCGCTGAACGAAGTGCATAAGGGATTGATCATTATCGCGGGGAGCGGCATGTG
TAACGGTGGCCGTATTCGTAGCCACTTAGAGCACAATTTATGGCGTCCTGAATGCGATGTGATTATCTGTGGTTATCAAG
CACTCGGCACACCGGGACGTGCCTTGGTCGACGGTGTTGAGGAGCTGACTATCCACGGAAACAGCATTAAAGTCGCGGCA
AAATTACACACAGTTGGCGGGCTTTCTGCCCATGCGGATCAAGCTGAGTTATTGCGTTGGTATCGCCACTTTGAAGGTCA
ACCGCCGCTGATTTTAGTCCACGGAGAACCCGATGCGCAGCATGGATTGGTCGATGTGGTTAACCAAGATCCTAAAACTA
AACCTCAAGCCACCGCGATTGCGACCCATGGCGACAGGTTAGATTTAACCGCGCTGCCACAGTTAGTGTGGAAGCCAGCT
TAA

Upstream 100 bases:

>100_bases
GAAAGTTGACATTGCTCGCATGCGACCAATTAATCCTTTTTCTTTGAGGAATAAGGGCATAGTCTAGCTTTATACAAGGT
AAAAACGTTGGAGGGACACC

Downstream 100 bases:

>100_bases
GTTAACCATCCTACTTAGCGGCGTATTGCTCGAGAGACTCCCTGCATACTCAATGCGGGGATTTTTTATTTATGTTGCAA
ATCAATATCTCACCGCTCGG

Product: RNA-metabolising metallo-beta-lactamase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 480; Mature: 480

Protein sequence:

>480_residues
MRMTLQFLGATEEVTGSCHLLSVDHEHLLLDCGLIQGGKADELRNHDPFAFDPESISAVVLSHAHIDHSGRLPLLVKAGF
DGPIYTHKATAELCAIMLKDAAMLQTRDTERVNKKRAKHDLEPLEPLFTVEDAEQAITQFVPLEYGQVTRVIPHVDICLS
DAGHILGSALVELWLGEGKSQKKVVFSGDLGRAGMPILRNPTLVDTADLVLMESTYGNRFHRSWTETLAELKDIFAKTVN
ESQGNILLPAFSVGRAQELLYLFHLYAKEWDLGRWKICLDSPMAIEATRVYVNNYPLMDEDFKRFTRQHPGQHPLLSNVE
FIQTTEESMALNEVHKGLIIIAGSGMCNGGRIRSHLEHNLWRPECDVIICGYQALGTPGRALVDGVEELTIHGNSIKVAA
KLHTVGGLSAHADQAELLRWYRHFEGQPPLILVHGEPDAQHGLVDVVNQDPKTKPQATAIATHGDRLDLTALPQLVWKPA

Sequences:

>Translated_480_residues
MRMTLQFLGATEEVTGSCHLLSVDHEHLLLDCGLIQGGKADELRNHDPFAFDPESISAVVLSHAHIDHSGRLPLLVKAGF
DGPIYTHKATAELCAIMLKDAAMLQTRDTERVNKKRAKHDLEPLEPLFTVEDAEQAITQFVPLEYGQVTRVIPHVDICLS
DAGHILGSALVELWLGEGKSQKKVVFSGDLGRAGMPILRNPTLVDTADLVLMESTYGNRFHRSWTETLAELKDIFAKTVN
ESQGNILLPAFSVGRAQELLYLFHLYAKEWDLGRWKICLDSPMAIEATRVYVNNYPLMDEDFKRFTRQHPGQHPLLSNVE
FIQTTEESMALNEVHKGLIIIAGSGMCNGGRIRSHLEHNLWRPECDVIICGYQALGTPGRALVDGVEELTIHGNSIKVAA
KLHTVGGLSAHADQAELLRWYRHFEGQPPLILVHGEPDAQHGLVDVVNQDPKTKPQATAIATHGDRLDLTALPQLVWKPA
>Mature_480_residues
MRMTLQFLGATEEVTGSCHLLSVDHEHLLLDCGLIQGGKADELRNHDPFAFDPESISAVVLSHAHIDHSGRLPLLVKAGF
DGPIYTHKATAELCAIMLKDAAMLQTRDTERVNKKRAKHDLEPLEPLFTVEDAEQAITQFVPLEYGQVTRVIPHVDICLS
DAGHILGSALVELWLGEGKSQKKVVFSGDLGRAGMPILRNPTLVDTADLVLMESTYGNRFHRSWTETLAELKDIFAKTVN
ESQGNILLPAFSVGRAQELLYLFHLYAKEWDLGRWKICLDSPMAIEATRVYVNNYPLMDEDFKRFTRQHPGQHPLLSNVE
FIQTTEESMALNEVHKGLIIIAGSGMCNGGRIRSHLEHNLWRPECDVIICGYQALGTPGRALVDGVEELTIHGNSIKVAA
KLHTVGGLSAHADQAELLRWYRHFEGQPPLILVHGEPDAQHGLVDVVNQDPKTKPQATAIATHGDRLDLTALPQLVWKPA

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI33300633, Length=458, Percent_Identity=24.8908296943231, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI7706427, Length=446, Percent_Identity=26.0089686098655, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI32564696, Length=487, Percent_Identity=25.0513347022587, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI32566029, Length=452, Percent_Identity=26.5486725663717, Blast_Score=101, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6323307, Length=460, Percent_Identity=24.7826086956522, Blast_Score=113, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24648013, Length=451, Percent_Identity=26.8292682926829, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI21358523, Length=449, Percent_Identity=26.9487750556793, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 53226; Mature: 53226

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMTLQFLGATEEVTGSCHLLSVDHEHLLLDCGLIQGGKADELRNHDPFAFDPESISAVV
CCEEEEECCCCHHCCCCEEEEEECCCEEEEEECCCCCCCCHHCCCCCCCCCCHHHHHEEE
LSHAHIDHSGRLPLLVKAGFDGPIYTHKATAELCAIMLKDAAMLQTRDTERVNKKRAKHD
EEHHCCCCCCCCCEEEEECCCCCCEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
LEPLEPLFTVEDAEQAITQFVPLEYGQVTRVIPHVDICLSDAGHILGSALVELWLGEGKS
CCCCCCCEEHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
QKKVVFSGDLGRAGMPILRNPTLVDTADLVLMESTYGNRFHRSWTETLAELKDIFAKTVN
CCEEEEECCCCCCCCCCCCCCCEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
ESQGNILLPAFSVGRAQELLYLFHLYAKEWDLGRWKICLDSPMAIEATRVYVNNYPLMDE
CCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEEECCCCCCCH
DFKRFTRQHPGQHPLLSNVEFIQTTEESMALNEVHKGLIIIAGSGMCNGGRIRSHLEHNL
HHHHHHHHCCCCCCCCCCCHHEECCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCC
WRPECDVIICGYQALGTPGRALVDGVEELTIHGNSIKVAAKLHTVGGLSAHADQAELLRW
CCCCCCEEEECCHHCCCCCHHHHCCCHHEEEECCEEEEEEEEEECCCCCCCCCHHHHHHH
YRHFEGQPPLILVHGEPDAQHGLVDVVNQDPKTKPQATAIATHGDRLDLTALPQLVWKPA
HHHHCCCCCEEEEECCCCCCCCHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MRMTLQFLGATEEVTGSCHLLSVDHEHLLLDCGLIQGGKADELRNHDPFAFDPESISAVV
CCEEEEECCCCHHCCCCEEEEEECCCEEEEEECCCCCCCCHHCCCCCCCCCCHHHHHEEE
LSHAHIDHSGRLPLLVKAGFDGPIYTHKATAELCAIMLKDAAMLQTRDTERVNKKRAKHD
EEHHCCCCCCCCCEEEEECCCCCCEECHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
LEPLEPLFTVEDAEQAITQFVPLEYGQVTRVIPHVDICLSDAGHILGSALVELWLGEGKS
CCCCCCCEEHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
QKKVVFSGDLGRAGMPILRNPTLVDTADLVLMESTYGNRFHRSWTETLAELKDIFAKTVN
CCEEEEECCCCCCCCCCCCCCCEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHC
ESQGNILLPAFSVGRAQELLYLFHLYAKEWDLGRWKICLDSPMAIEATRVYVNNYPLMDE
CCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEEEECCCCCCCH
DFKRFTRQHPGQHPLLSNVEFIQTTEESMALNEVHKGLIIIAGSGMCNGGRIRSHLEHNL
HHHHHHHHCCCCCCCCCCCHHEECCHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHCC
WRPECDVIICGYQALGTPGRALVDGVEELTIHGNSIKVAAKLHTVGGLSAHADQAELLRW
CCCCCCEEEECCHHCCCCCHHHHCCCHHEEEECCEEEEEEEEEECCCCCCCCCHHHHHHH
YRHFEGQPPLILVHGEPDAQHGLVDVVNQDPKTKPQATAIATHGDRLDLTALPQLVWKPA
HHHHCCCCCEEEEECCCCCCCCHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA