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The map label for this gene is fhs [H]

Identifier: 160877034

GI number: 160877034

Start: 4634049

End: 4635806

Strand: Reverse

Name: fhs [H]

Synonym: Sbal195_3930

Alternate gene names: 160877034

Gene position: 4635806-4634049 (Counterclockwise)

Preceding gene: 160877036

Following gene: 160877032

Centisome position: 86.69

GC content: 51.02

Gene sequence:

>1758_bases
ATGCTGACAGATATGGATATTTCGAGTCGCGCAAGCCTTAAAAACATCACCGAAATTGGCGTCGACTTAGGCCTGTTACC
CGAAGAGATGATGCTATTTGGTCACACTAAAGCCAAGGTGGAGCTCAGTGTGTTGCAGCGTTTAGCGGGGCAACGCAAAG
GTAAATTGATTATCGTCACCGCAGTTACGCCTACTCCCCACGGCGAAGGTAAAACGGTGACGAGCATTGGCTTAACACAA
TCGTTAAATGCCATAGGCCAAAAGGCCTGTGCTTGTATTCGCCAGCCTAGCATGGGACCTGTGTTTGGGGTGAAAGGCGG
TGCTGCGGGTGGCGGTTATGCGCAAGTGGTGCCCATGCAGGAGATGAACTTACATCTCACGGGTGACATTCATGCCGTCA
GCAGTGCCCACAATTTAGGGGCGGCGGCGATTGCGGCGCGGCTATTCCACGAGGCGCGCTTAGGTAAAACAGAATTTGAA
GCGCAATCTGGACAAGCGTTTTTGGATATAGCTCCCAACGAGATCCGCTGGCACCGAGTGGTCGATCATAATGATCGCTG
CCTTAGGCAAATTCATGTGGGCTTAGGTGATAATAACGGCCCAGAGTACGGATCTAGCTTTGATATTACCGCCGCCTCTG
AGTTGATGGCGATTTTAGCCTTAAGCCATGATTTGGCGGACATGCGGGTGCGGATCGGTCGTTTAGTGTTGGCCTTAAAT
ACCCAAGGGCAAGTGATTACCGCCGAAGATTTAGGTGTCGCTGGGGCGATGACGGCCATCATGGCCGATGCGATAAAACC
GACGTTAATGCAGACCTTAAATGGCTCGCCTTGTCTGATCCATTCGGGACCCTTTGCCAATATTGCCCACGGTAACTCGT
CGATCATTGCCGATGATATCGCCCTTAGGCTGGCGGACTTTGTGGTGACTGAAGGCGGTTTCGGCTCGGATATGGGCTTT
GAAAAGTTCTGTAATATCAAGGTTCGTCAATCGGGTCAGGCGCCAGCTGCCGCTGTGTTGGTGACGACTTTAAAAGCGCT
GAAGGCCAATAGTGGCTTGGCAACTGAGGTGGATAGCAATGTATCAAATATCCATGTGCCAAAGATCAATGCGGCAAACA
TCAATGCCCCAGATCAGGCTCGACTCGAAGCGGGCTTTGCAAATTTAAACTGGCATATCAACAATGTGGCGCGTTATGGC
ATTCCTGTGGTGGTTGCTATTAACCGTTTCGCCACTGATTCCGATGCTGAGTTGCAATGGCTAATGGAAGCCGTCAACGC
GAGTGCTGCCTTTGGCTGTGAAATTAGCGATGCCTTCAGCCAAGGGGAGGCGGGCGCTATTGCCTTAGCGCAAACTGTGG
TTCGCGCCGCTGAAATTGAGAGTCAGTTCAAGCTGTTATATCCAGATGAAGCGTCATTGGAGGCAAAGTTATCCACCTTA
GCCGAAGTGGGTTATGGCGCTGCAGGCGTGAGTCTTTCTATCGAGGCGAAACAGCAGGCGCAGCAACTGACCGCGCTTGG
CTATGGGCATTTGCCTTTGTGTATGGCCAAAACGCCGTTATCCATTAGCCACGATCCTAGCTTAAAGGGTGTTCCTAAGG
ATTTTGTGGTGCCAGTGCGAGAGTTAGTGTTACATGCGGGGGCGGGATTTATAACTGCCTTAGTGGGTAATGTGATGACT
ATGCCAGGACTTGGGCTTAAACCGGGATACTTGAAAATCGATATTGATGCCAAAGGTGAGATAGTCGGTTTAGGCTAA

Upstream 100 bases:

>100_bases
CTTAAAGCCAATCACCTAATATCCGCCCTATTCAATGAGTGTTGTGCTTAGCAACCCCTCATACTAAACCAAAGCGTATC
TGAAAGGGAGAAATCGACGT

Downstream 100 bases:

>100_bases
CGTTTAGATTCAAAACTAACATTTCAATGAAAACTCACGCTTAGATGCAAAAGCGCTGCAGAGATAAAAAAGGGCGAGCT
TGCTGCTACGCCCTTTGACT

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MLTDMDISSRASLKNITEIGVDLGLLPEEMMLFGHTKAKVELSVLQRLAGQRKGKLIIVTAVTPTPHGEGKTVTSIGLTQ
SLNAIGQKACACIRQPSMGPVFGVKGGAAGGGYAQVVPMQEMNLHLTGDIHAVSSAHNLGAAAIAARLFHEARLGKTEFE
AQSGQAFLDIAPNEIRWHRVVDHNDRCLRQIHVGLGDNNGPEYGSSFDITAASELMAILALSHDLADMRVRIGRLVLALN
TQGQVITAEDLGVAGAMTAIMADAIKPTLMQTLNGSPCLIHSGPFANIAHGNSSIIADDIALRLADFVVTEGGFGSDMGF
EKFCNIKVRQSGQAPAAAVLVTTLKALKANSGLATEVDSNVSNIHVPKINAANINAPDQARLEAGFANLNWHINNVARYG
IPVVVAINRFATDSDAELQWLMEAVNASAAFGCEISDAFSQGEAGAIALAQTVVRAAEIESQFKLLYPDEASLEAKLSTL
AEVGYGAAGVSLSIEAKQQAQQLTALGYGHLPLCMAKTPLSISHDPSLKGVPKDFVVPVRELVLHAGAGFITALVGNVMT
MPGLGLKPGYLKIDIDAKGEIVGLG

Sequences:

>Translated_585_residues
MLTDMDISSRASLKNITEIGVDLGLLPEEMMLFGHTKAKVELSVLQRLAGQRKGKLIIVTAVTPTPHGEGKTVTSIGLTQ
SLNAIGQKACACIRQPSMGPVFGVKGGAAGGGYAQVVPMQEMNLHLTGDIHAVSSAHNLGAAAIAARLFHEARLGKTEFE
AQSGQAFLDIAPNEIRWHRVVDHNDRCLRQIHVGLGDNNGPEYGSSFDITAASELMAILALSHDLADMRVRIGRLVLALN
TQGQVITAEDLGVAGAMTAIMADAIKPTLMQTLNGSPCLIHSGPFANIAHGNSSIIADDIALRLADFVVTEGGFGSDMGF
EKFCNIKVRQSGQAPAAAVLVTTLKALKANSGLATEVDSNVSNIHVPKINAANINAPDQARLEAGFANLNWHINNVARYG
IPVVVAINRFATDSDAELQWLMEAVNASAAFGCEISDAFSQGEAGAIALAQTVVRAAEIESQFKLLYPDEASLEAKLSTL
AEVGYGAAGVSLSIEAKQQAQQLTALGYGHLPLCMAKTPLSISHDPSLKGVPKDFVVPVRELVLHAGAGFITALVGNVMT
MPGLGLKPGYLKIDIDAKGEIVGLG
>Mature_585_residues
MLTDMDISSRASLKNITEIGVDLGLLPEEMMLFGHTKAKVELSVLQRLAGQRKGKLIIVTAVTPTPHGEGKTVTSIGLTQ
SLNAIGQKACACIRQPSMGPVFGVKGGAAGGGYAQVVPMQEMNLHLTGDIHAVSSAHNLGAAAIAARLFHEARLGKTEFE
AQSGQAFLDIAPNEIRWHRVVDHNDRCLRQIHVGLGDNNGPEYGSSFDITAASELMAILALSHDLADMRVRIGRLVLALN
TQGQVITAEDLGVAGAMTAIMADAIKPTLMQTLNGSPCLIHSGPFANIAHGNSSIIADDIALRLADFVVTEGGFGSDMGF
EKFCNIKVRQSGQAPAAAVLVTTLKALKANSGLATEVDSNVSNIHVPKINAANINAPDQARLEAGFANLNWHINNVARYG
IPVVVAINRFATDSDAELQWLMEAVNASAAFGCEISDAFSQGEAGAIALAQTVVRAAEIESQFKLLYPDEASLEAKLSTL
AEVGYGAAGVSLSIEAKQQAQQLTALGYGHLPLCMAKTPLSISHDPSLKGVPKDFVVPVRELVLHAGAGFITALVGNVMT
MPGLGLKPGYLKIDIDAKGEIVGLG

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=622, Percent_Identity=47.588424437299, Blast_Score=505, Evalue=1e-143,
Organism=Homo sapiens, GI36796743, Length=630, Percent_Identity=45.2380952380952, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI310124614, Length=81, Percent_Identity=48.1481481481481, Blast_Score=86, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17568737, Length=627, Percent_Identity=46.7304625199362, Blast_Score=503, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17568739, Length=627, Percent_Identity=46.7304625199362, Blast_Score=503, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6319558, Length=638, Percent_Identity=43.5736677115987, Blast_Score=468, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6321643, Length=632, Percent_Identity=43.9873417721519, Blast_Score=465, Evalue=1e-132,
Organism=Drosophila melanogaster, GI62472483, Length=625, Percent_Identity=43.04, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI45551871, Length=625, Percent_Identity=43.04, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24645718, Length=625, Percent_Identity=43.04, Blast_Score=455, Evalue=1e-128,
Organism=Drosophila melanogaster, GI17137370, Length=625, Percent_Identity=43.04, Blast_Score=455, Evalue=1e-128,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 61417; Mature: 61417

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00721 FTHFS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTDMDISSRASLKNITEIGVDLGLLPEEMMLFGHTKAKVELSVLQRLAGQRKGKLIIVT
CCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEHHHHHHHHCCCCCCEEEEE
AVTPTPHGEGKTVTSIGLTQSLNAIGQKACACIRQPSMGPVFGVKGGAAGGGYAQVVPMQ
EECCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEHH
EMNLHLTGDIHAVSSAHNLGAAAIAARLFHEARLGKTEFEAQSGQAFLDIAPNEIRWHRV
HCCEEEECCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEE
VDHNDRCLRQIHVGLGDNNGPEYGSSFDITAASELMAILALSHDLADMRVRIGRLVLALN
CCCCHHEEHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHEEEEEEEEEE
TQGQVITAEDLGVAGAMTAIMADAIKPTLMQTLNGSPCLIHSGPFANIAHGNSSIIADDI
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCCCEEHHHH
ALRLADFVVTEGGFGSDMGFEKFCNIKVRQSGQAPAAAVLVTTLKALKANSGLATEVDSN
HHHHHHHHEECCCCCCCCCHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCEECCCC
VSNIHVPKINAANINAPDQARLEAGFANLNWHINNVARYGIPVVVAINRFATDSDAELQW
CCEEECCCCCCCCCCCCCHHHHHCCCEEEEEEEECHHHCCCEEEEEEECCCCCCCHHHHH
LMEAVNASAAFGCEISDAFSQGEAGAIALAQTVVRAAEIESQFKLLYPDEASLEAKLSTL
HHHHHCCCCEECCEEHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHH
AEVGYGAAGVSLSIEAKQQAQQLTALGYGHLPLCMAKTPLSISHDPSLKGVPKDFVVPVR
HHHCCCCCCEEEEEHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHH
ELVLHAGAGFITALVGNVMTMPGLGLKPGYLKIDIDAKGEIVGLG
HHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEECC
>Mature Secondary Structure
MLTDMDISSRASLKNITEIGVDLGLLPEEMMLFGHTKAKVELSVLQRLAGQRKGKLIIVT
CCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEEHHHHHHHHCCCCCCEEEEE
AVTPTPHGEGKTVTSIGLTQSLNAIGQKACACIRQPSMGPVFGVKGGAAGGGYAQVVPMQ
EECCCCCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEHH
EMNLHLTGDIHAVSSAHNLGAAAIAARLFHEARLGKTEFEAQSGQAFLDIAPNEIRWHRV
HCCEEEECCEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEE
VDHNDRCLRQIHVGLGDNNGPEYGSSFDITAASELMAILALSHDLADMRVRIGRLVLALN
CCCCHHEEHHHEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHEEEEEEEEEE
TQGQVITAEDLGVAGAMTAIMADAIKPTLMQTLNGSPCLIHSGPFANIAHGNSSIIADDI
CCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEECCCCCCEEHHHH
ALRLADFVVTEGGFGSDMGFEKFCNIKVRQSGQAPAAAVLVTTLKALKANSGLATEVDSN
HHHHHHHHEECCCCCCCCCHHHHCCEEEECCCCCCHHHHHHHHHHHHHCCCCCCEECCCC
VSNIHVPKINAANINAPDQARLEAGFANLNWHINNVARYGIPVVVAINRFATDSDAELQW
CCEEECCCCCCCCCCCCCHHHHHCCCEEEEEEEECHHHCCCEEEEEEECCCCCCCHHHHH
LMEAVNASAAFGCEISDAFSQGEAGAIALAQTVVRAAEIESQFKLLYPDEASLEAKLSTL
HHHHHCCCCEECCEEHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCHHHHHHHH
AEVGYGAAGVSLSIEAKQQAQQLTALGYGHLPLCMAKTPLSISHDPSLKGVPKDFVVPVR
HHHCCCCCCEEEEEHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHHHH
ELVLHAGAGFITALVGNVMTMPGLGLKPGYLKIDIDAKGEIVGLG
HHHHHCCCHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA