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The map label for this gene is trpA [H]

Identifier: 160875917

GI number: 160875917

Start: 3340564

End: 3341385

Strand: Direct

Name: trpA [H]

Synonym: Sbal195_2806

Alternate gene names: 160875917

Gene position: 3340564-3341385 (Clockwise)

Preceding gene: 160875916

Following gene: 160875918

Centisome position: 62.47

GC content: 52.68

Gene sequence:

>822_bases
ATGAGTGACACGTCTACCAACACTGGCCGTTACCAAGCCACCTTTGCCAAACTCAAAACTGAAGGTCGTGGCGCTTTTGT
CCCATTCGTCACCCTTGGCGATCCTAGCCCTGTGTTATCGCTGAAAATTATCGATACCTTAGTGCAAAACGGTGCCGATG
CCTTAGAACTGGGCTTTCCGTTTTCCGATCCCTTGGCCGATGGCCCTGTGATCCAAGGTGCTAACCTGCGTTCTTTAGCG
GCGGGCACGACTCCAACGGCGTGTTTTGAATTACTGGCGCAAGTGCGTGCTAAATATCCTGAACTGCCAATCGGTTTGCT
GCTGTATGCGAACTTAGTTTTTGCTAATGGCATAGATGCGTTTTACGCCAAAGCGCAGCAAGCGGGTGTGGATTCAGTGC
TTATTGCCGACGTACCCGTAGAAGAATCGGCGCCCTTTAGCGAAGCCGCTAAAGCCCATGGTATCGCACCCATTTTTATC
GCGCCGCCCAATGCCGACAGTGAAACCCTTGCACTGGTTAGCGCCAGCGGCGAAGGTTACACCTATCTCTTATCCCGCGC
AGGGGTGACAGGCACAGACACTAAAGCTGGCGTTCCGGTGGAAGAAATTCTATCCAAATTGAAAACTTTTAATGCGCCGC
CACCGCTACTCGGCTTTGGTATTGCCGAACCGGCTCAAGTAACCGCCGCTATCAAAGCGGGCGCTGCTGGGGCGATTTCA
GGCTCTGCCGTTGTAAAAATTATCGAAACCCACCAGCACGATGAAGCTAAACTACTTGCGGCGCTTGGGGATTTTACTCG
CGCCATGAAAGCGGCGACCTAA

Upstream 100 bases:

>100_bases
GCACCAAGGAAACCATTTTAGTGGTCAATCTTTCCGGTCGTGGCGACAAAGATATTTTCACCGTTTCTGACATTTTGAAT
GGTAAAGAGGAATAATAAAC

Downstream 100 bases:

>100_bases
GTTAATCAAGATTTCAATCTCTGAGATAAATTACTGATTGAAATTGATAAACTAAGTCACTGATTTAAATTGATAGCCTA
AATCGCTAGCCTGAATCGCT

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MSDTSTNTGRYQATFAKLKTEGRGAFVPFVTLGDPSPVLSLKIIDTLVQNGADALELGFPFSDPLADGPVIQGANLRSLA
AGTTPTACFELLAQVRAKYPELPIGLLLYANLVFANGIDAFYAKAQQAGVDSVLIADVPVEESAPFSEAAKAHGIAPIFI
APPNADSETLALVSASGEGYTYLLSRAGVTGTDTKAGVPVEEILSKLKTFNAPPPLLGFGIAEPAQVTAAIKAGAAGAIS
GSAVVKIIETHQHDEAKLLAALGDFTRAMKAAT

Sequences:

>Translated_273_residues
MSDTSTNTGRYQATFAKLKTEGRGAFVPFVTLGDPSPVLSLKIIDTLVQNGADALELGFPFSDPLADGPVIQGANLRSLA
AGTTPTACFELLAQVRAKYPELPIGLLLYANLVFANGIDAFYAKAQQAGVDSVLIADVPVEESAPFSEAAKAHGIAPIFI
APPNADSETLALVSASGEGYTYLLSRAGVTGTDTKAGVPVEEILSKLKTFNAPPPLLGFGIAEPAQVTAAIKAGAAGAIS
GSAVVKIIETHQHDEAKLLAALGDFTRAMKAAT
>Mature_272_residues
SDTSTNTGRYQATFAKLKTEGRGAFVPFVTLGDPSPVLSLKIIDTLVQNGADALELGFPFSDPLADGPVIQGANLRSLAA
GTTPTACFELLAQVRAKYPELPIGLLLYANLVFANGIDAFYAKAQQAGVDSVLIADVPVEESAPFSEAAKAHGIAPIFIA
PPNADSETLALVSASGEGYTYLLSRAGVTGTDTKAGVPVEEILSKLKTFNAPPPLLGFGIAEPAQVTAAIKAGAAGAISG
SAVVKIIETHQHDEAKLLAALGDFTRAMKAAT

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=264, Percent_Identity=65.1515151515152, Blast_Score=334, Evalue=3e-93,
Organism=Saccharomyces cerevisiae, GI6321412, Length=251, Percent_Identity=31.8725099601594, Blast_Score=134, Evalue=1e-32,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 28081; Mature: 27950

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTSTNTGRYQATFAKLKTEGRGAFVPFVTLGDPSPVLSLKIIDTLVQNGADALELGFP
CCCCCCCCCEEEEHHHHHHCCCCCEEEEEEECCCCCCEEHHHHHHHHHHCCCCEEEECCC
FSDPLADGPVIQGANLRSLAAGTTPTACFELLAQVRAKYPELPIGLLLYANLVFANGIDA
CCCCCCCCCEECCCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHH
FYAKAQQAGVDSVLIADVPVEESAPFSEAAKAHGIAPIFIAPPNADSETLALVSASGEGY
HHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCE
TYLLSRAGVTGTDTKAGVPVEEILSKLKTFNAPPPLLGFGIAEPAQVTAAIKAGAAGAIS
EEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHCCCCCCCC
GSAVVKIIETHQHDEAKLLAALGDFTRAMKAAT
CHHHEEEEHHCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SDTSTNTGRYQATFAKLKTEGRGAFVPFVTLGDPSPVLSLKIIDTLVQNGADALELGFP
CCCCCCCCEEEEHHHHHHCCCCCEEEEEEECCCCCCEEHHHHHHHHHHCCCCEEEECCC
FSDPLADGPVIQGANLRSLAAGTTPTACFELLAQVRAKYPELPIGLLLYANLVFANGIDA
CCCCCCCCCEECCCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHH
FYAKAQQAGVDSVLIADVPVEESAPFSEAAKAHGIAPIFIAPPNADSETLALVSASGEGY
HHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCEEEEEEECCCCE
TYLLSRAGVTGTDTKAGVPVEEILSKLKTFNAPPPLLGFGIAEPAQVTAAIKAGAAGAIS
EEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCHHHHHHHHHCCCCCCCC
GSAVVKIIETHQHDEAKLLAALGDFTRAMKAAT
CHHHEEEEHHCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA