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The map label for this gene is pgl [H]

Identifier: 159899542

GI number: 159899542

Start: 3818910

End: 3819632

Strand: Direct

Name: pgl [H]

Synonym: Haur_3023

Alternate gene names: 159899542

Gene position: 3818910-3819632 (Clockwise)

Preceding gene: 159899541

Following gene: 159899543

Centisome position: 60.17

GC content: 53.11

Gene sequence:

>723_bases
ATGACGCTTCAGATTGCCCCAAGCCGCGAGGAATTGATGATCCTCGCGGCTGATCGGCTAGTAGCCGAGGCTCAAACCGC
CATCGCTCAACGTGGCCGCTGGACAATCGCGCTTTCGGGTGGCTCAACGCCCAAAGCGTTGTTTGAGTTATTAGCCAGCC
CACGCTACATTAATCAGATTCTTTGGGGGCGCTGTTTTTTATTTTGGGGCGATGAGCGCTGCGTCGGGCCTGACGATCTT
CAAAGCAACTATCGCATGACCAAAATCGCCTTGATCGATCATATTCCAATTCCCGTGGGTAATGTGTTGCGGATTCGCGG
TGAGTTAGCGCCAGAAAGTGCCGCCAGCCTGTATGCTCATGAAATTAAACGCATTTTTGGGCTAGCTGAAGGCCAATTTC
CTCAATTCGACACCATGCTGCTGGGCTTGGGCAACGATGGGCATACCGCCTCGCTCTTTCCAGCCAGCGATATTTTGGGT
CGCAACGATGTGTTGGTGGCCGAAACATGGGTCGCCAAACTCAAACAATATCGCATCTCGCTGACTGCGCCTGTGATCAA
CAACGCCCACAGCAAAATCTTTTTAGCGGCAGGCGACGATAAAGCTGGCGTTATTCGTGAGCTAATCGAGCAGACTGGGG
CGTATCAAAGCTACCCCGCCAGTTTGATCAACAACGCCGACTGGCTGATTGACCAAGCGGCGGCCAGCCAACTGCAACAT
TAA

Upstream 100 bases:

>100_bases
TGAATGAACTAAATATGTATAGTCATGATCGAGTTTATGAACGGGCTTTAGCGATTGTCGCCGCAATTGCTCAAGCAACC
GATCCCCATGGAGCACATGT

Downstream 100 bases:

>100_bases
CGGATCGTTAACAGATTTTCGTGGCACAATACTAGGCATGCACCATAGCATCGAAAGGAATGTTCATGACTGACCATCGA
CCAACCATTATGCTTGTGCA

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MTLQIAPSREELMILAADRLVAEAQTAIAQRGRWTIALSGGSTPKALFELLASPRYINQILWGRCFLFWGDERCVGPDDL
QSNYRMTKIALIDHIPIPVGNVLRIRGELAPESAASLYAHEIKRIFGLAEGQFPQFDTMLLGLGNDGHTASLFPASDILG
RNDVLVAETWVAKLKQYRISLTAPVINNAHSKIFLAAGDDKAGVIRELIEQTGAYQSYPASLINNADWLIDQAAASQLQH

Sequences:

>Translated_240_residues
MTLQIAPSREELMILAADRLVAEAQTAIAQRGRWTIALSGGSTPKALFELLASPRYINQILWGRCFLFWGDERCVGPDDL
QSNYRMTKIALIDHIPIPVGNVLRIRGELAPESAASLYAHEIKRIFGLAEGQFPQFDTMLLGLGNDGHTASLFPASDILG
RNDVLVAETWVAKLKQYRISLTAPVINNAHSKIFLAAGDDKAGVIRELIEQTGAYQSYPASLINNADWLIDQAAASQLQH
>Mature_239_residues
TLQIAPSREELMILAADRLVAEAQTAIAQRGRWTIALSGGSTPKALFELLASPRYINQILWGRCFLFWGDERCVGPDDLQ
SNYRMTKIALIDHIPIPVGNVLRIRGELAPESAASLYAHEIKRIFGLAEGQFPQFDTMLLGLGNDGHTASLFPASDILGR
NDVLVAETWVAKLKQYRISLTAPVINNAHSKIFLAAGDDKAGVIRELIEQTGAYQSYPASLINNADWLIDQAAASQLQH

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912586, Length=215, Percent_Identity=35.8139534883721, Blast_Score=109, Evalue=2e-24,
Organism=Homo sapiens, GI52145310, Length=210, Percent_Identity=35.7142857142857, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI115533058, Length=239, Percent_Identity=28.0334728033473, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115533060, Length=239, Percent_Identity=28.0334728033473, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6321957, Length=255, Percent_Identity=28.6274509803922, Blast_Score=86, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6319918, Length=223, Percent_Identity=30.9417040358744, Blast_Score=82, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6324362, Length=218, Percent_Identity=32.1100917431193, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321687, Length=230, Percent_Identity=30, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641119, Length=227, Percent_Identity=28.1938325991189, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900
- InterPro:   IPR006148 [H]

Pfam domain/function: PF01182 Glucosamine_iso [H]

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 26367; Mature: 26235

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLQIAPSREELMILAADRLVAEAQTAIAQRGRWTIALSGGSTPKALFELLASPRYINQI
CEEEECCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCHHHHHH
LWGRCFLFWGDERCVGPDDLQSNYRMTKIALIDHIPIPVGNVLRIRGELAPESAASLYAH
HHHEEEEEECCCCCCCCHHHHCCCEEEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHH
EIKRIFGLAEGQFPQFDTMLLGLGNDGHTASLFPASDILGRNDVLVAETWVAKLKQYRIS
HHHHHHHCCCCCCCCCCEEEEECCCCCCEEEECCHHHHCCCCCEEEHHHHHHHHHHHHEE
LTAPVINNAHSKIFLAAGDDKAGVIRELIEQTGAYQSYPASLINNADWLIDQAAASQLQH
EECCHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TLQIAPSREELMILAADRLVAEAQTAIAQRGRWTIALSGGSTPKALFELLASPRYINQI
EEEECCCCCCEEEEEHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHCCCHHHHHH
LWGRCFLFWGDERCVGPDDLQSNYRMTKIALIDHIPIPVGNVLRIRGELAPESAASLYAH
HHHEEEEEECCCCCCCCHHHHCCCEEEEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHH
EIKRIFGLAEGQFPQFDTMLLGLGNDGHTASLFPASDILGRNDVLVAETWVAKLKQYRIS
HHHHHHHCCCCCCCCCCEEEEECCCCCCEEEECCHHHHCCCCCEEEHHHHHHHHHHHHEE
LTAPVINNAHSKIFLAAGDDKAGVIRELIEQTGAYQSYPASLINNADWLIDQAAASQLQH
EECCHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231; 9298645 [H]