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The map label for this gene is degU [H]

Identifier: 159898087

GI number: 159898087

Start: 1814695

End: 1815468

Strand: Reverse

Name: degU [H]

Synonym: Haur_1563

Alternate gene names: 159898087

Gene position: 1815468-1814695 (Counterclockwise)

Preceding gene: 159898088

Following gene: 159898086

Centisome position: 28.61

GC content: 49.35

Gene sequence:

>774_bases
ATGTATGCAACAGTCAAAGTGCTGATGGTCGATGATCACCCATTGTTTCGGCAAGGGGTTCGTTGGGCGCTTTCGAGCGA
ACGCGATATCAAGATCATTGGAGAAGGTTCTAGTGCCGAAGAAGGCTTAGTCTTAATTTCTGAGCATGAGCCAGATGTAG
TCCTCACCGATTTGAATTTACCCAACATGGATGGCTTGGAGTTTACTCGCACAATTCGCCGCCAATATCCCAACATCGGC
GTGGTGATGTTGAGCGTTTACGAAAGCGATGAGCATGCCTTCAACGCCTTACGCGCTGGAGCCGCCGCCTATTATTCCAA
GGAAATTAGCCCCAAAACCTTGGCAACTGTCTTGCGGCGCGTCGCTCGTGGCGAATATGTGATCAACGATGTAATGTTTG
AAGATCCACGGGTCGCTGATCGGATTTTGACCCAGTTTCGTGGTTTGCAAACTGGCATCGTAGCCGAGCCAGACCTCGAT
ATTAGTTTGTTCTCGCCGTTGAGCGACCGTGAAATTGAGGTGCTAGAGCATATTGCCAGCGGTGCAACCAACAAAGATAT
CGCCGATGCGCTCAAAATTAGCACCCAAACCGTCAAAAACCATATTTCATCGATTTTGCGCAAGCTTTCGCTGAATGATC
GAACCCAAGCGGTGCTATACGCCCTGCGTCGTGGCTGGATCGAAACGCCAGCAACCTTGCTTGAAAGTATCGAACGTCGC
GGAGCACAGGCAGCACTGAATTTTAATAATGATGATGATAACGACGACGAATGA

Upstream 100 bases:

>100_bases
CAACGACTGCTAGCTTATTGACCCAAGCAGGAATCTATGTTCCCTACTCGGTCGAGCAAGCTTGGCAGCGCTGGCGTGCT
ACATTAGCAAAGGAACCACT

Downstream 100 bases:

>100_bases
AACGTGTAACAGTCATTCTTAATCCAAATGCCGGCAATGCCCACCAACGCCGCGCCATCGCCCAAGGCATCACTGAATGG
CGCAGCAACCAAGGCTGGCA

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MYATVKVLMVDDHPLFRQGVRWALSSERDIKIIGEGSSAEEGLVLISEHEPDVVLTDLNLPNMDGLEFTRTIRRQYPNIG
VVMLSVYESDEHAFNALRAGAAAYYSKEISPKTLATVLRRVARGEYVINDVMFEDPRVADRILTQFRGLQTGIVAEPDLD
ISLFSPLSDREIEVLEHIASGATNKDIADALKISTQTVKNHISSILRKLSLNDRTQAVLYALRRGWIETPATLLESIERR
GAQAALNFNNDDDNDDE

Sequences:

>Translated_257_residues
MYATVKVLMVDDHPLFRQGVRWALSSERDIKIIGEGSSAEEGLVLISEHEPDVVLTDLNLPNMDGLEFTRTIRRQYPNIG
VVMLSVYESDEHAFNALRAGAAAYYSKEISPKTLATVLRRVARGEYVINDVMFEDPRVADRILTQFRGLQTGIVAEPDLD
ISLFSPLSDREIEVLEHIASGATNKDIADALKISTQTVKNHISSILRKLSLNDRTQAVLYALRRGWIETPATLLESIERR
GAQAALNFNNDDDNDDE
>Mature_257_residues
MYATVKVLMVDDHPLFRQGVRWALSSERDIKIIGEGSSAEEGLVLISEHEPDVVLTDLNLPNMDGLEFTRTIRRQYPNIG
VVMLSVYESDEHAFNALRAGAAAYYSKEISPKTLATVLRRVARGEYVINDVMFEDPRVADRILTQFRGLQTGIVAEPDLD
ISLFSPLSDREIEVLEHIASGATNKDIADALKISTQTVKNHISSILRKLSLNDRTQAVLYALRRGWIETPATLLESIERR
GAQAALNFNNDDDNDDE

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=222, Percent_Identity=30.6306306306306, Blast_Score=117, Evalue=7e-28,
Organism=Escherichia coli, GI1788521, Length=221, Percent_Identity=34.3891402714932, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787473, Length=214, Percent_Identity=33.6448598130841, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1790102, Length=213, Percent_Identity=28.6384976525822, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1788712, Length=217, Percent_Identity=25.8064516129032, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082052, Length=130, Percent_Identity=36.1538461538462, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 28755; Mature: 28755

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYATVKVLMVDDHPLFRQGVRWALSSERDIKIIGEGSSAEEGLVLISEHEPDVVLTDLNL
CCEEEEEEEECCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEECCC
PNMDGLEFTRTIRRQYPNIGVVMLSVYESDEHAFNALRAGAAAYYSKEISPKTLATVLRR
CCCCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VARGEYVINDVMFEDPRVADRILTQFRGLQTGIVAEPDLDISLFSPLSDREIEVLEHIAS
HHCCCEEEHHHHCCCCHHHHHHHHHHHCCCCCCEECCCCCEEEECCCCCCHHHHHHHHHC
GATNKDIADALKISTQTVKNHISSILRKLSLNDRTQAVLYALRRGWIETPATLLESIERR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHC
GAQAALNFNNDDDNDDE
CCEEEEECCCCCCCCCC
>Mature Secondary Structure
MYATVKVLMVDDHPLFRQGVRWALSSERDIKIIGEGSSAEEGLVLISEHEPDVVLTDLNL
CCEEEEEEEECCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCEEEEECCCCCEEEEECCC
PNMDGLEFTRTIRRQYPNIGVVMLSVYESDEHAFNALRAGAAAYYSKEISPKTLATVLRR
CCCCCHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
VARGEYVINDVMFEDPRVADRILTQFRGLQTGIVAEPDLDISLFSPLSDREIEVLEHIAS
HHCCCEEEHHHHCCCCHHHHHHHHHHHCCCCCCEECCCCCEEEECCCCCCHHHHHHHHHC
GATNKDIADALKISTQTVKNHISSILRKLSLNDRTQAVLYALRRGWIETPATLLESIERR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHC
GAQAALNFNNDDDNDDE
CCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]