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The map label for this gene is hemA

Identifier: 159900061

GI number: 159900061

Start: 4460566

End: 4461810

Strand: Direct

Name: hemA

Synonym: Haur_3544

Alternate gene names: 159900061

Gene position: 4460566-4461810 (Clockwise)

Preceding gene: 159900060

Following gene: 159900062

Centisome position: 70.28

GC content: 54.06

Gene sequence:

>1245_bases
GTGCAACTGGTGGTTGTGGGGGCACATCAACGCACGGCCCCAATTTCAATTCGCGAGCGAATCGCCTTTGCCGAGGCCGA
GTTAGCTCAAGCCCTGAGCAGCCTACGCCAGATCGCCGTTGAGGGCTTTATTCTCTCAACCTGCAATCGGGTAGAGTTGT
ATGCCTTGGTCGAAGAAGCCGACGGCGGGCGTTCATTGCGCCAATTTTTGGCTCAGCAACGCTCAATCGATCTCGATGAA
CTTATGCCGCATGTCTATACCTATCTCGATGAGGATGCTGTGCGCCATTTGTTTCGGGTGGCTTCGGGCCTAGATTCGAT
GGCACTGGGCGAGGCTCAAATTTTGAGCCAAATCAAAACCGCCTATAACGCGGCCCAACAAACCGAGTTGCTGGGCACAA
CCATGCATCGTTTGATTCAGGCTGCCTTGACTACGGGTAAGTTGGTGCGCACCGAAACCCAATTGGCTCATGCTCAATTA
TCAGTCGTTTCGGTTGGCCTTAGTCTTGCCCGCCAACACCTCGATCTAACTAATCGTTCGGTGGTGATTATCGGGGCTGG
CCGCACTGGCGAGTTGGCACTCAAACACTATTTGGAATATACCAGCAACATCACTGTGCTCAGCCGCACATTTGAACGAG
CAGCGCGTTTGGCTGAGCATCATAAGGTTGCAGCCAAGCCAATCAGCGAACTTGCGGCGGTGTTGCAGGCTAGCGATGTG
GTGATTAGCTGTACGTCATCGCCTGAATTGATGCTTGATTTCGAGCAGGCTCAGCTGTTGCAAGCGCAACGCCAACGCCA
ATGGGTATTGCTCGATTTGGCCGTGCCCCGCGATATTGATCGCCATGTTGGGGCGTTGCCTGAGGTTTGGCTCTACGATG
TCGATGATATGCAGGCGATCTGCGAACGCAATCGGGCTAGCAAAGCTGCCGAAGTTGCCGGAGCCGAGGCGATTGTCGAA
CGCGAGTTGATTAAATGGCAGGAATGGTGGCTAACTCAAGCCGTGCTGCCAACGATTCGCGCCTTGCGTGCGCACGCCGA
GGCAATTCGTTTGGCCGAACTTGAACGCACACTCGCCCGTTTGGATCTTTCTGAGCAGCAGCAGCAAGCAGTTTCGGCCC
TGACCAGCGCGATTATCAATAAATTATTACATCAACCAATGCGGGCGATTAAAGATACTGCGGCCAGCCCACAGTTGGCC
CACGCCGCCCAGCAATTATTCCGCCTCGATTTTGAGGCAATCTAA

Upstream 100 bases:

>100_bases
CTCGTAAGTGCAAAAGCAAATTCGCATCGATCATGCTTTGGGGATTCTTGTTGGTTGCGCTCGATGATGATTGCTATTTG
CTTTTTACTGGGAGTTTACT

Downstream 100 bases:

>100_bases
TTCAGTTTTGATGGGCATCCATCACTGGTATAAAGGAATTAAGCTTCCATGGAAGACGTTAAATTGCCAAATTCCACCGA
AGGTCAATTGTTTGTTCAAT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MQLVVVGAHQRTAPISIRERIAFAEAELAQALSSLRQIAVEGFILSTCNRVELYALVEEADGGRSLRQFLAQQRSIDLDE
LMPHVYTYLDEDAVRHLFRVASGLDSMALGEAQILSQIKTAYNAAQQTELLGTTMHRLIQAALTTGKLVRTETQLAHAQL
SVVSVGLSLARQHLDLTNRSVVIIGAGRTGELALKHYLEYTSNITVLSRTFERAARLAEHHKVAAKPISELAAVLQASDV
VISCTSSPELMLDFEQAQLLQAQRQRQWVLLDLAVPRDIDRHVGALPEVWLYDVDDMQAICERNRASKAAEVAGAEAIVE
RELIKWQEWWLTQAVLPTIRALRAHAEAIRLAELERTLARLDLSEQQQQAVSALTSAIINKLLHQPMRAIKDTAASPQLA
HAAQQLFRLDFEAI

Sequences:

>Translated_414_residues
MQLVVVGAHQRTAPISIRERIAFAEAELAQALSSLRQIAVEGFILSTCNRVELYALVEEADGGRSLRQFLAQQRSIDLDE
LMPHVYTYLDEDAVRHLFRVASGLDSMALGEAQILSQIKTAYNAAQQTELLGTTMHRLIQAALTTGKLVRTETQLAHAQL
SVVSVGLSLARQHLDLTNRSVVIIGAGRTGELALKHYLEYTSNITVLSRTFERAARLAEHHKVAAKPISELAAVLQASDV
VISCTSSPELMLDFEQAQLLQAQRQRQWVLLDLAVPRDIDRHVGALPEVWLYDVDDMQAICERNRASKAAEVAGAEAIVE
RELIKWQEWWLTQAVLPTIRALRAHAEAIRLAELERTLARLDLSEQQQQAVSALTSAIINKLLHQPMRAIKDTAASPQLA
HAAQQLFRLDFEAI
>Mature_414_residues
MQLVVVGAHQRTAPISIRERIAFAEAELAQALSSLRQIAVEGFILSTCNRVELYALVEEADGGRSLRQFLAQQRSIDLDE
LMPHVYTYLDEDAVRHLFRVASGLDSMALGEAQILSQIKTAYNAAQQTELLGTTMHRLIQAALTTGKLVRTETQLAHAQL
SVVSVGLSLARQHLDLTNRSVVIIGAGRTGELALKHYLEYTSNITVLSRTFERAARLAEHHKVAAKPISELAAVLQASDV
VISCTSSPELMLDFEQAQLLQAQRQRQWVLLDLAVPRDIDRHVGALPEVWLYDVDDMQAICERNRASKAAEVAGAEAIVE
RELIKWQEWWLTQAVLPTIRALRAHAEAIRLAELERTLARLDLSEQQQQAVSALTSAIINKLLHQPMRAIKDTAASPQLA
HAAQQLFRLDFEAI

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=402, Percent_Identity=36.318407960199, Blast_Score=234, Evalue=6e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_HERA2 (A9B543)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001546308.1
- ProteinModelPortal:   A9B543
- SMR:   A9B543
- GeneID:   5735403
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_3544
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- ProtClustDB:   PRK00045
- BioCyc:   HAUR316274:HAUR_3544-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 45982; Mature: 45982

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 48-48 BINDING 106-106 BINDING 117-117

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLVVVGAHQRTAPISIRERIAFAEAELAQALSSLRQIAVEGFILSTCNRVELYALVEEA
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHC
DGGRSLRQFLAQQRSIDLDELMPHVYTYLDEDAVRHLFRVASGLDSMALGEAQILSQIKT
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHCCHHHHHHHHHH
AYNAAQQTELLGTTMHRLIQAALTTGKLVRTETQLAHAQLSVVSVGLSLARQHLDLTNRS
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VVIIGAGRTGELALKHYLEYTSNITVLSRTFERAARLAEHHKVAAKPISELAAVLQASDV
EEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
VISCTSSPELMLDFEQAQLLQAQRQRQWVLLDLAVPRDIDRHVGALPEVWLYDVDDMQAI
EEEECCCCCEEEEHHHHHHHHHHHCCCEEEEEECCCCCHHHHHCCCCCCEEECCHHHHHH
CERNRASKAAEVAGAEAIVERELIKWQEWWLTQAVLPTIRALRAHAEAIRLAELERTLAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDLSEQQQQAVSALTSAIINKLLHQPMRAIKDTAASPQLAHAAQQLFRLDFEAI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQLVVVGAHQRTAPISIRERIAFAEAELAQALSSLRQIAVEGFILSTCNRVELYALVEEA
CEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHC
DGGRSLRQFLAQQRSIDLDELMPHVYTYLDEDAVRHLFRVASGLDSMALGEAQILSQIKT
CCCHHHHHHHHHHHCCCHHHHHHHHHHHHCHHHHHHHHHHHHCCCHHHCCHHHHHHHHHH
AYNAAQQTELLGTTMHRLIQAALTTGKLVRTETQLAHAQLSVVSVGLSLARQHLDLTNRS
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
VVIIGAGRTGELALKHYLEYTSNITVLSRTFERAARLAEHHKVAAKPISELAAVLQASDV
EEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCE
VISCTSSPELMLDFEQAQLLQAQRQRQWVLLDLAVPRDIDRHVGALPEVWLYDVDDMQAI
EEEECCCCCEEEEHHHHHHHHHHHCCCEEEEEECCCCCHHHHHCCCCCCEEECCHHHHHH
CERNRASKAAEVAGAEAIVERELIKWQEWWLTQAVLPTIRALRAHAEAIRLAELERTLAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDLSEQQQQAVSALTSAIINKLLHQPMRAIKDTAASPQLAHAAQQLFRLDFEAI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA