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The map label for this gene is purK [H]

Identifier: 159897424

GI number: 159897424

Start: 1022779

End: 1023924

Strand: Reverse

Name: purK [H]

Synonym: Haur_0895

Alternate gene names: 159897424

Gene position: 1023924-1022779 (Counterclockwise)

Preceding gene: 159897425

Following gene: 159897423

Centisome position: 16.13

GC content: 54.19

Gene sequence:

>1146_bases
ATGACAAAACGTTTAGGAATTCTTGGTGGCGGCCAATTGGCGCGGATGTTGGTGCAAGCGGCGATTCCCTTGGGAATTGA
AACCGTGGTTTTGGCCAACCGCAACGATGAGCCAGCGGCATTGGTCAGCAAAGCGGTGGTTGGCGAGTGGAGTGATCGAG
CCTTGCTTGATCAATTTGCTCAAGCGGTTGATGTGGTAGTGCTGGAAAACGAGTTTATTGGCTCGGAAAAATTGGCCTAC
CTTGCCAGCAAAGGCGTGCAACTTGTCCCCGATCAGGCAACGCTGGGCTTGATTGAGGATAAAGCGCAACAAAAATTAAC
ATTGGCAGCCGCAGGCCTGCCTGTACCAGCCTTGGCCTTAATCGAATCGTTGGACGATGTGGCGGCCTTTGGGGCTGAAC
ATGGTTTCCCGTTGATGCTGAAAACGCGGCGCAACGGCTACGATGGCCGTGGCACGGCCAAAATCCGCAGCGCCGAAGAG
ATTGCCAGCGCTTGTAGCTCCTTGGGTTTTCCCGAAAATCCAGTGTTTGTTGAGGCATGGGTTCCCTTCGAAGCCGAGTT
GGCAACCTTGATTATTCGCTCGGTCAGCGGCGAACAATGCGTCTATCCAGTGATTGAAACCTACCAACCGAGCGGCGTTT
GTCGGGTGGTGCGTGCACCAGCACCCTTCTCAGCAGCAATTCAACAACAGGCCAGCGAGGTTGCTCAAGCGACGGCAGCA
GCGCTTGGTGGCTTAGGCATCTTGGCGGTTGAAATGTTTCTGACCAGCAAGGGCCAAATTTTGGTCAATGAGCTAGCGCC
CCGTCCACACAACACTGGTCACTATTCAATTGAGGGTTGTTATTGTTCACAATTTGAAAATACGATTCGTGCTGCGCTGG
GCTGGCCGTTGGGTGATCCTCAGTTGCGCCACCAAAGTGCCGTGATGGTCAATGTGCTCGCGCCAACCACACGACCACTT
GAAAGCAGCTTGATTCAAACGGCGCTCAAACCACAGGTGCATGTGCATTGGTACGACAAACGCAGCGCCAAGCCAGGCCG
TAAAATTGGCCATATCACCGCTGTAGGAGCCGAACCAAGCGAAGTCGAAGCGCGTGCCCAAGCCGCCGTCGATCAGCTAG
AGCGGGTTTTAGCTGAACCCGTATAA

Upstream 100 bases:

>100_bases
CGATCCTTACGAACCGTATGAATCATTACACCTATAATCAAAAGCTTCGTGCTCTTCATGGTTAAATCTAGACTATTAAC
TTATAGCTCATTAAGGCATT

Downstream 100 bases:

>100_bases
TTGAGCAAACCAACCCACATGTCAAGCCAATCGAGCGTTGCAATGACGCACCTCGATCAACGCTTGGCATTTTTAATTTC
TCGCCAAAGGAGCATTATGT

Product: phosphoribosylaminoimidazole carboxylase, ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 381; Mature: 380

Protein sequence:

>381_residues
MTKRLGILGGGQLARMLVQAAIPLGIETVVLANRNDEPAALVSKAVVGEWSDRALLDQFAQAVDVVVLENEFIGSEKLAY
LASKGVQLVPDQATLGLIEDKAQQKLTLAAAGLPVPALALIESLDDVAAFGAEHGFPLMLKTRRNGYDGRGTAKIRSAEE
IASACSSLGFPENPVFVEAWVPFEAELATLIIRSVSGEQCVYPVIETYQPSGVCRVVRAPAPFSAAIQQQASEVAQATAA
ALGGLGILAVEMFLTSKGQILVNELAPRPHNTGHYSIEGCYCSQFENTIRAALGWPLGDPQLRHQSAVMVNVLAPTTRPL
ESSLIQTALKPQVHVHWYDKRSAKPGRKIGHITAVGAEPSEVEARAQAAVDQLERVLAEPV

Sequences:

>Translated_381_residues
MTKRLGILGGGQLARMLVQAAIPLGIETVVLANRNDEPAALVSKAVVGEWSDRALLDQFAQAVDVVVLENEFIGSEKLAY
LASKGVQLVPDQATLGLIEDKAQQKLTLAAAGLPVPALALIESLDDVAAFGAEHGFPLMLKTRRNGYDGRGTAKIRSAEE
IASACSSLGFPENPVFVEAWVPFEAELATLIIRSVSGEQCVYPVIETYQPSGVCRVVRAPAPFSAAIQQQASEVAQATAA
ALGGLGILAVEMFLTSKGQILVNELAPRPHNTGHYSIEGCYCSQFENTIRAALGWPLGDPQLRHQSAVMVNVLAPTTRPL
ESSLIQTALKPQVHVHWYDKRSAKPGRKIGHITAVGAEPSEVEARAQAAVDQLERVLAEPV
>Mature_380_residues
TKRLGILGGGQLARMLVQAAIPLGIETVVLANRNDEPAALVSKAVVGEWSDRALLDQFAQAVDVVVLENEFIGSEKLAYL
ASKGVQLVPDQATLGLIEDKAQQKLTLAAAGLPVPALALIESLDDVAAFGAEHGFPLMLKTRRNGYDGRGTAKIRSAEEI
ASACSSLGFPENPVFVEAWVPFEAELATLIIRSVSGEQCVYPVIETYQPSGVCRVVRAPAPFSAAIQQQASEVAQATAAA
LGGLGILAVEMFLTSKGQILVNELAPRPHNTGHYSIEGCYCSQFENTIRAALGWPLGDPQLRHQSAVMVNVLAPTTRPLE
SSLIQTALKPQVHVHWYDKRSAKPGRKIGHITAVGAEPSEVEARAQAAVDQLERVLAEPV

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=376, Percent_Identity=31.1170212765957, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1788155, Length=379, Percent_Identity=25.8575197889182, Blast_Score=96, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6324702, Length=377, Percent_Identity=36.3395225464191, Blast_Score=229, Evalue=7e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 40603; Mature: 40472

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKRLGILGGGQLARMLVQAAIPLGIETVVLANRNDEPAALVSKAVVGEWSDRALLDQFA
CCCCEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHH
QAVDVVVLENEFIGSEKLAYLASKGVQLVPDQATLGLIEDKAQQKLTLAAAGLPVPALAL
HHHEEEEEECCCCCCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHEEEEECCCCHHHHHH
IESLDDVAAFGAEHGFPLMLKTRRNGYDGRGTAKIRSAEEIASACSSLGFPENPVFVEAW
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEECCHHHHHHHHHHCCCCCCCEEEEEE
VPFEAELATLIIRSVSGEQCVYPVIETYQPSGVCRVVRAPAPFSAAIQQQASEVAQATAA
CCCHHHHHHHHHHHCCCCCEEHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
ALGGLGILAVEMFLTSKGQILVNELAPRPHNTGHYSIEGCYCSQFENTIRAALGWPLGDP
HHCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEEEEHHHHHHHHHHHHCCCCCCH
QLRHQSAVMVNVLAPTTRPLESSLIQTALKPQVHVHWYDKRSAKPGRKIGHITAVGAEPS
HHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCH
EVEARAQAAVDQLERVLAEPV
HHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TKRLGILGGGQLARMLVQAAIPLGIETVVLANRNDEPAALVSKAVVGEWSDRALLDQFA
CCCEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHH
QAVDVVVLENEFIGSEKLAYLASKGVQLVPDQATLGLIEDKAQQKLTLAAAGLPVPALAL
HHHEEEEEECCCCCCHHHHHHHHCCCEEECCCHHHHHHHHHHHHHEEEEECCCCHHHHHH
IESLDDVAAFGAEHGFPLMLKTRRNGYDGRGTAKIRSAEEIASACSSLGFPENPVFVEAW
HHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCEECCHHHHHHHHHHCCCCCCCEEEEEE
VPFEAELATLIIRSVSGEQCVYPVIETYQPSGVCRVVRAPAPFSAAIQQQASEVAQATAA
CCCHHHHHHHHHHHCCCCCEEHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHH
ALGGLGILAVEMFLTSKGQILVNELAPRPHNTGHYSIEGCYCSQFENTIRAALGWPLGDP
HHCCHHHHHHHHHHCCCCCEEEECCCCCCCCCCCEEEEEEEHHHHHHHHHHHHCCCCCCH
QLRHQSAVMVNVLAPTTRPLESSLIQTALKPQVHVHWYDKRSAKPGRKIGHITAVGAEPS
HHHCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCEEEEECCCCH
EVEARAQAAVDQLERVLAEPV
HHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA