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The map label for this gene is yclK [H]

Identifier: 159896930

GI number: 159896930

Start: 467496

End: 468890

Strand: Direct

Name: yclK [H]

Synonym: Haur_0398

Alternate gene names: 159896930

Gene position: 467496-468890 (Clockwise)

Preceding gene: 159896925

Following gene: 159896931

Centisome position: 7.37

GC content: 52.11

Gene sequence:

>1395_bases
ATGAAGAAATTTAAACGCCCAAAAATTGTAACGCTGGCGGTACGATTGACTATCACCATGGTCGCGGTGAGTGTCGTGCC
GTTGGCATTAATTGCATTAATCATTCTGCTGGGAGTACGCATTAGCGAAGCTGATCGTCGCAGCCTAGAATTGAACAATC
AGCTTGAATTATATGTGGCTTTTGCTGAGCAACTGATTGCCAGCGATGGCGATTTGCAATCAGCCAGCAATATTTTGTTG
AGTCGGCCAGTTGGTAGTGGTGATGGTGCGATTCGGGTGTTTGGCAGTGCTGGCCAGATTTTTGGAGCCAATGGCTCAAA
CTCGGCTTTTCCCAGCCGTGCTGCAGCCAGCCAATTTGTGACCAGCATTCCAACCGTGTTTGTGGCCGAGACCCGTGGTC
GGCGTTATGTGGCTGGTCAAGTGCGTTGGCAGCAAAAAGTTGTGGGGGTGATTGAGGTTTCACAAAGCGTCGAAGACGAA
GATCGCTTATTGCGGGTGTTGATACGTTTTGTGTTTATCTCGATTGGTTTGGCTTTTGCGGCAGCCTTTTTAGGCTCTTC
GTTGGTCGCTCGTTGGTTGGCTCGCATGATTGGCCAATTGCGTGAAACAGCTGAGCAAGTGGCCGATGGCGATTTGACTG
AACGAGCGCTTGAACGCGGCCCCGCCGAATTTGTGCAATTGGCACGTTCAATCAACACCATGACCGACCAATTAGCCGAG
CGGTTATCGCGGATCGAGCAGCAATCTGAGGCTCAGCGGCGTTTTTATCGTGATGTTTCGCATGAATTGCGCACGCCCAT
GATGGCTTTGGGTGGCTACTTGGAAAATATCGAGGATGCCGAGAACGCCGATGAACAAGCTCAATCGATTCGCGCAATGC
AAGCCGAAATTGCCCGTTTGGCCCGTTTAGCTGATGAACTTTTGCGCAGCGATGCCCAACCAAGCCTGACGCTTGGCCCC
AAACAAACCCTTGATCTTGGCGCGATGATTCACGAATTGGTGCAGAATTTGAGTGGGCGGGCGCAACGGAGCGGGGTTGA
ATTATTGGCCCAAGTTCCGCCACGCCCAATTGTGGTCGAGGCTGATCATGACCGTTTAAAGCAGGCTTTATTAAATTTGT
TTGATAATGCTTTGCGAGCTACCCCACCTAGCGGCCAAATTAGCATGCGCGTTAGTTTGACCGCCGAGCAAGTGGTGATT
GATGTGCAAGATACTGGCGAAGGGATTCCGCCTGCCTTGCGCGAGGCGATTTGGGAGCGGGGCGTGCGTGGTGCTGAAGG
TGGCTCAGGCTTAGGCTTAGCCATTGTCCGCACGATTTTGCGTGCTCATGGCGGCGAAGCTGCGCTAATTCCCAGCGAGC
AAGGTGCCCATATTCAGTTACGCCTGCCAATCTAA

Upstream 100 bases:

>100_bases
TACATCAGGGTTAATTATCAGGTTTCACACAATGGGAGATTTTTTCTCAAAAGCGATTATATCATGCCATGCAAGTGGCT
AGCTATGCGATAATACAGCT

Downstream 100 bases:

>100_bases
TGCTTTGGATACACAACCTTGATGTCATCAGTGTCCAGCCAAATAGCTCGAGTGAACCAAATAAGCGCTAAGCATGCTGA
CAGATATCAGCCATAAATCA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MKKFKRPKIVTLAVRLTITMVAVSVVPLALIALIILLGVRISEADRRSLELNNQLELYVAFAEQLIASDGDLQSASNILL
SRPVGSGDGAIRVFGSAGQIFGANGSNSAFPSRAAASQFVTSIPTVFVAETRGRRYVAGQVRWQQKVVGVIEVSQSVEDE
DRLLRVLIRFVFISIGLAFAAAFLGSSLVARWLARMIGQLRETAEQVADGDLTERALERGPAEFVQLARSINTMTDQLAE
RLSRIEQQSEAQRRFYRDVSHELRTPMMALGGYLENIEDAENADEQAQSIRAMQAEIARLARLADELLRSDAQPSLTLGP
KQTLDLGAMIHELVQNLSGRAQRSGVELLAQVPPRPIVVEADHDRLKQALLNLFDNALRATPPSGQISMRVSLTAEQVVI
DVQDTGEGIPPALREAIWERGVRGAEGGSGLGLAIVRTILRAHGGEAALIPSEQGAHIQLRLPI

Sequences:

>Translated_464_residues
MKKFKRPKIVTLAVRLTITMVAVSVVPLALIALIILLGVRISEADRRSLELNNQLELYVAFAEQLIASDGDLQSASNILL
SRPVGSGDGAIRVFGSAGQIFGANGSNSAFPSRAAASQFVTSIPTVFVAETRGRRYVAGQVRWQQKVVGVIEVSQSVEDE
DRLLRVLIRFVFISIGLAFAAAFLGSSLVARWLARMIGQLRETAEQVADGDLTERALERGPAEFVQLARSINTMTDQLAE
RLSRIEQQSEAQRRFYRDVSHELRTPMMALGGYLENIEDAENADEQAQSIRAMQAEIARLARLADELLRSDAQPSLTLGP
KQTLDLGAMIHELVQNLSGRAQRSGVELLAQVPPRPIVVEADHDRLKQALLNLFDNALRATPPSGQISMRVSLTAEQVVI
DVQDTGEGIPPALREAIWERGVRGAEGGSGLGLAIVRTILRAHGGEAALIPSEQGAHIQLRLPI
>Mature_464_residues
MKKFKRPKIVTLAVRLTITMVAVSVVPLALIALIILLGVRISEADRRSLELNNQLELYVAFAEQLIASDGDLQSASNILL
SRPVGSGDGAIRVFGSAGQIFGANGSNSAFPSRAAASQFVTSIPTVFVAETRGRRYVAGQVRWQQKVVGVIEVSQSVEDE
DRLLRVLIRFVFISIGLAFAAAFLGSSLVARWLARMIGQLRETAEQVADGDLTERALERGPAEFVQLARSINTMTDQLAE
RLSRIEQQSEAQRRFYRDVSHELRTPMMALGGYLENIEDAENADEQAQSIRAMQAEIARLARLADELLRSDAQPSLTLGP
KQTLDLGAMIHELVQNLSGRAQRSGVELLAQVPPRPIVVEADHDRLKQALLNLFDNALRATPPSGQISMRVSLTAEQVVI
DVQDTGEGIPPALREAIWERGVRGAEGGSGLGLAIVRTILRAHGGEAALIPSEQGAHIQLRLPI

Specific function: Could be member of the two-component regulatory system yclK/yclJ. Potentially phosphorylates yclJ [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=277, Percent_Identity=31.4079422382672, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1790346, Length=259, Percent_Identity=30.1158301158301, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790436, Length=208, Percent_Identity=33.6538461538462, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1790861, Length=325, Percent_Identity=27.6923076923077, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786783, Length=262, Percent_Identity=29.3893129770992, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1786600, Length=220, Percent_Identity=31.3636363636364, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87082128, Length=256, Percent_Identity=29.296875, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI87081816, Length=229, Percent_Identity=30.1310043668122, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI48994928, Length=231, Percent_Identity=29.004329004329, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1790300, Length=229, Percent_Identity=30.1310043668122, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1787894, Length=299, Percent_Identity=29.0969899665552, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI145693157, Length=242, Percent_Identity=28.099173553719, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1788549, Length=209, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786912, Length=248, Percent_Identity=27.4193548387097, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1789808, Length=332, Percent_Identity=25.9036144578313, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787374, Length=226, Percent_Identity=26.5486725663717, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1789403, Length=241, Percent_Identity=29.045643153527, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1788279, Length=250, Percent_Identity=26, Blast_Score=65, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50447; Mature: 50447

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKFKRPKIVTLAVRLTITMVAVSVVPLALIALIILLGVRISEADRRSLELNNQLELYVA
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHH
FAEQLIASDGDLQSASNILLSRPVGSGDGAIRVFGSAGQIFGANGSNSAFPSRAAASQFV
HHHHHHHCCCCHHHHHHHHEECCCCCCCCCEEEEECCCCEECCCCCCCCCCCHHHHHHHH
TSIPTVFVAETRGRRYVAGQVRWQQKVVGVIEVSQSVEDEDRLLRVLIRFVFISIGLAFA
HHCCCEEEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
AAFLGSSLVARWLARMIGQLRETAEQVADGDLTERALERGPAEFVQLARSINTMTDQLAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
RLSRIEQQSEAQRRFYRDVSHELRTPMMALGGYLENIEDAENADEQAQSIRAMQAEIARL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ARLADELLRSDAQPSLTLGPKQTLDLGAMIHELVQNLSGRAQRSGVELLAQVPPRPIVVE
HHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEE
ADHDRLKQALLNLFDNALRATPPSGQISMRVSLTAEQVVIDVQDTGEGIPPALREAIWER
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEHEEEEECCCCCCCCHHHHHHHHHC
GVRGAEGGSGLGLAIVRTILRAHGGEAALIPSEQGAHIQLRLPI
CCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCEEEEEECC
>Mature Secondary Structure
MKKFKRPKIVTLAVRLTITMVAVSVVPLALIALIILLGVRISEADRRSLELNNQLELYVA
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCHHHHHHH
FAEQLIASDGDLQSASNILLSRPVGSGDGAIRVFGSAGQIFGANGSNSAFPSRAAASQFV
HHHHHHHCCCCHHHHHHHHEECCCCCCCCCEEEEECCCCEECCCCCCCCCCCHHHHHHHH
TSIPTVFVAETRGRRYVAGQVRWQQKVVGVIEVSQSVEDEDRLLRVLIRFVFISIGLAFA
HHCCCEEEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
AAFLGSSLVARWLARMIGQLRETAEQVADGDLTERALERGPAEFVQLARSINTMTDQLAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
RLSRIEQQSEAQRRFYRDVSHELRTPMMALGGYLENIEDAENADEQAQSIRAMQAEIARL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ARLADELLRSDAQPSLTLGPKQTLDLGAMIHELVQNLSGRAQRSGVELLAQVPPRPIVVE
HHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEE
ADHDRLKQALLNLFDNALRATPPSGQISMRVSLTAEQVVIDVQDTGEGIPPALREAIWER
CCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEHEEEEECCCCCCCCHHHHHHHHHC
GVRGAEGGSGLGLAIVRTILRAHGGEAALIPSEQGAHIQLRLPI
CCCCCCCCCCCHHHHHHHHHHHCCCCEEECCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]