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The map label for this gene is hmrR [H]

Identifier: 159046604

GI number: 159046604

Start: 125896

End: 126294

Strand: Direct

Name: hmrR [H]

Synonym: Dshi_4066

Alternate gene names: 159046604

Gene position: 125896-126294 (Clockwise)

Preceding gene: 159046603

Following gene: NA

Centisome position: 99.68

GC content: 59.65

Gene sequence:

>399_bases
ATGAACATCGGAGACGTTGCCCGACAATCGGGTGTGCCCCCAAAAACAATCCGCTACTACGAGGACATCGGGCTGATCCG
CCCGAACCGTAGCGAGAACGGCTACCGCGCGTTCACCGAGAGCCACATTCACAAGCTGGCGTTTCTGGGTCGCGCACGGG
CCTTGGGGTTCACCATCGAAGATTGCAGGACGCTCCTGTCGCTCTACGAGGATGAAAACCGCGAAAGCATGCAAGTGAAG
GCGGTTGCGGAAGACCATCTGCGCCAGATCGAGGAAAAGATCGCGAAACTGCAATCCATGCGCGCGACGCTCGCCGAACT
GGTGGAAAAATGTGCCGGGGATCACCGGCCCGACTGCCCCATCATCGAGGATCTGTCGCCGGAGCGGTTGGCCAAGTGA

Upstream 100 bases:

>100_bases
GCGGCTGCGGCGCATCGCGCCTGCGATGGACGAGCAGCGCGCAATCCCGGCAGAGCTGGCAGCCGCCACTCCTGCTCCAG
CAGAATAACGGAGGTTCGAC

Downstream 100 bases:

>100_bases
CAGGCAAGAAGGGGCTGTACCTCAGAACCAGATCGCGCGGACCGGCATCCAGATACCCATGAAGATCATCATCAGGTTTT
CCGTCAGCGAAATGAACCCC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 132; Mature: 132

Protein sequence:

>132_residues
MNIGDVARQSGVPPKTIRYYEDIGLIRPNRSENGYRAFTESHIHKLAFLGRARALGFTIEDCRTLLSLYEDENRESMQVK
AVAEDHLRQIEEKIAKLQSMRATLAELVEKCAGDHRPDCPIIEDLSPERLAK

Sequences:

>Translated_132_residues
MNIGDVARQSGVPPKTIRYYEDIGLIRPNRSENGYRAFTESHIHKLAFLGRARALGFTIEDCRTLLSLYEDENRESMQVK
AVAEDHLRQIEEKIAKLQSMRATLAELVEKCAGDHRPDCPIIEDLSPERLAK
>Mature_132_residues
MNIGDVARQSGVPPKTIRYYEDIGLIRPNRSENGYRAFTESHIHKLAFLGRARALGFTIEDCRTLLSLYEDENRESMQVK
AVAEDHLRQIEEKIAKLQSMRATLAELVEKCAGDHRPDCPIIEDLSPERLAK

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=127, Percent_Identity=46.4566929133858, Blast_Score=117, Evalue=3e-28,
Organism=Escherichia coli, GI1789687, Length=127, Percent_Identity=38.5826771653543, Blast_Score=89, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15037; Mature: 15037

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIGDVARQSGVPPKTIRYYEDIGLIRPNRSENGYRAFTESHIHKLAFLGRARALGFTIE
CCHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
DCRTLLSLYEDENRESMQVKAVAEDHLRQIEEKIAKLQSMRATLAELVEKCAGDHRPDCP
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
IIEDLSPERLAK
CCCCCCHHHHCC
>Mature Secondary Structure
MNIGDVARQSGVPPKTIRYYEDIGLIRPNRSENGYRAFTESHIHKLAFLGRARALGFTIE
CCHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
DCRTLLSLYEDENRESMQVKAVAEDHLRQIEEKIAKLQSMRATLAELVEKCAGDHRPDCP
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
IIEDLSPERLAK
CCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]