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The map label for this gene is zitB [H]

Identifier: 160875486

GI number: 160875486

Start: 2800838

End: 2802139

Strand: Reverse

Name: zitB [H]

Synonym: Sbal195_2374

Alternate gene names: 160875486

Gene position: 2802139-2800838 (Counterclockwise)

Preceding gene: 160875488

Following gene: 160875485

Centisome position: 52.4

GC content: 48.23

Gene sequence:

>1302_bases
ATGAAATCAACTACAGCCGAGCAAGCGACAGGGCATCAAGCTTCTGCCCACCGCCAAGGGCACTCACTCACCCAATGGCA
ACACTCACATGAGTTTTCGAATCAGAACCGCGATGGCGAAAAAAACACACGCTATGTACTGTATTTAACTGTGATCACTA
TGATGGCCGAAATTGCTGCCGGAACCATATACGGTTCTATGGCATTGCTCGCCGACGGTTGGCACATGGGCACCCATGCC
GCGGCCTTTATGATCACCCTGTTTGCCTATTCCTATGCTCGTAAACACGCTAACGATCCCGCCTTTGCCTTTGGCACAGG
TAAGGTCAGTGTGCTTGGCGGTTACACCAGTGCAATAGCCTTAGGTTTAGTGGCATTGGTGATGTTGATTGAATCGGGAA
TGCGGCTGATTAGTCCTGAGCAAATTCATTTCAACGAAGCTATTTTTGTGGCCGTTATTGGTTTAAGCGTCAATATACTG
AGTGTATTTTTACTAAAAGATCATCATACCCACGACCATGGGCATCACCACGGGCATGGACATGATCATAGTCACGACCA
TGATCATGAAGACGAACATGCTCACGCGCATCATAACAGCCAAGCACACACCCATGACGATCATGCACATACAGCGCATT
CACATGATGTGGATCTGCACCTGCACCATGACTCACATGCACACGATGAAAGTCATCATGATCATAGTCATTGCCAACAT
GAACAGGATCATCAACATAGTGCTGAGCATGAGCATGAGCATGAGCATGAGCATGAGCATGAGCATGAGCATGAGCATGA
GCATGAGCATGAGCATGAGCATGAGCACAAGAGCCAGAAGGCCCACGGTAGCCATGATCACAACCTACGCGCGGCCTATT
TTCACGTACTAGCCGATGCGTTAACGTCAGTGCTGGCCATCGCTGCCTTGTTGTTTGGTAAATACATGGGACTAACTTGG
CTCGACCCGATTATGGGGATTGTCGGCGCTGTGATTATCAGCCGTTGGTCTTGGGGACTTATTCAGCAAACCAGTCCTAT
TTTACTGGACGGTGGCGTTAAAGCGTCATTGCAACGTAAAGTCACACAAACCATTGAAGCTGTAACGGATCATCAAGTGG
CCGATTTACATCTTTGGCGAGTGAGCGCCGATCACCATGCTATTATGGTGTCCATCGTGTCCCATTCACCAAAAGATGTC
AGTTATTTTAATCAGTTACTGTCACAATTTCCTGAGTTGGCCCATATCACCATCGAACTCCATACTTGCCGTCAGCGCGA
GTGTATGGCTAAGGAAGCCTAA

Upstream 100 bases:

>100_bases
ATAGTTAATTTGATCTTCATATATTTTGATTTTCAAACTATAATTCAGGCAACACGTTTTTTATCATTGATAGCGATGGA
CATGGAGTAGGAATTACACA

Downstream 100 bases:

>100_bases
TGACAGTTGAACATCATCATTCATCAAACCTGCATTCAAGTGAGCCACATTCGACCGATCATGCATTAAATCATGTGATT
ATTGAATTTTACGAAAAGCT

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MKSTTAEQATGHQASAHRQGHSLTQWQHSHEFSNQNRDGEKNTRYVLYLTVITMMAEIAAGTIYGSMALLADGWHMGTHA
AAFMITLFAYSYARKHANDPAFAFGTGKVSVLGGYTSAIALGLVALVMLIESGMRLISPEQIHFNEAIFVAVIGLSVNIL
SVFLLKDHHTHDHGHHHGHGHDHSHDHDHEDEHAHAHHNSQAHTHDDHAHTAHSHDVDLHLHHDSHAHDESHHDHSHCQH
EQDHQHSAEHEHEHEHEHEHEHEHEHEHEHEHEHEHKSQKAHGSHDHNLRAAYFHVLADALTSVLAIAALLFGKYMGLTW
LDPIMGIVGAVIISRWSWGLIQQTSPILLDGGVKASLQRKVTQTIEAVTDHQVADLHLWRVSADHHAIMVSIVSHSPKDV
SYFNQLLSQFPELAHITIELHTCRQRECMAKEA

Sequences:

>Translated_433_residues
MKSTTAEQATGHQASAHRQGHSLTQWQHSHEFSNQNRDGEKNTRYVLYLTVITMMAEIAAGTIYGSMALLADGWHMGTHA
AAFMITLFAYSYARKHANDPAFAFGTGKVSVLGGYTSAIALGLVALVMLIESGMRLISPEQIHFNEAIFVAVIGLSVNIL
SVFLLKDHHTHDHGHHHGHGHDHSHDHDHEDEHAHAHHNSQAHTHDDHAHTAHSHDVDLHLHHDSHAHDESHHDHSHCQH
EQDHQHSAEHEHEHEHEHEHEHEHEHEHEHEHEHEHKSQKAHGSHDHNLRAAYFHVLADALTSVLAIAALLFGKYMGLTW
LDPIMGIVGAVIISRWSWGLIQQTSPILLDGGVKASLQRKVTQTIEAVTDHQVADLHLWRVSADHHAIMVSIVSHSPKDV
SYFNQLLSQFPELAHITIELHTCRQRECMAKEA
>Mature_433_residues
MKSTTAEQATGHQASAHRQGHSLTQWQHSHEFSNQNRDGEKNTRYVLYLTVITMMAEIAAGTIYGSMALLADGWHMGTHA
AAFMITLFAYSYARKHANDPAFAFGTGKVSVLGGYTSAIALGLVALVMLIESGMRLISPEQIHFNEAIFVAVIGLSVNIL
SVFLLKDHHTHDHGHHHGHGHDHSHDHDHEDEHAHAHHNSQAHTHDDHAHTAHSHDVDLHLHHDSHAHDESHHDHSHCQH
EQDHQHSAEHEHEHEHEHEHEHEHEHEHEHEHEHEHKSQKAHGSHDHNLRAAYFHVLADALTSVLAIAALLFGKYMGLTW
LDPIMGIVGAVIISRWSWGLIQQTSPILLDGGVKASLQRKVTQTIEAVTDHQVADLHLWRVSADHHAIMVSIVSHSPKDV
SYFNQLLSQFPELAHITIELHTCRQRECMAKEA

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI222080086, Length=377, Percent_Identity=23.0769230769231, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI40255009, Length=377, Percent_Identity=23.0769230769231, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI20070323, Length=138, Percent_Identity=28.9855072463768, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786966, Length=131, Percent_Identity=33.587786259542, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17550442, Length=378, Percent_Identity=23.015873015873, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17550440, Length=378, Percent_Identity=23.015873015873, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI32564488, Length=114, Percent_Identity=35.0877192982456, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6323899, Length=357, Percent_Identity=26.3305322128852, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324892, Length=318, Percent_Identity=25.7861635220126, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585900, Length=358, Percent_Identity=21.7877094972067, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24585898, Length=358, Percent_Identity=21.7877094972067, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24585896, Length=358, Percent_Identity=21.7877094972067, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19921672, Length=358, Percent_Identity=21.7877094972067, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 48748; Mature: 48748

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSTTAEQATGHQASAHRQGHSLTQWQHSHEFSNQNRDGEKNTRYVLYLTVITMMAEIAA
CCCCCCHHHCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHH
GTIYGSMALLADGWHMGTHAAAFMITLFAYSYARKHANDPAFAFGTGKVSVLGGYTSAIA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCHHHHHH
LGLVALVMLIESGMRLISPEQIHFNEAIFVAVIGLSVNILSVFLLKDHHTHDHGHHHGHG
HHHHHHHHHHHCCCCCCCCCHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
HDHSHDHDHEDEHAHAHHNSQAHTHDDHAHTAHSHDVDLHLHHDSHAHDESHHDHSHCQH
CCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHCC
EQDHQHSAEHEHEHEHEHEHEHEHEHEHEHEHEHEHKSQKAHGSHDHNLRAAYFHVLADA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LTSVLAIAALLFGKYMGLTWLDPIMGIVGAVIISRWSWGLIQQTSPILLDGGVKASLQRK
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEECCCHHHHHHH
VTQTIEAVTDHQVADLHLWRVSADHHAIMVSIVSHSPKDVSYFNQLLSQFPELAHITIEL
HHHHHHHHHCCCHHEEEEEEECCCCCEEEEEEHHCCCCHHHHHHHHHHHCCCCEEEEEEE
HTCRQRECMAKEA
ECHHHHHHHCCCC
>Mature Secondary Structure
MKSTTAEQATGHQASAHRQGHSLTQWQHSHEFSNQNRDGEKNTRYVLYLTVITMMAEIAA
CCCCCCHHHCCCHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHHHHHHH
GTIYGSMALLADGWHMGTHAAAFMITLFAYSYARKHANDPAFAFGTGKVSVLGGYTSAIA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEECCHHHHHH
LGLVALVMLIESGMRLISPEQIHFNEAIFVAVIGLSVNILSVFLLKDHHTHDHGHHHGHG
HHHHHHHHHHHCCCCCCCCCHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
HDHSHDHDHEDEHAHAHHNSQAHTHDDHAHTAHSHDVDLHLHHDSHAHDESHHDHSHCQH
CCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHCC
EQDHQHSAEHEHEHEHEHEHEHEHEHEHEHEHEHEHKSQKAHGSHDHNLRAAYFHVLADA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
LTSVLAIAALLFGKYMGLTWLDPIMGIVGAVIISRWSWGLIQQTSPILLDGGVKASLQRK
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHCCCCEEEECCCHHHHHHH
VTQTIEAVTDHQVADLHLWRVSADHHAIMVSIVSHSPKDVSYFNQLLSQFPELAHITIEL
HHHHHHHHHCCCHHEEEEEEECCCCCEEEEEEHHCCCCHHHHHHHHHHHCCCCEEEEEEE
HTCRQRECMAKEA
ECHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]