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The map label for this gene is nhaA2 [H]

Identifier: 159046601

GI number: 159046601

Start: 122245

End: 122976

Strand: Direct

Name: nhaA2 [H]

Synonym: Dshi_4063

Alternate gene names: 159046601

Gene position: 122245-122976 (Clockwise)

Preceding gene: 159046600

Following gene: 159046603

Centisome position: 96.79

GC content: 59.56

Gene sequence:

>732_bases
ATGCGTTTCAGACAAGCCTTCACGACGGTCGCGATAGCTGCCTTGCTTCCGATACCGGCACTCGCGGACGAACTGTCAGA
GTCCCGGGTCAAGGAACTTGTGCTCGAGGCAATCCGCGAGAACCCGGAGATTGTCATGGAGGCCGTGGCGATCCTCGAAC
AAAGGCAGGCGCAAGCGCAGGAGCTCAGTCAGGCCCAAGTTCTGAATGACCAGCGCGATCTGATCGAGAACGATCCGAAT
GCGCCGGTTCTCGGCAACCTGGAAGGGGACGTCACTGTTGTGGAATTTTTCGACTACAACTGTCCCTATTGTCGGCGGGT
CAAACCCGAGGTGCGGGCTTTGATCGAAGACGATCCCAACATTCGCCTCGTCTATCGTGAATGGCCCATTCTCGGAGACG
GATCGGTGTTTGCCGCGAAAGCGGCCTTGGCAGCGCGCAAGCAGGACAAATACGAAGAGTTTCACTGGGCAATGATGGGG
CTGGAAGGCCGCGCGGAAGAGGCCTCCGTGCTGCGCGTGGCCGAGGAGATCGGCCTGGATATCGCGCAGTTGCGCAAGGA
CATGGAGGCCCCCGAGGTCGAAGAGCACATTGCGACCTCCATGCAACTGACCCAAGCTCTGGGCTTTAACGGCACGCCGT
CTTTCGTGATCGGGGATGCGCTGGTCCCGGGCTTCGTCGAAAAGGCGCAGCTTGCCGACTTGGTCGAGGAAGCCCGCAAA
GTCGAAGACTGA

Upstream 100 bases:

>100_bases
CACAACATCCTGGCCTTCATCCGGTCCACCTGGCCAGACCGCATCCGCGAAGTCCAGGCCGCGCGGACAGAAGCCGACGA
ACAACGGGGAGAGAACTAAA

Downstream 100 bases:

>100_bases
AATTCTGTGCCCGGACCACCCTTGGGTGGTCCAGGCACTGCATCAAGCGGCCGCAGGTTCCACGTTGTAGCCCGCATCCC
GAATGATCGCTTGGACCTGA

Product: DSBA oxidoreductase

Products: NA

Alternate protein names: Sodium/proton antiporter nhaA 2 [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MRFRQAFTTVAIAALLPIPALADELSESRVKELVLEAIRENPEIVMEAVAILEQRQAQAQELSQAQVLNDQRDLIENDPN
APVLGNLEGDVTVVEFFDYNCPYCRRVKPEVRALIEDDPNIRLVYREWPILGDGSVFAAKAALAARKQDKYEEFHWAMMG
LEGRAEEASVLRVAEEIGLDIAQLRKDMEAPEVEEHIATSMQLTQALGFNGTPSFVIGDALVPGFVEKAQLADLVEEARK
VED

Sequences:

>Translated_243_residues
MRFRQAFTTVAIAALLPIPALADELSESRVKELVLEAIRENPEIVMEAVAILEQRQAQAQELSQAQVLNDQRDLIENDPN
APVLGNLEGDVTVVEFFDYNCPYCRRVKPEVRALIEDDPNIRLVYREWPILGDGSVFAAKAALAARKQDKYEEFHWAMMG
LEGRAEEASVLRVAEEIGLDIAQLRKDMEAPEVEEHIATSMQLTQALGFNGTPSFVIGDALVPGFVEKAQLADLVEEARK
VED
>Mature_243_residues
MRFRQAFTTVAIAALLPIPALADELSESRVKELVLEAIRENPEIVMEAVAILEQRQAQAQELSQAQVLNDQRDLIENDPN
APVLGNLEGDVTVVEFFDYNCPYCRRVKPEVRALIEDDPNIRLVYREWPILGDGSVFAAKAALAARKQDKYEEFHWAMMG
LEGRAEEASVLRVAEEIGLDIAQLRKDMEAPEVEEHIATSMQLTQALGFNGTPSFVIGDALVPGFVEKAQLADLVEEARK
VED

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG1651

COG function: function code O; Protein-disulfide isomerase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001853
- InterPro:   IPR023171
- InterPro:   IPR004670
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01323 DSBA; PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 27103; Mature: 27103

Theoretical pI: Translated: 4.18; Mature: 4.18

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFRQAFTTVAIAALLPIPALADELSESRVKELVLEAIRENPEIVMEAVAILEQRQAQAQ
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
ELSQAQVLNDQRDLIENDPNAPVLGNLEGDVTVVEFFDYNCPYCRRVKPEVRALIEDDPN
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEEEECCCCCHHHCCCHHHHHHHCCCCC
IRLVYREWPILGDGSVFAAKAALAARKQDKYEEFHWAMMGLEGRAEEASVLRVAEEIGLD
EEEEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
IAQLRKDMEAPEVEEHIATSMQLTQALGFNGTPSFVIGDALVPGFVEKAQLADLVEEARK
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHH
VED
CCC
>Mature Secondary Structure
MRFRQAFTTVAIAALLPIPALADELSESRVKELVLEAIRENPEIVMEAVAILEQRQAQAQ
CCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
ELSQAQVLNDQRDLIENDPNAPVLGNLEGDVTVVEFFDYNCPYCRRVKPEVRALIEDDPN
HHHHHHHHHHHHHHHCCCCCCCEEECCCCCEEEEEEECCCCCHHHCCCHHHHHHHCCCCC
IRLVYREWPILGDGSVFAAKAALAARKQDKYEEFHWAMMGLEGRAEEASVLRVAEEIGLD
EEEEEEECCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCC
IAQLRKDMEAPEVEEHIATSMQLTQALGFNGTPSFVIGDALVPGFVEKAQLADLVEEARK
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHHHHHHHHH
VED
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]