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The map label for this gene is kynA

Identifier: 159898042

GI number: 159898042

Start: 1769431

End: 1770213

Strand: Reverse

Name: kynA

Synonym: Haur_1517

Alternate gene names: 159898042

Gene position: 1770213-1769431 (Counterclockwise)

Preceding gene: 159898043

Following gene: 159898035

Centisome position: 27.89

GC content: 48.4

Gene sequence:

>783_bases
ATGTCTCAGGCCTTAACCTATGCTAGTTATTTAAAAATTGACGAACTGTTGAATTTACAAACGCCCCGCAGCCATGGCCC
CGAACATGATGAATTATTGTTCATCGTGATTCATCAGGTTTATGAGTTGTGGTTTAAGCAAATTTTGCACGAACTTGATT
ATTTGTGCGATCTGTTGCGAGCCAACGATACAGGCCGCGCCAACCAAAGCATCCGCCGGATTTTGACCATTCTCAAAACT
ATCGTGGCCCAAGTCGATGTGATGGAAACCATGACTCCCCTGCAATTCAATGCCTTTCGTGGCTCGCTTGAATCGGCCAG
CGGTTTTCAATCATTGCAATTTCGCGAAATTGAGTTTGTGCTCGGCTACAAACGCCCAGCAATTTTGCAACATTTTGCCG
CATTACCAAGCCATGAACGGCTCGAACAGCGCTACCAAGAACCAAGCCTGTGGGATAGCTTTTTACACTATCTACAGCTG
AATGGCTATGCGATTCCCAGCGAGCAAATCGGGCGTGATGTCACCCAATCGCTTGTAGCATCACCCGCAATTCAAACGAT
CTTGATCACGGTGTATCGCCAAAATCCTTTGGTCAGCAACCTCTGCGAACGGTTGATCGACCTCGACGAGGGCTTTCAGG
AGTGGCGCTATCGCCATGTTAAAATGGTGGAACGCACGATTGGCATGAAACAAGGCACTGGTGGTTCAAGCGGTGCGGCC
TATCTTGCCAGCACGATCAAGCCATTCTTCCCCGATTTGTGGGCGATTCGTGCCGATTTGTAA

Upstream 100 bases:

>100_bases
GGTTGATTGCCAGGTGGTGGTTTTTTGTAGACGACGATCAAGGCCTGTGTTAAACTTGCGCCGCAACCCCAATTGAAACG
CCGCATCCAAGGAGTGTGCC

Downstream 100 bases:

>100_bases
TTAACTAGTTGCCTATTGCGGAGCCTGCCAAGCATAACCCAAACGGACAGCAATTTGGCCAAACAAGCCAGCATGATCAA
GTTCATATGGGTTGCTAAAA

Product: tryptophan 23-dioxygenase

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MSQALTYASYLKIDELLNLQTPRSHGPEHDELLFIVIHQVYELWFKQILHELDYLCDLLRANDTGRANQSIRRILTILKT
IVAQVDVMETMTPLQFNAFRGSLESASGFQSLQFREIEFVLGYKRPAILQHFAALPSHERLEQRYQEPSLWDSFLHYLQL
NGYAIPSEQIGRDVTQSLVASPAIQTILITVYRQNPLVSNLCERLIDLDEGFQEWRYRHVKMVERTIGMKQGTGGSSGAA
YLASTIKPFFPDLWAIRADL

Sequences:

>Translated_260_residues
MSQALTYASYLKIDELLNLQTPRSHGPEHDELLFIVIHQVYELWFKQILHELDYLCDLLRANDTGRANQSIRRILTILKT
IVAQVDVMETMTPLQFNAFRGSLESASGFQSLQFREIEFVLGYKRPAILQHFAALPSHERLEQRYQEPSLWDSFLHYLQL
NGYAIPSEQIGRDVTQSLVASPAIQTILITVYRQNPLVSNLCERLIDLDEGFQEWRYRHVKMVERTIGMKQGTGGSSGAA
YLASTIKPFFPDLWAIRADL
>Mature_259_residues
SQALTYASYLKIDELLNLQTPRSHGPEHDELLFIVIHQVYELWFKQILHELDYLCDLLRANDTGRANQSIRRILTILKTI
VAQVDVMETMTPLQFNAFRGSLESASGFQSLQFREIEFVLGYKRPAILQHFAALPSHERLEQRYQEPSLWDSFLHYLQLN
GYAIPSEQIGRDVTQSLVASPAIQTILITVYRQNPLVSNLCERLIDLDEGFQEWRYRHVKMVERTIGMKQGTGGSSGAAY
LASTIKPFFPDLWAIRADL

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family

Homologues:

Organism=Homo sapiens, GI5032165, Length=128, Percent_Identity=43.75, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI32564651, Length=141, Percent_Identity=39.7163120567376, Blast_Score=94, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17552370, Length=136, Percent_Identity=40.4411764705882, Blast_Score=94, Evalue=8e-20,
Organism=Drosophila melanogaster, GI17530891, Length=315, Percent_Identity=35.5555555555556, Blast_Score=139, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): T23O_HERA2 (A9B4J6)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001544289.1
- ProteinModelPortal:   A9B4J6
- SMR:   A9B4J6
- GeneID:   5733404
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_1517
- HOGENOM:   HBG647485
- OMA:   QWSVLAT
- ProtClustDB:   CLSK946558
- BioCyc:   HAUR316274:HAUR_1517-MONOMER
- InterPro:   IPR004981
- PANTHER:   PTHR10138

Pfam domain/function: PF03301 Trp_dioxygenase

EC number: =1.13.11.11

Molecular weight: Translated: 29917; Mature: 29785

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: BINDING 100-100 BINDING 107-107 BINDING 233-233

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQALTYASYLKIDELLNLQTPRSHGPEHDELLFIVIHQVYELWFKQILHELDYLCDLLR
CCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANDTGRANQSIRRILTILKTIVAQVDVMETMTPLQFNAFRGSLESASGFQSLQFREIEFV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHCCCHHHHHHHHHHHH
LGYKRPAILQHFAALPSHERLEQRYQEPSLWDSFLHYLQLNGYAIPSEQIGRDVTQSLVA
HCCCCHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHCCEECCHHHHHHHHHHHHHH
SPAIQTILITVYRQNPLVSNLCERLIDLDEGFQEWRYRHVKMVERTIGMKQGTGGSSGAA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
YLASTIKPFFPDLWAIRADL
HHHHHHHHHCCHHHHHHCCC
>Mature Secondary Structure 
SQALTYASYLKIDELLNLQTPRSHGPEHDELLFIVIHQVYELWFKQILHELDYLCDLLR
CCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANDTGRANQSIRRILTILKTIVAQVDVMETMTPLQFNAFRGSLESASGFQSLQFREIEFV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHCCCHHHHHHHHHHHH
LGYKRPAILQHFAALPSHERLEQRYQEPSLWDSFLHYLQLNGYAIPSEQIGRDVTQSLVA
HCCCCHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHCCEECCHHHHHHHHHHHHHH
SPAIQTILITVYRQNPLVSNLCERLIDLDEGFQEWRYRHVKMVERTIGMKQGTGGSSGAA
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
YLASTIKPFFPDLWAIRADL
HHHHHHHHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA