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The map label for this gene is purK [H]

Identifier: 160874256

GI number: 160874256

Start: 1346356

End: 1347459

Strand: Reverse

Name: purK [H]

Synonym: Sbal195_1136

Alternate gene names: 160874256

Gene position: 1347459-1346356 (Counterclockwise)

Preceding gene: 160874257

Following gene: 160874255

Centisome position: 25.2

GC content: 49.09

Gene sequence:

>1104_bases
ATGACCCAGACAAACACTAAACCTAAGGTTTGGGTATTAGGTAATGGTCAGCTGGGCGCCATGTTAACCCACGCTGGCGA
GCCATTAGCGATTGAAGTTAACGCCGTTGATATCATGACGCCTACGGATGACATCCTGCCACTCGCGCCACACGACATCA
TCACCGCCGAGCGCGAACAGTGGCCTGAATCCGCCCTTAGCTTACAACTCAGCTCACACCCCCATTTTGTTAATGGTCCG
GTATTTAGCCGTTTAGCCGACCGTTTTAGCCAAAAAAGTCTACTCGACCAGCTCAGTGTTCCCACAGCGCCTTGGACCTT
AGTTGACGATAACACCCAAGTCGATACCCTGTATCAGCACTATGGCCCAAGAGTCTTGATGAAACGCCGTACCGGTGGTT
ATGACGGTAAAGGTCAACACTGGCTTAAACAAGCCGAAGCGGGTGATATTCCAAACGATTGGCGTAACCTTGCAATTGCT
GAGCAAGCGATTAATTTTGATGAAGAAGTATCATTAGTTGGCGTCCGTACTCGCGAAGGCGAATGCGTGTTTTATCCGCT
GACGCTGAACTTACATCAAGATGGCATTTTAATGGCGTCGATTTCGCCACTGACACGCTTAAGCCTTTTGCAAGCCCAAG
CCGAAGCTATGCTCAGCGCCATTATGCATGAGCTTGAATACGTTGGCGTGATGGCGATGGAATGCTTCCGTGTTGGCGAT
GAGTTATTGGTGAATGAACTGGCACCGCGAGTGCACAACTCAGGCCATTGGACTCAAGCCGGAACCCATATGGATCAATT
CCAGCTGCATTTGCGTGCACTTTGCGGAATTGCGATCCCACAGCCACAAGTGAATTTTCAGTGTGTTATGGTCAATCTTA
TCGGTATCGATAATGATCCACGCTGGTTAAGTTTGCCTAATGCTGAGTTGTACTGGTACAACAAAGAAGTGCGCCCTGGT
CGTAAAGTTGGCCATTTGAACCTATCAGTGCCTAACCAAACTGTGCTCAACCAGAGCATAGCCGCACTGCAAAAGTGGAT
GCCCATCCAATACCAAGCTCCTTTAGCCTGGATATTGGCCGAATACGCAGAAAATTCGCGTTAA

Upstream 100 bases:

>100_bases
TCCTTGCGAATAACGATGCTGAATTAGCGGCTCGTGTTGACGCTTTCAGAGAAGAACAGACCCGTGCGGTACTGGACAAT
CCAGATCCGAGGGAAGTTTA

Downstream 100 bases:

>100_bases
TTCAGTATTTAGTACCAAAATCACTGATATGAAATTGTTCGCAGTTTCATATCAGTTTATATTTCAATTTTCGTTATATA
CTTAACAGAACTCAGTGTGG

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MTQTNTKPKVWVLGNGQLGAMLTHAGEPLAIEVNAVDIMTPTDDILPLAPHDIITAEREQWPESALSLQLSSHPHFVNGP
VFSRLADRFSQKSLLDQLSVPTAPWTLVDDNTQVDTLYQHYGPRVLMKRRTGGYDGKGQHWLKQAEAGDIPNDWRNLAIA
EQAINFDEEVSLVGVRTREGECVFYPLTLNLHQDGILMASISPLTRLSLLQAQAEAMLSAIMHELEYVGVMAMECFRVGD
ELLVNELAPRVHNSGHWTQAGTHMDQFQLHLRALCGIAIPQPQVNFQCVMVNLIGIDNDPRWLSLPNAELYWYNKEVRPG
RKVGHLNLSVPNQTVLNQSIAALQKWMPIQYQAPLAWILAEYAENSR

Sequences:

>Translated_367_residues
MTQTNTKPKVWVLGNGQLGAMLTHAGEPLAIEVNAVDIMTPTDDILPLAPHDIITAEREQWPESALSLQLSSHPHFVNGP
VFSRLADRFSQKSLLDQLSVPTAPWTLVDDNTQVDTLYQHYGPRVLMKRRTGGYDGKGQHWLKQAEAGDIPNDWRNLAIA
EQAINFDEEVSLVGVRTREGECVFYPLTLNLHQDGILMASISPLTRLSLLQAQAEAMLSAIMHELEYVGVMAMECFRVGD
ELLVNELAPRVHNSGHWTQAGTHMDQFQLHLRALCGIAIPQPQVNFQCVMVNLIGIDNDPRWLSLPNAELYWYNKEVRPG
RKVGHLNLSVPNQTVLNQSIAALQKWMPIQYQAPLAWILAEYAENSR
>Mature_366_residues
TQTNTKPKVWVLGNGQLGAMLTHAGEPLAIEVNAVDIMTPTDDILPLAPHDIITAEREQWPESALSLQLSSHPHFVNGPV
FSRLADRFSQKSLLDQLSVPTAPWTLVDDNTQVDTLYQHYGPRVLMKRRTGGYDGKGQHWLKQAEAGDIPNDWRNLAIAE
QAINFDEEVSLVGVRTREGECVFYPLTLNLHQDGILMASISPLTRLSLLQAQAEAMLSAIMHELEYVGVMAMECFRVGDE
LLVNELAPRVHNSGHWTQAGTHMDQFQLHLRALCGIAIPQPQVNFQCVMVNLIGIDNDPRWLSLPNAELYWYNKEVRPGR
KVGHLNLSVPNQTVLNQSIAALQKWMPIQYQAPLAWILAEYAENSR

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=358, Percent_Identity=51.6759776536313, Blast_Score=344, Evalue=6e-96,
Organism=Escherichia coli, GI1788155, Length=239, Percent_Identity=23.8493723849372, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324702, Length=361, Percent_Identity=28.2548476454294, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 41160; Mature: 41028

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTNTKPKVWVLGNGQLGAMLTHAGEPLAIEVNAVDIMTPTDDILPLAPHDIITAEREQ
CCCCCCCCEEEEEECCCEEEHEECCCCCEEEEEEEEEEECCCCCCCCCCCCHHEECCHHH
WPESALSLQLSSHPHFVNGPVFSRLADRFSQKSLLDQLSVPTAPWTLVDDNTQVDTLYQH
CCCHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHH
YGPRVLMKRRTGGYDGKGQHWLKQAEAGDIPNDWRNLAIAEQAINFDEEVSLVGVRTREG
CCCEEEEEECCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCC
ECVFYPLTLNLHQDGILMASISPLTRLSLLQAQAEAMLSAIMHELEYVGVMAMECFRVGD
CEEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
ELLVNELAPRVHNSGHWTQAGTHMDQFQLHLRALCGIAIPQPQVNFQCVMVNLIGIDNDP
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCC
RWLSLPNAELYWYNKEVRPGRKVGHLNLSVPNQTVLNQSIAALQKWMPIQYQAPLAWILA
CEEECCCCEEEEECCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCEECCCHHHHHH
EYAENSR
HHHHCCC
>Mature Secondary Structure 
TQTNTKPKVWVLGNGQLGAMLTHAGEPLAIEVNAVDIMTPTDDILPLAPHDIITAEREQ
CCCCCCCEEEEEECCCEEEHEECCCCCEEEEEEEEEEECCCCCCCCCCCCHHEECCHHH
WPESALSLQLSSHPHFVNGPVFSRLADRFSQKSLLDQLSVPTAPWTLVDDNTQVDTLYQH
CCCHHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHH
YGPRVLMKRRTGGYDGKGQHWLKQAEAGDIPNDWRNLAIAEQAINFDEEVSLVGVRTREG
CCCEEEEEECCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEEECCC
ECVFYPLTLNLHQDGILMASISPLTRLSLLQAQAEAMLSAIMHELEYVGVMAMECFRVGD
CEEEEEEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
ELLVNELAPRVHNSGHWTQAGTHMDQFQLHLRALCGIAIPQPQVNFQCVMVNLIGIDNDP
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEEECCCCC
RWLSLPNAELYWYNKEVRPGRKVGHLNLSVPNQTVLNQSIAALQKWMPIQYQAPLAWILA
CEEECCCCEEEEECCCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCEECCCHHHHHH
EYAENSR
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]