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The map label for this gene is hrcA

Identifier: 159896970

GI number: 159896970

Start: 513139

End: 514203

Strand: Direct

Name: hrcA

Synonym: Haur_0438

Alternate gene names: 159896970

Gene position: 513139-514203 (Clockwise)

Preceding gene: 159896968

Following gene: 159896971

Centisome position: 8.09

GC content: 53.05

Gene sequence:

>1065_bases
ATGCATCTTGAACTCAATGAGCGGCGACGACGGGTTCTTAAGGCGGTTATTCAACAATACATCGATACGGCAACGCCAGT
AGCCTCGCAAGACCTTGCTAGGAGTTTGGGGGTTAGTTCGGCGACTGTCCGCAACGAAATGGCGGCGTTAGAAGATGCTG
GCCTGTTGACGCATTTGCATACCTCGGCTGGGCGTTTGCCAACTGATGCTGGCTATCGCTTTTTTGTCGAAAATTTGATG
GATCGGGCGGCGCTTTCGACCCAAGAACAGCGCATGATCCAACATCAGTTTTATCAAATCCGCTCGGAATTGAACCAATG
GATTCATTTGGCAGCAGCGGTTTTGGCTCGCACCGCCCAAACGGCGGCGGTGGTTACGCCCCCGCGAGCCTACGAGAGCC
GCTTCAAACATATCGAGTTAATTTCAATCAACGATGCCTTGGTCTTGTTGGTGTTGGTGTTGCACGAAGGCTCGGTCAAG
CAGCAAACGCTGCCTGCCGACCCCAATACGACCCAAGAGCAACTAAGCCGCATCGCCGGACGAATTAATGAGTTGTGTCA
TGAAGCCTCAGCCAAGGCGATTGCCAACATCGCTCACAATCAGTCAACCAACCAGCCGCCGCTTAGCAGTTTTGAAGTGC
TGGTGATCGAGAGCGTGGCGCGGGCCATGCAACAATTCGAGGAGCATGTCAACGAATTAATTCATCACGATGGCCTGCTA
GAGATGTTGCATCAACCAGAATTTGGCCAGGTGACGCGGGTACGCGAGGTGCTTTCGATCCTTGAAGGCGGCACCATGCT
TGAGTCGTTGATTCCCCAAGCCTTGGCTTCGGATGGCGTGCAAGTGATCATCGGTGGTGAACATAGCCGCGATGAACTGC
GCGACTATAGCGTGATTTTGTCGCGTTACGGGGTCAATGGCGATGTTGCTGGTGTGGTAGGGGTTTTAGGGCCGCGTCGC
ATGGCCTATCCACGTTCCATCTCCAGCGTGCGTTATATTGCTGGCGTGATGAGCGATTTGATGGGCGATTTATATGGCGA
ACGCAAAATAGAACCATCAGAATAG

Upstream 100 bases:

>100_bases
GCGGCGTGTTACAATATTCAGCGGCGTGCGGCGAGCACGCCACTCTTATAACTTACCGAGTTAGCACTCCTCGGCCAAGA
GTGCTAAAGCGAGGTGAGCG

Downstream 100 bases:

>100_bases
TGCTAGACGCTAGGCTGTGATCATACAAGTTTGATCTTTACGGAGGTACGGAGTTCTCATGACGGAAGAAGTGCAAGCAC
AATCAACTGACGATACCAAT

Product: heat-inducible transcription repressor HrcA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MHLELNERRRRVLKAVIQQYIDTATPVASQDLARSLGVSSATVRNEMAALEDAGLLTHLHTSAGRLPTDAGYRFFVENLM
DRAALSTQEQRMIQHQFYQIRSELNQWIHLAAAVLARTAQTAAVVTPPRAYESRFKHIELISINDALVLLVLVLHEGSVK
QQTLPADPNTTQEQLSRIAGRINELCHEASAKAIANIAHNQSTNQPPLSSFEVLVIESVARAMQQFEEHVNELIHHDGLL
EMLHQPEFGQVTRVREVLSILEGGTMLESLIPQALASDGVQVIIGGEHSRDELRDYSVILSRYGVNGDVAGVVGVLGPRR
MAYPRSISSVRYIAGVMSDLMGDLYGERKIEPSE

Sequences:

>Translated_354_residues
MHLELNERRRRVLKAVIQQYIDTATPVASQDLARSLGVSSATVRNEMAALEDAGLLTHLHTSAGRLPTDAGYRFFVENLM
DRAALSTQEQRMIQHQFYQIRSELNQWIHLAAAVLARTAQTAAVVTPPRAYESRFKHIELISINDALVLLVLVLHEGSVK
QQTLPADPNTTQEQLSRIAGRINELCHEASAKAIANIAHNQSTNQPPLSSFEVLVIESVARAMQQFEEHVNELIHHDGLL
EMLHQPEFGQVTRVREVLSILEGGTMLESLIPQALASDGVQVIIGGEHSRDELRDYSVILSRYGVNGDVAGVVGVLGPRR
MAYPRSISSVRYIAGVMSDLMGDLYGERKIEPSE
>Mature_354_residues
MHLELNERRRRVLKAVIQQYIDTATPVASQDLARSLGVSSATVRNEMAALEDAGLLTHLHTSAGRLPTDAGYRFFVENLM
DRAALSTQEQRMIQHQFYQIRSELNQWIHLAAAVLARTAQTAAVVTPPRAYESRFKHIELISINDALVLLVLVLHEGSVK
QQTLPADPNTTQEQLSRIAGRINELCHEASAKAIANIAHNQSTNQPPLSSFEVLVIESVARAMQQFEEHVNELIHHDGLL
EMLHQPEFGQVTRVREVLSILEGGTMLESLIPQALASDGVQVIIGGEHSRDELRDYSVILSRYGVNGDVAGVVGVLGPRR
MAYPRSISSVRYIAGVMSDLMGDLYGERKIEPSE

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_HERA2 (A9AUH0)

Other databases:

- EMBL:   CP000875
- RefSeq:   YP_001543217.1
- GeneID:   5732337
- GenomeReviews:   CP000875_GR
- KEGG:   hau:Haur_0438
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   CLSK935568
- BioCyc:   HAUR316274:HAUR_0438-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR013196
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA; PF08279 HTH_11

EC number: NA

Molecular weight: Translated: 39218; Mature: 39218

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLELNERRRRVLKAVIQQYIDTATPVASQDLARSLGVSSATVRNEMAALEDAGLLTHLH
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
TSAGRLPTDAGYRFFVENLMDRAALSTQEQRMIQHQFYQIRSELNQWIHLAAAVLARTAQ
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAAVVTPPRAYESRFKHIELISINDALVLLVLVLHEGSVKQQTLPADPNTTQEQLSRIAG
HHEEECCCHHHHHHCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
RINELCHEASAKAIANIAHNQSTNQPPLSSFEVLVIESVARAMQQFEEHVNELIHHDGLL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
EMLHQPEFGQVTRVREVLSILEGGTMLESLIPQALASDGVQVIIGGEHSRDELRDYSVIL
HHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHH
SRYGVNGDVAGVVGVLGPRRMAYPRSISSVRYIAGVMSDLMGDLYGERKIEPSE
HHHCCCCCHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MHLELNERRRRVLKAVIQQYIDTATPVASQDLARSLGVSSATVRNEMAALEDAGLLTHLH
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
TSAGRLPTDAGYRFFVENLMDRAALSTQEQRMIQHQFYQIRSELNQWIHLAAAVLARTAQ
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAAVVTPPRAYESRFKHIELISINDALVLLVLVLHEGSVKQQTLPADPNTTQEQLSRIAG
HHEEECCCHHHHHHCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHH
RINELCHEASAKAIANIAHNQSTNQPPLSSFEVLVIESVARAMQQFEEHVNELIHHDGLL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
EMLHQPEFGQVTRVREVLSILEGGTMLESLIPQALASDGVQVIIGGEHSRDELRDYSVIL
HHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHH
SRYGVNGDVAGVVGVLGPRRMAYPRSISSVRYIAGVMSDLMGDLYGERKIEPSE
HHHCCCCCHHHHHHHCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA