Click here to switch to the map view.

The map label for this gene is lysC [H]

Identifier: 160876944

GI number: 160876944

Start: 4521276

End: 4522631

Strand: Reverse

Name: lysC [H]

Synonym: Sbal195_3840

Alternate gene names: 160876944

Gene position: 4522631-4521276 (Counterclockwise)

Preceding gene: 160876945

Following gene: 160876943

Centisome position: 84.58

GC content: 50.29

Gene sequence:

>1356_bases
ATGTCCCTCGTTGTCGCAAAATTTGGTGGCACCTCAGTCGCCGACTATAACGCTATGAATCGCTGTGCCGACATAGTGTT
AGCTAATCCTCATTGCCGTTTAGTCGTGGTCAGCGCATCTAGTGGCGTGACCAATCTGTTAGTGGAATTGACCCAAGAAT
CGATTAACGACGATGGTCGATTACAGCGATTAAAACAAATTGCCCAAATTCAATATGCGATTTTAGATAAGCTCGGTCGC
CCTAACGATGTGGCCGCCGCATTAGATAAATTATTGAGTCGCATGTCAGTATTGAGTGACGCGCTCGCATCACAACGCAG
CAAAGCGACCATGGATGAGTTGTTGTCCCTCGGTGAGCAATGTTCTTCGGCGTTGTTTTCAGCAGTCATCCGCGAGAAAG
GTGTTAACTCTAGTGCCTTCGATGTGCGTCGAGTATTACGTACCGACAGCCACTTTGGCCGCGCGGAACCCCTGGTTGAG
CAGATTGCGACTTTAGCTCGTGATTATCTACAGCCACTGTTAGCGGAACAAGTGATTGTCACACAAGGCTTTATCGGTGC
CGATGAAGCAGGTCAAACGACCACATTAGGCCGCGGTGGTAGTGATTATTCTGCTGCGCTGTTAGCCGAAGCGTTACGCG
CCTCAGCGGTAGAGATTTGGACCGATGTAGCGGGGATTTATACAACCGATCCGCGCCTTGCGCCCAATGCTTTTCCGATT
GCCGAGATCAGCTTTAATGAAGCCGCCGAGATGGCGACCTTTGGTGCCAAGGTATTGCATCCTGCGACCATTCTTCCTGC
CGTTCGTCAGCAAATTCAAGTGTTTGTGGGTTCAAGTAAAGAGCCTGAAAAGGGCGGGACTTGGATCCGTCATCAAGTGG
AAGATGCGCCCGTATTCCGCGCTGTGGCTTTGCGCCGCGATCAAACGCTGTTAAATCTTCACAGCTTGCAAATGTTGCAT
GCGCAGGGCTTTTTAGCGGAAACCTTTGCGACTTTGGCGCGACATAAGATCAGTGTGGATTTAATTACCACCTCAGAAGT
GAATGTGTCTTTAACCCTCGATAAAACTGGCTCTGATTCAAGTGGTCAAGGTCTGTTGAGTGAGGCATTGTTGCAAGAAT
TATCACAGCATTGCCGGGTGCGCGTCGAAGATGGATTAGCCTTAGTGGCGATTATCGGTAACCGCATTGCGACCACGCCG
GGTATTTGTCGCCGTGTGTTTGAAGTGCTGGAGCCACACAATGTGCGGATGATTTGCCAAGGCGCCAGCCCACATAACCT
GTGTGTGTTAGTGGCAGAATCGGAAGCGGCGCAAGTGGTGAAATCGCTGCATCAAAATCTGTTCGAAGGCGCTTAA

Upstream 100 bases:

>100_bases
TTCGAACGAAGTTAGTTCGGAGTGTGATCATGTTAGTTAATCAATATTTTATTCAATCTGCGTTTATTTCTTGCCCTACG
TGTTTCACGGAGGTGCGCTA

Downstream 100 bases:

>100_bases
TATGCCGCCGACAAGATCGTCCCTGCAAATTGGGGAGCTTGCCGCAGGGCAAGCGCTCACCTTGCCTATTTACCATTTTA
AGCCCAGCGACGATAAGGCG

Product: aspartate kinase III

Products: NA

Alternate protein names: Aspartate kinase III; AKIII; Lysine-sensitive aspartokinase III [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MSLVVAKFGGTSVADYNAMNRCADIVLANPHCRLVVVSASSGVTNLLVELTQESINDDGRLQRLKQIAQIQYAILDKLGR
PNDVAAALDKLLSRMSVLSDALASQRSKATMDELLSLGEQCSSALFSAVIREKGVNSSAFDVRRVLRTDSHFGRAEPLVE
QIATLARDYLQPLLAEQVIVTQGFIGADEAGQTTTLGRGGSDYSAALLAEALRASAVEIWTDVAGIYTTDPRLAPNAFPI
AEISFNEAAEMATFGAKVLHPATILPAVRQQIQVFVGSSKEPEKGGTWIRHQVEDAPVFRAVALRRDQTLLNLHSLQMLH
AQGFLAETFATLARHKISVDLITTSEVNVSLTLDKTGSDSSGQGLLSEALLQELSQHCRVRVEDGLALVAIIGNRIATTP
GICRRVFEVLEPHNVRMICQGASPHNLCVLVAESEAAQVVKSLHQNLFEGA

Sequences:

>Translated_451_residues
MSLVVAKFGGTSVADYNAMNRCADIVLANPHCRLVVVSASSGVTNLLVELTQESINDDGRLQRLKQIAQIQYAILDKLGR
PNDVAAALDKLLSRMSVLSDALASQRSKATMDELLSLGEQCSSALFSAVIREKGVNSSAFDVRRVLRTDSHFGRAEPLVE
QIATLARDYLQPLLAEQVIVTQGFIGADEAGQTTTLGRGGSDYSAALLAEALRASAVEIWTDVAGIYTTDPRLAPNAFPI
AEISFNEAAEMATFGAKVLHPATILPAVRQQIQVFVGSSKEPEKGGTWIRHQVEDAPVFRAVALRRDQTLLNLHSLQMLH
AQGFLAETFATLARHKISVDLITTSEVNVSLTLDKTGSDSSGQGLLSEALLQELSQHCRVRVEDGLALVAIIGNRIATTP
GICRRVFEVLEPHNVRMICQGASPHNLCVLVAESEAAQVVKSLHQNLFEGA
>Mature_450_residues
SLVVAKFGGTSVADYNAMNRCADIVLANPHCRLVVVSASSGVTNLLVELTQESINDDGRLQRLKQIAQIQYAILDKLGRP
NDVAAALDKLLSRMSVLSDALASQRSKATMDELLSLGEQCSSALFSAVIREKGVNSSAFDVRRVLRTDSHFGRAEPLVEQ
IATLARDYLQPLLAEQVIVTQGFIGADEAGQTTTLGRGGSDYSAALLAEALRASAVEIWTDVAGIYTTDPRLAPNAFPIA
EISFNEAAEMATFGAKVLHPATILPAVRQQIQVFVGSSKEPEKGGTWIRHQVEDAPVFRAVALRRDQTLLNLHSLQMLHA
QGFLAETFATLARHKISVDLITTSEVNVSLTLDKTGSDSSGQGLLSEALLQELSQHCRVRVEDGLALVAIIGNRIATTPG
ICRRVFEVLEPHNVRMICQGASPHNLCVLVAESEAAQVVKSLHQNLFEGA

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=447, Percent_Identity=60.4026845637584, Blast_Score=493, Evalue=1e-141,
Organism=Escherichia coli, GI1786183, Length=466, Percent_Identity=31.5450643776824, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI1790376, Length=451, Percent_Identity=28.6031042128603, Blast_Score=144, Evalue=8e-36,
Organism=Saccharomyces cerevisiae, GI6320893, Length=495, Percent_Identity=27.0707070707071, Blast_Score=154, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 48581; Mature: 48450

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVVAKFGGTSVADYNAMNRCADIVLANPHCRLVVVSASSGVTNLLVELTQESINDDGR
CCEEEEECCCCCCHHHHHHHHHHHHEEECCCEEEEEEECCCCHHHHHHHHHHHHCCCCHH
LQRLKQIAQIQYAILDKLGRPNDVAAALDKLLSRMSVLSDALASQRSKATMDELLSLGEQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CSSALFSAVIREKGVNSSAFDVRRVLRTDSHFGRAEPLVEQIATLARDYLQPLLAEQVIV
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TQGFIGADEAGQTTTLGRGGSDYSAALLAEALRASAVEIWTDVAGIYTTDPRLAPNAFPI
HCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCE
AEISFNEAAEMATFGAKVLHPATILPAVRQQIQVFVGSSKEPEKGGTWIRHQVEDAPVFR
EEECHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCHHHH
AVALRRDQTLLNLHSLQMLHAQGFLAETFATLARHKISVDLITTSEVNVSLTLDKTGSDS
HHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEEEEECCEEEEEEEECCCCCC
SGQGLLSEALLQELSQHCRVRVEDGLALVAIIGNRIATTPGICRRVFEVLEPHNVRMICQ
CCCHHHHHHHHHHHHHHCCEEECCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEE
GASPHNLCVLVAESEAAQVVKSLHQNLFEGA
CCCCCCEEEEEECCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLVVAKFGGTSVADYNAMNRCADIVLANPHCRLVVVSASSGVTNLLVELTQESINDDGR
CEEEEECCCCCCHHHHHHHHHHHHEEECCCEEEEEEECCCCHHHHHHHHHHHHCCCCHH
LQRLKQIAQIQYAILDKLGRPNDVAAALDKLLSRMSVLSDALASQRSKATMDELLSLGEQ
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
CSSALFSAVIREKGVNSSAFDVRRVLRTDSHFGRAEPLVEQIATLARDYLQPLLAEQVIV
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TQGFIGADEAGQTTTLGRGGSDYSAALLAEALRASAVEIWTDVAGIYTTDPRLAPNAFPI
HCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCCCCE
AEISFNEAAEMATFGAKVLHPATILPAVRQQIQVFVGSSKEPEKGGTWIRHQVEDAPVFR
EEECHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCHHHH
AVALRRDQTLLNLHSLQMLHAQGFLAETFATLARHKISVDLITTSEVNVSLTLDKTGSDS
HHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHEEEEEEEECCEEEEEEEECCCCCC
SGQGLLSEALLQELSQHCRVRVEDGLALVAIIGNRIATTPGICRRVFEVLEPHNVRMICQ
CCCHHHHHHHHHHHHHHCCEEECCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEE
GASPHNLCVLVAESEAAQVVKSLHQNLFEGA
CCCCCCEEEEEECCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3003049; 8265357; 9278503; 6312411 [H]