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The map label for this gene is serA [H]

Identifier: 159897613

GI number: 159897613

Start: 1240956

End: 1242530

Strand: Reverse

Name: serA [H]

Synonym: Haur_1084

Alternate gene names: 159897613

Gene position: 1242530-1240956 (Counterclockwise)

Preceding gene: 159897615

Following gene: 159897612

Centisome position: 19.58

GC content: 52.89

Gene sequence:

>1575_bases
ATGGATCGTATCCTGGTCACGGAGAAGATTGGTGCCGAAGGCCTTGCGGCGCTTAAAGAGGTCGCCGAGGTTGATGTTCG
TCTTGATCTTACACCAGAAACCCTGTTGGAGGCTTTGCCACAGTACGATGCCTTGATCGTGCGTTCGCAAACCAAAGTTA
CCGCTAAAGTGCTTGCCGCAGGCACCAAACTTCGAGTTGTTGGCCGCGCCGGGACGGGTGTTGACAACATCGATTTGGCC
GCCGCCAATCAGCAAGGAATTTTGGTGGTCAATGCTCCAGCATCAAACAGTATTGCAGTCGCTGAACTGACGATTGGTTT
GATGATTGGTCTTGCTCGTAACATTCCCCAAGCCCACACTGCCTTGCAAAATGGCAAATGGGAACGCAGCAAATATGGCG
GTTGGGAAGTACGCGGCAAAACTTTAGGCTTGGTCGGCTTTGGCCGAATTGCCTCAGAAGTTGCTCGTCGCGCCCGCGCC
TTGGAAATGAATATTATCGCCTACGACCCAATTATCAATGCTGAACGTGCAGCCCAACTTGGTGTGACCCCAGTAACGCT
TGATGAATTAACCAGCCGCGCTGATGTTATTTCATTGCACATTCCATTGATCGATGCTACGCGCAATTTGTTCGATGCCC
AACGCCTGAGCCAAATGAAAAAAGGCAGCTATATCATCAATTGTGCCCGTGGTGGCGTGATCGATGAAGAAGCCTTGTTC
GAAGCTTTGGAATCAGGCCATCTTGGCGGCGCAGCCCTCGACGTATTTGCCAAAGAGCCACCAACTGGCCCCATCGTTAC
CCACCCCAAAGCGATTGTCCTGCCGCACTTAGGCGCTTCAACCGAAGAAGCTCAAGCCTTGACCGCCGCCGATGTGGCCG
AAGGGATTGTTGATGTATTGGCTGGGCGATCACCACGCTATGCAGTCAACGCACCGTTTGTTGCGCCAGAAGAGTGGGCA
ATCGTTGGGCCATATCTCGATCTTGGCCGCAAATTAGCGCGGCTCAGCACTCAATTGGTCGATCTGCCAGCCCAATCGTA
TCAAATTGTCTACAACGGTGCTTTGGCAGGCCTGACCAGCGAACCAATTAAGTTAGCCGTTTTGCAAGGCTTGCTCGAAG
GCGGCTCAGAAGGTCGGGTTACTCCGGTTAATGCGCCATTCTTGGCTCGCGAACGCGGCTTAACCATCAACGAAACTCAT
CGCCCCGATGCTGAAACCTACACCGAATTGTTGCAATTGGTGGTGACCACCAGCGATGGTGTGGTGCATACCTTCGGCGG
AACGGTGGTACGTGGCGAGGCTCACATCGTCCAAATCAACGAATTTTGGCTCGATTTGGTGCCAACCAGCTCGATGTTAT
TCACCTTCCACCAAGATCGGCCTGGCTTTATCGGGCGGATTGGCACATTGCTGGGCACGGCTGATATCAACATTTCGGCG
ATGCACGTTGGTCGCTCAAGCCCACGCGGCACAGCAATTATGGTGCTCACGGTTGATGAAGCCATTCCAAGCGAGACCCT
AACCGATATTAACAACCAAGTTGATATCGAACGCGCCTACAGCGTGTTGCTCTAA

Upstream 100 bases:

>100_bases
CTTGTGATACAATACACAAAACTCCCATCAGCCAGTGCTGGCAGCGGCAGAGCGTGTCCATCTGCCCTTTTTTGTTTACT
ACCACAGGAGTAACTACCTC

Downstream 100 bases:

>100_bases
ACCGCAAACTGAACACTCAAGCCGCCACGATTCAATGGCGAAACGTGGCTTTTGCTATTGGTAAGGATTTTAACACCATT
TGGTTATCCTCTCTTAACCC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MDRILVTEKIGAEGLAALKEVAEVDVRLDLTPETLLEALPQYDALIVRSQTKVTAKVLAAGTKLRVVGRAGTGVDNIDLA
AANQQGILVVNAPASNSIAVAELTIGLMIGLARNIPQAHTALQNGKWERSKYGGWEVRGKTLGLVGFGRIASEVARRARA
LEMNIIAYDPIINAERAAQLGVTPVTLDELTSRADVISLHIPLIDATRNLFDAQRLSQMKKGSYIINCARGGVIDEEALF
EALESGHLGGAALDVFAKEPPTGPIVTHPKAIVLPHLGASTEEAQALTAADVAEGIVDVLAGRSPRYAVNAPFVAPEEWA
IVGPYLDLGRKLARLSTQLVDLPAQSYQIVYNGALAGLTSEPIKLAVLQGLLEGGSEGRVTPVNAPFLARERGLTINETH
RPDAETYTELLQLVVTTSDGVVHTFGGTVVRGEAHIVQINEFWLDLVPTSSMLFTFHQDRPGFIGRIGTLLGTADINISA
MHVGRSSPRGTAIMVLTVDEAIPSETLTDINNQVDIERAYSVLL

Sequences:

>Translated_524_residues
MDRILVTEKIGAEGLAALKEVAEVDVRLDLTPETLLEALPQYDALIVRSQTKVTAKVLAAGTKLRVVGRAGTGVDNIDLA
AANQQGILVVNAPASNSIAVAELTIGLMIGLARNIPQAHTALQNGKWERSKYGGWEVRGKTLGLVGFGRIASEVARRARA
LEMNIIAYDPIINAERAAQLGVTPVTLDELTSRADVISLHIPLIDATRNLFDAQRLSQMKKGSYIINCARGGVIDEEALF
EALESGHLGGAALDVFAKEPPTGPIVTHPKAIVLPHLGASTEEAQALTAADVAEGIVDVLAGRSPRYAVNAPFVAPEEWA
IVGPYLDLGRKLARLSTQLVDLPAQSYQIVYNGALAGLTSEPIKLAVLQGLLEGGSEGRVTPVNAPFLARERGLTINETH
RPDAETYTELLQLVVTTSDGVVHTFGGTVVRGEAHIVQINEFWLDLVPTSSMLFTFHQDRPGFIGRIGTLLGTADINISA
MHVGRSSPRGTAIMVLTVDEAIPSETLTDINNQVDIERAYSVLL
>Mature_524_residues
MDRILVTEKIGAEGLAALKEVAEVDVRLDLTPETLLEALPQYDALIVRSQTKVTAKVLAAGTKLRVVGRAGTGVDNIDLA
AANQQGILVVNAPASNSIAVAELTIGLMIGLARNIPQAHTALQNGKWERSKYGGWEVRGKTLGLVGFGRIASEVARRARA
LEMNIIAYDPIINAERAAQLGVTPVTLDELTSRADVISLHIPLIDATRNLFDAQRLSQMKKGSYIINCARGGVIDEEALF
EALESGHLGGAALDVFAKEPPTGPIVTHPKAIVLPHLGASTEEAQALTAADVAEGIVDVLAGRSPRYAVNAPFVAPEEWA
IVGPYLDLGRKLARLSTQLVDLPAQSYQIVYNGALAGLTSEPIKLAVLQGLLEGGSEGRVTPVNAPFLARERGLTINETH
RPDAETYTELLQLVVTTSDGVVHTFGGTVVRGEAHIVQINEFWLDLVPTSSMLFTFHQDRPGFIGRIGTLLGTADINISA
MHVGRSSPRGTAIMVLTVDEAIPSETLTDINNQVDIERAYSVLL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=380, Percent_Identity=43.9473684210526, Blast_Score=310, Evalue=3e-84,
Organism=Homo sapiens, GI145580578, Length=285, Percent_Identity=35.7894736842105, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4557499, Length=285, Percent_Identity=35.7894736842105, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI61743967, Length=276, Percent_Identity=34.7826086956522, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI4557497, Length=276, Percent_Identity=34.7826086956522, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI145580575, Length=274, Percent_Identity=36.4963503649635, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI6912396, Length=297, Percent_Identity=30.3030303030303, Blast_Score=128, Evalue=1e-29,
Organism=Escherichia coli, GI1789279, Length=327, Percent_Identity=35.1681957186544, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI87082289, Length=273, Percent_Identity=32.6007326007326, Blast_Score=145, Evalue=8e-36,
Organism=Escherichia coli, GI1787645, Length=187, Percent_Identity=37.9679144385027, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI1788660, Length=283, Percent_Identity=31.4487632508834, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI87081824, Length=149, Percent_Identity=30.2013422818792, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=305, Percent_Identity=46.2295081967213, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI25147481, Length=305, Percent_Identity=34.7540983606557, Blast_Score=150, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6322116, Length=331, Percent_Identity=34.441087613293, Blast_Score=191, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6320925, Length=331, Percent_Identity=34.1389728096677, Blast_Score=189, Evalue=9e-49,
Organism=Saccharomyces cerevisiae, GI6324055, Length=249, Percent_Identity=30.5220883534137, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324964, Length=241, Percent_Identity=30.2904564315353, Blast_Score=104, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6324980, Length=149, Percent_Identity=30.2013422818792, Blast_Score=68, Evalue=4e-12,
Organism=Drosophila melanogaster, GI19921140, Length=324, Percent_Identity=45.0617283950617, Blast_Score=268, Evalue=7e-72,
Organism=Drosophila melanogaster, GI24646446, Length=280, Percent_Identity=35.7142857142857, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24646448, Length=280, Percent_Identity=35.7142857142857, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24646452, Length=280, Percent_Identity=35.7142857142857, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24646450, Length=280, Percent_Identity=35.7142857142857, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI62472511, Length=280, Percent_Identity=35.7142857142857, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24585514, Length=320, Percent_Identity=28.4375, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI28574282, Length=320, Percent_Identity=28.4375, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24585516, Length=277, Percent_Identity=28.5198555956679, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI28574284, Length=320, Percent_Identity=28.4375, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI45551003, Length=320, Percent_Identity=28.4375, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI45552429, Length=320, Percent_Identity=28.4375, Blast_Score=138, Evalue=9e-33,
Organism=Drosophila melanogaster, GI28574286, Length=309, Percent_Identity=28.1553398058252, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI28571528, Length=299, Percent_Identity=31.7725752508361, Blast_Score=120, Evalue=3e-27,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 55910; Mature: 55910

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRILVTEKIGAEGLAALKEVAEVDVRLDLTPETLLEALPQYDALIVRSQTKVTAKVLAA
CCCEEEECCCCHHHHHHHHHHHHCCEEEECCHHHHHHHCCCCCEEEEECCCHHHHHHHHC
GTKLRVVGRAGTGVDNIDLAAANQQGILVVNAPASNSIAVAELTIGLMIGLARNIPQAHT
CCEEEEEECCCCCCCCCEEEECCCCCEEEEECCCCCCEEEHHHHHHHHHHHHHCCCHHHH
ALQNGKWERSKYGGWEVRGKTLGLVGFGRIASEVARRARALEMNIIAYDPIINAERAAQL
HHHCCCCCCCCCCCEEECCCEEEEEEHHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHC
GVTPVTLDELTSRADVISLHIPLIDATRNLFDAQRLSQMKKGSYIINCARGGVIDEEALF
CCCEEEHHHHCCCCCEEEEEEEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHH
EALESGHLGGAALDVFAKEPPTGPIVTHPKAIVLPHLGASTEEAQALTAADVAEGIVDVL
HHHHCCCCCCEEEEEEECCCCCCCEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
AGRSPRYAVNAPFVAPEEWAIVGPYLDLGRKLARLSTQLVDLPAQSYQIVYNGALAGLTS
CCCCCCEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEECEECCCCC
EPIKLAVLQGLLEGGSEGRVTPVNAPFLARERGLTINETHRPDAETYTELLQLVVTTSDG
CCHHHHHHHHHHCCCCCCCEEECCCCHHHHCCCCEECCCCCCCHHHHHHHHHHEEECCCC
VVHTFGGTVVRGEAHIVQINEFWLDLVPTSSMLFTFHQDRPGFIGRIGTLLGTADINISA
EEEECCCEEEECCEEEEEEEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHEECCCEEEE
MHVGRSSPRGTAIMVLTVDEAIPSETLTDINNQVDIERAYSVLL
EECCCCCCCCCEEEEEEECCCCCCHHHHHCCCCEEHHHHHHHCC
>Mature Secondary Structure
MDRILVTEKIGAEGLAALKEVAEVDVRLDLTPETLLEALPQYDALIVRSQTKVTAKVLAA
CCCEEEECCCCHHHHHHHHHHHHCCEEEECCHHHHHHHCCCCCEEEEECCCHHHHHHHHC
GTKLRVVGRAGTGVDNIDLAAANQQGILVVNAPASNSIAVAELTIGLMIGLARNIPQAHT
CCEEEEEECCCCCCCCCEEEECCCCCEEEEECCCCCCEEEHHHHHHHHHHHHHCCCHHHH
ALQNGKWERSKYGGWEVRGKTLGLVGFGRIASEVARRARALEMNIIAYDPIINAERAAQL
HHHCCCCCCCCCCCEEECCCEEEEEEHHHHHHHHHHHHHHEEEEEEEECCCCCCHHHHHC
GVTPVTLDELTSRADVISLHIPLIDATRNLFDAQRLSQMKKGSYIINCARGGVIDEEALF
CCCEEEHHHHCCCCCEEEEEEEEEHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHH
EALESGHLGGAALDVFAKEPPTGPIVTHPKAIVLPHLGASTEEAQALTAADVAEGIVDVL
HHHHCCCCCCEEEEEEECCCCCCCEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
AGRSPRYAVNAPFVAPEEWAIVGPYLDLGRKLARLSTQLVDLPAQSYQIVYNGALAGLTS
CCCCCCEEECCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEECEECCCCC
EPIKLAVLQGLLEGGSEGRVTPVNAPFLARERGLTINETHRPDAETYTELLQLVVTTSDG
CCHHHHHHHHHHCCCCCCCEEECCCCHHHHCCCCEECCCCCCCHHHHHHHHHHEEECCCC
VVHTFGGTVVRGEAHIVQINEFWLDLVPTSSMLFTFHQDRPGFIGRIGTLLGTADINISA
EEEECCCEEEECCEEEEEEEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHEECCCEEEE
MHVGRSSPRGTAIMVLTVDEAIPSETLTDINNQVDIERAYSVLL
EECCCCCCCCCEEEEEEECCCCCCHHHHHCCCCEEHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]