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The map label for this gene is selB [H]

Identifier: 159897652

GI number: 159897652

Start: 1286736

End: 1288619

Strand: Direct

Name: selB [H]

Synonym: Haur_1123

Alternate gene names: 159897652

Gene position: 1286736-1288619 (Clockwise)

Preceding gene: 159897651

Following gene: 159897653

Centisome position: 20.27

GC content: 52.65

Gene sequence:

>1884_bases
ATGGCAATTACGCTCGGCACTGCTGGCCATGTTGATCATGGCAAATCAAGCCTCGTTCAAGCCCTGACAGGCATCAACCC
CGATCGTTGGGAAGAAGAACAACGCCGCCAAATGACGCTTGATCTGGGCTTTGCCTGGTTCAGCACGCCCGCTGGTCATT
CGGTCAATCTGGTTGATGTGCCAGGCCATGAACGGCTAATCAAAAATATGTTGGCTGGGGTAACTGGTTTTGATGGAGTG
TTGTTCGTCGTTGCCGCCGATGAAGGCATGCAGCCACAAAGCCATGAACATTTACAAATTCTCAATCAATTGGGCATTGA
GCATGGGCTGATCATCATTAGCAAAATTGATCTGGTTGATGCTGAATGGCTTGAATTTATCAGCGGCGACATTCAGGCGC
AATTTGCCGCTACCAGCCTGGCCAATGCGCCAATCGTGCCAGTTTCGGCGCGAACTGGGGCTGGCATGGCTCAATTGCTC
CAAGCGCTTGACCAATTAATCAGCCAATTGCCAGCCCGAACAATCCAGAAACAGCATCCGCACTTGCCGATCGATCGGGT
GTTTAGCATCGATGGCTTTGGCACAGTCGTCACCGGAACGCTGCGCGACGGCAATTTAAGCGTGGGCATGGAAATCGAAA
TTTTGCCGCAACAACTGCGTGGGCGAATTCGCGGCTTGCAATCGCAGCAAATCAGTTACGTCAGCGTGCAGGCAGGCATG
CGCGTGGCGGTTAATCTGAGCGGCATCGAACGCCAAAGTCTCAAGCGTGGCGATGTATTGACATTGCCTCAAACTTTTGA
GCCAACCAACTTGCTTGATGTGTTGATTGAAACCACCACCGCTGCCCCAAGCTTGAGCCATAATCAGCCTCTACAACTCT
ATCTCGGGAGCGCCGAACTGAGTTGCACCCTCGCCTTGCTCGATTGCGACACGTTGCCAGCCAAGCAGCAAGCCTTTGGC
CAATTGCGTTTACAACACCCAACCATTGCCCAACGCGGCGATCGTGGAATTTTACGGCGTGCCTCGCCAGCCGCCACAGT
GGCGGGAATACGGGTGCTCGATGCGCATCCACAACGGCATCGGCGTATGCGCCCAGCTGTGATTGAACAGTTGCAACAAC
TAGCCAATGGCTTGCCCCATGAAATTCTGTTACAGCACATTCAACAGCAATGTTTAACCTGGCAGGAGCTGCAACAACGC
AGCGGCTTCGATTCGCCAACTGCCCTAGCCGCGCTCAATATCGGCTGCAACAACGGCTTAATCAGCATCGTCTCAGCAAC
AATGGCGACACTCACGGCCAGCAGTTTAATTACGAGCACAGCTTATTGGAGCCAATTACAAGCCAATTTGCGCCAGATTC
TGGCCGAATATCATGCCATGTGGCCGTTGCGCACAGCTATGCCCCGCGAGGAATTACGCAAACGGATGGGTTTAGCAGCC
AACAGCTTTAATCAAATATTAAATGCTTTAGCTGCACAACCATGGCTAAGTGTTGAAGCTACGCAGATTAAGCTGACTGA
ACATCAAGCCCAACCTAGCCCCGGTCAACAAGCCCAAATCCAAGCCTTGTTGGGATTGTGGCAGAGCAACCCAGCCCTAC
CGCCAAGCCGTGAGCAATGGCCCAAGCTTGATCCAGAACTATGGCGCTATCTACTACAAACTGAGCAATTGATTCAGATT
GGCGCAGAGGTCTATTTCTTGCCGAAGCAATACCACCAGATGCATACTTGGGTGCTAGAGCAACTTGCTGCTGGCCAAAG
CATCAGTCTTGCCCAAGCCCGTGATGCTTGGCAAACCAGCCGTAAATATGCCCAAGCCATGCTCGAACACTGCGATCAAC
TGCGCATTACCCGCCGCGTCGGCGATCTACGGGTAGCCTATTGA

Upstream 100 bases:

>100_bases
AAGCCCATATTGATCAATTGCAACAGGAATATCCTAAAGGCGAGTTGCGCCGCATCAGCAGCGCCGTTGGCAAGGATTTT
CTGGTGTTTCATTTACGCTA

Downstream 100 bases:

>100_bases
GCTTAACAAAGTGTTAGAAAAGCTTGGCACGCCTAGCCCCACCCAAATGCTCGTGTTATGCTGAAGTGAATGGCGTTTGT
GCCAGCGGAAAGGATGTCGA

Product: selenocysteine-specific translation elongation factor

Products: NA

Alternate protein names: SelB translation factor [H]

Number of amino acids: Translated: 627; Mature: 626

Protein sequence:

>627_residues
MAITLGTAGHVDHGKSSLVQALTGINPDRWEEEQRRQMTLDLGFAWFSTPAGHSVNLVDVPGHERLIKNMLAGVTGFDGV
LFVVAADEGMQPQSHEHLQILNQLGIEHGLIIISKIDLVDAEWLEFISGDIQAQFAATSLANAPIVPVSARTGAGMAQLL
QALDQLISQLPARTIQKQHPHLPIDRVFSIDGFGTVVTGTLRDGNLSVGMEIEILPQQLRGRIRGLQSQQISYVSVQAGM
RVAVNLSGIERQSLKRGDVLTLPQTFEPTNLLDVLIETTTAAPSLSHNQPLQLYLGSAELSCTLALLDCDTLPAKQQAFG
QLRLQHPTIAQRGDRGILRRASPAATVAGIRVLDAHPQRHRRMRPAVIEQLQQLANGLPHEILLQHIQQQCLTWQELQQR
SGFDSPTALAALNIGCNNGLISIVSATMATLTASSLITSTAYWSQLQANLRQILAEYHAMWPLRTAMPREELRKRMGLAA
NSFNQILNALAAQPWLSVEATQIKLTEHQAQPSPGQQAQIQALLGLWQSNPALPPSREQWPKLDPELWRYLLQTEQLIQI
GAEVYFLPKQYHQMHTWVLEQLAAGQSISLAQARDAWQTSRKYAQAMLEHCDQLRITRRVGDLRVAY

Sequences:

>Translated_627_residues
MAITLGTAGHVDHGKSSLVQALTGINPDRWEEEQRRQMTLDLGFAWFSTPAGHSVNLVDVPGHERLIKNMLAGVTGFDGV
LFVVAADEGMQPQSHEHLQILNQLGIEHGLIIISKIDLVDAEWLEFISGDIQAQFAATSLANAPIVPVSARTGAGMAQLL
QALDQLISQLPARTIQKQHPHLPIDRVFSIDGFGTVVTGTLRDGNLSVGMEIEILPQQLRGRIRGLQSQQISYVSVQAGM
RVAVNLSGIERQSLKRGDVLTLPQTFEPTNLLDVLIETTTAAPSLSHNQPLQLYLGSAELSCTLALLDCDTLPAKQQAFG
QLRLQHPTIAQRGDRGILRRASPAATVAGIRVLDAHPQRHRRMRPAVIEQLQQLANGLPHEILLQHIQQQCLTWQELQQR
SGFDSPTALAALNIGCNNGLISIVSATMATLTASSLITSTAYWSQLQANLRQILAEYHAMWPLRTAMPREELRKRMGLAA
NSFNQILNALAAQPWLSVEATQIKLTEHQAQPSPGQQAQIQALLGLWQSNPALPPSREQWPKLDPELWRYLLQTEQLIQI
GAEVYFLPKQYHQMHTWVLEQLAAGQSISLAQARDAWQTSRKYAQAMLEHCDQLRITRRVGDLRVAY
>Mature_626_residues
AITLGTAGHVDHGKSSLVQALTGINPDRWEEEQRRQMTLDLGFAWFSTPAGHSVNLVDVPGHERLIKNMLAGVTGFDGVL
FVVAADEGMQPQSHEHLQILNQLGIEHGLIIISKIDLVDAEWLEFISGDIQAQFAATSLANAPIVPVSARTGAGMAQLLQ
ALDQLISQLPARTIQKQHPHLPIDRVFSIDGFGTVVTGTLRDGNLSVGMEIEILPQQLRGRIRGLQSQQISYVSVQAGMR
VAVNLSGIERQSLKRGDVLTLPQTFEPTNLLDVLIETTTAAPSLSHNQPLQLYLGSAELSCTLALLDCDTLPAKQQAFGQ
LRLQHPTIAQRGDRGILRRASPAATVAGIRVLDAHPQRHRRMRPAVIEQLQQLANGLPHEILLQHIQQQCLTWQELQQRS
GFDSPTALAALNIGCNNGLISIVSATMATLTASSLITSTAYWSQLQANLRQILAEYHAMWPLRTAMPREELRKRMGLAAN
SFNQILNALAAQPWLSVEATQIKLTEHQAQPSPGQQAQIQALLGLWQSNPALPPSREQWPKLDPELWRYLLQTEQLIQIG
AEVYFLPKQYHQMHTWVLEQLAAGQSISLAQARDAWQTSRKYAQAMLEHCDQLRITRRVGDLRVAY

Specific function: Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP [H]

COG id: COG3276

COG function: function code J; Selenocysteine-specific translation elongation factor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. SelB subfamily [H]

Homologues:

Organism=Homo sapiens, GI34147630, Length=374, Percent_Identity=31.283422459893, Blast_Score=159, Evalue=7e-39,
Organism=Homo sapiens, GI54607086, Length=297, Percent_Identity=28.6195286195286, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI4503507, Length=259, Percent_Identity=30.8880308880309, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI4503475, Length=405, Percent_Identity=23.2098765432099, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI223555963, Length=319, Percent_Identity=24.7648902821317, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI5729864, Length=319, Percent_Identity=24.7648902821317, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI2367247, Length=635, Percent_Identity=29.1338582677165, Blast_Score=214, Evalue=2e-56,
Organism=Escherichia coli, GI1790412, Length=342, Percent_Identity=31.8713450292398, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1789737, Length=342, Percent_Identity=31.8713450292398, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1789108, Length=251, Percent_Identity=27.4900398406374, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17556456, Length=295, Percent_Identity=32.2033898305085, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI25141371, Length=279, Percent_Identity=30.4659498207885, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17506081, Length=253, Percent_Identity=29.6442687747036, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17509919, Length=263, Percent_Identity=31.5589353612167, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17552884, Length=407, Percent_Identity=23.8329238329238, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17569207, Length=407, Percent_Identity=23.8329238329238, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI115532065, Length=334, Percent_Identity=23.3532934131737, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI115532067, Length=387, Percent_Identity=22.7390180878553, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324761, Length=295, Percent_Identity=35.2542372881356, Blast_Score=150, Evalue=6e-37,
Organism=Saccharomyces cerevisiae, GI6320863, Length=304, Percent_Identity=28.2894736842105, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6325337, Length=406, Percent_Identity=23.6453201970443, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319594, Length=406, Percent_Identity=23.6453201970443, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI281363316, Length=369, Percent_Identity=29.2682926829268, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI17864358, Length=369, Percent_Identity=29.2682926829268, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI19921738, Length=282, Percent_Identity=32.9787234042553, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI19922690, Length=286, Percent_Identity=30.7692307692308, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24647046, Length=263, Percent_Identity=30.0380228136882, Blast_Score=100, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24647048, Length=263, Percent_Identity=30.0380228136882, Blast_Score=99, Evalue=9e-21,
Organism=Drosophila melanogaster, GI45553807, Length=405, Percent_Identity=22.962962962963, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI45553816, Length=405, Percent_Identity=22.962962962963, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24651721, Length=405, Percent_Identity=22.962962962963, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI17864154, Length=405, Percent_Identity=22.962962962963, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24652838, Length=405, Percent_Identity=23.2098765432099, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17137572, Length=405, Percent_Identity=23.2098765432099, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17137380, Length=305, Percent_Identity=23.6065573770492, Blast_Score=83, Evalue=7e-16,
Organism=Drosophila melanogaster, GI45550900, Length=298, Percent_Identity=23.489932885906, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015189
- InterPro:   IPR015190
- InterPro:   IPR015191
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR004535
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2; PF09105 SelB-wing_1; PF09106 SelB-wing_2; PF09107 SelB-wing_3 [H]

EC number: NA

Molecular weight: Translated: 69327; Mature: 69195

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAITLGTAGHVDHGKSSLVQALTGINPDRWEEEQRRQMTLDLGFAWFSTPAGHSVNLVDV
CEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHEECCHHHCCCCCCEEEEEEC
PGHERLIKNMLAGVTGFDGVLFVVAADEGMQPQSHEHLQILNQLGIEHGLIIISKIDLVD
CCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCC
AEWLEFISGDIQAQFAATSLANAPIVPVSARTGAGMAQLLQALDQLISQLPARTIQKQHP
HHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCC
HLPIDRVFSIDGFGTVVTGTLRDGNLSVGMEIEILPQQLRGRIRGLQSQQISYVSVQAGM
CCCHHHEEECCCCCEEEEEEEECCCEEECEEEEECCHHHHHHHCCCCCCCEEEEEECCCC
RVAVNLSGIERQSLKRGDVLTLPQTFEPTNLLDVLIETTTAAPSLSHNQPLQLYLGSAEL
EEEEEECCCCHHHHCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCC
SCTLALLDCDTLPAKQQAFGQLRLQHPTIAQRGDRGILRRASPAATVAGIRVLDAHPQRH
EEEEEEEECCCCCHHHHHHHCEEECCCCHHHCCCCCHHHCCCCCHHHHHEEEECCCCHHH
RRMRPAVIEQLQQLANGLPHEILLQHIQQQCLTWQELQQRSGFDSPTALAALNIGCNNGL
HCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEEECCCCCCH
ISIVSATMATLTASSLITSTAYWSQLQANLRQILAEYHAMWPLRTAMPREELRKRMGLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHCCCH
NSFNQILNALAAQPWLSVEATQIKLTEHQAQPSPGQQAQIQALLGLWQSNPALPPSREQW
HHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
PKLDPELWRYLLQTEQLIQIGAEVYFLPKQYHQMHTWVLEQLAAGQSISLAQARDAWQTS
CCCCHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHH
RKYAQAMLEHCDQLRITRRVGDLRVAY
HHHHHHHHHHHHHHHHHHHHCCEEECC
>Mature Secondary Structure 
AITLGTAGHVDHGKSSLVQALTGINPDRWEEEQRRQMTLDLGFAWFSTPAGHSVNLVDV
EEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHEECCHHHCCCCCCEEEEEEC
PGHERLIKNMLAGVTGFDGVLFVVAADEGMQPQSHEHLQILNQLGIEHGLIIISKIDLVD
CCHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCC
AEWLEFISGDIQAQFAATSLANAPIVPVSARTGAGMAQLLQALDQLISQLPARTIQKQHP
HHHHHHHCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCHHHHHHCCC
HLPIDRVFSIDGFGTVVTGTLRDGNLSVGMEIEILPQQLRGRIRGLQSQQISYVSVQAGM
CCCHHHEEECCCCCEEEEEEEECCCEEECEEEEECCHHHHHHHCCCCCCCEEEEEECCCC
RVAVNLSGIERQSLKRGDVLTLPQTFEPTNLLDVLIETTTAAPSLSHNQPLQLYLGSAEL
EEEEEECCCCHHHHCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCC
SCTLALLDCDTLPAKQQAFGQLRLQHPTIAQRGDRGILRRASPAATVAGIRVLDAHPQRH
EEEEEEEECCCCCHHHHHHHCEEECCCCHHHCCCCCHHHCCCCCHHHHHEEEECCCCHHH
RRMRPAVIEQLQQLANGLPHEILLQHIQQQCLTWQELQQRSGFDSPTALAALNIGCNNGL
HCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCEEEEEECCCCCCH
ISIVSATMATLTASSLITSTAYWSQLQANLRQILAEYHAMWPLRTAMPREELRKRMGLAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHCCCH
NSFNQILNALAAQPWLSVEATQIKLTEHQAQPSPGQQAQIQALLGLWQSNPALPPSREQW
HHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCC
PKLDPELWRYLLQTEQLIQIGAEVYFLPKQYHQMHTWVLEQLAAGQSISLAQARDAWQTS
CCCCHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHH
RKYAQAMLEHCDQLRITRRVGDLRVAY
HHHHHHHHHHHHHHHHHHHHCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8893853 [H]