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The map label for this gene is pepB [H]

Identifier: 159900691

GI number: 159900691

Start: 5327805

End: 5329490

Strand: Direct

Name: pepB [H]

Synonym: Haur_4178

Alternate gene names: 159900691

Gene position: 5327805-5329490 (Clockwise)

Preceding gene: 159900690

Following gene: 159900694

Centisome position: 83.95

GC content: 49.7

Gene sequence:

>1686_bases
ATGAGTTTGAAGATTGACCCACGCGATTGGGCCACAGTTCAGCCCTACTACGATTCACTTGCAGCCGAAGAGCTTACGGC
TGCCAATGCAACTGCTTGGTTAGGCCGTTGGAGTGAGTTGGAAGCCCATTTGCAAGAATTCGGCTTCAAGGCCTATCGGG
CGATGACCGAAAATACGCAGGATCAGGCCGCCGAAGAGCTGTACCTCTACACAATTGAGGAGTTGACCCCGAAATCCAAG
GTTGCCGCCCAAACCTTGAAAGAAAAAATTTTGGCGCTTGATCCAACGCTGTTGCCAGCCAAAATGCAAGAAATGCTGCG
GCGATTTCATGCTGAAGCCAATTTATTCCGCGAAGAAAATGTGCCACTATTGACCGAAGTTGAGCGCCTGAGTGCGGAAT
TTAGCAAATTGATGGGTGCAATGAGCGTTGAGTGGCAAGGCGAAACCCTGACCATGCAAGCAGTCGTTAAGCTGTTTAGC
GACCCAGATCGCAGTGTGCGCGAAGCTGCATTTAAGGCTTATCATAGCCGTTTTTTGCAAGACCGAGCAGCTTTCAACGA
GATTTATCTCAAGCAACTTAAGCTTCGTCGCCAAATTGCCACCAATGCAGGTAAAGCCAGCTATTTGGATTATGTCTGGG
ATCTCTATGGGCGCTTCGATTATACGCCTGCCGATTGCCGCACCTTCCACGATGCAATTGAACATGAAGTTGTGCCGTTG
GTTGAAAAATGGTTGGCAGTCCATCAAGCCGAATTAGGCGTTGATAGCTTGCGACCATGGGATATTTTGGTTGATTCGCA
ATCACGCCCAGCTTTAACTCCATTCCAAAGCGCCGATGAACTCGAAAGCGTCTGCCAAACAATCTTCGATCGCGTTGATC
CTGAACTGGGAGCGCAATACACTCGCATGCGTGATGGCTGGCTTGATTTGGATTCACGGCCTGGTAAAGCACCTGGTGGT
TATTGTGGCGGGATGTTTGTTTCCAAAGTGCCCTACATTTTTATGAATGCGGTTGGCACCCATGATGATGTCCAAACCAT
GTTGCACGAAGGTGGCCATGCTTTCCACTTTATGGAATCATCGGCAACCAACGATTTGATTTGGAATTACGATGGGCCAA
CTGAATTTTGTGAAGTCGCTTCGATGGCGATGGAATTGTTGGCAGCGCCCTATTTAGCCAACGCTAAGGGCGGTTTCTAC
AGCGAAACTGATGCCCGTCGTGCTCGTGCAGAGCATCTTTGGAGTATGCTCAAATTCTTGCCCTATATGGCGACCGTCGA
TGCCTTCCAACATTGGGTCTACATTGAAGCGCCTGAAGATGTAACGGCTGAGCAGCTTGATGCCGTGTGGAAAGACCTCT
ATCAGCGCTTTATGAGTGGGGTGAATTGGGATGGCTTCGAAGATGTACAGACCACAGGCTGGCATCGCAAGCAGCATATT
TTTGAAGCTCCGCTCTATTATGTAGAGTATGGCTTAGCCCAATTGGGGGCGCAACAAGTTTGGCGCAACGCTTTAGCTGA
TCAAGCGCAGGCCGTAGCACAATATCGCGCAGCCTTAGCCTTGGGCAATACCAAACCACTGAGTCAATTATTTGCAGCGG
CTGGGGCAAAATTTGCCTTCGATCGGGCAACTGTCGGCGAATTAGCCCGCTTAGTCGATCAGCATCTGACCACACTCCGT
GATTAA

Upstream 100 bases:

>100_bases
CTCGCAAATCGCCCTCGTTGAGGGCGATTTTTTATTTGTGTAGGTTTTTGCGGTGGTTTAGCCCTTTGAGAGTAGCAACA
ATCTAGCAAGGAGTTCTGGC

Downstream 100 bases:

>100_bases
TCGCCAAACCAATTCAAAACCGGATCAAGGCTTGCCAGCGCTTGATCCGGTTTTGATATTTAGCATTGGGCCTACGCATT
AACGTTTACTACTAGGCAAC

Product: peptidase M3A and M3B thimet/oligopeptidase F

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 561; Mature: 560

Protein sequence:

>561_residues
MSLKIDPRDWATVQPYYDSLAAEELTAANATAWLGRWSELEAHLQEFGFKAYRAMTENTQDQAAEELYLYTIEELTPKSK
VAAQTLKEKILALDPTLLPAKMQEMLRRFHAEANLFREENVPLLTEVERLSAEFSKLMGAMSVEWQGETLTMQAVVKLFS
DPDRSVREAAFKAYHSRFLQDRAAFNEIYLKQLKLRRQIATNAGKASYLDYVWDLYGRFDYTPADCRTFHDAIEHEVVPL
VEKWLAVHQAELGVDSLRPWDILVDSQSRPALTPFQSADELESVCQTIFDRVDPELGAQYTRMRDGWLDLDSRPGKAPGG
YCGGMFVSKVPYIFMNAVGTHDDVQTMLHEGGHAFHFMESSATNDLIWNYDGPTEFCEVASMAMELLAAPYLANAKGGFY
SETDARRARAEHLWSMLKFLPYMATVDAFQHWVYIEAPEDVTAEQLDAVWKDLYQRFMSGVNWDGFEDVQTTGWHRKQHI
FEAPLYYVEYGLAQLGAQQVWRNALADQAQAVAQYRAALALGNTKPLSQLFAAAGAKFAFDRATVGELARLVDQHLTTLR
D

Sequences:

>Translated_561_residues
MSLKIDPRDWATVQPYYDSLAAEELTAANATAWLGRWSELEAHLQEFGFKAYRAMTENTQDQAAEELYLYTIEELTPKSK
VAAQTLKEKILALDPTLLPAKMQEMLRRFHAEANLFREENVPLLTEVERLSAEFSKLMGAMSVEWQGETLTMQAVVKLFS
DPDRSVREAAFKAYHSRFLQDRAAFNEIYLKQLKLRRQIATNAGKASYLDYVWDLYGRFDYTPADCRTFHDAIEHEVVPL
VEKWLAVHQAELGVDSLRPWDILVDSQSRPALTPFQSADELESVCQTIFDRVDPELGAQYTRMRDGWLDLDSRPGKAPGG
YCGGMFVSKVPYIFMNAVGTHDDVQTMLHEGGHAFHFMESSATNDLIWNYDGPTEFCEVASMAMELLAAPYLANAKGGFY
SETDARRARAEHLWSMLKFLPYMATVDAFQHWVYIEAPEDVTAEQLDAVWKDLYQRFMSGVNWDGFEDVQTTGWHRKQHI
FEAPLYYVEYGLAQLGAQQVWRNALADQAQAVAQYRAALALGNTKPLSQLFAAAGAKFAFDRATVGELARLVDQHLTTLR
D
>Mature_560_residues
SLKIDPRDWATVQPYYDSLAAEELTAANATAWLGRWSELEAHLQEFGFKAYRAMTENTQDQAAEELYLYTIEELTPKSKV
AAQTLKEKILALDPTLLPAKMQEMLRRFHAEANLFREENVPLLTEVERLSAEFSKLMGAMSVEWQGETLTMQAVVKLFSD
PDRSVREAAFKAYHSRFLQDRAAFNEIYLKQLKLRRQIATNAGKASYLDYVWDLYGRFDYTPADCRTFHDAIEHEVVPLV
EKWLAVHQAELGVDSLRPWDILVDSQSRPALTPFQSADELESVCQTIFDRVDPELGAQYTRMRDGWLDLDSRPGKAPGGY
CGGMFVSKVPYIFMNAVGTHDDVQTMLHEGGHAFHFMESSATNDLIWNYDGPTEFCEVASMAMELLAAPYLANAKGGFYS
ETDARRARAEHLWSMLKFLPYMATVDAFQHWVYIEAPEDVTAEQLDAVWKDLYQRFMSGVNWDGFEDVQTTGWHRKQHIF
EAPLYYVEYGLAQLGAQQVWRNALADQAQAVAQYRAALALGNTKPLSQLFAAAGAKFAFDRATVGELARLVDQHLTTLRD

Specific function: Has oligopeptidase activity and degrades a variety of small bioactive peptides, including bradykinin, neurotensin, and peptide fragments of substance P and adrenocorticotropin. Also hydrolyzes the synthetic collagen-like substrate N-(3-[2- furyl]acryloyl)

COG id: COG1164

COG function: function code E; Oligoendopeptidase F

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567
- InterPro:   IPR004438
- InterPro:   IPR013647 [H]

Pfam domain/function: PF01432 Peptidase_M3; PF08439 Peptidase_M3_N [H]

EC number: NA

Molecular weight: Translated: 63783; Mature: 63651

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKIDPRDWATVQPYYDSLAAEELTAANATAWLGRWSELEAHLQEFGFKAYRAMTENTQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DQAAEELYLYTIEELTPKSKVAAQTLKEKILALDPTLLPAKMQEMLRRFHAEANLFREEN
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCC
VPLLTEVERLSAEFSKLMGAMSVEWQGETLTMQAVVKLFSDPDRSVREAAFKAYHSRFLQ
CCHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
DRAAFNEIYLKQLKLRRQIATNAGKASYLDYVWDLYGRFDYTPADCRTFHDAIEHEVVPL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VEKWLAVHQAELGVDSLRPWDILVDSQSRPALTPFQSADELESVCQTIFDRVDPELGAQY
HHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCHHH
TRMRDGWLDLDSRPGKAPGGYCGGMFVSKVPYIFMNAVGTHDDVQTMLHEGGHAFHFMES
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECC
SATNDLIWNYDGPTEFCEVASMAMELLAAPYLANAKGGFYSETDARRARAEHLWSMLKFL
CCCCCEEECCCCHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
PYMATVDAFQHWVYIEAPEDVTAEQLDAVWKDLYQRFMSGVNWDGFEDVQTTGWHRKQHI
HHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHH
FEAPLYYVEYGLAQLGAQQVWRNALADQAQAVAQYRAALALGNTKPLSQLFAAAGAKFAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHH
DRATVGELARLVDQHLTTLRD
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLKIDPRDWATVQPYYDSLAAEELTAANATAWLGRWSELEAHLQEFGFKAYRAMTENTQ
CCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
DQAAEELYLYTIEELTPKSKVAAQTLKEKILALDPTLLPAKMQEMLRRFHAEANLFREEN
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCC
VPLLTEVERLSAEFSKLMGAMSVEWQGETLTMQAVVKLFSDPDRSVREAAFKAYHSRFLQ
CCHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
DRAAFNEIYLKQLKLRRQIATNAGKASYLDYVWDLYGRFDYTPADCRTFHDAIEHEVVPL
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
VEKWLAVHQAELGVDSLRPWDILVDSQSRPALTPFQSADELESVCQTIFDRVDPELGAQY
HHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHCHHH
TRMRDGWLDLDSRPGKAPGGYCGGMFVSKVPYIFMNAVGTHDDVQTMLHEGGHAFHFMES
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECC
SATNDLIWNYDGPTEFCEVASMAMELLAAPYLANAKGGFYSETDARRARAEHLWSMLKFL
CCCCCEEECCCCHHHHHHHHHHHHHHHHCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHHH
PYMATVDAFQHWVYIEAPEDVTAEQLDAVWKDLYQRFMSGVNWDGFEDVQTTGWHRKQHI
HHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHH
FEAPLYYVEYGLAQLGAQQVWRNALADQAQAVAQYRAALALGNTKPLSQLFAAAGAKFAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHH
DRATVGELARLVDQHLTTLRD
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757883; 12354221 [H]