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The map label for this gene is glcA [C]

Identifier: 160874495

GI number: 160874495

Start: 1649391

End: 1651034

Strand: Reverse

Name: glcA [C]

Synonym: Sbal195_1377

Alternate gene names: 160874495

Gene position: 1651034-1649391 (Counterclockwise)

Preceding gene: 160874496

Following gene: 160874494

Centisome position: 30.88

GC content: 49.82

Gene sequence:

>1644_bases
ATGACAATACTTCAACTCCTCGCCAGCTTGACGCCTGTGCTCAGTGTAATGCTATTCCTAGTATTACTCAGAATGCCCGC
ATCAAAGGCTATGCCCATTTCCATGCTAGTCACTGCGCTCGCCGCTGTGTTTATTTGGCAAATGGATACCACATTACTGG
CGGCATCGGTCCTCGAAGGACTGCTCTCAGCCATCACACCTTTAACCATCATTTTTGGTGCTGTGTTCCTACTGAATACC
CTGAAATATTCAGGTGCGATGGACACTATCCGCGCAGGTTTCACTAACATCAGCGCCGATGCCCGTGTGCAAGTGATCAT
CATCTGTTGGTTATTTGGTGCCTTTATCGAAGGCAGTGCAGGCTTTGGTACACCCGCCGCGATTGGCGCCCCACTGCTCG
TACTGCTTGGCGTGCCACCGGTTGCCGCAGCAGTTGTTGCTTTGATTGCCGACTCTGCCTGTGTGTCCTTCGGTGCGATT
GGTCTACCCGTACTCTTTGGTATGGAGCAAGGCTTGACCCAAGGCGGCGTAAGCATGGCTGCGGCGCAAATTGCTGAACA
TGGCGGCACCTATGCTGACTTTGCGCAGTTTATTGCAATGCACATGATCACTATCGATTTAATCACAGGTTCGTTAATTC
CATTGGTGATGGTGTCGATTCTGACAGGCTTCTTTGGTCGCAATAAATCCTTCAAAGAAGGCTTAGCGATTTGGAAATTT
GCGATTTTTGCAGGTCTTTCGTTTACCGTTCCAGCGTGGATCATCAACTATGTTGCTGGCCCAGAATTCCCATCGGTTAT
CGGTTCTTTAATCGGTATGGCAATGGTGATCCCAGTCGCTCGCAAAGGCTACTTACTGCCTAAAGCCGCTTGGAATGATT
TTGCCGAAAATGACAACCAAGAAACCGCCAAAGTGGAAACCACGGCTAAATTTTCCCAAATCGCCGCTTGGACACCTTAC
ATCATCATGGCTGCGCTGTTAGTGCTGTCACGTACTGTTGCACCGCTAAAAGCCTGGTTATCTGGCTTTAACATCAGCTG
GACGGGCTTGATGGGCACAGAACTTAAGGCGAGCTTTGCTACACTATATGCGCCCGGCGCCTTCTTCGTTGCCGTGTGTA
TCTTAGGTTTCTTCCTCTTCAAAATGAAAAGCCCTGCGATTAAGCAAACGGTCGGTGTGTCATGTAAATCCATGTTACCC
ACCATTATTTCATTAGGTGCTTCCGTGCCTATGGTGAAAATCTTCTTAAACTCAGGTGTGAATGGTGCGGGCCTAGCCTC
TATGCCTGTCGCATTAGCAGATATGTTGGCAGGTTCCATGGGCGCAGTATGGGCTTGGATGGCGCCTATCGTCGGTATTT
TTGGTGCCTTCCTATCGGGTTCAGCAACCTTCTCCAACATGATGTTCTCAGGCCTACAGTACAGTGTGGCTGACAATATC
GGCATGAACCACGCTCTCGTCCTTGCCCTACAAGGCATAGGTGCGAACGCGGGTAACATGATGTGTGTGATGAACGTGGT
TGCGGCTGCAACGGTAGTCGGTATGGCGGGTAGAGAGTCTGAAATCATCCGTAAAACCATGCCAGTCGCCATTGGTTATG
CATTACTTGCGGGCACTATTGCTACCCTTTGGGGTGGTTTCTAA

Upstream 100 bases:

>100_bases
AGTATTAACTGCTGATTTATCGGTCTGGGAAGTCGACATGAAGGCAGATGAAAAATTCTAATATCAATAATAAGACAGAC
CACTTTATGAAGAGGCAAGC

Downstream 100 bases:

>100_bases
GCCCATTGAAAACTAAGGTCGCTGCGGCGGCCTTGGTCATTTTTAGCGTTAAGAGAGTAGCCTTATGTCAATTAATTATG
ACGTTGTATATAAAGACTTA

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MTILQLLASLTPVLSVMLFLVLLRMPASKAMPISMLVTALAAVFIWQMDTTLLAASVLEGLLSAITPLTIIFGAVFLLNT
LKYSGAMDTIRAGFTNISADARVQVIIICWLFGAFIEGSAGFGTPAAIGAPLLVLLGVPPVAAAVVALIADSACVSFGAI
GLPVLFGMEQGLTQGGVSMAAAQIAEHGGTYADFAQFIAMHMITIDLITGSLIPLVMVSILTGFFGRNKSFKEGLAIWKF
AIFAGLSFTVPAWIINYVAGPEFPSVIGSLIGMAMVIPVARKGYLLPKAAWNDFAENDNQETAKVETTAKFSQIAAWTPY
IIMAALLVLSRTVAPLKAWLSGFNISWTGLMGTELKASFATLYAPGAFFVAVCILGFFLFKMKSPAIKQTVGVSCKSMLP
TIISLGASVPMVKIFLNSGVNGAGLASMPVALADMLAGSMGAVWAWMAPIVGIFGAFLSGSATFSNMMFSGLQYSVADNI
GMNHALVLALQGIGANAGNMMCVMNVVAAATVVGMAGRESEIIRKTMPVAIGYALLAGTIATLWGGF

Sequences:

>Translated_547_residues
MTILQLLASLTPVLSVMLFLVLLRMPASKAMPISMLVTALAAVFIWQMDTTLLAASVLEGLLSAITPLTIIFGAVFLLNT
LKYSGAMDTIRAGFTNISADARVQVIIICWLFGAFIEGSAGFGTPAAIGAPLLVLLGVPPVAAAVVALIADSACVSFGAI
GLPVLFGMEQGLTQGGVSMAAAQIAEHGGTYADFAQFIAMHMITIDLITGSLIPLVMVSILTGFFGRNKSFKEGLAIWKF
AIFAGLSFTVPAWIINYVAGPEFPSVIGSLIGMAMVIPVARKGYLLPKAAWNDFAENDNQETAKVETTAKFSQIAAWTPY
IIMAALLVLSRTVAPLKAWLSGFNISWTGLMGTELKASFATLYAPGAFFVAVCILGFFLFKMKSPAIKQTVGVSCKSMLP
TIISLGASVPMVKIFLNSGVNGAGLASMPVALADMLAGSMGAVWAWMAPIVGIFGAFLSGSATFSNMMFSGLQYSVADNI
GMNHALVLALQGIGANAGNMMCVMNVVAAATVVGMAGRESEIIRKTMPVAIGYALLAGTIATLWGGF
>Mature_546_residues
TILQLLASLTPVLSVMLFLVLLRMPASKAMPISMLVTALAAVFIWQMDTTLLAASVLEGLLSAITPLTIIFGAVFLLNTL
KYSGAMDTIRAGFTNISADARVQVIIICWLFGAFIEGSAGFGTPAAIGAPLLVLLGVPPVAAAVVALIADSACVSFGAIG
LPVLFGMEQGLTQGGVSMAAAQIAEHGGTYADFAQFIAMHMITIDLITGSLIPLVMVSILTGFFGRNKSFKEGLAIWKFA
IFAGLSFTVPAWIINYVAGPEFPSVIGSLIGMAMVIPVARKGYLLPKAAWNDFAENDNQETAKVETTAKFSQIAAWTPYI
IMAALLVLSRTVAPLKAWLSGFNISWTGLMGTELKASFATLYAPGAFFVAVCILGFFLFKMKSPAIKQTVGVSCKSMLPT
IISLGASVPMVKIFLNSGVNGAGLASMPVALADMLAGSMGAVWAWMAPIVGIFGAFLSGSATFSNMMFSGLQYSVADNIG
MNHALVLALQGIGANAGNMMCVMNVVAAATVVGMAGRESEIIRKTMPVAIGYALLAGTIATLWGGF

Specific function: May play a role in L-lactate transport [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=576, Percent_Identity=28.6458333333333, Blast_Score=158, Evalue=8e-40,
Organism=Escherichia coli, GI1790031, Length=562, Percent_Identity=27.0462633451957, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 57114; Mature: 56983

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTILQLLASLTPVLSVMLFLVLLRMPASKAMPISMLVTALAAVFIWQMDTTLLAASVLEG
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLSAITPLTIIFGAVFLLNTLKYSGAMDTIRAGFTNISADARVQVIIICWLFGAFIEGSA
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCC
GFGTPAAIGAPLLVLLGVPPVAAAVVALIADSACVSFGAIGLPVLFGMEQGLTQGGVSMA
CCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
AAQIAEHGGTYADFAQFIAMHMITIDLITGSLIPLVMVSILTGFFGRNKSFKEGLAIWKF
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AIFAGLSFTVPAWIINYVAGPEFPSVIGSLIGMAMVIPVARKGYLLPKAAWNDFAENDNQ
HHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCC
ETAKVETTAKFSQIAAWTPYIIMAALLVLSRTVAPLKAWLSGFNISWTGLMGTELKASFA
CHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHH
TLYAPGAFFVAVCILGFFLFKMKSPAIKQTVGVSCKSMLPTIISLGASVPMVKIFLNSGV
HHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHCCC
NGAGLASMPVALADMLAGSMGAVWAWMAPIVGIFGAFLSGSATFSNMMFSGLQYSVADNI
CCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHCC
GMNHALVLALQGIGANAGNMMCVMNVVAAATVVGMAGRESEIIRKTMPVAIGYALLAGTI
CCCHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ATLWGGF
HHHHCCC
>Mature Secondary Structure 
TILQLLASLTPVLSVMLFLVLLRMPASKAMPISMLVTALAAVFIWQMDTTLLAASVLEG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH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HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]