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The map label for this gene is hutU

Identifier: 159897158

GI number: 159897158

Start: 725085

End: 726743

Strand: Direct

Name: hutU

Synonym: Haur_0629

Alternate gene names: 159897158

Gene position: 725085-726743 (Clockwise)

Preceding gene: 159897154

Following gene: 159897159

Centisome position: 11.42

GC content: 55.09

Gene sequence:

>1659_bases
ATGACTTCATCGCGCATTGTGCGTGCACCACGCGGCTCAGAATTATCGTGCAAAGGGTGGGCGCAAGAAGCAGCGTTGCG
AATGCTGATGAATAATCTTGATCCTGATGTGGCCGAAGATCCGCAAAATTTGATTGTCTACGGCGGCACGGGGAAGGCTG
CCCGCAATTGGCAATGCTTCGATGCGATTGTGCGTTCGTTGCAAGAACTCAACGATGATGAAACCTTGTTGGTGCAATCG
GGCAAACCTGTTGCTGTATTTCGTAGCCATCGCGATGCTCCACGGGTGCTGATTGCCAATTCGATGCTCGTGCCACATTG
GGCCACATGGGAGAACTTCCGCGAATTGGAGCAGGCTGGCTTGACGATGTATGGCCAAATGACCGCTGGCTCGTGGATTT
ATATTGGTACACAAGGAATTTTGCAAGGCACTTATGAGACACTGGCCGCCATTGCCCGCCAACATTTTGGTGGCTCGTTG
CGCGGTCGTTGGACGCTCACCGCTGGCCTTGGCGGTATGGGCGGCGCACAACCTTTGGCCGTCACCATGAACGATGGCGT
GGCCTTGGTGGTTGAAGTTGATCGCCAGCGCATGCAGCGCCGCTTGGATACGCGCTATCTCGACGTGGCGGTTGATACGC
TTGAAGAAGCCATGACCTTGGTTGATGAAGCGGTGCGCGACGGCAAAGCACTTTCGGTTGGTTTATTGGGCAACGCCGCC
GAAGTCTTTGGCGAATTGTATAAGCGTGGTGTGCGCCCCGATATTGTGACCGACCAAACCAGTGCCCACGACCCGCTTGA
GGGCTATGTGCCAGCTGGCATGAGCCTTGAGCAGGCACTCGAATTGCGTCAACGCGACCCCGAAGAATATGTCAAGCATT
CAACTGCTTCAATGGTTGAGCATGTTAAAGCTATGGTTGCCTTCGCTGATGCTGGCTCGATCGTGTTTGATTATGGCAAT
AATTTGCGTGGTGTAGCTAAGGCTGCTGGTTATGATCGAGCATTTGCCTATCCTGGCTTTGTGCCTGCCTATATTCGCCC
ATTGTTCTGCGAAGGCAAAGGGCCATTCCGTTGGGCAGCGCTTTCGGGCGACCCCGCTGATATTGCCAAAACCGATGAAG
CCTTGCTCGAATTGTTCCCAGAGGATCAAGCATTGCATCGCTGGATTCGCGCCGCTCAAGAGCGGGTTCAATTCCAAGGT
TTGCCCGCCCGCATTTGCTGGCTCGGCTATGGCGAACGGGCCAAGGCTGGCGCGTTATTCAACAAATTGGTGCGTGATGG
CGTTGTGAGTGCGCCAATCGTGATTGGACGCGACCACCTCGATTGTGGTTCAGTCGCTTCGCCCAACCGCGAAACCGAAG
CTATGCGCGATGGCTCCGATGCAATTGGCGATTGGCCCATTTTGAATGCGATGATCAATGCGGTCAATGGTGCAACCTGG
GTCAGCGTGCATCATGGCGGCGGCGTTGGCATCGGCTATTCGCTGCATGCTGGCATGGTGATTGTGGCTGATGGCACTGC
TGAAGCCGATCACCGCCTAGAGCGGGTGCTCACCAGCGATCCGGGCATGGGCGTGGTGCGTCACGTTGATGCAGGCTACG
ATGAAGCAATTGCCGTAGCCCAAGAGCGCAACGTGCATATTCCAATGCTGAAACAATAG

Upstream 100 bases:

>100_bases
CTGATCCCTATCCTATGTTCTTTGCTCTATGTTCTTATTTTCAACAAAATCAACTATCATAGAGCCAACCGACAATCCTG
TGTACAAGGAGAACTGTCTC

Downstream 100 bases:

>100_bases
CTCATCGAGTGGTAGTGTTGGAGTCAACACTACCACTTAAATCCCCCCAAATTTTGGCACAGCCTATGCTAAGATGATCA
AACCTTAGATTTAAGCCTGA

Product: urocanate hydratase

Products: NA

Alternate protein names: Urocanase; Imidazolonepropionate hydrolase

Number of amino acids: Translated: 552; Mature: 551

Protein sequence:

>552_residues
MTSSRIVRAPRGSELSCKGWAQEAALRMLMNNLDPDVAEDPQNLIVYGGTGKAARNWQCFDAIVRSLQELNDDETLLVQS
GKPVAVFRSHRDAPRVLIANSMLVPHWATWENFRELEQAGLTMYGQMTAGSWIYIGTQGILQGTYETLAAIARQHFGGSL
RGRWTLTAGLGGMGGAQPLAVTMNDGVALVVEVDRQRMQRRLDTRYLDVAVDTLEEAMTLVDEAVRDGKALSVGLLGNAA
EVFGELYKRGVRPDIVTDQTSAHDPLEGYVPAGMSLEQALELRQRDPEEYVKHSTASMVEHVKAMVAFADAGSIVFDYGN
NLRGVAKAAGYDRAFAYPGFVPAYIRPLFCEGKGPFRWAALSGDPADIAKTDEALLELFPEDQALHRWIRAAQERVQFQG
LPARICWLGYGERAKAGALFNKLVRDGVVSAPIVIGRDHLDCGSVASPNRETEAMRDGSDAIGDWPILNAMINAVNGATW
VSVHHGGGVGIGYSLHAGMVIVADGTAEADHRLERVLTSDPGMGVVRHVDAGYDEAIAVAQERNVHIPMLKQ

Sequences:

>Translated_552_residues
MTSSRIVRAPRGSELSCKGWAQEAALRMLMNNLDPDVAEDPQNLIVYGGTGKAARNWQCFDAIVRSLQELNDDETLLVQS
GKPVAVFRSHRDAPRVLIANSMLVPHWATWENFRELEQAGLTMYGQMTAGSWIYIGTQGILQGTYETLAAIARQHFGGSL
RGRWTLTAGLGGMGGAQPLAVTMNDGVALVVEVDRQRMQRRLDTRYLDVAVDTLEEAMTLVDEAVRDGKALSVGLLGNAA
EVFGELYKRGVRPDIVTDQTSAHDPLEGYVPAGMSLEQALELRQRDPEEYVKHSTASMVEHVKAMVAFADAGSIVFDYGN
NLRGVAKAAGYDRAFAYPGFVPAYIRPLFCEGKGPFRWAALSGDPADIAKTDEALLELFPEDQALHRWIRAAQERVQFQG
LPARICWLGYGERAKAGALFNKLVRDGVVSAPIVIGRDHLDCGSVASPNRETEAMRDGSDAIGDWPILNAMINAVNGATW
VSVHHGGGVGIGYSLHAGMVIVADGTAEADHRLERVLTSDPGMGVVRHVDAGYDEAIAVAQERNVHIPMLKQ
>Mature_551_residues
TSSRIVRAPRGSELSCKGWAQEAALRMLMNNLDPDVAEDPQNLIVYGGTGKAARNWQCFDAIVRSLQELNDDETLLVQSG
KPVAVFRSHRDAPRVLIANSMLVPHWATWENFRELEQAGLTMYGQMTAGSWIYIGTQGILQGTYETLAAIARQHFGGSLR
GRWTLTAGLGGMGGAQPLAVTMNDGVALVVEVDRQRMQRRLDTRYLDVAVDTLEEAMTLVDEAVRDGKALSVGLLGNAAE
VFGELYKRGVRPDIVTDQTSAHDPLEGYVPAGMSLEQALELRQRDPEEYVKHSTASMVEHVKAMVAFADAGSIVFDYGNN
LRGVAKAAGYDRAFAYPGFVPAYIRPLFCEGKGPFRWAALSGDPADIAKTDEALLELFPEDQALHRWIRAAQERVQFQGL
PARICWLGYGERAKAGALFNKLVRDGVVSAPIVIGRDHLDCGSVASPNRETEAMRDGSDAIGDWPILNAMINAVNGATWV
SVHHGGGVGIGYSLHAGMVIVADGTAEADHRLERVLTSDPGMGVVRHVDAGYDEAIAVAQERNVHIPMLKQ

Specific function: Unknown

COG id: COG2987

COG function: function code E; Urocanate hydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the urocanase family

Homologues:

Organism=Homo sapiens, GI21389467, Length=561, Percent_Identity=34.7593582887701, Blast_Score=319, Evalue=4e-87,
Organism=Homo sapiens, GI260306182, Length=230, Percent_Identity=37.3913043478261, Blast_Score=162, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI71997891, Length=562, Percent_Identity=35.5871886120996, Blast_Score=332, Evalue=3e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTU_HERA2 (A9AW39)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001543405.1
- ProteinModelPortal:   A9AW39
- SMR:   A9AW39
- GeneID:   5732527
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_0629
- HOGENOM:   HBG305285
- OMA:   IRQMAFE
- ProtClustDB:   PRK05414
- BioCyc:   HAUR316274:HAUR_0629-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00577
- InterPro:   IPR000193
- PIRSF:   PIRSF001423
- TIGRFAMs:   TIGR01228

Pfam domain/function: PF01175 Urocanase; SSF111326 Urocanase

EC number: =4.2.1.49

Molecular weight: Translated: 60032; Mature: 59901

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: PS01233 UROCANASE

Important sites: ACT_SITE 406-406

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSRIVRAPRGSELSCKGWAQEAALRMLMNNLDPDVAEDPQNLIVYGGTGKAARNWQCF
CCCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHH
DAIVRSLQELNDDETLLVQSGKPVAVFRSHRDAPRVLIANSMLVPHWATWENFRELEQAG
HHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEECCEECCCCCCHHHHHHHHHCC
LTMYGQMTAGSWIYIGTQGILQGTYETLAAIARQHFGGSLRGRWTLTAGLGGMGGAQPLA
CEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEE
VTMNDGVALVVEVDRQRMQRRLDTRYLDVAVDTLEEAMTLVDEAVRDGKALSVGLLGNAA
EEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHH
EVFGELYKRGVRPDIVTDQTSAHDPLEGYVPAGMSLEQALELRQRDPEEYVKHSTASMVE
HHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHH
HVKAMVAFADAGSIVFDYGNNLRGVAKAAGYDRAFAYPGFVPAYIRPLFCEGKGPFRWAA
HHHHHHHHCCCCCEEEECCCCCCHHHHHCCCCCCCCCCCCCHHHHCEEEECCCCCEEEEE
LSGDPADIAKTDEALLELFPEDQALHRWIRAAQERVQFQGLPARICWLGYGERAKAGALF
ECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
NKLVRDGVVSAPIVIGRDHLDCGSVASPNRETEAMRDGSDAIGDWPILNAMINAVNGATW
HHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCEE
VSVHHGGGVGIGYSLHAGMVIVADGTAEADHRLERVLTSDPGMGVVRHVDAGYDEAIAVA
EEEECCCCCCCCEEECCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHH
QERNVHIPMLKQ
HCCCCCCCCCCC
>Mature Secondary Structure 
TSSRIVRAPRGSELSCKGWAQEAALRMLMNNLDPDVAEDPQNLIVYGGTGKAARNWQCF
CCCCEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCHHH
DAIVRSLQELNDDETLLVQSGKPVAVFRSHRDAPRVLIANSMLVPHWATWENFRELEQAG
HHHHHHHHHCCCCCEEEEECCCCEEEEECCCCCCEEEEECCEECCCCCCHHHHHHHHHCC
LTMYGQMTAGSWIYIGTQGILQGTYETLAAIARQHFGGSLRGRWTLTAGLGGMGGAQPLA
CEEEEEECCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCEEE
VTMNDGVALVVEVDRQRMQRRLDTRYLDVAVDTLEEAMTLVDEAVRDGKALSVGLLGNAA
EEECCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHH
EVFGELYKRGVRPDIVTDQTSAHDPLEGYVPAGMSLEQALELRQRDPEEYVKHSTASMVE
HHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHH
HVKAMVAFADAGSIVFDYGNNLRGVAKAAGYDRAFAYPGFVPAYIRPLFCEGKGPFRWAA
HHHHHHHHCCCCCEEEECCCCCCHHHHHCCCCCCCCCCCCCHHHHCEEEECCCCCEEEEE
LSGDPADIAKTDEALLELFPEDQALHRWIRAAQERVQFQGLPARICWLGYGERAKAGALF
ECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
NKLVRDGVVSAPIVIGRDHLDCGSVASPNRETEAMRDGSDAIGDWPILNAMINAVNGATW
HHHHHCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHCCCCEE
VSVHHGGGVGIGYSLHAGMVIVADGTAEADHRLERVLTSDPGMGVVRHVDAGYDEAIAVA
EEEECCCCCCCCEEECCCEEEEECCCCHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHH
QERNVHIPMLKQ
HCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA