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The map label for this gene is gmk [H]

Identifier: 159897148

GI number: 159897148

Start: 715409

End: 716041

Strand: Direct

Name: gmk [H]

Synonym: Haur_0619

Alternate gene names: 159897148

Gene position: 715409-716041 (Clockwise)

Preceding gene: 159897146

Following gene: 159897149

Centisome position: 11.27

GC content: 53.08

Gene sequence:

>633_bases
GTGTCACACCCAGAACTCAACCCGATTTTGCACAACCAAGCTCCTGTGCCATTACTGGTCATTATTTCAGGCCCATCAGG
GGTTGGCAAAGATACGGTGTTGATGCGAATGCGCGAATTTGGCATGCCCTTTCATTTTGTGGTCACCACTACCAGCCGTG
GCCAACGCCCAGGTGAATTAGAGGGCTTTGATTATAATTTTGTTTCCAAAGCCGAGTTTGAGACCATGATCGCCCAAAAC
GACCTTTTGGAGCATGCGGTCGTTTATGGCGAATACAAGGGCATTCCCAAATCGCAGGTACGCGATGCCTTGGCGAGCGG
CAAAGATGTAATTTTGCGGATCGATGTGCAGGGCGCGGCCACCATGCGCAAATTAGTGCCCGATGCGGTGTTGATTTTCA
TCGTGCCACCTTCAAGCGCCGAATTGGCCAACCGCTTACGCCTACGCCGCACCGAATCAGCAGAGGGCTTAGAACGGCGC
ATGGCCTTGGCCGAAGAAGAAATGGGTCGCGTCGATGAATTTGATTATGTGGTGATGAACCCCGAATCGCGGCCTGACGA
AGCCGCCAGCATGATTCAAGCGATCATTCGCGCCGAAAAATCACGCATCCGCCCCCGCCGCATTAAACTGTAG

Upstream 100 bases:

>100_bases
CAACTAGCGCATCAATGTGCATAGACGATTCTCCTTCAATGGCTCAATCGTACTCAAGCATTGGCAGAACGTCAATAATT
CCCTTAGTTTAGGAGGCATT

Downstream 100 bases:

>100_bases
CCTCTCAAATGGGCTTAATTGGCCAAAGCATGGCTGATTAAGCCCATTTCCTCAGCATTTTTTCATCAAACGAGTACTTT
CGTGCAAACGAAAAACCCCC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MSHPELNPILHNQAPVPLLVIISGPSGVGKDTVLMRMREFGMPFHFVVTTTSRGQRPGELEGFDYNFVSKAEFETMIAQN
DLLEHAVVYGEYKGIPKSQVRDALASGKDVILRIDVQGAATMRKLVPDAVLIFIVPPSSAELANRLRLRRTESAEGLERR
MALAEEEMGRVDEFDYVVMNPESRPDEAASMIQAIIRAEKSRIRPRRIKL

Sequences:

>Translated_210_residues
MSHPELNPILHNQAPVPLLVIISGPSGVGKDTVLMRMREFGMPFHFVVTTTSRGQRPGELEGFDYNFVSKAEFETMIAQN
DLLEHAVVYGEYKGIPKSQVRDALASGKDVILRIDVQGAATMRKLVPDAVLIFIVPPSSAELANRLRLRRTESAEGLERR
MALAEEEMGRVDEFDYVVMNPESRPDEAASMIQAIIRAEKSRIRPRRIKL
>Mature_209_residues
SHPELNPILHNQAPVPLLVIISGPSGVGKDTVLMRMREFGMPFHFVVTTTSRGQRPGELEGFDYNFVSKAEFETMIAQND
LLEHAVVYGEYKGIPKSQVRDALASGKDVILRIDVQGAATMRKLVPDAVLIFIVPPSSAELANRLRLRRTESAEGLERRM
ALAEEEMGRVDEFDYVVMNPESRPDEAASMIQAIIRAEKSRIRPRRIKL

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874833, Length=168, Percent_Identity=38.0952380952381, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI4504221, Length=168, Percent_Identity=38.0952380952381, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI226874831, Length=168, Percent_Identity=38.0952380952381, Blast_Score=104, Evalue=4e-23,
Organism=Homo sapiens, GI14780902, Length=203, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI38570142, Length=124, Percent_Identity=33.0645161290323, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1790080, Length=188, Percent_Identity=41.4893617021277, Blast_Score=137, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17508835, Length=168, Percent_Identity=37.5, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI193203132, Length=168, Percent_Identity=37.5, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320662, Length=186, Percent_Identity=39.247311827957, Blast_Score=123, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21356141, Length=156, Percent_Identity=38.4615384615385, Blast_Score=103, Evalue=9e-23,
Organism=Drosophila melanogaster, GI45554489, Length=167, Percent_Identity=27.5449101796407, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24640542, Length=167, Percent_Identity=27.5449101796407, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI116007136, Length=167, Percent_Identity=27.5449101796407, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI85724806, Length=167, Percent_Identity=27.5449101796407, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI161077626, Length=167, Percent_Identity=27.5449101796407, Blast_Score=67, Evalue=8e-12,
Organism=Drosophila melanogaster, GI45554481, Length=167, Percent_Identity=27.5449101796407, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 23542; Mature: 23410

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHPELNPILHNQAPVPLLVIISGPSGVGKDTVLMRMREFGMPFHFVVTTTSRGQRPGEL
CCCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCC
EGFDYNFVSKAEFETMIAQNDLLEHAVVYGEYKGIPKSQVRDALASGKDVILRIDVQGAA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEECCCHH
TMRKLVPDAVLIFIVPPSSAELANRLRLRRTESAEGLERRMALAEEEMGRVDEFDYVVMN
HHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEC
PESRPDEAASMIQAIIRAEKSRIRPRRIKL
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SHPELNPILHNQAPVPLLVIISGPSGVGKDTVLMRMREFGMPFHFVVTTTSRGQRPGEL
CCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCC
EGFDYNFVSKAEFETMIAQNDLLEHAVVYGEYKGIPKSQVRDALASGKDVILRIDVQGAA
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEEEEECCCHH
TMRKLVPDAVLIFIVPPSSAELANRLRLRRTESAEGLERRMALAEEEMGRVDEFDYVVMN
HHHHHCCCEEEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEC
PESRPDEAASMIQAIIRAEKSRIRPRRIKL
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA