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The map label for this gene is thrA [H]

Identifier: 159897630

GI number: 159897630

Start: 1261589

End: 1262593

Strand: Direct

Name: thrA [H]

Synonym: Haur_1101

Alternate gene names: 159897630

Gene position: 1261589-1262593 (Clockwise)

Preceding gene: 159897629

Following gene: 159897636

Centisome position: 19.88

GC content: 55.32

Gene sequence:

>1005_bases
ATGCACAATTTAGCAATTTATGGCTTTGGTGGAGTCGGGCGGGCGGTGTTGGCCCAAGCCTTGCCGCACTTCAACCTTGC
CTTGGTGGCTGATCGTTCTGGGTATGTGGCGGGACCATTGAGCAATGAACGTTGGTTGGCGGTGGCGACGGCCAAAGCCC
AAGGCGCAACCCTAGCTAGTTTGCCCGAGGGAAGCAGCGGTGATTGGCGAGCCGCCTTGCCCGCTGGTTGTTTGGTGGCT
GATACGACCGCCGAAGCCAATGCCGCCCAGTTGGTTGAATTGGTTGGGCGTGGAATGCGTTTGGCCTTGGCCAATAAAAA
ACCGTTGTGCGAAGATTTAAATTTGTTTCAAGCCTTGGTTGCTGAGCGCTGCACCCGCTACGAGGCTACGGTTGGGGCTG
GCTTGCCGATTGTGGTGACCACCAATTTACTGCGCGATACTGGCGATCAGGTTCAGCGCATCGAAGGCGGTTTGAGTGGT
ACACTGGGGTTTTTGCTCTCATCAATCGAACAAGGCCAGCCTTATTCGGCGGCTGTGCGTGAAGCTAAAGCCTTGGGCTG
GACGGAACCCGACCCGCGTGATGATTTGGGCGGTGTTGACGTAGCGCGTAAAGCTTTGATTTTGGCGCGTACTTTGGGCT
ATCAATGGAACTTGAGCGATATTACGATTGAGCCATTGTATCCGGCTGAGTTTGCTGATTTGAGCATTGCTGAATTTATG
GCGCAACTTGAGCAACTTGATCCTGGTTATGCCCAACGCCAAGCCGAAGCTGTTGCCCAAGGCCAAACCTTGCGCTATGT
GGCGGCGATCACGTCTGAGGGTGCGCGAGTTGGCTTGCAAGCAGTTGCTAAAGATAGCCCGCTTGGCTCGCTCAAAGGGC
CAGATAATATGGTGGCTTGGACAACCAACCGCTACCAAGAGCGCCCGTTGGTGGTACGCGGGCCTGGCGCAGGAGTCGAA
GTGACCGCTTCGGCAGTCTTGTTTGATCTCTTGGCCTTCCGTTAA

Upstream 100 bases:

>100_bases
TTTACGCCAAGTTTGCTTCCTTGTGCTCAGCATTTTTTGCCTAAATAGCTGGCTAACCCGTACAATACAGCCCGACACAT
CAGATTAAGGAAGCTCTACG

Downstream 100 bases:

>100_bases
ATAAAAACCGTGGTCAACGAAGACCACGGCTCAAACCCTCTTGATAATTGTGAACTATTGACCTGCCATATCCCGCCGCT
GGAACAAGAGAATTCCTAAC

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: AK-HD; Aspartokinase; Homoserine dehydrogenase [H]

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MHNLAIYGFGGVGRAVLAQALPHFNLALVADRSGYVAGPLSNERWLAVATAKAQGATLASLPEGSSGDWRAALPAGCLVA
DTTAEANAAQLVELVGRGMRLALANKKPLCEDLNLFQALVAERCTRYEATVGAGLPIVVTTNLLRDTGDQVQRIEGGLSG
TLGFLLSSIEQGQPYSAAVREAKALGWTEPDPRDDLGGVDVARKALILARTLGYQWNLSDITIEPLYPAEFADLSIAEFM
AQLEQLDPGYAQRQAEAVAQGQTLRYVAAITSEGARVGLQAVAKDSPLGSLKGPDNMVAWTTNRYQERPLVVRGPGAGVE
VTASAVLFDLLAFR

Sequences:

>Translated_334_residues
MHNLAIYGFGGVGRAVLAQALPHFNLALVADRSGYVAGPLSNERWLAVATAKAQGATLASLPEGSSGDWRAALPAGCLVA
DTTAEANAAQLVELVGRGMRLALANKKPLCEDLNLFQALVAERCTRYEATVGAGLPIVVTTNLLRDTGDQVQRIEGGLSG
TLGFLLSSIEQGQPYSAAVREAKALGWTEPDPRDDLGGVDVARKALILARTLGYQWNLSDITIEPLYPAEFADLSIAEFM
AQLEQLDPGYAQRQAEAVAQGQTLRYVAAITSEGARVGLQAVAKDSPLGSLKGPDNMVAWTTNRYQERPLVVRGPGAGVE
VTASAVLFDLLAFR
>Mature_334_residues
MHNLAIYGFGGVGRAVLAQALPHFNLALVADRSGYVAGPLSNERWLAVATAKAQGATLASLPEGSSGDWRAALPAGCLVA
DTTAEANAAQLVELVGRGMRLALANKKPLCEDLNLFQALVAERCTRYEATVGAGLPIVVTTNLLRDTGDQVQRIEGGLSG
TLGFLLSSIEQGQPYSAAVREAKALGWTEPDPRDDLGGVDVARKALILARTLGYQWNLSDITIEPLYPAEFADLSIAEFM
AQLEQLDPGYAQRQAEAVAQGQTLRYVAAITSEGARVGLQAVAKDSPLGSLKGPDNMVAWTTNRYQERPLVVRGPGAGVE
VTASAVLFDLLAFR

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the homoserine dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=261, Percent_Identity=41.7624521072797, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1790376, Length=270, Percent_Identity=41.1111111111111, Blast_Score=168, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6322599, Length=338, Percent_Identity=32.8402366863905, Blast_Score=158, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR005106
- InterPro:   IPR001341
- InterPro:   IPR018042
- InterPro:   IPR011147
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00696 AA_kinase; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =2.7.2.4; =1.1.1.3 [H]

Molecular weight: Translated: 35329; Mature: 35329

Theoretical pI: Translated: 4.80; Mature: 4.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNLAIYGFGGVGRAVLAQALPHFNLALVADRSGYVAGPLSNERWLAVATAKAQGATLAS
CCCEEEEECCCHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCEEEEEECCCCCCEEEE
LPEGSSGDWRAALPAGCLVADTTAEANAAQLVELVGRGMRLALANKKPLCEDLNLFQALV
CCCCCCCCEEEECCCCEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHH
AERCTRYEATVGAGLPIVVTTNLLRDTGDQVQRIEGGLSGTLGFLLSSIEQGQPYSAAVR
HHHHHHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHH
EAKALGWTEPDPRDDLGGVDVARKALILARTLGYQWNLSDITIEPLYPAEFADLSIAEFM
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEECCCCEEECCCCCCHHCCCHHHHHH
AQLEQLDPGYAQRQAEAVAQGQTLRYVAAITSEGARVGLQAVAKDSPLGSLKGPDNMVAW
HHHHHCCCCHHHHHHHHHHCCCCEEEEEEHHCCCHHHHHHHHHCCCCCCCCCCCCCEEEE
TTNRYQERPLVVRGPGAGVEVTASAVLFDLLAFR
ECCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MHNLAIYGFGGVGRAVLAQALPHFNLALVADRSGYVAGPLSNERWLAVATAKAQGATLAS
CCCEEEEECCCHHHHHHHHHCCCCCEEEEECCCCEEECCCCCCCEEEEEECCCCCCEEEE
LPEGSSGDWRAALPAGCLVADTTAEANAAQLVELVGRGMRLALANKKPLCEDLNLFQALV
CCCCCCCCEEEECCCCEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHH
AERCTRYEATVGAGLPIVVTTNLLRDTGDQVQRIEGGLSGTLGFLLSSIEQGQPYSAAVR
HHHHHHHHHHHCCCCCEEEEHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHH
EAKALGWTEPDPRDDLGGVDVARKALILARTLGYQWNLSDITIEPLYPAEFADLSIAEFM
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEECCCCEEECCCCCCHHCCCHHHHHH
AQLEQLDPGYAQRQAEAVAQGQTLRYVAAITSEGARVGLQAVAKDSPLGSLKGPDNMVAW
HHHHHCCCCHHHHHHHHHHCCCCEEEEEEHHCCCHHHHHHHHHCCCCCCCCCCCCCEEEE
TTNRYQERPLVVRGPGAGVEVTASAVLFDLLAFR
ECCCCCCCCEEEECCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]