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The map label for this gene is mutM

Identifier: 159897723

GI number: 159897723

Start: 1376249

End: 1377070

Strand: Direct

Name: mutM

Synonym: Haur_1194

Alternate gene names: 159897723

Gene position: 1376249-1377070 (Clockwise)

Preceding gene: 159897722

Following gene: 159897725

Centisome position: 21.68

GC content: 52.19

Gene sequence:

>822_bases
ATGCCAGAATTACCAGAAGTTGAAACCGTTCGTCGTTCGCTTGAGCAAGAGCTTGTTGGGCGGTATTTTGTGGCATTGCG
CAGCCTTGGCTGGCCCAAAATTGTCGATACCCATAGCCCTGAATTGTTTGCCGAGGCTATCGCCCAACGCCAGATTCAGC
AAGTTCAGCGGCGGGCCAAATATTTGCTGATCGAGCTTGATAACCACGAAACCTTGATTGTGCATCTGCGCATGACTGGC
CAAATGTTGGTTGTGGCTGCCGACGAACCTGCCGATCGCCATACGCATGTGGTGGTAGCGCTGGATAATGGCCGCGAACT
ACGGTTTCACGACCCACGCAAATTTGGCCGTTGGAGTCTTGTTGATCGCAGTGGCGTGGCGGCGCTCAATCAACGTTTAG
GACCAGAGCCGCTTGGCGACGATTTTACTTTAGATGATTTTGCGCAACGCTTGAGTCGCAAAGCTACCAAAATCAAGCCA
ACCTTGCTTGATCAAAGTGTCTTGGCGGGAGTTGGCAATATTTATGCTGATGAAGCGTTGTGGTTGGCCAAAATTCACCC
CTTGCGCTCCGCCAATAGCCTAAACGCCAACGAAATTGCCGAGCTATTCGAGGCGATTAAAACTGTACTGCGCAACTCAA
TTGAGCATCGTGGCACAACCTTGGTCAATTATCGCGATGCCTATGGGGCAAGCGGCGAAAACCAATATCACCTTGAGGCT
TATGGACGAACTGGCGAGCCATGCCGGCGCTGTGGCACGCCAATCGAGCGCATCGTCGTGGCCCAACGCTCTACCCATAT
TTGCCCAGTATGCCAAGCTTAA

Upstream 100 bases:

>100_bases
GGCGGCGGCGGCCATAGCGCCCTTGGCACGCCCGAACGTTAATCAGCAAACCAGCGGCTTGCAACTGCAATCCGCTTATC
TATTTTAGAAACAAACGCTT

Downstream 100 bases:

>100_bases
GAGCATAGAGCAAAGAACATAGGGGCATGTGGCTAAAGGCTATCGGCTTTTGGATCATTTGAAATGCTAGAAAATATTCC
GATAGCCAATAGCCTCATAG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM

Number of amino acids: Translated: 273; Mature: 272

Protein sequence:

>273_residues
MPELPEVETVRRSLEQELVGRYFVALRSLGWPKIVDTHSPELFAEAIAQRQIQQVQRRAKYLLIELDNHETLIVHLRMTG
QMLVVAADEPADRHTHVVVALDNGRELRFHDPRKFGRWSLVDRSGVAALNQRLGPEPLGDDFTLDDFAQRLSRKATKIKP
TLLDQSVLAGVGNIYADEALWLAKIHPLRSANSLNANEIAELFEAIKTVLRNSIEHRGTTLVNYRDAYGASGENQYHLEA
YGRTGEPCRRCGTPIERIVVAQRSTHICPVCQA

Sequences:

>Translated_273_residues
MPELPEVETVRRSLEQELVGRYFVALRSLGWPKIVDTHSPELFAEAIAQRQIQQVQRRAKYLLIELDNHETLIVHLRMTG
QMLVVAADEPADRHTHVVVALDNGRELRFHDPRKFGRWSLVDRSGVAALNQRLGPEPLGDDFTLDDFAQRLSRKATKIKP
TLLDQSVLAGVGNIYADEALWLAKIHPLRSANSLNANEIAELFEAIKTVLRNSIEHRGTTLVNYRDAYGASGENQYHLEA
YGRTGEPCRRCGTPIERIVVAQRSTHICPVCQA
>Mature_272_residues
PELPEVETVRRSLEQELVGRYFVALRSLGWPKIVDTHSPELFAEAIAQRQIQQVQRRAKYLLIELDNHETLIVHLRMTGQ
MLVVAADEPADRHTHVVVALDNGRELRFHDPRKFGRWSLVDRSGVAALNQRLGPEPLGDDFTLDDFAQRLSRKATKIKPT
LLDQSVLAGVGNIYADEALWLAKIHPLRSANSLNANEIAELFEAIKTVLRNSIEHRGTTLVNYRDAYGASGENQYHLEAY
GRTGEPCRRCGTPIERIVVAQRSTHICPVCQA

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger

Homologues:

Organism=Escherichia coli, GI1790066, Length=276, Percent_Identity=43.8405797101449, Blast_Score=211, Evalue=4e-56,
Organism=Escherichia coli, GI1786932, Length=285, Percent_Identity=27.3684210526316, Blast_Score=88, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FPG_HERA2 (A9B0X2)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001543970.1
- ProteinModelPortal:   A9B0X2
- SMR:   A9B0X2
- GeneID:   5733087
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_1194
- HOGENOM:   HBG690070
- OMA:   RMTGQLL
- ProtClustDB:   PRK01103
- BioCyc:   HAUR316274:HAUR_1194-MONOMER
- HAMAP:   MF_00103
- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663
- SMART:   SM00898
- TIGRFAMs:   TIGR00577

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS; SSF81624 Form_DNAglyc_cat; SSF46946 Ribosomal_H2TH

EC number: =3.2.2.23; =4.2.99.18

Molecular weight: Translated: 30801; Mature: 30669

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS51068 FPG_CAT; PS01242 ZF_FPG_1; PS51066 ZF_FPG_2

Important sites: ACT_SITE 2-2 ACT_SITE 3-3 ACT_SITE 60-60 ACT_SITE 263-263 BINDING 94-94 BINDING 113-113 BINDING 154-154

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRRSLEQELVGRYFVALRSLGWPKIVDTHSPELFAEAIAQRQIQQVQRRAK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHC
YLLIELDNHETLIVHLRMTGQMLVVAADEPADRHTHVVVALDNGRELRFHDPRKFGRWSL
EEEEEECCCCEEEEEEEECCCEEEEECCCCCCCCEEEEEEECCCCEEEECCCCCCCCEEE
VDRSGVAALNQRLGPEPLGDDFTLDDFAQRLSRKATKIKPTLLDQSVLAGVGNIYADEAL
ECCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
WLAKIHPLRSANSLNANEIAELFEAIKTVLRNSIEHRGTTLVNYRDAYGASGENQYHLEA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHCCCCCCCCEEEEE
YGRTGEPCRRCGTPIERIVVAQRSTHICPVCQA
CCCCCCHHHHHCCHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVRRSLEQELVGRYFVALRSLGWPKIVDTHSPELFAEAIAQRQIQQVQRRAK
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHC
YLLIELDNHETLIVHLRMTGQMLVVAADEPADRHTHVVVALDNGRELRFHDPRKFGRWSL
EEEEEECCCCEEEEEEEECCCEEEEECCCCCCCCEEEEEEECCCCEEEECCCCCCCCEEE
VDRSGVAALNQRLGPEPLGDDFTLDDFAQRLSRKATKIKPTLLDQSVLAGVGNIYADEAL
ECCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
WLAKIHPLRSANSLNANEIAELFEAIKTVLRNSIEHRGTTLVNYRDAYGASGENQYHLEA
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHCCCCCCCCEEEEE
YGRTGEPCRRCGTPIERIVVAQRSTHICPVCQA
CCCCCCHHHHHCCHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA