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The map label for this gene is ycdW [C]

Identifier: 160877011

GI number: 160877011

Start: 4604157

End: 4605092

Strand: Direct

Name: ycdW [C]

Synonym: Sbal195_3907

Alternate gene names: 160877011

Gene position: 4604157-4605092 (Clockwise)

Preceding gene: 160877009

Following gene: 160877013

Centisome position: 86.1

GC content: 47.44

Gene sequence:

>936_bases
ATGGGGCACAAGTTACTCTTGCTAACGAAGGCAAATCAACAGTATCGCGATTTGATTGAGGCGCAGGAACTCCCTGATTT
AGAGATACTCGACGATAATCCAGCGGGCATAATTGATGCTGATATTTGGTTAGCCGAACCTAAACTCGCCGCGCCCCTAT
TGCCCCATGCTAAAAATCTGCAATGGTTACAATCAAGCTTTGCTGGCATAGATGCTCTGATGAGCCCAAGGGGCAGAAAA
GACTATCAACTCACCAATATTAAAGGCATTTTTGGCCCGCTGATGAGTGAGTTTGTGTTCGGTTATTTACTCGCGCATAT
CCGTAGTCATGGTTTTTATCGCCAGCAGCAACTGCAAAAACAGTGGCAAGTTCAACCCCCCATACGCCACTCAAGTTTAC
AAGGAATGCGATTACTCATACTCGGTACTGGCTCAATTGCCCAGCATCTCGCTAAGACGGCAAAGCACTTTGGCATGCAT
GTCACAGGGATCAATCGTAGTGGTAATACAGTTGAAGGTTTTGATGCTATTGAAGCGATGGCCAATTTAGCCCAGATGTT
GATGCAAGCCGATGTGGTGGTCAATTTACTGCCCTGCACTCCGGCAACCCAGAACCTGCTTAACGCTGAAACCTTAGGTA
AGCTAAAAGATGATGCAGTGCTGTTTAACGTCGGCCGCGGTGATGCACTCGAGCTCAATGCGCTAAATATCCAGCTTATC
GCTAAACCTGCTCAACAAGCGGTTTTGGATGTTTTTGCTCAAGAACCTTTGCCCAATAGTCATCCCATTTGGGAGCGGGG
AAATGCCATCATCACGCCGCATATTTCTGCGCCAAGCCATCCCGCACAAATCGTCGAGATTTTTAGCCAAAACTATGGCC
GCTACATTAGCGGTGAGCCACTGCAGAATCGAATCGACTTTAGTAAGGGCTACTGA

Upstream 100 bases:

>100_bases
ATCCATAATGACTCAACCTAAAAAGATGCTGCACAATCCCTCGACGTGGCCGCGACAGCACATTGAAAAATAACAATAAC
CAAGCATAAAGGGAGACGCC

Downstream 100 bases:

>100_bases
GTGAGCGCTCAGGAATTAATTCAGAGAGCAGAAATTAAGTTAGAAAAATGAAATTGAGTCAGGGAGCAGAAAAAGCAAAG
GCAATAGTCAGACTATTGCC

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NADPH; glyoxylate; glycerate [C]

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 310

Protein sequence:

>311_residues
MGHKLLLLTKANQQYRDLIEAQELPDLEILDDNPAGIIDADIWLAEPKLAAPLLPHAKNLQWLQSSFAGIDALMSPRGRK
DYQLTNIKGIFGPLMSEFVFGYLLAHIRSHGFYRQQQLQKQWQVQPPIRHSSLQGMRLLILGTGSIAQHLAKTAKHFGMH
VTGINRSGNTVEGFDAIEAMANLAQMLMQADVVVNLLPCTPATQNLLNAETLGKLKDDAVLFNVGRGDALELNALNIQLI
AKPAQQAVLDVFAQEPLPNSHPIWERGNAIITPHISAPSHPAQIVEIFSQNYGRYISGEPLQNRIDFSKGY

Sequences:

>Translated_311_residues
MGHKLLLLTKANQQYRDLIEAQELPDLEILDDNPAGIIDADIWLAEPKLAAPLLPHAKNLQWLQSSFAGIDALMSPRGRK
DYQLTNIKGIFGPLMSEFVFGYLLAHIRSHGFYRQQQLQKQWQVQPPIRHSSLQGMRLLILGTGSIAQHLAKTAKHFGMH
VTGINRSGNTVEGFDAIEAMANLAQMLMQADVVVNLLPCTPATQNLLNAETLGKLKDDAVLFNVGRGDALELNALNIQLI
AKPAQQAVLDVFAQEPLPNSHPIWERGNAIITPHISAPSHPAQIVEIFSQNYGRYISGEPLQNRIDFSKGY
>Mature_310_residues
GHKLLLLTKANQQYRDLIEAQELPDLEILDDNPAGIIDADIWLAEPKLAAPLLPHAKNLQWLQSSFAGIDALMSPRGRKD
YQLTNIKGIFGPLMSEFVFGYLLAHIRSHGFYRQQQLQKQWQVQPPIRHSSLQGMRLLILGTGSIAQHLAKTAKHFGMHV
TGINRSGNTVEGFDAIEAMANLAQMLMQADVVVNLLPCTPATQNLLNAETLGKLKDDAVLFNVGRGDALELNALNIQLIA
KPAQQAVLDVFAQEPLPNSHPIWERGNAIITPHISAPSHPAQIVEIFSQNYGRYISGEPLQNRIDFSKGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=257, Percent_Identity=25.2918287937743, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI87081824, Length=221, Percent_Identity=30.7692307692308, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082289, Length=148, Percent_Identity=33.7837837837838, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1789279, Length=178, Percent_Identity=29.2134831460674, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=176, Percent_Identity=30.6818181818182, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320925, Length=311, Percent_Identity=24.7588424437299, Blast_Score=74, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6322116, Length=259, Percent_Identity=24.7104247104247, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324055, Length=195, Percent_Identity=26.6666666666667, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI28574286, Length=277, Percent_Identity=26.3537906137184, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571528, Length=146, Percent_Identity=32.1917808219178, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24585514, Length=279, Percent_Identity=26.1648745519713, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28574282, Length=279, Percent_Identity=26.1648745519713, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28574284, Length=279, Percent_Identity=26.1648745519713, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19921140, Length=268, Percent_Identity=27.6119402985075, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45551003, Length=279, Percent_Identity=26.1648745519713, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI45552429, Length=279, Percent_Identity=26.1648745519713, Blast_Score=71, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: NA

Molecular weight: Translated: 34440; Mature: 34309

Theoretical pI: Translated: 6.92; Mature: 6.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHKLLLLTKANQQYRDLIEAQELPDLEILDDNPAGIIDADIWLAEPKLAAPLLPHAKNL
CCCEEEEEECCCHHHHHHHHHHCCCCCEEECCCCCCEEECCEEEECCCCCCCCCCCCCHH
QWLQSSFAGIDALMSPRGRKDYQLTNIKGIFGPLMSEFVFGYLLAHIRSHGFYRQQQLQK
HHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QWQVQPPIRHSSLQGMRLLILGTGSIAQHLAKTAKHFGMHVTGINRSGNTVEGFDAIEAM
HCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHH
ANLAQMLMQADVVVNLLPCTPATQNLLNAETLGKLKDDAVLFNVGRGDALELNALNIQLI
HHHHHHHHHHHHHEEEECCCCHHHHHHCHHHHHCCCCCEEEEECCCCCEEEEEEEEEEEE
AKPAQQAVLDVFAQEPLPNSHPIWERGNAIITPHISAPSHPAQIVEIFSQNYGRYISGEP
ECHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCC
LQNRIDFSKGY
CHHHCCCCCCC
>Mature Secondary Structure 
GHKLLLLTKANQQYRDLIEAQELPDLEILDDNPAGIIDADIWLAEPKLAAPLLPHAKNL
CCEEEEEECCCHHHHHHHHHHCCCCCEEECCCCCCEEECCEEEECCCCCCCCCCCCCHH
QWLQSSFAGIDALMSPRGRKDYQLTNIKGIFGPLMSEFVFGYLLAHIRSHGFYRQQQLQK
HHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
QWQVQPPIRHSSLQGMRLLILGTGSIAQHLAKTAKHFGMHVTGINRSGNTVEGFDAIEAM
HCCCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHH
ANLAQMLMQADVVVNLLPCTPATQNLLNAETLGKLKDDAVLFNVGRGDALELNALNIQLI
HHHHHHHHHHHHHEEEECCCCHHHHHHCHHHHHCCCCCEEEEECCCCCEEEEEEEEEEEE
AKPAQQAVLDVFAQEPLPNSHPIWERGNAIITPHISAPSHPAQIVEIFSQNYGRYISGEP
ECHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCC
LQNRIDFSKGY
CHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycolate; NADP; hydroxypyruvate; NADPH [C]

Specific reaction: glycolate + NADP = NADPH + glyoxylate hydroxypyruvate + NADPH = glycerate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]