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The map label for this gene is tyrR [H]

Identifier: 160874634

GI number: 160874634

Start: 1828046

End: 1829584

Strand: Direct

Name: tyrR [H]

Synonym: Sbal195_1517

Alternate gene names: 160874634

Gene position: 1828046-1829584 (Clockwise)

Preceding gene: 160874633

Following gene: 160874635

Centisome position: 34.19

GC content: 48.6

Gene sequence:

>1539_bases
ATGCGCTTGGAAGTCAGCTGTCAGGATCGTGTTGGTTTAGCCAAAGATATCTTAGTCGTATTAGAGCGTTATGGTATTAA
TTTAATTGCCATTGATGCCAGTAACCAAGGATTCCTGTACTTACAATTTGCCGAAATCAGTTTTGAAACCTTAAGTGCCT
TGATGCCGCAGATCCGCAAAGTGGAAAGTGTCCACGATGTGCGTACTGTGTCGTTTATGCCCTCAGAGCAAGAACATTAC
GCCCTTAAAACCTTGCTCAAAACCTTACCCGACTCCGTTTTCTCCATCGATGCTAAAGCGCGTATTCGTATCGTTAACGA
GTCCGCCTTGCTCAATATCGGTATGGGTGAGCACGAAGTGCTCGAAGAGTCGCTCAATCATTGGGTGCAAGGTTTTAACT
TCAGCCGCTGGTTGAGCGAAAGCCAAGTCTTACCGCAAGCGGCGAGGGTACAAATTGGTCCAAACGAATATTTAGCCGAA
ATGCTGCCGATTTACCTGCCCGATGAGGATGAGAAAACTATCTTAGTTGGCGCTGTGGTGTCGCTAAAATCCCCCGCGCG
GGTTGGAAAACAATTTAACGCGCTGCAGAATCAAACTACTGGCTTTGAAAATGTATTAGCCAGCAGTGACAAAATGAAGG
AAGTGCTTAAGCAAGCGCGGCGGATGGCCCAGCTCGATGCGCCTTTATTGATCACAGGTGAAACGGGTACTGGTAAAGAA
TTAATGGCCAGAGCCAGCCACGATGCCAGCATGCGCCGCGAGAAACCCTTTATCGCCATCAACTGCGCCGCTCTGCCCGA
CAGCGCCGCCGAAGAAGAACTATTCGGTTATGTCAGTCAGGGCAAAGTCGTTAAACGGGGTTTCTTTGAAGAAGCTAAAG
GCGGCACAGTATTTCTCGATGAAGTGGCTGAGATGTCCAAGGCCGCACAAGTTAAGCTGCTTCGTCTATTGCAAGATGGC
ACCTTTAGACGTATCGGCGGCGATGAAGAAGTCCGTGCCGATGTGCGGATCATTTGCTCAACCCAGAAAAATTTAGCCGA
ACTGTGCCAAACCGGTGAGTTTAGGGAAGATTTGTACTATCGCATCCATGTGCTCAGTTATCACATACCGTCACTGCGCG
AGCGTAAAGTCGATATCATTCCACTGACAGAAATGTTCCTCGAACATTACAGCCAACAGTTATCTAGCCCAGTGCGACGG
ATTTCGGCCCAGTGCCGCGATCATTTGCTCACCTACGCTTGGCCAGGTAACGTACGCCAATTAAAGAACGCAGTATTTAG
AGCTGTGTCTATGTGGGATGGTTCGGCCGAGTTGACGGTAGAACAATTAAAACTGCCGTCCTACGCCGAAGGTTTTGGTT
ACTTTGACAATGAGTTTGAAGGCAATCTCGACGATGCGATGAAGCAGTTTGAAGCGAGTCTGTTGCGTCGATTATATCCA
GCCTATCCGAGTACTCGTCAGTTAGCGAAAAAGCTCGGGGTGTCGCACACCGCTATTGCCAATAAGCTGCGTGAGTACAA
GATAGCCAAGCGTCGTTAA

Upstream 100 bases:

>100_bases
TGCCTAGCAAGCGTCATTTTTGTTGTAAAGCTTAAGGCGAAAAATAGCTCTGCACGGTTTATCCCCAAAATTCGAATCAA
AAAAGGGAATATCAGTCATT

Downstream 100 bases:

>100_bases
GCCGAGTCTTGCTGGCTTGACTCGACAGATGTAACAGTATCGTTCCACTTAGTTGCCGACTTTTCAGGCATATTGCTTAC
CGAGATATTGATAAGCGGCA

Product: transcriptional regulator TyrR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 512; Mature: 512

Protein sequence:

>512_residues
MRLEVSCQDRVGLAKDILVVLERYGINLIAIDASNQGFLYLQFAEISFETLSALMPQIRKVESVHDVRTVSFMPSEQEHY
ALKTLLKTLPDSVFSIDAKARIRIVNESALLNIGMGEHEVLEESLNHWVQGFNFSRWLSESQVLPQAARVQIGPNEYLAE
MLPIYLPDEDEKTILVGAVVSLKSPARVGKQFNALQNQTTGFENVLASSDKMKEVLKQARRMAQLDAPLLITGETGTGKE
LMARASHDASMRREKPFIAINCAALPDSAAEEELFGYVSQGKVVKRGFFEEAKGGTVFLDEVAEMSKAAQVKLLRLLQDG
TFRRIGGDEEVRADVRIICSTQKNLAELCQTGEFREDLYYRIHVLSYHIPSLRERKVDIIPLTEMFLEHYSQQLSSPVRR
ISAQCRDHLLTYAWPGNVRQLKNAVFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDNEFEGNLDDAMKQFEASLLRRLYP
AYPSTRQLAKKLGVSHTAIANKLREYKIAKRR

Sequences:

>Translated_512_residues
MRLEVSCQDRVGLAKDILVVLERYGINLIAIDASNQGFLYLQFAEISFETLSALMPQIRKVESVHDVRTVSFMPSEQEHY
ALKTLLKTLPDSVFSIDAKARIRIVNESALLNIGMGEHEVLEESLNHWVQGFNFSRWLSESQVLPQAARVQIGPNEYLAE
MLPIYLPDEDEKTILVGAVVSLKSPARVGKQFNALQNQTTGFENVLASSDKMKEVLKQARRMAQLDAPLLITGETGTGKE
LMARASHDASMRREKPFIAINCAALPDSAAEEELFGYVSQGKVVKRGFFEEAKGGTVFLDEVAEMSKAAQVKLLRLLQDG
TFRRIGGDEEVRADVRIICSTQKNLAELCQTGEFREDLYYRIHVLSYHIPSLRERKVDIIPLTEMFLEHYSQQLSSPVRR
ISAQCRDHLLTYAWPGNVRQLKNAVFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDNEFEGNLDDAMKQFEASLLRRLYP
AYPSTRQLAKKLGVSHTAIANKLREYKIAKRR
>Mature_512_residues
MRLEVSCQDRVGLAKDILVVLERYGINLIAIDASNQGFLYLQFAEISFETLSALMPQIRKVESVHDVRTVSFMPSEQEHY
ALKTLLKTLPDSVFSIDAKARIRIVNESALLNIGMGEHEVLEESLNHWVQGFNFSRWLSESQVLPQAARVQIGPNEYLAE
MLPIYLPDEDEKTILVGAVVSLKSPARVGKQFNALQNQTTGFENVLASSDKMKEVLKQARRMAQLDAPLLITGETGTGKE
LMARASHDASMRREKPFIAINCAALPDSAAEEELFGYVSQGKVVKRGFFEEAKGGTVFLDEVAEMSKAAQVKLLRLLQDG
TFRRIGGDEEVRADVRIICSTQKNLAELCQTGEFREDLYYRIHVLSYHIPSLRERKVDIIPLTEMFLEHYSQQLSSPVRR
ISAQCRDHLLTYAWPGNVRQLKNAVFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDNEFEGNLDDAMKQFEASLLRRLYP
AYPSTRQLAKKLGVSHTAIANKLREYKIAKRR

Specific function: Involved in transcriptional regulation of aromatic amino acid biosynthesis and transport. Modulates the expression of at least 8 unlinked operons. Seven of these operons are regulated in response to changes in the concentration of the three aromatic amino

COG id: COG3283

COG function: function code KE; Transcriptional regulator of aromatic amino acids metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1787583, Length=514, Percent_Identity=48.2490272373541, Blast_Score=485, Evalue=1e-138,
Organism=Escherichia coli, GI1788550, Length=349, Percent_Identity=35.8166189111748, Blast_Score=218, Evalue=1e-57,
Organism=Escherichia coli, GI1788905, Length=288, Percent_Identity=41.6666666666667, Blast_Score=205, Evalue=5e-54,
Organism=Escherichia coli, GI1790437, Length=268, Percent_Identity=38.8059701492537, Blast_Score=198, Evalue=7e-52,
Organism=Escherichia coli, GI87082117, Length=325, Percent_Identity=34.4615384615385, Blast_Score=196, Evalue=4e-51,
Organism=Escherichia coli, GI1790299, Length=286, Percent_Identity=38.4615384615385, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1789233, Length=467, Percent_Identity=29.1220556745182, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI87082152, Length=250, Percent_Identity=44.8, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1789087, Length=321, Percent_Identity=35.5140186915888, Blast_Score=188, Evalue=7e-49,
Organism=Escherichia coli, GI1786524, Length=281, Percent_Identity=40.5693950177936, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI87081872, Length=232, Percent_Identity=40.0862068965517, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1789828, Length=260, Percent_Identity=30, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI87081858, Length=384, Percent_Identity=25.5208333333333, Blast_Score=111, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR000014
- InterPro:   IPR002078 [H]

Pfam domain/function: PF01842 ACT; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 57874; Mature: 57874

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS50112 PAS ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLEVSCQDRVGLAKDILVVLERYGINLIAIDASNQGFLYLQFAEISFETLSALMPQIRK
CEEEECCHHCCCHHHHHHHHHHHHCCEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHH
VESVHDVRTVSFMPSEQEHYALKTLLKTLPDSVFSIDAKARIRIVNESALLNIGMGEHEV
HHHHHHHHEEEECCCCHHHHHHHHHHHHCCHHHEEECCCEEEEEEECCEEEECCCCHHHH
LEESLNHWVQGFNFSRWLSESQVLPQAARVQIGPNEYLAEMLPIYLPDEDEKTILVGAVV
HHHHHHHHHHCCCHHHHHHHHHCCCHHHEEEECCHHHHHHHCCEECCCCCCCEEEEEEHH
SLKSPARVGKQFNALQNQTTGFENVLASSDKMKEVLKQARRMAQLDAPLLITGETGTGKE
HCCCHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHH
LMARASHDASMRREKPFIAINCAALPDSAAEEELFGYVSQGKVVKRGFFEEAKGGTVFLD
HHHHHCCCHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCHHHHCCHHHCCCCEEEHH
EVAEMSKAAQVKLLRLLQDGTFRRIGGDEEVRADVRIICSTQKNLAELCQTGEFREDLYY
HHHHHHHHHHHHHHHHHHCCCEEECCCCHHHCCCEEEEECCHHHHHHHHHCCCHHHHHHH
RIHVLSYHIPSLRERKVDIIPLTEMFLEHYSQQLSSPVRRISAQCRDHLLTYAWPGNVRQ
EEEEEHCCCCCHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHH
LKNAVFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDNEFEGNLDDAMKQFEASLLRRLYP
HHHHHHHHHHHCCCCCCEEHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
AYPSTRQLAKKLGVSHTAIANKLREYKIAKRR
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLEVSCQDRVGLAKDILVVLERYGINLIAIDASNQGFLYLQFAEISFETLSALMPQIRK
CEEEECCHHCCCHHHHHHHHHHHHCCEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHH
VESVHDVRTVSFMPSEQEHYALKTLLKTLPDSVFSIDAKARIRIVNESALLNIGMGEHEV
HHHHHHHHEEEECCCCHHHHHHHHHHHHCCHHHEEECCCEEEEEEECCEEEECCCCHHHH
LEESLNHWVQGFNFSRWLSESQVLPQAARVQIGPNEYLAEMLPIYLPDEDEKTILVGAVV
HHHHHHHHHHCCCHHHHHHHHHCCCHHHEEEECCHHHHHHHCCEECCCCCCCEEEEEEHH
SLKSPARVGKQFNALQNQTTGFENVLASSDKMKEVLKQARRMAQLDAPLLITGETGTGKE
HCCCHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCEEEECCCCCCHH
LMARASHDASMRREKPFIAINCAALPDSAAEEELFGYVSQGKVVKRGFFEEAKGGTVFLD
HHHHHCCCHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHCCCHHHHCCHHHCCCCEEEHH
EVAEMSKAAQVKLLRLLQDGTFRRIGGDEEVRADVRIICSTQKNLAELCQTGEFREDLYY
HHHHHHHHHHHHHHHHHHCCCEEECCCCHHHCCCEEEEECCHHHHHHHHHCCCHHHHHHH
RIHVLSYHIPSLRERKVDIIPLTEMFLEHYSQQLSSPVRRISAQCRDHLLTYAWPGNVRQ
EEEEEHCCCCCHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCHHH
LKNAVFRAVSMWDGSAELTVEQLKLPSYAEGFGYFDNEFEGNLDDAMKQFEASLLRRLYP
HHHHHHHHHHHCCCCCCEEHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
AYPSTRQLAKKLGVSHTAIANKLREYKIAKRR
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11055921 [H]