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The map label for this gene is pepQ [H]

Identifier: 159899270

GI number: 159899270

Start: 3508481

End: 3509581

Strand: Direct

Name: pepQ [H]

Synonym: Haur_2751

Alternate gene names: 159899270

Gene position: 3508481-3509581 (Clockwise)

Preceding gene: 159899269

Following gene: 159899271

Centisome position: 55.28

GC content: 54.59

Gene sequence:

>1101_bases
ATGAGTGGCGTGCGAATTCGACGTTTGGCTAGCGCTGCCCGCCCGCAAGGGATGGATTATGTGGTGTTGATGCCTGGGGC
TAACTTACAATATTTTACGGGCTTGACCTTGCATTTAAGTGAGCGTTTGGCCTTGGCGTTGATCGCTGCTGATGGTCAGA
GCATCAATATTGTGCTGCCAGCCTTGGAGCAACCGCGTGCTTTAGCCGAATATAGCGGCGAAGTGGCGGTACGTTGGTTT
CCATGGAGCGATGATGAAGGCCCAATGAATGCTTTGCGCAATGCAGCGGCAGGCCTGATTGGTCGCACAGTTGGCGTGGA
ATATACGACGATGCGGGTGCTAGAATTACGCGCTTTAGAAGAAGTTGCGGGCGTACATAGCATCGATGCCAGCGCCGCGA
TCGCCAGTTTGCGCATGCAAAAGGGCGCTGATGAAATTGCCCTGATGCGCGAAGCTGTGCGCATTGTTGAGGCTGGGCTT
AAAACCGCAATTGAGGCGCTTCATCCAGGCCGAACCGAGCGCGAAATTGCCCGCATTTGGGAAGAAGCGATGCAACTTGA
GGGTGGCGAAGGCCCATCATTTGCGACGATTGTGGCGAGTGGCCCAAATAGTGCTAATCCACACCATACGACGGGCGAGC
GCCAAATCCAAACTGGCGATTTGGTAATTTTGGATGGTGGGGCGTTGTATCGCGGCTATTGCTCGGATATTACCCGCACT
GTTTGCGTTGGCGAGCCAAACGAGCAACAACGGATGCTCTATGAAACCGTTTTGGCGGCCAATCGCGCTGCCTGTGCCGG
AGCCAAACCAGGCATGAGCGGCGCACAGGTTGATCGGCTCGCACGGCAAGTGGTTGAGGATGCCGAATTAGGCCGTTACT
TCATCCATCGCACAGGCCATGGCTTGGGTATGGAAATTCACGAGCCGCCCTATATCGCTAGCACCAACACCGTTGCCCTG
CCAATTGGCACGGTTTTTACGGTTGAGCCAGGCACCTATGTTGCTGGAATTGGTGGCGTGCGGATTGAAGATGATGTGCT
GTTGACCCCCACTGGCGCTGAATGTTTGACCAACTTTCCACGGGAGTTGATTGTCAAATGA

Upstream 100 bases:

>100_bases
ATCTATAAAATCAATAAACTCTCCATAAATTATCCACATTGATCAATGCCTTGAGCGAGAGTGCTATACTGAGCATATTC
TATTTGGTGGAGGTTGTAGC

Downstream 100 bases:

>100_bases
TCGTGCTGGCCCAAACTATCGCCCAAGATCCACCGTTGTGGGCGATGATTCTCGCGCTTGGCGTGGGCAATATTGTTGGA
ATTATTGGCATTTGGTGGTG

Product: peptidase M24

Products: NA

Alternate protein names: X-Pro dipeptidase; Imidodipeptidase; Proline dipeptidase; Prolidase [H]

Number of amino acids: Translated: 366; Mature: 365

Protein sequence:

>366_residues
MSGVRIRRLASAARPQGMDYVVLMPGANLQYFTGLTLHLSERLALALIAADGQSINIVLPALEQPRALAEYSGEVAVRWF
PWSDDEGPMNALRNAAAGLIGRTVGVEYTTMRVLELRALEEVAGVHSIDASAAIASLRMQKGADEIALMREAVRIVEAGL
KTAIEALHPGRTEREIARIWEEAMQLEGGEGPSFATIVASGPNSANPHHTTGERQIQTGDLVILDGGALYRGYCSDITRT
VCVGEPNEQQRMLYETVLAANRAACAGAKPGMSGAQVDRLARQVVEDAELGRYFIHRTGHGLGMEIHEPPYIASTNTVAL
PIGTVFTVEPGTYVAGIGGVRIEDDVLLTPTGAECLTNFPRELIVK

Sequences:

>Translated_366_residues
MSGVRIRRLASAARPQGMDYVVLMPGANLQYFTGLTLHLSERLALALIAADGQSINIVLPALEQPRALAEYSGEVAVRWF
PWSDDEGPMNALRNAAAGLIGRTVGVEYTTMRVLELRALEEVAGVHSIDASAAIASLRMQKGADEIALMREAVRIVEAGL
KTAIEALHPGRTEREIARIWEEAMQLEGGEGPSFATIVASGPNSANPHHTTGERQIQTGDLVILDGGALYRGYCSDITRT
VCVGEPNEQQRMLYETVLAANRAACAGAKPGMSGAQVDRLARQVVEDAELGRYFIHRTGHGLGMEIHEPPYIASTNTVAL
PIGTVFTVEPGTYVAGIGGVRIEDDVLLTPTGAECLTNFPRELIVK
>Mature_365_residues
SGVRIRRLASAARPQGMDYVVLMPGANLQYFTGLTLHLSERLALALIAADGQSINIVLPALEQPRALAEYSGEVAVRWFP
WSDDEGPMNALRNAAAGLIGRTVGVEYTTMRVLELRALEEVAGVHSIDASAAIASLRMQKGADEIALMREAVRIVEAGLK
TAIEALHPGRTEREIARIWEEAMQLEGGEGPSFATIVASGPNSANPHHTTGERQIQTGDLVILDGGALYRGYCSDITRTV
CVGEPNEQQRMLYETVLAANRAACAGAKPGMSGAQVDRLARQVVEDAELGRYFIHRTGHGLGMEIHEPPYIASTNTVALP
IGTVFTVEPGTYVAGIGGVRIEDDVLLTPTGAECLTNFPRELIVK

Specific function: Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position [H]

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family. Archaeal-type prolidase subfamily [H]

Homologues:

Organism=Homo sapiens, GI149589008, Length=291, Percent_Identity=29.2096219931272, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI260593665, Length=291, Percent_Identity=29.2096219931272, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI93141226, Length=286, Percent_Identity=29.7202797202797, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI260593663, Length=312, Percent_Identity=28.525641025641, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI264681563, Length=167, Percent_Identity=34.7305389221557, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI11559925, Length=279, Percent_Identity=29.0322580645161, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI264681565, Length=164, Percent_Identity=32.9268292682927, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1788728, Length=240, Percent_Identity=43.3333333333333, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1789275, Length=263, Percent_Identity=32.319391634981, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1790282, Length=307, Percent_Identity=25.7328990228013, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17508215, Length=292, Percent_Identity=27.0547945205479, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17509539, Length=164, Percent_Identity=34.1463414634146, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320922, Length=272, Percent_Identity=26.1029411764706, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6321118, Length=284, Percent_Identity=26.4084507042254, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322999, Length=171, Percent_Identity=30.4093567251462, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19920384, Length=266, Percent_Identity=29.6992481203008, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI21357079, Length=292, Percent_Identity=26.7123287671233, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17137632, Length=168, Percent_Identity=33.9285714285714, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161078230, Length=238, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357287, Length=238, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000587
- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR001131 [H]

Pfam domain/function: PF01321 Creatinase_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.13.9 [H]

Molecular weight: Translated: 39278; Mature: 39147

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGVRIRRLASAARPQGMDYVVLMPGANLQYFTGLTLHLSERLALALIAADGQSINIVLP
CCCCHHHHHHHHCCCCCCCEEEEECCCCEEEECCEEEEECCCEEEEEEEECCCEEEEEEC
ALEQPRALAEYSGEVAVRWFPWSDDEGPMNALRNAAAGLIGRTVGVEYTTMRVLELRALE
CCCCCHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
EVAGVHSIDASAAIASLRMQKGADEIALMREAVRIVEAGLKTAIEALHPGRTEREIARIW
HHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EEAMQLEGGEGPSFATIVASGPNSANPHHTTGERQIQTGDLVILDGGALYRGYCSDITRT
HHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCEEEECCCCEEHHHHHHHHHE
VCVGEPNEQQRMLYETVLAANRAACAGAKPGMSGAQVDRLARQVVEDAELGRYFIHRTGH
EECCCCCHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
GLGMEIHEPPYIASTNTVALPIGTVFTVEPGTYVAGIGGVRIEDDVLLTPTGAECLTNFP
CCCEEECCCCEEECCCEEEEEECEEEEECCCCEEEECCCEEEECCEEECCCCHHHHHCCC
RELIVK
HHHHCC
>Mature Secondary Structure 
SGVRIRRLASAARPQGMDYVVLMPGANLQYFTGLTLHLSERLALALIAADGQSINIVLP
CCCHHHHHHHHCCCCCCCEEEEECCCCEEEECCEEEEECCCEEEEEEEECCCEEEEEEC
ALEQPRALAEYSGEVAVRWFPWSDDEGPMNALRNAAAGLIGRTVGVEYTTMRVLELRALE
CCCCCHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
EVAGVHSIDASAAIASLRMQKGADEIALMREAVRIVEAGLKTAIEALHPGRTEREIARIW
HHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
EEAMQLEGGEGPSFATIVASGPNSANPHHTTGERQIQTGDLVILDGGALYRGYCSDITRT
HHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEECCEEEECCCCEEHHHHHHHHHE
VCVGEPNEQQRMLYETVLAANRAACAGAKPGMSGAQVDRLARQVVEDAELGRYFIHRTGH
EECCCCCHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
GLGMEIHEPPYIASTNTVALPIGTVFTVEPGTYVAGIGGVRIEDDVLLTPTGAECLTNFP
CCCEEECCCCEEECCCEEEEEECEEEEECCCCEEEECCCEEEECCEEECCCCHHHHHCCC
RELIVK
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9733678; 11223522; 11210522 [H]