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The map label for this gene is cobB [H]

Identifier: 160875733

GI number: 160875733

Start: 3106024

End: 3106755

Strand: Reverse

Name: cobB [H]

Synonym: Sbal195_2621

Alternate gene names: 160875733

Gene position: 3106755-3106024 (Counterclockwise)

Preceding gene: 160875735

Following gene: 160875732

Centisome position: 58.1

GC content: 50.96

Gene sequence:

>732_bases
ATGTACCAGCAAATTGTGGTGTTAACCGGCGCAGGGATCTCTGCTGAGTCGGGATTACGCACCTTTCGCGATCAAGATGG
TCTGTGGGAAGAACATCATATTGAAGACGTGGCTACGCCAGAAGGGTATGAACGTGATGCTGAGCTTGTGGAACGTTTTT
ACAATAGTCGTTGGCAGCAATTGCACAGTGGCACAGTTGAGCCCAATGCGGCGCACCTTGCCTTGGCAAAGTTAGAGGCA
GAATTTCAAGGCCAGTTATTGGTTGTGACCCAGAATATTGATGATTTGCATGAGCGTTCGGGTTCACGTCGATTGCTGCA
CATGCATGGCGAGCTATCCAAAGGGCGATGCCCGCGCTCACGTCAGACCTTTATTCTGCGTGAGCCTTTTGGTGTCGATA
ATTGTTGTACCTGCTGTATTCCTGCCCAGCGTTTACGCCCCCATGTGGTGTGGTTTGGTGAAATGCCCTTAGGGATGGAT
CGTATCCACGATGCGCTGGATAACTGCGACTTGTTTATTGCCATTGGCACCTCTGGCACTGTGTATCCTGCCGCAGGCTT
TGTGGATACCGCTAACCATCACGGCGCGCAAACGGTTGAAGTAAATATGATGGCACCCGATAGACACAGTCAGTTCCAGT
ATCATTTGACTGGCAAAGCGGGGGAGTTAGTGCCTCAGTTGGTCGAGACTATTTTAGCGGGCCGAGTGATTGGCAGTGAG
TCGAACACATGA

Upstream 100 bases:

>100_bases
ATTCAAGCATAGTTTTTGTATGGTTATACCAAGGAATAATATTCACGGCCGCCAAAGTCAGTGAGAATAATTCAAATAAA
TAAAATAATAAGGAATCGGC

Downstream 100 bases:

>100_bases
GTGAGAAAATCGCGATAATTATGCGTGGTTTACCGGGCAGTGGTAAGTCACATTGGGTTGAAACTTATATTCTTTCCCTT
CCTTTAGAACAAGCCATTGG

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MYQQIVVLTGAGISAESGLRTFRDQDGLWEEHHIEDVATPEGYERDAELVERFYNSRWQQLHSGTVEPNAAHLALAKLEA
EFQGQLLVVTQNIDDLHERSGSRRLLHMHGELSKGRCPRSRQTFILREPFGVDNCCTCCIPAQRLRPHVVWFGEMPLGMD
RIHDALDNCDLFIAIGTSGTVYPAAGFVDTANHHGAQTVEVNMMAPDRHSQFQYHLTGKAGELVPQLVETILAGRVIGSE
SNT

Sequences:

>Translated_243_residues
MYQQIVVLTGAGISAESGLRTFRDQDGLWEEHHIEDVATPEGYERDAELVERFYNSRWQQLHSGTVEPNAAHLALAKLEA
EFQGQLLVVTQNIDDLHERSGSRRLLHMHGELSKGRCPRSRQTFILREPFGVDNCCTCCIPAQRLRPHVVWFGEMPLGMD
RIHDALDNCDLFIAIGTSGTVYPAAGFVDTANHHGAQTVEVNMMAPDRHSQFQYHLTGKAGELVPQLVETILAGRVIGSE
SNT
>Mature_243_residues
MYQQIVVLTGAGISAESGLRTFRDQDGLWEEHHIEDVATPEGYERDAELVERFYNSRWQQLHSGTVEPNAAHLALAKLEA
EFQGQLLVVTQNIDDLHERSGSRRLLHMHGELSKGRCPRSRQTFILREPFGVDNCCTCCIPAQRLRPHVVWFGEMPLGMD
RIHDALDNCDLFIAIGTSGTVYPAAGFVDTANHHGAQTVEVNMMAPDRHSQFQYHLTGKAGELVPQLVETILAGRVIGSE
SNT

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=236, Percent_Identity=36.0169491525424, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI6912664, Length=254, Percent_Identity=33.8582677165354, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI13787215, Length=242, Percent_Identity=33.8842975206612, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI7657575, Length=247, Percent_Identity=27.5303643724696, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI308199517, Length=236, Percent_Identity=56.7796610169492, Blast_Score=270, Evalue=8e-74,
Organism=Caenorhabditis elegans, GI17541892, Length=197, Percent_Identity=31.9796954314721, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI28571445, Length=119, Percent_Identity=37.8151260504202, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27115; Mature: 27115

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQQIVVLTGAGISAESGLRTFRDQDGLWEEHHIEDVATPEGYERDAELVERFYNSRWQQ
CCCEEEEEECCCCCCHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LHSGTVEPNAAHLALAKLEAEFQGQLLVVTQNIDDLHERSGSRRLLHMHGELSKGRCPRS
HHCCCCCCCHHHHHHHHHHHHHCCEEEEEECCHHHHHHCCCCCEEEEECCCCCCCCCCCC
RQTFILREPFGVDNCCTCCIPAQRLRPHVVWFGEMPLGMDRIHDALDNCDLFIAIGTSGT
CCEEEEECCCCCCCCEEECCCHHHCCCEEEEEECCCCCHHHHHHHHCCCEEEEEECCCCC
VYPAAGFVDTANHHGAQTVEVNMMAPDRHSQFQYHLTGKAGELVPQLVETILAGRVIGSE
EEECCCCEECCCCCCCEEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHCEEECCC
SNT
CCC
>Mature Secondary Structure
MYQQIVVLTGAGISAESGLRTFRDQDGLWEEHHIEDVATPEGYERDAELVERFYNSRWQQ
CCCEEEEEECCCCCCHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LHSGTVEPNAAHLALAKLEAEFQGQLLVVTQNIDDLHERSGSRRLLHMHGELSKGRCPRS
HHCCCCCCCHHHHHHHHHHHHHCCEEEEEECCHHHHHHCCCCCEEEEECCCCCCCCCCCC
RQTFILREPFGVDNCCTCCIPAQRLRPHVVWFGEMPLGMDRIHDALDNCDLFIAIGTSGT
CCEEEEECCCCCCCCEEECCCHHHCCCEEEEEECCCCCHHHHHHHHCCCEEEEEECCCCC
VYPAAGFVDTANHHGAQTVEVNMMAPDRHSQFQYHLTGKAGELVPQLVETILAGRVIGSE
EEECCCCEECCCCCCCEEEEEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHCEEECCC
SNT
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]